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Conserved domains on  [gi|387177|gb|AAA37726|]
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glycerol-3-phosphate dehydrogenase, partial [Mus musculus]

Protein Classification

glycerol-3-phosphate dehydrogenase family protein( domain architecture ID 11496765)

glycerol-3-phosphate dehydrogenase family protein is similar to human L-alpha-glycerol-3-phosphate dehydrogenase 1 (GPD1), which catalyzes the reversible biological conversion of dihydroxyacetone (DHAP) to glycerol-3-phosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 5-342 0e+00

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


:

Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 543.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177       5 KVCIVGSGNWGSAIAKIVGSNAGRLAH-FDPRVTMWVFEEDIGGRKLTEIINTQHENVKYLPGHKLPPNVVAIPDVVQAA 83
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALPElFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLVAVPDLVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177      84 TGADILVFVVPHQFIGKICDQLKGHLKANTIGISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVAEEKFCE 163
Cdd:TIGR03376  81 KGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEVSKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177     164 TTIGCKDPAQ----GQLLKDLMQTPNFRITVVQEVDTVEICGALKNIVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFA 239
Cdd:TIGR03376 161 TTVGYRDPADfdvdARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKFA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177     240 KLFCSGIVSSATFlESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKEMLNGQKLQGPQTARELHSILQHKGLVDKF 319
Cdd:TIGR03376 241 RMFFPTGEVTFTF-ESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDEF 319

                         330       340
                  ....*....|....*....|...
gi 387177     320 PLFTAVYKVCYEGQPVGEFIRCL 342
Cdd:TIGR03376 320 PLFEAVYQILYEGLPPKKLPECL 342
 
Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 5-342 0e+00

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 543.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177       5 KVCIVGSGNWGSAIAKIVGSNAGRLAH-FDPRVTMWVFEEDIGGRKLTEIINTQHENVKYLPGHKLPPNVVAIPDVVQAA 83
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALPElFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLVAVPDLVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177      84 TGADILVFVVPHQFIGKICDQLKGHLKANTIGISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVAEEKFCE 163
Cdd:TIGR03376  81 KGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEVSKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177     164 TTIGCKDPAQ----GQLLKDLMQTPNFRITVVQEVDTVEICGALKNIVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFA 239
Cdd:TIGR03376 161 TTVGYRDPADfdvdARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKFA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177     240 KLFCSGIVSSATFlESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKEMLNGQKLQGPQTARELHSILQHKGLVDKF 319
Cdd:TIGR03376 241 RMFFPTGEVTFTF-ESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDEF 319

                         330       340
                  ....*....|....*....|...
gi 387177     320 PLFTAVYKVCYEGQPVGEFIRCL 342
Cdd:TIGR03376 320 PLFEAVYQILYEGLPPKKLPECL 342
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 1-344 3.92e-159

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 449.86  E-value: 3.92e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177      1 MAGKKVCIVGSGNWGSAIAKIVGSNAGRLAHFDPRVTMWVFEEDIGGRKLTEIINTQHENVKYLPGHKLPPNVVAIPDVV 80
Cdd:PTZ00345   9 CGPLKVSVIGSGNWGSAISKVVGENTQRNYIFHNEVRMWVLEEIVEGEKLSDIINTKHENVKYLPGIKLPDNIVAVSDLK 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177     81 QAATGADILVFVVPHQFIGKICDQLK--GHLKANTIGISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVAE 158
Cdd:PTZ00345  89 EAVEDADLLIFVIPHQFLESVLSQIKenNNLKKHARAISLTKGIIVENGKPVLCSDVIEEELGIPCCALSGANVANDVAR 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177    159 EKFCETTIGCKDPAQGQLLKDLMQTPNFRITVVQEVDTVEICGALKNIVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAF 238
Cdd:PTZ00345 169 EEFSEATIGCEDKDDALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTNTKSAIIRIGLEEMKLF 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177    239 AKLFCSGIVSSaTFLESCGVADLITTCYGGRNRKVAEAFARTG--KSIEQLEKEMLNGQKLQGPQTARELHSILQHKGLV 316
Cdd:PTZ00345 249 GKIFFPNVMDE-TFFESCGLADLITTCLGGRNVRCAAEFAKRNgkKSWEEIEAELLNGQKLQGTVTLKEVYEVLESHDLK 327

                        330       340
                 ....*....|....*....|....*...
gi 387177    317 DKFPLFTAVYKVCYEGQPVGEFIRCLQN 344
Cdd:PTZ00345 328 KEFPLFTVTYKIAFEGADPSSLIDVLST 355
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 4-342 4.56e-96

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 288.09  E-value: 4.56e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177     4 KKVCIVGSGNWGSAIAKIVGSNaGRlahfdpRVTMWVFEEDIggrklTEIINTQHENVKYLPGHKLPPNVVAIPDVVQAA 83
Cdd:COG0240   1 MKIAVLGAGSWGTALAKVLARN-GH------EVTLWGRDPEV-----AEEINETRENPRYLPGVKLPENLRATSDLEEAL 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177    84 TGADILVFVVPHQFIGKICDQLKGHLKANTIGISLIKGVDegPNGLKLISEVIGERLG--IPMSVLMGANIASEVAEEKF 161
Cdd:COG0240  69 AGADLVLLAVPSQALREVLEQLAPLLPPGAPVVSATKGIE--PGTGLLMSEVIAEELPgaLRIAVLSGPSFAEEVARGLP 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177   162 CETTIGCKDPAQGQLLKDLMQTPNFRITVVQEVDTVEICGALKNIVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKL 241
Cdd:COG0240 147 TAVVVASEDEEVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVA 226

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177   242 FcsGIvSSATFLESCGVADLITTCYG--GRNRKVAEAFARtGKSIEQLEKEMlnGQKLQGPQTARELHSILQHKGlVDkF 319
Cdd:COG0240 227 L--GA-RPETFMGLAGLGDLVLTCTSdlSRNRRFGLALGK-GKSLEEALAEM--GMVAEGVYTAKAVYELAEKLG-VE-M 298

                       330       340
                ....*....|....*....|...
gi 387177   320 PLFTAVYKVCYEGQPVGEFIRCL 342
Cdd:COG0240 299 PITEAVYAVLYEGKSPREAVEAL 321
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
 5-172 2.02e-66

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 206.27  E-value: 2.02e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177       5 KVCIVGSGNWGSAIAKIVGSNAgrlahfdPRVTMWVFEEDiggrkLTEIINTQHENVKYLPGHKLPPNVVAIPDVVQAAT 84
Cdd:pfam01210   1 KIAVLGAGSWGTALAKVLADNG-------HEVRLWGRDEE-----LIEEINTTHENVRYLPGIKLPENLKATTDLAEALK 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177      85 GADILVFVVPHQFIGKICDQLKGHLKANTIGISLIKGVDEGpnGLKLISEVIGERLGI--PMSVLMGANIASEVAEEKFC 162
Cdd:pfam01210  69 GADIIVIVVPSQALREVLKQLKGLLKPDAILVSLSKGIEPG--TLKLLSEVIEEELGIqpPIAVLSGPSHAEEVAQGLPT 146

                         170
                  ....*....|
gi 387177     163 ETTIGCKDPA 172
Cdd:pfam01210 147 ATVIASKDEE 156
 
Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 5-342 0e+00

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 543.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177       5 KVCIVGSGNWGSAIAKIVGSNAGRLAH-FDPRVTMWVFEEDIGGRKLTEIINTQHENVKYLPGHKLPPNVVAIPDVVQAA 83
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALPElFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLVAVPDLVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177      84 TGADILVFVVPHQFIGKICDQLKGHLKANTIGISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVAEEKFCE 163
Cdd:TIGR03376  81 KGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEVSKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177     164 TTIGCKDPAQ----GQLLKDLMQTPNFRITVVQEVDTVEICGALKNIVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFA 239
Cdd:TIGR03376 161 TTVGYRDPADfdvdARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKFA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177     240 KLFCSGIVSSATFlESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKEMLNGQKLQGPQTARELHSILQHKGLVDKF 319
Cdd:TIGR03376 241 RMFFPTGEVTFTF-ESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDEF 319

                         330       340
                  ....*....|....*....|...
gi 387177     320 PLFTAVYKVCYEGQPVGEFIRCL 342
Cdd:TIGR03376 320 PLFEAVYQILYEGLPPKKLPECL 342
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 1-344 3.92e-159

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 449.86  E-value: 3.92e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177      1 MAGKKVCIVGSGNWGSAIAKIVGSNAGRLAHFDPRVTMWVFEEDIGGRKLTEIINTQHENVKYLPGHKLPPNVVAIPDVV 80
Cdd:PTZ00345   9 CGPLKVSVIGSGNWGSAISKVVGENTQRNYIFHNEVRMWVLEEIVEGEKLSDIINTKHENVKYLPGIKLPDNIVAVSDLK 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177     81 QAATGADILVFVVPHQFIGKICDQLK--GHLKANTIGISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVAE 158
Cdd:PTZ00345  89 EAVEDADLLIFVIPHQFLESVLSQIKenNNLKKHARAISLTKGIIVENGKPVLCSDVIEEELGIPCCALSGANVANDVAR 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177    159 EKFCETTIGCKDPAQGQLLKDLMQTPNFRITVVQEVDTVEICGALKNIVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAF 238
Cdd:PTZ00345 169 EEFSEATIGCEDKDDALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTNTKSAIIRIGLEEMKLF 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177    239 AKLFCSGIVSSaTFLESCGVADLITTCYGGRNRKVAEAFARTG--KSIEQLEKEMLNGQKLQGPQTARELHSILQHKGLV 316
Cdd:PTZ00345 249 GKIFFPNVMDE-TFFESCGLADLITTCLGGRNVRCAAEFAKRNgkKSWEEIEAELLNGQKLQGTVTLKEVYEVLESHDLK 327

                        330       340
                 ....*....|....*....|....*...
gi 387177    317 DKFPLFTAVYKVCYEGQPVGEFIRCLQN 344
Cdd:PTZ00345 328 KEFPLFTVTYKIAFEGADPSSLIDVLST 355
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 4-342 4.56e-96

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 288.09  E-value: 4.56e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177     4 KKVCIVGSGNWGSAIAKIVGSNaGRlahfdpRVTMWVFEEDIggrklTEIINTQHENVKYLPGHKLPPNVVAIPDVVQAA 83
Cdd:COG0240   1 MKIAVLGAGSWGTALAKVLARN-GH------EVTLWGRDPEV-----AEEINETRENPRYLPGVKLPENLRATSDLEEAL 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177    84 TGADILVFVVPHQFIGKICDQLKGHLKANTIGISLIKGVDegPNGLKLISEVIGERLG--IPMSVLMGANIASEVAEEKF 161
Cdd:COG0240  69 AGADLVLLAVPSQALREVLEQLAPLLPPGAPVVSATKGIE--PGTGLLMSEVIAEELPgaLRIAVLSGPSFAEEVARGLP 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177   162 CETTIGCKDPAQGQLLKDLMQTPNFRITVVQEVDTVEICGALKNIVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKL 241
Cdd:COG0240 147 TAVVVASEDEEVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVA 226

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177   242 FcsGIvSSATFLESCGVADLITTCYG--GRNRKVAEAFARtGKSIEQLEKEMlnGQKLQGPQTARELHSILQHKGlVDkF 319
Cdd:COG0240 227 L--GA-RPETFMGLAGLGDLVLTCTSdlSRNRRFGLALGK-GKSLEEALAEM--GMVAEGVYTAKAVYELAEKLG-VE-M 298

                       330       340
                ....*....|....*....|...
gi 387177   320 PLFTAVYKVCYEGQPVGEFIRCL 342
Cdd:COG0240 299 PITEAVYAVLYEGKSPREAVEAL 321
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
4-342 2.90e-85

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 260.39  E-value: 2.90e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177      4 KKVCIVGSGNWGSAIAkIVGSNAGRlahfdpRVTMWVFEEDIggrklTEIINTQHENVKYLPGHKLPPNVVAIPDVVQAA 83
Cdd:PRK00094   2 MKIAVLGAGSWGTALA-IVLARNGH------DVTLWARDPEQ-----AAEINADRENPRYLPGIKLPDNLRATTDLAEAL 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177     84 TGADILVFVVPHQFIGKICDQLKGHLKANTIGISLIKGVDEGPngLKLISEVIGERLG--IPMSVLMGANIASEVAEEKF 161
Cdd:PRK00094  70 ADADLILVAVPSQALREVLKQLKPLLPPDAPIVWATKGIEPGT--GKLLSEVLEEELPdlAPIAVLSGPSFAKEVARGLP 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177    162 CETTIGCKDPAQGQLLKDLMQTPNFRITVVQEVDTVEICGALKNIVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKL 241
Cdd:PRK00094 148 TAVVIASTDEELAERVQELFHSPYFRVYTNTDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEITRLGVA 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177    242 FCSgivSSATFLESCGVADLITTCYG--GRNRKVAEAFARtGKSIEQLEKEMlnGQKLQGPQTARELHSILQHKGLvdKF 319
Cdd:PRK00094 228 LGA---NPETFLGLAGLGDLVLTCTSplSRNRRFGLALGQ-GKSLEEALAEI--GMVAEGVRTAKAVYELAKKLGV--EM 299

                        330       340
                 ....*....|....*....|...
gi 387177    320 PLFTAVYKVCYEGQPVGEFIRCL 342
Cdd:PRK00094 300 PITEAVYAVLYEGKDPREAVEDL 322
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
 5-172 2.02e-66

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 206.27  E-value: 2.02e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177       5 KVCIVGSGNWGSAIAKIVGSNAgrlahfdPRVTMWVFEEDiggrkLTEIINTQHENVKYLPGHKLPPNVVAIPDVVQAAT 84
Cdd:pfam01210   1 KIAVLGAGSWGTALAKVLADNG-------HEVRLWGRDEE-----LIEEINTTHENVRYLPGIKLPENLKATTDLAEALK 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177      85 GADILVFVVPHQFIGKICDQLKGHLKANTIGISLIKGVDEGpnGLKLISEVIGERLGI--PMSVLMGANIASEVAEEKFC 162
Cdd:pfam01210  69 GADIIVIVVPSQALREVLKQLKGLLKPDAILVSLSKGIEPG--TLKLLSEVIEEELGIqpPIAVLSGPSHAEEVAQGLPT 146

                         170
                  ....*....|
gi 387177     163 ETTIGCKDPA 172
Cdd:pfam01210 147 ATVIASKDEE 156
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 194-340 1.78e-63

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 198.38  E-value: 1.78e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177     194 VDTVEICGALKNIVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKLFCSgivSSATFLESCGVADLITTCYGG--RNR 271
Cdd:pfam07479   2 VIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALGA---KPETFFGLAGLGDLIVTCTSGlsRNR 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 387177     272 KVAEAFARtGKSIEQLEKEMlnGQKLQGPQTARELHSILQHKGLvdKFPLFTAVYKVCYEGQPVGEFIR 340
Cdd:pfam07479  79 RFGEALGK-GKSLEEAEKEL--GQVAEGVYTAKAVYELAKKLGV--EMPIFEAVYRILYEGKSPEEALE 142
PRK12439 PRK12439
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 5-344 3.56e-49

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 171500 [Multi-domain]  Cd Length: 341  Bit Score: 168.04  E-value: 3.56e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177      5 KVCIVGSGNWGSAIAKIVGSNAGRLahfdprvtMWVFEEDIggrklTEIINTQHENVKYLP-GHKLPPNVVAIPDVVQAA 83
Cdd:PRK12439   9 KVVVLGGGSWGTTVASICARRGPTL--------QWVRSAET-----ADDINDNHRNSRYLGnDVVLSDTLRATTDFAEAA 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177     84 TGADILVFVVP-HQFIGkICDQLKGHLKANTIGISLIKGVDEGPNglKLISEVIGERL-GIPMSVLMGANIASEVAEEKF 161
Cdd:PRK12439  76 NCADVVVMGVPsHGFRG-VLTELAKELRPWVPVVSLVKGLEQGTN--MRMSQIIEEVLpGHPAGILAGPNIAREVAEGYA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177    162 CETTIGCKDPAQGQLLKDLMQTPNFRITVVQEVDTVEICGALKNIVAVGAGFCDGLGFGDNTKAAVIRLGLMEMiafAKL 241
Cdd:PRK12439 153 AAAVLAMPDQHLATRLSPLFRTRRFRVYTTDDVVGVEMAGALKNVFAIAVGMGYSLGIGENTRAMVIARALREM---TKL 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177    242 FCSGIVSSATFLESCGVADLITTCYG--GRNRKVAEAFARtGKSIEQLEKEMlnGQKLQGPQTARELHSILQHKGLvdKF 319
Cdd:PRK12439 230 GVAMGGNPETFAGLAGMGDLIVTCTSqrSRNRHVGEQLGA-GKPIDEIIASM--NQVAEGVKAASVVMEFADEYGL--NM 304

                        330       340
                 ....*....|....*....|....*
gi 387177    320 PLFTAVYKVCYEGQPVGEFIRCLQN 344
Cdd:PRK12439 305 PIAREVDAVINHGSTVEQAYRGLIA 329
PRK14618 PRK14618
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 2-347 4.86e-47

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237770 [Multi-domain]  Cd Length: 328  Bit Score: 162.35  E-value: 4.86e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177      2 AGKKVCIVGSGNWGSAIAkivgSNAGRLAHfdpRVTMWVFEEDIGGRklteiINTQHENVKYLPGHKLPPNVVAIPDVVQ 81
Cdd:PRK14618   3 HGMRVAVLGAGAWGTALA----VLAASKGV---PVRLWARRPEFAAA-----LAAERENREYLPGVALPAELYPTADPEE 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177     82 AATGADILVFVVPHQFIGKICDQLKGHLKAntigISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVAEEKF 161
Cdd:PRK14618  71 ALAGADFAVVAVPSKALRETLAGLPRALGY----VSCAKGLAPDGGRLSELARVLEFLTQARVAVLSGPNHAEEIARFLP 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177    162 CETTIGCKDPAQGQLLKDLMQTPNFRITVVQEVDTVEICGALKNIVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFakL 241
Cdd:PRK14618 147 AATVVASPEPGLARRVQAAFSGPSFRVYTSRDRVGVELGGALKNVIALAAGMVDGLKLGDNAKAALITRGLREMVRF--G 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177    242 FCSGiVSSATFLESCGVADLITTCYG--GRNRKVAEAFARtGKSIEQLEKEmlnGQKLQGPQTARELHSILQHKGlVDkF 319
Cdd:PRK14618 225 VALG-AEEATFYGLSGLGDLIATATSphSRNRAAGEAIVR-GVDREHLEAG---GKVVEGLYTVKALDAWAKAHG-HD-L 297

                        330       340
                 ....*....|....*....|....*....
gi 387177    320 PLFTAVYKVCYEG-QPVGEFIRCLQNHPE 347
Cdd:PRK14618 298 PIVEAVARVARGGwDPLAGLRSLMGREAK 326
PRK14620 PRK14620
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 5-339 7.91e-39

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 173083 [Multi-domain]  Cd Length: 326  Bit Score: 140.35  E-value: 7.91e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177      5 KVCIVGSGNWGSAIAKIVGSNAgrlahfdPRVTMWVFEEDIggrklTEIINTQHENVKYLPGHKLPPNVV---AIPDVVq 81
Cdd:PRK14620   2 KISILGAGSFGTAIAIALSSKK-------ISVNLWGRNHTT-----FESINTKRKNLKYLPTCHLPDNISvksAIDEVL- 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177     82 aATGADILVFVVPHQFIGKICDQLKG-HLKANTIGISLIKGVDEgpNGLKLISEVIGERL-GIPMSVLMGANIASEVAEE 159
Cdd:PRK14620  69 -SDNATCIILAVPTQQLRTICQQLQDcHLKKNTPILICSKGIEK--SSLKFPSEIVNEILpNNPIAILSGPSFAKEIAEK 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177    160 KFCETTIGCKDPAQGQLLKDLMQTPNFRITVVQEVDTVEICGALKNIVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAF- 238
Cdd:PRK14620 146 LPCSIVLAGQNETLGSSLISKLSNENLKIIYSQDIIGVQIGAALKNIIAIACGIVLGKNLGNNAHAAVITKGMNEIKTLy 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177    239 -AKlfcSGIVSSATFLESCGVADLITTCYGGRNRKVAEAFA-RTGKSIEQLEKEmlNGQKLQGPQTARELHSILqhKGLV 316
Cdd:PRK14620 226 sAK---NGSIDLNTLIGPSCLGDLILTCTTLHSRNMSFGFKiGNGFNINQILSE--GKSVIEGFSTVKPLISLA--KKLN 298

                        330       340
                 ....*....|....*....|...
gi 387177    317 DKFPLFTAVYKVCYEGQPVGEFI 339
Cdd:PRK14620 299 IELPICESIYNLLYENISLEKTI 321
PRK14619 PRK14619
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 4-328 1.46e-25

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237771 [Multi-domain]  Cd Length: 308  Bit Score: 104.30  E-value: 1.46e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177      4 KKVCIVGSGNWGSAIAKIVGSNagrlahfDPRVTMWVFEediGGRKLTEIIntqhenvkylpghklppnvvaipdvvqaa 83
Cdd:PRK14619   5 KTIAILGAGAWGSTLAGLASAN-------GHRVRVWSRR---SGLSLAAVL----------------------------- 45

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177     84 TGADILVFVVPHQFIGKICDQLKG-HLKANTIGISLIKGVDegPNGLKLISEVIGERLGI-PMSVLMGANIASEVAEEKF 161
Cdd:PRK14619  46 ADADVIVSAVSMKGVRPVAEQVQAlNLPPETIIVTATKGLD--PETTRTPSQIWQAAFPNhPVVVLSGPNLSKEIQQGLP 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177    162 CETTIGCKDPAQGQLLKDLMQTPNFRITVVQEVDTVEICGALKNIVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKL 241
Cdd:PRK14619 124 AATVVASRDLAAAETVQQIFSSERFRVYTNSDPLGTELGGTLKNVIAIAAGVCDGLQLGTNAKAALVTRALPEMIRVGTH 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177    242 FCSgivSSATFLESCGVADLITTCYG--GRNRKVAEAFARtGKSIEQ-LEKemLNGQKlQGPQTARELHSILQHKGLVdk 318
Cdd:PRK14619 204 LGA---QTETFYGLSGLGDLLATCTSplSRNYQVGYGLAQ-GKSLEQiLAE--LEGTA-EGVNTANVLVQLAQQQNIA-- 274

                        330
                 ....*....|
gi 387177    319 FPLFTAVYKV 328
Cdd:PRK14619 275 VPITEQVYRL 284
GPD_NAD_C_bact pfam20618
Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent ...
 256-325 2.86e-06

Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent glycerol-3-phosphate dehydrogenase (GPD) from bacteria and archaea. GPD catalyzes the reversible reduction of dihydroxyacetone phosphate to glycerol-3-phosphate.


Pssm-ID: 466767 [Multi-domain]  Cd Length: 66  Bit Score: 44.41  E-value: 2.86e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 387177     256 CGVADLITTCYGG--RNRKVAEAFARtGKSIEqlekEMLNGQKLQGPQTARELHSILQHKGLVDkFPLFTAV 325
Cdd:pfam20618   1 AGLGDLVLTCTSDlsRNRTFGLLLGK-GMTLA----EAGNGQVAEGVRTAKAVAAILARAHNVE-MPILEAV 66
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
 4-150 8.16e-06

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 46.60  E-value: 8.16e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387177     4 KKVCIVGSGNWGSAIAKivgsnaGRLAHFDPRVTMWVFeeDIGGRKLTEIINTqhenvkylpghklpPNVVAIPDVVQAA 83
Cdd:COG0345   3 MKIGFIGAGNMGSAIIK------GLLKSGVPPEDIIVS--DRSPERLEALAER--------------YGVRVTTDNAEAA 60

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 387177    84 TGADILVFVVPHQFIGKICDQLKGHLKANTIGISLIKGVDegpngLKLISEVIGERLGI-------PMSVLMGA 150
Cdd:COG0345  61 AQADVVVLAVKPQDLAEVLEELAPLLDPDKLVISIAAGVT-----LATLEEALGGGAPVvrampntPALVGEGV 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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