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Conserved domains on  [gi|160419152|sp|A4D2B8|]
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PUTATIVE PSEUDOGENE: RecName: Full=Putative postmeiotic segregation increased 2-like protein 1; AltName: Full=PMS2-related protein 2; AltName: Full=Postmeiotic segregation increased 2-like protein 13; AltName: Full=Postmeiotic segregation increased 2-like protein 6; AltName: Full=Postmeiotic segregation increased 2-like protein 8; AltName: Full=Postmeiotic segregation increased protein 3; Short=hPMS3; AltName: Full=Postmeiotic segregation increased protein 8; AltName: Full=Putative postmeiotic segregation increased 2 pseudogene 1

Protein Classification

DNA mismatch repair MutL family protein( domain architecture ID 1001378)

DNA mismatch repair MutL family protein is required for DNA mismatch repair (MMR), correcting base-base mismatches and insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage, or recombination events

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
mutl super family cl36694
DNA mismatch repair protein MutL; All proteins in this family for which the functions are ...
 213-379 1.16e-74

DNA mismatch repair protein MutL; All proteins in this family for which the functions are known are involved in the process of generalized mismatch repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


The actual alignment was detected with superfamily member TIGR00585:

Pssm-ID: 273155 [Multi-domain]  Cd Length: 312  Bit Score: 236.00  E-value: 1.16e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160419152  213 KAIKPIDRKSVHQICSGPVVPSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSGNGCGVEEENFEGLTLKHHTSKI 292
Cdd:TIGR00585   1 MTIKPLPPELVNKIAAGEVIERPASVVKELVENSLDAGATRIDVEIEEGGLKLIEVSDNGSGIDKEDLPLACERHATSKI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160419152  293 QEFADLPQVETFGFRGEALSSLCALSDVTISTCHV-SAKVGTRLVFDHyGKIIQKTPYPHPRGMTVSVKQLFSTLPVHHK 371
Cdd:TIGR00585  81 QSFEDLERIETLGFRGEALASISSVSRLTITTKTSaADGLAYQALLEG-GMIESIKPAPRPVGTTVEVRDLFYNLPVRRK 159


                  ....*...
gi 160419152  372 eFQRNIKK 379
Cdd:TIGR00585 160 -FLKSPKK 166
 
Name Accession Description Interval E-value
mutl TIGR00585
DNA mismatch repair protein MutL; All proteins in this family for which the functions are ...
 213-379 1.16e-74

DNA mismatch repair protein MutL; All proteins in this family for which the functions are known are involved in the process of generalized mismatch repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273155 [Multi-domain]  Cd Length: 312  Bit Score: 236.00  E-value: 1.16e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160419152  213 KAIKPIDRKSVHQICSGPVVPSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSGNGCGVEEENFEGLTLKHHTSKI 292
Cdd:TIGR00585   1 MTIKPLPPELVNKIAAGEVIERPASVVKELVENSLDAGATRIDVEIEEGGLKLIEVSDNGSGIDKEDLPLACERHATSKI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160419152  293 QEFADLPQVETFGFRGEALSSLCALSDVTISTCHV-SAKVGTRLVFDHyGKIIQKTPYPHPRGMTVSVKQLFSTLPVHHK 371
Cdd:TIGR00585  81 QSFEDLERIETLGFRGEALASISSVSRLTITTKTSaADGLAYQALLEG-GMIESIKPAPRPVGTTVEVRDLFYNLPVRRK 159


                  ....*...
gi 160419152  372 eFQRNIKK 379
Cdd:TIGR00585 160 -FLKSPKK 166
HATPase_MutL-MLH-PMS-like cd16926
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ...
 222-379 7.77e-73

Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease.


Pssm-ID: 340403 [Multi-domain]  Cd Length: 188  Bit Score: 226.93  E-value: 7.77e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160419152 222 SVHQICSGPVVPSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSGNGCGVEEENFEGLTLKHHTSKIQEFADLPQV 301
Cdd:cd16926    1 VVNKIAAGEVIERPASVVKELVENSIDAGATRIDVEIEEGGLKLIRVTDNGSGISREDLELAFERHATSKISSFEDLFSI 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 160419152 302 ETFGFRGEALSSLCALSDVTISTCHVSAKVGTRLVFDHYGKIIQKTPYPHPRGMTVSVKQLFSTLPVHHKeFQRNIKK 379
Cdd:cd16926   81 TTLGFRGEALASIASVSRLTITTRTADDDVGTRLVVDGGGIIEEVKPAAAPVGTTVTVRDLFYNTPARRK-FLKSPKT 157
MutL COG0323
DNA mismatch repair ATPase MutL [Replication, recombination and repair];
223-368 2.03e-44

DNA mismatch repair ATPase MutL [Replication, recombination and repair];


Pssm-ID: 440092 [Multi-domain]  Cd Length: 515  Bit Score: 162.14  E-value: 2.03e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160419152 223 VHQICSGPVV--PSlStAVKELVENSLDAGATNIDLKLKDYGVDLIEVSGNGCGVEEENFEgLTLKHH-TSKIQEFADLP 299
Cdd:COG0323   12 ANQIAAGEVVerPA-S-VVKELVENAIDAGATRIEVEIEEGGKSLIRVTDNGCGMSPEDLP-LAFERHaTSKIRSAEDLF 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 160419152 300 QVETFGFRGEALSSLCALSDVTISTCHVSAKVGTRLVFDHyGKIIQKTPYPHPRGMTVSVKQLFSTLPV 368
Cdd:COG0323   89 RIRTLGFRGEALASIASVSRLTLTTRTAGAELGTRIEVEG-GKVVEVEPAAAPKGTTVEVRDLFFNTPA 156
mutL PRK00095
DNA mismatch repair endonuclease MutL;
214-363 4.92e-43

DNA mismatch repair endonuclease MutL;


Pssm-ID: 234630 [Multi-domain]  Cd Length: 617  Bit Score: 160.00  E-value: 4.92e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160419152 214 AIKPIDRKSVHQICSGPVVPSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSGNGCGVEEENfegLTL---KHHTS 290
Cdd:PRK00095   2 PIQLLPPQLANQIAAGEVVERPASVVKELVENALDAGATRIDIEIEEGGLKLIRVRDNGCGISKED---LALalaRHATS 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 160419152 291 KIQEFADLPQVETFGFRGEALSSLCALSDVTISTCHVSAKVGTRLVFDHyGKIIQKTPYPHPRGMTVSVKQLF 363
Cdd:PRK00095  79 KIASLDDLEAIRTLGFRGEALPSIASVSRLTLTSRTADAAEGWQIVYEG-GEIVEVKPAAHPVGTTIEVRDLF 150
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 235-326 8.56e-07

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 48.10  E-value: 8.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160419152  235 LSTAVKELVENSLDAGATNIDLKLKDY--GVDLIEVSGNGCGVEEENF-EGLTLkHHTSKIQEFaDLPQVETFGFrGEAL 311
Cdd:pfam13589   1 LEGALAELIDNSIDADATNIKIEVNKNrgGGTEIVIEDDGHGMSPEELiNALRL-ATSAKEAKR-GSTDLGRYGI-GLKL 77

                          90
                  ....*....|....*
gi 160419152  312 SSLCALSDVTISTCH 326
Cdd:pfam13589  78 ASLSLGAKLTVTSKK 92
 
Name Accession Description Interval E-value
mutl TIGR00585
DNA mismatch repair protein MutL; All proteins in this family for which the functions are ...
 213-379 1.16e-74

DNA mismatch repair protein MutL; All proteins in this family for which the functions are known are involved in the process of generalized mismatch repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273155 [Multi-domain]  Cd Length: 312  Bit Score: 236.00  E-value: 1.16e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160419152  213 KAIKPIDRKSVHQICSGPVVPSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSGNGCGVEEENFEGLTLKHHTSKI 292
Cdd:TIGR00585   1 MTIKPLPPELVNKIAAGEVIERPASVVKELVENSLDAGATRIDVEIEEGGLKLIEVSDNGSGIDKEDLPLACERHATSKI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160419152  293 QEFADLPQVETFGFRGEALSSLCALSDVTISTCHV-SAKVGTRLVFDHyGKIIQKTPYPHPRGMTVSVKQLFSTLPVHHK 371
Cdd:TIGR00585  81 QSFEDLERIETLGFRGEALASISSVSRLTITTKTSaADGLAYQALLEG-GMIESIKPAPRPVGTTVEVRDLFYNLPVRRK 159


                  ....*...
gi 160419152  372 eFQRNIKK 379
Cdd:TIGR00585 160 -FLKSPKK 166
HATPase_MutL-MLH-PMS-like cd16926
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ...
 222-379 7.77e-73

Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease.


Pssm-ID: 340403 [Multi-domain]  Cd Length: 188  Bit Score: 226.93  E-value: 7.77e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160419152 222 SVHQICSGPVVPSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSGNGCGVEEENFEGLTLKHHTSKIQEFADLPQV 301
Cdd:cd16926    1 VVNKIAAGEVIERPASVVKELVENSIDAGATRIDVEIEEGGLKLIRVTDNGSGISREDLELAFERHATSKISSFEDLFSI 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 160419152 302 ETFGFRGEALSSLCALSDVTISTCHVSAKVGTRLVFDHYGKIIQKTPYPHPRGMTVSVKQLFSTLPVHHKeFQRNIKK 379
Cdd:cd16926   81 TTLGFRGEALASIASVSRLTITTRTADDDVGTRLVVDGGGIIEEVKPAAAPVGTTVTVRDLFYNTPARRK-FLKSPKT 157
MutL COG0323
DNA mismatch repair ATPase MutL [Replication, recombination and repair];
223-368 2.03e-44

DNA mismatch repair ATPase MutL [Replication, recombination and repair];


Pssm-ID: 440092 [Multi-domain]  Cd Length: 515  Bit Score: 162.14  E-value: 2.03e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160419152 223 VHQICSGPVV--PSlStAVKELVENSLDAGATNIDLKLKDYGVDLIEVSGNGCGVEEENFEgLTLKHH-TSKIQEFADLP 299
Cdd:COG0323   12 ANQIAAGEVVerPA-S-VVKELVENAIDAGATRIEVEIEEGGKSLIRVTDNGCGMSPEDLP-LAFERHaTSKIRSAEDLF 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 160419152 300 QVETFGFRGEALSSLCALSDVTISTCHVSAKVGTRLVFDHyGKIIQKTPYPHPRGMTVSVKQLFSTLPV 368
Cdd:COG0323   89 RIRTLGFRGEALASIASVSRLTLTTRTAGAELGTRIEVEG-GKVVEVEPAAAPKGTTVEVRDLFFNTPA 156
mutL PRK00095
DNA mismatch repair endonuclease MutL;
214-363 4.92e-43

DNA mismatch repair endonuclease MutL;


Pssm-ID: 234630 [Multi-domain]  Cd Length: 617  Bit Score: 160.00  E-value: 4.92e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160419152 214 AIKPIDRKSVHQICSGPVVPSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSGNGCGVEEENfegLTL---KHHTS 290
Cdd:PRK00095   2 PIQLLPPQLANQIAAGEVVERPASVVKELVENALDAGATRIDIEIEEGGLKLIRVRDNGCGISKED---LALalaRHATS 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 160419152 291 KIQEFADLPQVETFGFRGEALSSLCALSDVTISTCHVSAKVGTRLVFDHyGKIIQKTPYPHPRGMTVSVKQLF 363
Cdd:PRK00095  79 KIASLDDLEAIRTLGFRGEALPSIASVSRLTLTSRTADAAEGWQIVYEG-GEIVEVKPAAHPVGTTIEVRDLF 150
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 235-326 8.56e-07

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 48.10  E-value: 8.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160419152  235 LSTAVKELVENSLDAGATNIDLKLKDY--GVDLIEVSGNGCGVEEENF-EGLTLkHHTSKIQEFaDLPQVETFGFrGEAL 311
Cdd:pfam13589   1 LEGALAELIDNSIDADATNIKIEVNKNrgGGTEIVIEDDGHGMSPEELiNALRL-ATSAKEAKR-GSTDLGRYGI-GLKL 77

                          90
                  ....*....|....*
gi 160419152  312 SSLCALSDVTISTCH 326
Cdd:pfam13589  78 ASLSLGAKLTVTSKK 92
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 235-337 2.25e-03

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 37.73  E-value: 2.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160419152  235 LSTAVKELVENSLD--AGATNIDLKLKDYGVDLIEVSGNGCGVEEENFEGLtlkhhtskiqeFADLPQVETFGFRGEALS 312
Cdd:pfam02518   6 LRQVLSNLLDNALKhaAKAGEITVTLSEGGELTLTVEDNGIGIPPEDLPRI-----------FEPFSTADKRGGGGTGLG 74

                          90       100       110
                  ....*....|....*....|....*....|
gi 160419152  313 -----SLCALSDVTIsTCHVSAKVGTRLVF 337
Cdd:pfam02518  75 lsivrKLVELLGGTI-TVESEPGGGTTVTL 103
PRK04184 PRK04184
DNA topoisomerase VI subunit B; Validated
 234-279 4.16e-03

DNA topoisomerase VI subunit B; Validated


Pssm-ID: 235246 [Multi-domain]  Cd Length: 535  Bit Score: 39.49  E-value: 4.16e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 160419152 234 SLSTAVKELVENSLDAGATN-------IDLKLKDYGVDL--IEVSGNGCGVEEEN 279
Cdd:PRK04184  36 ALYTTVKELVDNSLDACEEAgilpdikIEIKRVDEGKDHyrVTVEDNGPGIPPEE 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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