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Conserved domains on  [gi|327478551|sp|A2RRH5|]
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RecName: Full=WD repeat-containing protein 27

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
515-823 1.15e-35

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.05  E-value: 1.15e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 515 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSAR-GAELALLL 593
Cdd:COG2319  122 AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLT 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 594 GKdmfSKPIQSAqfyyidAF-----ILLSSGPEFQLLRYHIDTckdeikrykqkskSKLICRLST-TGAVdmTSLSAVND 667
Cdd:COG2319  202 GH---TGAVRSV------AFspdgkLLASGSADGTVRLWDLAT-------------GKLLRTLTGhSGSV--RSVAFSPD 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 668 fySHIVLAAGRNRTVEVFDLNAGcSAAVIAEAHSRPVHQICqnkgssFTtqqPQayNLFLTTAIGDGM-RLWDLRTLRCE 746
Cdd:COG2319  258 --GRLLASGSADGTVRLWDLATG-ELLRTLTGHSGGVNSVA------FS---PD--GKLLASGSDDGTvRLWDLATGKLL 323

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 327478551 747 RHFEGHptRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNPSAPQLATATLDGKLQL 823
Cdd:COG2319  324 RTLTGH--TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-236 2.51e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 86.23  E-value: 2.51e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAFGnkVNPLLICSASLD-YVIMWNLDECRE-KVLQGLVprgtvmgsllGK 125
Cdd:cd00200  114 DKT-IKVWDVETGK-CLTTLRGHTDWVNSVAFS--PDGTFVASSSQDgTIKLWDLRTGKCvATLTGHT----------GE 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 126 VLCLQLSLDDHVVAVCAGNK-IFMLDIETQAVRAELQGHLGPVTAVEFCPWRaGTLISASEDRGFKVWDHCTGSLIYsss 204
Cdd:cd00200  180 VNSVAFSPDGEKLLSSSSDGtIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG-YLLASGSEDGTIRVWDLRTGECVQ--- 255

                        170       180       190
                 ....*....|....*....|....*....|....
gi 327478551 205 VLSAY--PLLSLFIDAESRQLVTGCADGQLWIFS 236
Cdd:cd00200  256 TLSGHtnSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
515-823 1.15e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.05  E-value: 1.15e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 515 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSAR-GAELALLL 593
Cdd:COG2319  122 AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLT 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 594 GKdmfSKPIQSAqfyyidAF-----ILLSSGPEFQLLRYHIDTckdeikrykqkskSKLICRLST-TGAVdmTSLSAVND 667
Cdd:COG2319  202 GH---TGAVRSV------AFspdgkLLASGSADGTVRLWDLAT-------------GKLLRTLTGhSGSV--RSVAFSPD 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 668 fySHIVLAAGRNRTVEVFDLNAGcSAAVIAEAHSRPVHQICqnkgssFTtqqPQayNLFLTTAIGDGM-RLWDLRTLRCE 746
Cdd:COG2319  258 --GRLLASGSADGTVRLWDLATG-ELLRTLTGHSGGVNSVA------FS---PD--GKLLASGSDDGTvRLWDLATGKLL 323

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 327478551 747 RHFEGHptRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNPSAPQLATATLDGKLQL 823
Cdd:COG2319  324 RTLTGH--TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 515-824 1.68e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.75  E-value: 1.68e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 515 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSAR-GAELALLL 593
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLEtGECVRTLT 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 594 GkdmFSKPIQSAQFYYiDAFILLSSGPEFQLLRYHIDTCKdeikrykqksksKLICRLSTTGAVDMTSLSAVNDFyshiV 673
Cdd:cd00200   91 G---HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGK------------CLTTLRGHTDWVNSVAFSPDGTF----V 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 674 LAAGRNRTVEVFDLNAGCSAAVIaEAHSRPVHQICQNkgssfttqqPQAYNLFltTAIGDG-MRLWDLRTLRCERHFEGH 752
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFS---------PDGEKLL--SSSSDGtIKLWDLSTGKCLGTLRGH 218

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 327478551 753 ptRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNPSAPQLATATLDGKLQLF 824
Cdd:cd00200  219 --ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-236 2.51e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 86.23  E-value: 2.51e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAFGnkVNPLLICSASLD-YVIMWNLDECRE-KVLQGLVprgtvmgsllGK 125
Cdd:cd00200  114 DKT-IKVWDVETGK-CLTTLRGHTDWVNSVAFS--PDGTFVASSSQDgTIKLWDLRTGKCvATLTGHT----------GE 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 126 VLCLQLSLDDHVVAVCAGNK-IFMLDIETQAVRAELQGHLGPVTAVEFCPWRaGTLISASEDRGFKVWDHCTGSLIYsss 204
Cdd:cd00200  180 VNSVAFSPDGEKLLSSSSDGtIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG-YLLASGSEDGTIRVWDLRTGECVQ--- 255

                        170       180       190
                 ....*....|....*....|....*....|....
gi 327478551 205 VLSAY--PLLSLFIDAESRQLVTGCADGQLWIFS 236
Cdd:cd00200  256 TLSGHtnSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
48-237 2.07e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.18  E-value: 2.07e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAF---GNkvnplLICSASLDYVIM-WNLDECREKvlqglvprgTVMGSLL 123
Cdd:COG2319  225 DGT-VRLWDLATGK-LLRTLTGHSGSVRSVAFspdGR-----LLASGSADGTVRlWDLATGELL---------RTLTGHS 288

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 124 GKVLCLQLSLDDHVVAV-CAGNKIFMLDIETQAVRAELQGHLGPVTAVEFCPWRaGTLISASEDRGFKVWDHCTGSLIYS 202
Cdd:COG2319  289 GGVNSVAFSPDGKLLASgSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-KTLASGSDDGTVRLWDLATGELLRT 367

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 327478551 203 SSVLSAyPLLSLFIDAESRQLVTGCADGQLWIFSL 237
Cdd:COG2319  368 LTGHTG-AVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 549-583 2.85e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 2.85e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 327478551   549 AVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWS 583
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
549-583 3.01e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.04  E-value: 3.01e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 327478551  549 AVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWS 583
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 153-193 5.48e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 5.48e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 327478551   153 TQAVRAELQGHLGPVTAVEFCPwRAGTLISASEDRGFKVWD 193
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
158-193 7.86e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 7.86e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 327478551  158 AELQGHLGPVTAVEFCPWRAgTLISASEDRGFKVWD 193
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
515-823 1.15e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 140.05  E-value: 1.15e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 515 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSAR-GAELALLL 593
Cdd:COG2319  122 AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLT 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 594 GKdmfSKPIQSAqfyyidAF-----ILLSSGPEFQLLRYHIDTckdeikrykqkskSKLICRLST-TGAVdmTSLSAVND 667
Cdd:COG2319  202 GH---TGAVRSV------AFspdgkLLASGSADGTVRLWDLAT-------------GKLLRTLTGhSGSV--RSVAFSPD 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 668 fySHIVLAAGRNRTVEVFDLNAGcSAAVIAEAHSRPVHQICqnkgssFTtqqPQayNLFLTTAIGDGM-RLWDLRTLRCE 746
Cdd:COG2319  258 --GRLLASGSADGTVRLWDLATG-ELLRTLTGHSGGVNSVA------FS---PD--GKLLASGSDDGTvRLWDLATGKLL 323

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 327478551 747 RHFEGHptRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNPSAPQLATATLDGKLQL 823
Cdd:COG2319  324 RTLTGH--TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 515-824 1.68e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.75  E-value: 1.68e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 515 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSAR-GAELALLL 593
Cdd:cd00200   11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLEtGECVRTLT 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 594 GkdmFSKPIQSAQFYYiDAFILLSSGPEFQLLRYHIDTCKdeikrykqksksKLICRLSTTGAVDMTSLSAVNDFyshiV 673
Cdd:cd00200   91 G---HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGK------------CLTTLRGHTDWVNSVAFSPDGTF----V 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 674 LAAGRNRTVEVFDLNAGCSAAVIaEAHSRPVHQICQNkgssfttqqPQAYNLFltTAIGDG-MRLWDLRTLRCERHFEGH 752
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFS---------PDGEKLL--SSSSDGtIKLWDLSTGKCLGTLRGH 218

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 327478551 753 ptRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNPSAPQLATATLDGKLQLF 824
Cdd:cd00200  219 --ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
515-824 2.54e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.48  E-value: 2.54e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 515 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSAR-GAELALLL 593
Cdd:COG2319   80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAtGKLLRTLT 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 594 GKdmfSKPIQSAQFyyidafillssgpefqllryhidtckdeikrykqksksklicrlSTTGavdmtslsavndfysHIV 673
Cdd:COG2319  160 GH---SGAVTSVAF--------------------------------------------SPDG---------------KLL 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 674 LAAGRNRTVEVFDLNAGCSAAVIaEAHSRPVHQIcqnkgsSFTtqqPQayNLFLTTAIGDGM-RLWDLRTLRCERHFEGH 752
Cdd:COG2319  178 ASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSV------AFS---PD--GKLLASGSADGTvRLWDLATGKLLRTLTGH 245

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 327478551 753 ptRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNPSAPQLATATLDGKLQLF 824
Cdd:COG2319  246 --SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
521-824 3.38e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 3.38e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 521 YSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSARGAELALLLGKdmFSK 600
Cdd:COG2319   44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG--HTG 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 601 PIQSAQFyyidafillssgpefqllryhidtckdeikrykqksksklicrlSTTGavdmtslsavndfysHIVLAAGRNR 680
Cdd:COG2319  122 AVRSVAF--------------------------------------------SPDG---------------KTLASGSADG 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 681 TVEVFDLNAGCSAAVIaEAHSRPVHQIcqnkgsSFTTQqpqayNLFLTTAIGDG-MRLWDLRTLRCERHFEGHPTRGYpc 759
Cdd:COG2319  143 TVRLWDLATGKLLRTL-TGHSGAVTSV------AFSPD-----GKLLASGSDDGtVRLWDLATGKLLRTLTGHTGAVR-- 208

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 327478551 760 GIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNPSAPQLATATLDGKLQLF 824
Cdd:COG2319  209 SVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
515-786 4.33e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 4.33e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 515 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSARGAELALLLG 594
Cdd:COG2319  164 AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 595 KDmfSKPIQSAqfyyidAF-----ILLSSGPEFQLLRYHIDTckdeikrykqkskSKLICRLST-TGAVdmTSLSAVNDf 668
Cdd:COG2319  244 GH--SGSVRSV------AFspdgrLLASGSADGTVRLWDLAT-------------GELLRTLTGhSGGV--NSVAFSPD- 299

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 669 ySHIVLAAGRNRTVEVFDLNAGCSAAVIaEAHSRPVHQIcqnkgsSFTtqqpqAYNLFLTTAIGDGM-RLWDLRTLRCER 747
Cdd:COG2319  300 -GKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSV------AFS-----PDGKTLASGSDDGTvRLWDLATGELLR 366

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 327478551 748 HFEGHptRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGS 786
Cdd:COG2319  367 TLTGH--TGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-236 2.51e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 86.23  E-value: 2.51e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAFGnkVNPLLICSASLD-YVIMWNLDECRE-KVLQGLVprgtvmgsllGK 125
Cdd:cd00200  114 DKT-IKVWDVETGK-CLTTLRGHTDWVNSVAFS--PDGTFVASSSQDgTIKLWDLRTGKCvATLTGHT----------GE 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 126 VLCLQLSLDDHVVAVCAGNK-IFMLDIETQAVRAELQGHLGPVTAVEFCPWRaGTLISASEDRGFKVWDHCTGSLIYsss 204
Cdd:cd00200  180 VNSVAFSPDGEKLLSSSSDGtIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG-YLLASGSEDGTIRVWDLRTGECVQ--- 255

                        170       180       190
                 ....*....|....*....|....*....|....
gi 327478551 205 VLSAY--PLLSLFIDAESRQLVTGCADGQLWIFS 236
Cdd:cd00200  256 TLSGHtnSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
48-237 2.07e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.18  E-value: 2.07e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAF---GNkvnplLICSASLDYVIM-WNLDECREKvlqglvprgTVMGSLL 123
Cdd:COG2319  225 DGT-VRLWDLATGK-LLRTLTGHSGSVRSVAFspdGR-----LLASGSADGTVRlWDLATGELL---------RTLTGHS 288

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 124 GKVLCLQLSLDDHVVAV-CAGNKIFMLDIETQAVRAELQGHLGPVTAVEFCPWRaGTLISASEDRGFKVWDHCTGSLIYS 202
Cdd:COG2319  289 GGVNSVAFSPDGKLLASgSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-KTLASGSDDGTVRLWDLATGELLRT 367

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 327478551 203 SSVLSAyPLLSLFIDAESRQLVTGCADGQLWIFSL 237
Cdd:COG2319  368 LTGHTG-AVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
48-240 6.30e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.64  E-value: 6.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAF---GNkvnpLLIcSASLDYVI-MWNLDECRE-KVLQGLVprgtvmgsl 122
Cdd:COG2319  141 DGT-VRLWDLATGK-LLRTLTGHSGAVTSVAFspdGK----LLA-SGSDDGTVrLWDLATGKLlRTLTGHT--------- 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 123 lGKVLCLQLSLDDHVVAVCAGNK-IFMLDIETQAVRAELQGHLGPVTAVEFCPWRAgTLISASEDRGFKVWDHCTGSLIY 201
Cdd:COG2319  205 -GAVRSVAFSPDGKLLASGSADGtVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGELLR 282

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 327478551 202 SSSVLSAyPLLSLFIDAESRQLVTGCADGQLWIFSLMDG 240
Cdd:COG2319  283 TLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATG 320
WD40 COG2319
WD40 repeat [General function prediction only];
48-237 3.81e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 3.81e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAF---GNkvnplLICSASLD-YVIMWNLDECRE-KVLQGLVPRgtvmgsl 122
Cdd:COG2319  183 DGT-VRLWDLATGK-LLRTLTGHTGAVRSVAFspdGK-----LLASGSADgTVRLWDLATGKLlRTLTGHSGS------- 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 123 lgkVLCLQLSLDDHVVAVC-AGNKIFMLDIETQAVRAELQGHLGPVTAVEFCPwRAGTLISASEDRGFKVWDHCTGSLIY 201
Cdd:COG2319  249 ---VRSVAFSPDGRLLASGsADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLR 324

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 327478551 202 SSSVlSAYPLLSLFIDAESRQLVTGCADGQLWIFSL 237
Cdd:COG2319  325 TLTG-HTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 67-242 3.66e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.66  E-value: 3.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551  67 LRGHHQPITAMAFGNKVNplLICSASLD-YVIMWNLDECR-EKVLQG---------LVPRGTVM--GSL----------- 122
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGK--LLATGSGDgTIKVWDLETGElLRTLKGhtgpvrdvaASADGTYLasGSSdktirlwdlet 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 123 ----------LGKVLCLQLSLDDHVVAVCAGNK-IFMLDIETQAVRAELQGHLGPVTAVEFCPwrAGTLI-SASEDRGFK 190
Cdd:cd00200   83 gecvrtltghTSYVSSVAFSPDGRILSSSSRDKtIKVWDVETGKCLTTLRGHTDWVNSVAFSP--DGTFVaSSSQDGTIK 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 327478551 191 VWDHCTGSLIYsssVLSAY--PLLSLFIDAESRQLVTGCADGQLWIFSLMDGHH 242
Cdd:cd00200  161 LWDLRTGKCVA---TLTGHtgEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC 211
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 515-583 2.01e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.74  E-value: 2.01e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 327478551 515 RVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWS 583
Cdd:cd00200  221 GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
55-240 9.40e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 9.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551  55 WNTKDPSHQLLILRGHHQPITAMAFGNKVNPLLicSASLDYVI-MWNLDecrekvlQGLVPRgtVMGSLLGKVLCLQLSL 133
Cdd:COG2319   62 LLDAAAGALLATLLGHTAAVLSVAFSPDGRLLA--SASADGTVrLWDLA-------TGLLLR--TLTGHTGAVRSVAFSP 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 134 DDHVVAVCAGNK-IFMLDIETQAVRAELQGHLGPVTAVEFCPwrAG-TLISASEDRGFKVWDHCTGSLIYSSSVLSAyPL 211
Cdd:COG2319  131 DGKTLASGSADGtVRLWDLATGKLLRTLTGHSGAVTSVAFSP--DGkLLASGSDDGTVRLWDLATGKLLRTLTGHTG-AV 207

                        170       180
                 ....*....|....*....|....*....
gi 327478551 212 LSLFIDAESRQLVTGCADGQLWIFSLMDG 240
Cdd:COG2319  208 RSVAFSPDGKLLASGSADGTVRLWDLATG 236
WD40 COG2319
WD40 repeat [General function prediction only];
63-240 2.69e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.84  E-value: 2.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551  63 QLLILRGHHQPITAMAFGNKVNPLLICSASLDYVIMWNLDECREKVLQGLVPRgtvmgsllgkVLCLQLSLDDHVVAVCA 142
Cdd:COG2319   28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA----------VLSVAFSPDGRLLASAS 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 143 GNKIFML-DIETQAVRAELQGHLGPVTAVEFCPwRAGTLISASEDRGFKVWDHCTGSLIYSSSVLSAyPLLSLFIDAESR 221
Cdd:COG2319   98 ADGTVRLwDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLTGHSG-AVTSVAFSPDGK 175

                        170
                 ....*....|....*....
gi 327478551 222 QLVTGCADGQLWIFSLMDG 240
Cdd:COG2319  176 LLASGSDDGTVRLWDLATG 194
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 549-583 2.85e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 2.85e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 327478551   549 AVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWS 583
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 114-240 2.92e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.19  E-value: 2.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 114 PRGTVMGSLlGKVLCLQLSLD-DHVVAVCAGNKIFMLDIETQAVRAELQGHLGPVTAVEFCPWRaGTLISASEDRGFKVW 192
Cdd:cd00200    1 LRRTLKGHT-GGVTCVAFSPDgKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLW 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 327478551 193 D----HCTGSLI-YSSSVlsayplLSLFIDAESRQLVTGCADGQLWIFSLMDG 240
Cdd:cd00200   79 DletgECVRTLTgHTSYV------SSVAFSPDGRILSSSSRDKTIKVWDVETG 125
WD40 pfam00400
WD domain, G-beta repeat;
549-583 3.01e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.04  E-value: 3.01e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 327478551  549 AVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWS 583
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 157-241 3.93e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.72  E-value: 3.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 327478551 157 RAELQGHLGPVTAVEFCPWRaGTLISASEDRGFKVWDHCTGSLIYSSSVLSAyPLLSLFIDAESRQLVTGCADGQLWIFS 236
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTLKGHTG-PVRDVAASADGTYLASGSSDKTIRLWD 79


                 ....*
gi 327478551 237 LMDGH 241
Cdd:cd00200   80 LETGE 84
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 786-824 8.13e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 8.13e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 327478551   786 SSTFSHRLAGHTDTVTGVAFNPSAPQLATATLDGKLQLF 824
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 153-193 5.48e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 5.48e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 327478551   153 TQAVRAELQGHLGPVTAVEFCPwRAGTLISASEDRGFKVWD 193
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
791-824 8.32e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 8.32e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 327478551  791 HRLAGHTDTVTGVAFNPSAPQLATATLDGKLQLF 824
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
158-193 7.86e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 7.86e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 327478551  158 AELQGHLGPVTAVEFCPWRAgTLISASEDRGFKVWD 193
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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