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Conserved domains on  [gi|2536992814|pdb|8FLA|NL]
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Chain NL, Ribosome biogenesis protein NOP53

Protein Classification

ribosome biogenesis protein NOP53( domain architecture ID 12083027)

ribosome biogenesis protein NOP53 is a nucleolar protein which is involved in the regulation of several cell functions, including integration of 5S RNP into ribosomal large subunit, ribosome biogenesis, sensor-regulating the activation of p53/TP53 in response to stress conditions, and tumor suppression.

Gene Ontology:  GO:0000027|GO:0006364

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nop53 pfam07767
Nop53 (60S ribosomal biogenesis); This nucleolar family of proteins are involved in 60S ...
 48-445 1.76e-80

Nop53 (60S ribosomal biogenesis); This nucleolar family of proteins are involved in 60S ribosomal biogenesis. They are specifically involved in the processing beyond the 27S stage of 25S rRNA maturation. This family contains sequences that bear similarity to the glioma tumour suppressor candidate region gene 2 protein (p60). This protein has been found to interact with herpes simplex type 1 regulatory proteins.


:

Pssm-ID: 462259 [Multi-domain]  Cd Length: 353  Bit Score: 253.76  E-value: 1.76e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
8FLA_NL        48 WRRLAQEPlglEVDQFLEDVRLQERTsGGLLSEAPNEKLFFVDTGSKEKGLTKKRTKVQKKSlllkkplRVDLILENTSK 127
Cdd:pfam07767   8 WRKNIDIT---DVEDGLEEVREEIIT-GGVLSEKPDDELFVVDTKGDEELKKKLRKKIKKPL-------KSDEILAQRSA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
8FLA_NL       128 VPAPKdvLAHQVPNAKKLRRKEQLWEKLAKQGELPREVRRAqARLLNPSATRAKPGPQDtverpfYDLWASDNPLDRPLV 207
Cdd:pfam07767  77 VPAVS--HKRKRPGAKKLKKKKVSKKELARLRKLAKGKRKG-EKKLEKSAKDGLVFSGT------YDLWGEEEEPEVEKK 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
8FLA_NL       208 GQDEFFLEQTKKKGVKRPARLHTKP---SQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQRQKEAEKLERQLALPAT 284
Cdd:pfam07767 148 EEEHTLSFLEKKKKVKAPKTLKHKPislTALPAVEVPHAGTSYNPSFEDHQELLQKAVEAEKKRLKEEEKLERVLEKIAE 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
8FLA_NL       285 EQAatqestfqelceglleesdgegepgqgegpEAGDAEVcptparlattEKKTEQQRRREKAVHRLRVQQAALRAARLR 364
Cdd:pfam07767 228 SAA------------------------------TAEAREE----------KRKTKAQRNKEKRRKEEEREAKEEKALKKK 267

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
8FLA_NL       365 HQELFRLRGIKAQVALRLAELARRQRRRQ-----ARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILR 439
Cdd:pfam07767 268 LAQLERLKEIAKEIAEKEKEREEKAEARKrekrkKKKEEKKLRPRKLGKHKVPEPDLEVQLPDELSGSLRLLKPEGNLLK 347


                  ....*.
8FLA_NL       440 DRFKSF 445
Cdd:pfam07767 348 DRFKSL 353
 
Name Accession Description Interval E-value
Nop53 pfam07767
Nop53 (60S ribosomal biogenesis); This nucleolar family of proteins are involved in 60S ...
 48-445 1.76e-80

Nop53 (60S ribosomal biogenesis); This nucleolar family of proteins are involved in 60S ribosomal biogenesis. They are specifically involved in the processing beyond the 27S stage of 25S rRNA maturation. This family contains sequences that bear similarity to the glioma tumour suppressor candidate region gene 2 protein (p60). This protein has been found to interact with herpes simplex type 1 regulatory proteins.


Pssm-ID: 462259 [Multi-domain]  Cd Length: 353  Bit Score: 253.76  E-value: 1.76e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
8FLA_NL        48 WRRLAQEPlglEVDQFLEDVRLQERTsGGLLSEAPNEKLFFVDTGSKEKGLTKKRTKVQKKSlllkkplRVDLILENTSK 127
Cdd:pfam07767   8 WRKNIDIT---DVEDGLEEVREEIIT-GGVLSEKPDDELFVVDTKGDEELKKKLRKKIKKPL-------KSDEILAQRSA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
8FLA_NL       128 VPAPKdvLAHQVPNAKKLRRKEQLWEKLAKQGELPREVRRAqARLLNPSATRAKPGPQDtverpfYDLWASDNPLDRPLV 207
Cdd:pfam07767  77 VPAVS--HKRKRPGAKKLKKKKVSKKELARLRKLAKGKRKG-EKKLEKSAKDGLVFSGT------YDLWGEEEEPEVEKK 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
8FLA_NL       208 GQDEFFLEQTKKKGVKRPARLHTKP---SQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQRQKEAEKLERQLALPAT 284
Cdd:pfam07767 148 EEEHTLSFLEKKKKVKAPKTLKHKPislTALPAVEVPHAGTSYNPSFEDHQELLQKAVEAEKKRLKEEEKLERVLEKIAE 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
8FLA_NL       285 EQAatqestfqelceglleesdgegepgqgegpEAGDAEVcptparlattEKKTEQQRRREKAVHRLRVQQAALRAARLR 364
Cdd:pfam07767 228 SAA------------------------------TAEAREE----------KRKTKAQRNKEKRRKEEEREAKEEKALKKK 267

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
8FLA_NL       365 HQELFRLRGIKAQVALRLAELARRQRRRQ-----ARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILR 439
Cdd:pfam07767 268 LAQLERLKEIAKEIAEKEKEREEKAEARKrekrkKKKEEKKLRPRKLGKHKVPEPDLEVQLPDELSGSLRLLKPEGNLLK 347


                  ....*.
8FLA_NL       440 DRFKSF 445
Cdd:pfam07767 348 DRFKSL 353
 
Name Accession Description Interval E-value
Nop53 pfam07767
Nop53 (60S ribosomal biogenesis); This nucleolar family of proteins are involved in 60S ...
 48-445 1.76e-80

Nop53 (60S ribosomal biogenesis); This nucleolar family of proteins are involved in 60S ribosomal biogenesis. They are specifically involved in the processing beyond the 27S stage of 25S rRNA maturation. This family contains sequences that bear similarity to the glioma tumour suppressor candidate region gene 2 protein (p60). This protein has been found to interact with herpes simplex type 1 regulatory proteins.


Pssm-ID: 462259 [Multi-domain]  Cd Length: 353  Bit Score: 253.76  E-value: 1.76e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
8FLA_NL        48 WRRLAQEPlglEVDQFLEDVRLQERTsGGLLSEAPNEKLFFVDTGSKEKGLTKKRTKVQKKSlllkkplRVDLILENTSK 127
Cdd:pfam07767   8 WRKNIDIT---DVEDGLEEVREEIIT-GGVLSEKPDDELFVVDTKGDEELKKKLRKKIKKPL-------KSDEILAQRSA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
8FLA_NL       128 VPAPKdvLAHQVPNAKKLRRKEQLWEKLAKQGELPREVRRAqARLLNPSATRAKPGPQDtverpfYDLWASDNPLDRPLV 207
Cdd:pfam07767  77 VPAVS--HKRKRPGAKKLKKKKVSKKELARLRKLAKGKRKG-EKKLEKSAKDGLVFSGT------YDLWGEEEEPEVEKK 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
8FLA_NL       208 GQDEFFLEQTKKKGVKRPARLHTKP---SQAPAVEVAPAGASYNPSFEDHQTLLSAAHEVELQRQKEAEKLERQLALPAT 284
Cdd:pfam07767 148 EEEHTLSFLEKKKKVKAPKTLKHKPislTALPAVEVPHAGTSYNPSFEDHQELLQKAVEAEKKRLKEEEKLERVLEKIAE 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
8FLA_NL       285 EQAatqestfqelceglleesdgegepgqgegpEAGDAEVcptparlattEKKTEQQRRREKAVHRLRVQQAALRAARLR 364
Cdd:pfam07767 228 SAA------------------------------TAEAREE----------KRKTKAQRNKEKRRKEEEREAKEEKALKKK 267

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
8FLA_NL       365 HQELFRLRGIKAQVALRLAELARRQRRRQ-----ARREAEADKPRRLGRLKYQAPDIDVQLSSELTDSLRTLKPEGNILR 439
Cdd:pfam07767 268 LAQLERLKEIAKEIAEKEKEREEKAEARKrekrkKKKEEKKLRPRKLGKHKVPEPDLEVQLPDELSGSLRLLKPEGNLLK 347


                  ....*.
8FLA_NL       440 DRFKSF 445
Cdd:pfam07767 348 DRFKSL 353
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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