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Conserved domains on  [gi|2431413420|pdb|7W4L|G]
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Chain G, Acyl carrier protein

Protein Classification

acyl carrier protein( domain architecture ID 516)

acyl carrier protein may function as a carrier of the growing fatty acid chain in fatty acid biosynthesis or as the carrier of activated (amino) acid groups in polyketide synthases and non-ribosomal peptide synthases

Gene Ontology:  GO:0006633
PubMed:  30543875

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PP-binding super family cl09936
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 6-84 9.34e-22

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


The actual alignment was detected with superfamily member PTZ00171:

Pssm-ID: 447865  Cd Length: 148  Bit Score: 82.44  E-value: 9.34e-22
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
7W4L_G         6 LTLEAIKDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKK 84
Cdd:PTZ00171  66 LSKEDVLTRVKKVVKNFEKVDASKITPESNFVKDLGADSLDVVELLIAIEQEFNLTIPDHDAEKIKTVQDAIDYIEQNN 144
 
Name Accession Description Interval E-value
PTZ00171 PTZ00171
acyl carrier protein; Provisional
 6-84 9.34e-22

acyl carrier protein; Provisional


Pssm-ID: 240304  Cd Length: 148  Bit Score: 82.44  E-value: 9.34e-22
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
7W4L_G         6 LTLEAIKDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKK 84
Cdd:PTZ00171  66 LSKEDVLTRVKKVVKNFEKVDASKITPESNFVKDLGADSLDVVELLIAIEQEFNLTIPDHDAEKIKTVQDAIDYIEQNN 144
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 10-84 3.12e-16

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 66.27  E-value: 3.12e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
7W4L_G        10 AIKDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKK 84
Cdd:TIGR00517  3 EIFEKVKAIIKEQLNVDEDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEEAEKIATVGDAVNYIEENQ 77
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 7-84 1.00e-15

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 65.26  E-value: 1.00e-15
                       10        20        30        40        50        60        70
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
7W4L_G       7 TLEAIKDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKK 84
Cdd:COG0236  2 PREELEERLAEIIAEVLGVDPEEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEKL 79
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 24-66 4.13e-07

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 42.94  E-value: 4.13e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
7W4L_G        24 KIDPEKLSVNSHFMkDLGLDSLDQVEIIMAMEDEFGFEIPDID 66
Cdd:pfam00550 12 GVPAEEIDPDTDLF-DLGLDSLLAVELIARLEEEFGVEIPPSD 53
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 1-63 1.97e-03

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 33.76  E-value: 1.97e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
7W4L_G          1 SDAPPLTLEAIKDRVLYVLKLydkIDPEKLSVNSHFmKDLGLDSLDQVEIIMAMEDEFGFEIP 63
Cdd:smart00823  7 AERRRLLLDLVREQVAAVLGH---AAAEAIDPDRPF-RDLGLDSLMAVELRNRLEAATGLRLP 65
 
Name Accession Description Interval E-value
PTZ00171 PTZ00171
acyl carrier protein; Provisional
 6-84 9.34e-22

acyl carrier protein; Provisional


Pssm-ID: 240304  Cd Length: 148  Bit Score: 82.44  E-value: 9.34e-22
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
7W4L_G         6 LTLEAIKDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKK 84
Cdd:PTZ00171  66 LSKEDVLTRVKKVVKNFEKVDASKITPESNFVKDLGADSLDVVELLIAIEQEFNLTIPDHDAEKIKTVQDAIDYIEQNN 144
acpP CHL00124
acyl carrier protein; Validated
 25-86 4.05e-17

acyl carrier protein; Validated


Pssm-ID: 177047 [Multi-domain]  Cd Length: 82  Bit Score: 68.89  E-value: 4.05e-17
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
7W4L_G       25 IDPEKLSVNSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKKDV 86
Cdd:CHL00124 20 IEKSEVTLDANFTRDLGADSLDVVELVMAIEEKFDIEIPDEDAEKISTLQEAVDFISQKINK 81
acpP PRK00982
acyl carrier protein; Provisional
 25-84 6.37e-17

acyl carrier protein; Provisional


Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 68.27  E-value: 6.37e-17
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
7W4L_G       25 IDPEKLSVNSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKK 84
Cdd:PRK00982 18 VDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKHQ 77
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 10-84 3.12e-16

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 66.27  E-value: 3.12e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
7W4L_G        10 AIKDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKK 84
Cdd:TIGR00517  3 EIFEKVKAIIKEQLNVDEDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEEAEKIATVGDAVNYIEENQ 77
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 7-84 1.00e-15

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 65.26  E-value: 1.00e-15
                       10        20        30        40        50        60        70
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
7W4L_G       7 TLEAIKDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKK 84
Cdd:COG0236  2 PREELEERLAEIIAEVLGVDPEEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEKL 79
PRK12449 PRK12449
acyl carrier protein; Provisional
 6-84 2.11e-10

acyl carrier protein; Provisional


Pssm-ID: 183533 [Multi-domain]  Cd Length: 80  Bit Score: 51.63  E-value: 2.11e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
7W4L_G        6 LTLEAIKDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKK 84
Cdd:PRK12449  1 MTREEIFERLINLIQKQRSYLSLAITEQTHLKDDLAVDSIELVEFIINVEDEFHIAIPDEDVEDMVSMGDLLDYLVQRL 79
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 24-66 4.13e-07

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 42.94  E-value: 4.13e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
7W4L_G        24 KIDPEKLSVNSHFMkDLGLDSLDQVEIIMAMEDEFGFEIPDID 66
Cdd:pfam00550 12 GVPAEEIDPDTDLF-DLGLDSLLAVELIARLEEEFGVEIPPSD 53
PRK06508 PRK06508
acyl carrier protein; Provisional
 13-63 1.22e-06

acyl carrier protein; Provisional


Pssm-ID: 180597  Cd Length: 93  Bit Score: 42.50  E-value: 1.22e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
7W4L_G       13 DRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLDQVEIIMAMEDEFGFEIP 63
Cdd:PRK06508  6 DKVADIIAETSDIPRDTITPESHTIDDLGIDSLDFLDIVFAIDKAFGIKLP 56
PRK07081 PRK07081
acyl carrier protein; Provisional
 39-64 3.78e-04

acyl carrier protein; Provisional


Pssm-ID: 180828  Cd Length: 83  Bit Score: 35.70  E-value: 3.78e-04
                        10        20
                ....*....|....*....|....*.
7W4L_G       39 DLGLDSLDQVEIIMAMEDEFGFEIPD 64
Cdd:PRK07081 30 EAGLSSLATVQLMLAIEDAFDIEIPD 55
PKS_PP smart00823
Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the ...
 1-63 1.97e-03

Phosphopantetheine attachment site; Phosphopantetheine (or pantetheine 4' phosphate) is the prosthetic group of acyl carrier proteins (ACP) in some multienzyme complexes where it serves as a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups.


Pssm-ID: 214834 [Multi-domain]  Cd Length: 86  Bit Score: 33.76  E-value: 1.97e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
7W4L_G          1 SDAPPLTLEAIKDRVLYVLKLydkIDPEKLSVNSHFmKDLGLDSLDQVEIIMAMEDEFGFEIP 63
Cdd:smart00823  7 AERRRLLLDLVREQVAAVLGH---AAAEAIDPDRPF-RDLGLDSLMAVELRNRLEAATGLRLP 65
PRK05828 PRK05828
acyl carrier protein; Validated
 37-86 2.25e-03

acyl carrier protein; Validated


Pssm-ID: 180278  Cd Length: 84  Bit Score: 33.69  E-value: 2.25e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
7W4L_G       37 MKDLGLDSLDQVEIIMAMEDEFGFEIPDidaEKLMCPQEIVDYIADKKDV 86
Cdd:PRK05828 32 YRELKIDSLDMFSIIVSLESEFNIEFSD---EKLMKLKNLADLILEVKEL 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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