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Conserved domains on  [gi|1951684930|pdb|6Z74|C]
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Chain C, Transcriptional regulator, GntR family

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448455)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain; controls the expression of genes with diverse biological functions

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  33509775
SCOP:  4000155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
12-231 6.39e-44

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 147.76  E-value: 6.39e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C       12 RAVIELREKILSGELPGGMRLFEVSTAELLDISRTPVREALSRLTEEGLLNRLPGGGFVVRRFGFADVVDAIEVRGVMEG 91
Cdd:COG1802  15 QVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIRELYEVRAALEG 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C       92 TAARLAAERGvSKVALEEIDATVQQLDlcfgDRVDDVDFDGYAALNRIFHHQLAALCGSEMIRREVERASSLPFASPSAF 171
Cdd:COG1802  95 LAARLAAERA-TPADLARLRALLEELE----AAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRRYRRLS 169

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C      172 LPDkanigafRRSLRGAQEQHKAIVAAIVAREGARAEAVAREHSRTARTNLEYMIREAPE 231
Cdd:COG1802 170 LRS-------PGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAAAA 222
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
12-231 6.39e-44

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 147.76  E-value: 6.39e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C       12 RAVIELREKILSGELPGGMRLFEVSTAELLDISRTPVREALSRLTEEGLLNRLPGGGFVVRRFGFADVVDAIEVRGVMEG 91
Cdd:COG1802  15 QVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIRELYEVRAALEG 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C       92 TAARLAAERGvSKVALEEIDATVQQLDlcfgDRVDDVDFDGYAALNRIFHHQLAALCGSEMIRREVERASSLPFASPSAF 171
Cdd:COG1802  95 LAARLAAERA-TPADLARLRALLEELE----AAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRRYRRLS 169

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C      172 LPDkanigafRRSLRGAQEQHKAIVAAIVAREGARAEAVAREHSRTARTNLEYMIREAPE 231
Cdd:COG1802 170 LRS-------PGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAAAA 222
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 16-72 8.29e-14

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 64.39  E-value: 8.29e-14
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
6Z74_C       16 ELREKILSGELPGGMRL-FEVSTAELLDISRTPVREALSRLTEEGLLNRLPGGGFVVR 72
Cdd:cd07377   9 QLREAILSGELKPGDRLpSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 81-214 3.13e-13

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 64.69  E-value: 3.13e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C          81 DAIEVRGVMEGTAARLAAERGvSKVALEEIDATVQQLDLCFGDrvdDVDFDGYAALNRIFHHQLAALCGSEMIRREVERA 160
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERA-TDEDLAALEALLDAMEAAAAA---GDDLEEFAELDREFHRALAEAAGNPVLLELLESL 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
6Z74_C         161 SSLPFASPSAFLpdkanigafrRSLRGAQEQHKAIVAAIVAREGARAEAVAREH 214
Cdd:smart00895  77 RARLRRLRRLSL----------EAARRALDEHRAILDAIRARDAEAARAAMREH 120
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 16-71 1.34e-11

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 58.39  E-value: 1.34e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
6Z74_C         16 ELREKILSGELPGGMRLFEVST-AELLDISRTPVREALSRLTEEGLLNRLPGGGFVV 71
Cdd:pfam00392   8 RLREDILSGRLRPGDKLPSERElAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
 17-214 3.18e-10

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 58.37  E-value: 3.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C        17 LREKILSGELPGGMRLFEVSTAELLDISRTPVREALSRLTEEGLLNRLPGGGFVVRRFGFADVVDAIEVRGVMEGTAARL 96
Cdd:PRK11534  16 LKNDIIRGNFQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDARANMEAMLVSL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C        97 AAERG-----VSKVA-------LEEIDATVQQLDLcfgdrvddvdfdgYAALNRIFHHQLAALCGSEMIRREVERASSLp 164
Cdd:PRK11534  96 AIARGgdeweADVLAkahllskLEACDASEKMLDE-------------WDLRHQAFHTAIVAGCGSHYLLQMRERLFDL- 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
6Z74_C       165 fASPSAFLPDKANIGAFrRSLRGAQEQHKAIVAAIVAREGARAEAVAREH 214
Cdd:PRK11534 162 -AARYRFIWLRRTVLSV-EMLEDKHDQHQTLTAAILARDTARASELMRQH 209
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
12-231 6.39e-44

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 147.76  E-value: 6.39e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C       12 RAVIELREKILSGELPGGMRLFEVSTAELLDISRTPVREALSRLTEEGLLNRLPGGGFVVRRFGFADVVDAIEVRGVMEG 91
Cdd:COG1802  15 QVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIRELYEVRAALEG 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C       92 TAARLAAERGvSKVALEEIDATVQQLDlcfgDRVDDVDFDGYAALNRIFHHQLAALCGSEMIRREVERASSLPFASPSAF 171
Cdd:COG1802  95 LAARLAAERA-TPADLARLRALLEELE----AAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRRYRRLS 169

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C      172 LPDkanigafRRSLRGAQEQHKAIVAAIVAREGARAEAVAREHSRTARTNLEYMIREAPE 231
Cdd:COG1802 170 LRS-------PGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAAAA 222
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
16-231 2.19e-24

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 96.93  E-value: 2.19e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C       16 ELREKILSGELPGGMRL-FEVSTAELLDISRTPVREALSRLTEEGLLNRLPGGGFVVRRFGFADVVDAI----------- 83
Cdd:COG2186  15 QLRELILSGELKPGDRLpSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLDPLalllalddasl 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C       84 ----EVRGVMEGTAARLAAERGvSKVALEEIDATVQQLDLCFGDRVDDVDFDgyaalnRIFHHQLAALCGSEMIRREVER 159
Cdd:COG2186  95 rdllEARLALEPEAARLAAERA-TDEDLARLEAALAEMEAAADDGEAFAEAD------LAFHRAIAEASGNPLLALLLES 167

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
6Z74_C      160 ASSLPFASPSAFLPDKANigafrrsLRGAQEQHKAIVAAIVAREGARAEAVAREHSRTARTNLEYMIREAPE 231
Cdd:COG2186 168 LRELLRRSVRLTLRSPEA-------RERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLREALAERAR 232
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 16-72 8.29e-14

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 64.39  E-value: 8.29e-14
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
6Z74_C       16 ELREKILSGELPGGMRL-FEVSTAELLDISRTPVREALSRLTEEGLLNRLPGGGFVVR 72
Cdd:cd07377   9 QLREAILSGELKPGDRLpSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 81-214 3.13e-13

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 64.69  E-value: 3.13e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C          81 DAIEVRGVMEGTAARLAAERGvSKVALEEIDATVQQLDLCFGDrvdDVDFDGYAALNRIFHHQLAALCGSEMIRREVERA 160
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERA-TDEDLAALEALLDAMEAAAAA---GDDLEEFAELDREFHRALAEAAGNPVLLELLESL 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
6Z74_C         161 SSLPFASPSAFLpdkanigafrRSLRGAQEQHKAIVAAIVAREGARAEAVAREH 214
Cdd:smart00895  77 RARLRRLRRLSL----------EAARRALDEHRAILDAIRARDAEAARAAMREH 120
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 16-71 1.34e-11

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 58.39  E-value: 1.34e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
6Z74_C         16 ELREKILSGELPGGMRLFEVST-AELLDISRTPVREALSRLTEEGLLNRLPGGGFVV 71
Cdd:pfam00392   8 RLREDILSGRLRPGDKLPSERElAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 81-213 2.41e-11

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 59.31  E-value: 2.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C         81 DAIEVRGVMEGTAARLAAERGvSKVALEEIDATVQQLDlcfgDRVDDVDFDGYAALNRIFHHQLAALCGSEMIRREVERA 160
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERA-TDEDLAELEALLEALE----AAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESL 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
6Z74_C        161 SSLPFASPSAFLPDkanigafRRSLRGAQEQHKAIVAAIVAREGARAEAVARE 213
Cdd:pfam07729  76 WDRLRRLRRLLLSS-------PGRLRASLEEHRAILDAIRARDPEAARAAMRR 121
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
16-71 8.70e-11

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 56.04  E-value: 8.70e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
6Z74_C          16 ELREKILSGELPGGMRLFEVST-AELLDISRTPVREALSRLTEEGLLNRLPGGGFVV 71
Cdd:smart00345   4 RLREDIVSGELRPGDKLPSERElAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
 17-214 3.18e-10

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 58.37  E-value: 3.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C        17 LREKILSGELPGGMRLFEVSTAELLDISRTPVREALSRLTEEGLLNRLPGGGFVVRRFGFADVVDAIEVRGVMEGTAARL 96
Cdd:PRK11534  16 LKNDIIRGNFQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDARANMEAMLVSL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C        97 AAERG-----VSKVA-------LEEIDATVQQLDLcfgdrvddvdfdgYAALNRIFHHQLAALCGSEMIRREVERASSLp 164
Cdd:PRK11534  96 AIARGgdeweADVLAkahllskLEACDASEKMLDE-------------WDLRHQAFHTAIVAGCGSHYLLQMRERLFDL- 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
6Z74_C       165 fASPSAFLPDKANIGAFrRSLRGAQEQHKAIVAAIVAREGARAEAVAREH 214
Cdd:PRK11534 162 -AARYRFIWLRRTVLSV-EMLEDKHDQHQTLTAAILARDTARASELMRQH 209
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
16-87 2.60e-08

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 52.94  E-value: 2.60e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C       16 ELREKILSGELPGGMRL-FEVSTAELLDISRTPVREALSRLTEEGLLNRLPGGG-FVVRR------FGFADVVDAIEVRG 87
Cdd:COG2188  13 ALRERIESGELPPGDRLpSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGtFVAEPkieyplSRLTSFTEELRARG 92
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
16-220 2.69e-07

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 50.02  E-value: 2.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C        16 ELREKILSGEL-PGGMRLFEVSTAELLDISRTPVREALSRLTEEGLLNRLPGGG-FVVRRF--GFADVV----------- 80
Cdd:PRK09464  18 QLEFLILEGTLrPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGtFVQSSLwqSFSDPLvellsdhpesq 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C        81 -DAIEVRGVMEGTAARLAAERGVskvalEEIDATVQQLDLCFGDRVDDVDFDGYAALNRIFHHQLA-----------ALC 148
Cdd:PRK09464  98 fDLLETRHALEGIAAYYAALRGT-----DEDFERIRECHHAIELAQQSGDLDAEANAVMQYQIAVTeaahnvvllhlLRC 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C       149 GSEMIRREVERASSLPFAspsaflpdkanigafRRSLRGAQEQHKA-IVAAIVAREGARA-EA--------------VAR 212
Cdd:PRK09464 173 MEPMLEQNVRQNFELLYR---------------RREMLPKVSSHRArIFEAIVAGKPEKArEAshrhlafieeilldLSR 237


                 ....*...
6Z74_C       213 EHSRTART 220
Cdd:PRK09464 238 EESRRERS 245
PRK11414 PRK11414
GntR family transcriptional regulator;
16-100 5.41e-07

GntR family transcriptional regulator;


Pssm-ID: 183126 [Multi-domain]  Cd Length: 221  Bit Score: 49.10  E-value: 5.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C        16 ELREKILSGELPGGMRLFEVSTAELLDISRTPVREALSRLTEEGLLNRLPGGGFVVRRFGFADVVDAIEVRGVMEGTAAR 95
Cdd:PRK11414  19 DLKHQLSIGALKPGARLITKNLAEQLGMSITPVREALLRLVSVNALSVAPAQAFTVPEVSKRQLDEINRIRYELELMAVA 98


                 ....*
6Z74_C        96 LAAER 100
Cdd:PRK11414  99 LAVEN 103
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 17-73 1.86e-06

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 48.29  E-value: 1.86e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C       17 LREKILSGELPGGMRLFevST---AELLDISRTPVREALSRLTEEGLLNRLPGGGFVVRR 73
Cdd:COG1167  21 LREAILSGRLPPGDRLP--SSrelAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAA 78
PRK09764 PRK09764
GntR family transcriptional regulator;
17-125 6.19e-05

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 42.89  E-value: 6.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C        17 LREKILSGEL-PGGMRLFEVSTAELLDISRTPVREALSRLTEEGLLNRLPGGGFVVR--RFGFadvvDAIEVRGVMEGTA 93
Cdd:PRK09764  14 IREQIARGELkPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKeeRVNY----DIFQLTSFDEKLS 89

                         90       100       110
                 ....*....|....*....|....*....|....*.
6Z74_C        94 ARLAAERgvSKVALEEI----DATVQQLDLCFGDRV 125
Cdd:PRK09764  90 DRHVDTH--SEVLIFEVipadDFLQQQLQITAQDRV 123
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 26-233 9.47e-05

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 42.45  E-value: 9.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C        26 LPGGMRLfevstAELLDISRTPVREALSRLTEEGLLNRLPG-GGFVVRRFGFAD--------------VVDAIEVRGVME 90
Cdd:PRK09990  31 LPSERRL-----CEKLGFSRSALREGLTVLRGRGIIETAQGrGSFVARLNRVQDasplmhlfssqprtLYDLLEVRALLE 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C        91 GTAARLAAERG------VSKVALEEIdatvqqldLCFGDRVDDVDFDGYAALNRIFHhqlAALCGSEMIRREVERASSLP 164
Cdd:PRK09990 106 GESARLAALRGtqadfvLITRRYEEM--------LAAHENNKEIDPIEHARLDHAFH---LAICEASHNPVLVHTLQSLT 174

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
6Z74_C       165 FASPSAFLPDKANIGAFRRSLRGAQEQHKAIVAAIVAREGARAEAVAREHSRTARTNLEYMIREAPELI 233
Cdd:PRK09990 175 DLMLSSVFASVNNLYHRPQQKKQIDRQHARLYNAVLQRLPEQAQRAARDHIRTVRDNLREIEQEEQRLV 243
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 12-100 8.27e-04

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 39.75  E-value: 8.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C        12 RAVIELREKILSGELPGGMRL-FEVSTAELLDISRTPVREALSRLTEEGLLNRLPGGGFVVR------------------ 72
Cdd:PRK10421   6 EVADRVRALIEEKNLEAGMKLpAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRwrhetwseqnivqplktl 85

                         90       100       110
                 ....*....|....*....|....*....|....*
6Z74_C        73 -------RFgfadvvDAIEVRGVMEGTAARLAAER 100
Cdd:PRK10421  86 maddpdySF------DILEARHAIEASTAWHAAMR 114
PRK11523 PRK11523
transcriptional regulator ExuR;
16-136 9.32e-04

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 39.44  E-value: 9.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C        16 ELREKILSGELPGGMRL-FEVSTAELLDISRTPVREALSRLTEEGLLNRLPGGGFVV--------------RRFGFADVV 80
Cdd:PRK11523  16 ELKERIEQGVYLVGDKLpAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVvsnqprhqqaadnnMEFANYGPF 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
6Z74_C        81 DAIEVRGVMEGTAARLAAERgVSK---VALEEIDATVQQLDlCFGDRVDDVDFDGYAAL 136
Cdd:PRK11523  96 ELLQARQLIESNIAEFAATQ-VTKqdiMKLMAIQEQARGED-CFRDSEWDLQFHVQVAL 152
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
15-70 1.26e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 38.02  E-value: 1.26e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C       15 IELREKILsgELPGGMRLFEVstAELLDISRTPVREALSRLTEEGLLNR----LPGGGFV 70
Cdd:COG3355  30 AEVYLILL--ENGEPLTVEEL--AEALDRSRSTVYRSLQKLLEAGLVERekrnLEGGGYP 85
PRK14999 PRK14999
histidine utilization repressor; Provisional
 16-116 5.59e-03

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 37.22  E-value: 5.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6Z74_C        16 ELREKILSGELPGGMRLfeVSTAELL---DISRTPVREALSRLTEEGLLNRLPG-GGFVVRRFGFADVvdaIEVRGVMEG 91
Cdd:PRK14999  20 DICKKIAGGVWQPHDRI--PSEAELVaqyGFSRMTINRALRELTDEGWLVRLQGvGTFVAEPKGQSAL---FEVRSIAEE 94

                         90       100
                 ....*....|....*....|....*
6Z74_C        92 TAARLAAERgVSKVALEEIDATVQQ 116
Cdd:PRK14999  95 IAARRHQHR-CEVLTLERVRANAIQ 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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