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Conserved domains on  [gi|1621110512|pdb|6NIH|A]
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Chain A, Toll-like receptor 1,Variable lymphocyte receptor B

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469631)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3439 super family cl13373
Domain of unknown function (DUF3439); This presumed domain is functionally uncharacterized. ...
 507-545 4.79e-17

Domain of unknown function (DUF3439); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 46 to 94 amino acids in length. This domain is found associated with pfam01462, pfam00560.


The actual alignment was detected with superfamily member pfam11921:

Pssm-ID: 288750  Cd Length: 122  Bit Score: 77.30  E-value: 4.79e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
6NIH_A        507 SCPRIDYLSRWLNKNSQKEQG--------SAKCSGSGKPVRSIICPT 545
Cdd:pfam11921   1 TCPGIDYLSRWIQKNSGIVKDssgyvdpdSAKCSGSGKPVRSIICPT 47
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
369-502 6.18e-12

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 6.18e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A      369 GHLTELETLILQMNQLKELSKIaemTTQMKSLQQLDISQNSVSY-DEKKGDCswtKSLLSLNMSSNILTD---TIFRClp 444
Cdd:COG4886 110 SNLTNLESLDLSGNQLTDLPEE---LANLTNLKELDLSNNQLTDlPEPLGNL---TNLKSLDLSNNQLTDlpeELGNL-- 181

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
6NIH_A      445 PRIKVLDLHSNKIKSIPKQVVKLEALQELNVASNQLKSVPDGIfDRLTSLQKIWLHTN 502
Cdd:COG4886 182 TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNN 238
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-152 1.34e-10

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.41  E-value: 1.34e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A       29 VDRSKNGLIHVPKDLSQKT--TILNISQNYISELwTSDILSLSKLRILIISHNRIQYLDISVFKFNQeLEYLDLSHNKLV 106
Cdd:COG4886 118 LDLSGNQLTDLPEELANLTnlKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQIT 195

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
6NIH_A      107 KISCHPT--VNLKHLDLSFNAFDALPicKEFGNMSQLKFLGLSTTHLE 152
Cdd:COG4886 196 DLPEPLGnlTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLT 241
 
Name Accession Description Interval E-value
DUF3439 pfam11921
Domain of unknown function (DUF3439); This presumed domain is functionally uncharacterized. ...
 507-545 4.79e-17

Domain of unknown function (DUF3439); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 46 to 94 amino acids in length. This domain is found associated with pfam01462, pfam00560.


Pssm-ID: 288750  Cd Length: 122  Bit Score: 77.30  E-value: 4.79e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
6NIH_A        507 SCPRIDYLSRWLNKNSQKEQG--------SAKCSGSGKPVRSIICPT 545
Cdd:pfam11921   1 TCPGIDYLSRWIQKNSGIVKDssgyvdpdSAKCSGSGKPVRSIICPT 47
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
369-502 6.18e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 6.18e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A      369 GHLTELETLILQMNQLKELSKIaemTTQMKSLQQLDISQNSVSY-DEKKGDCswtKSLLSLNMSSNILTD---TIFRClp 444
Cdd:COG4886 110 SNLTNLESLDLSGNQLTDLPEE---LANLTNLKELDLSNNQLTDlPEPLGNL---TNLKSLDLSNNQLTDlpeELGNL-- 181

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
6NIH_A      445 PRIKVLDLHSNKIKSIPKQVVKLEALQELNVASNQLKSVPDGIfDRLTSLQKIWLHTN 502
Cdd:COG4886 182 TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNN 238
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-152 1.34e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.41  E-value: 1.34e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A       29 VDRSKNGLIHVPKDLSQKT--TILNISQNYISELwTSDILSLSKLRILIISHNRIQYLDISVFKFNQeLEYLDLSHNKLV 106
Cdd:COG4886 118 LDLSGNQLTDLPEELANLTnlKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQIT 195

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
6NIH_A      107 KISCHPT--VNLKHLDLSFNAFDALPicKEFGNMSQLKFLGLSTTHLE 152
Cdd:COG4886 196 DLPEPLGnlTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLT 241
LRR_8 pfam13855
Leucine rich repeat;
69-126 6.62e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 6.62e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
6NIH_A         69 SKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKIS---CHPTVNLKHLDLSFNAF 126
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 352-510 1.37e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.47  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A       352 HLDFSNNLLTDTVFENCGHLTELETLILQMNQLKelSKIAEMTTQMKSLQQLDISQNSVSyDEKKGDCSWTKSLLSLNMS 431
Cdd:PLN00113 240 HLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLS--GPIPPSIFSLQKLISLDLSDNSLS-GEIPELVIQLQNLEILHLF 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A       432 SNILTDTIFRCLP--PRIKVLDLHSNKIK-SIPKQVVKLEALQELNVASNQLKS-VPDGIFDRlTSLQKIWLHTNPWDCS 507
Cdd:PLN00113 317 SNNFTGKIPVALTslPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGeIPEGLCSS-GNLFKLILFSNSLEGE 395


                 ...
6NIH_A       508 CPR 510
Cdd:PLN00113 396 IPK 398
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 351-503 7.93e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.09  E-value: 7.93e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A      351 LHLdFSNNLltdTVFENCGHLTELETLILQMNQLKELskiaEMTTQMKSLQQLDISQNSVSYDEKKGDCSwtkSLLSLNM 430
Cdd:cd21340  29 LYL-YDNKI---TKIENLEFLTNLTHLYLQNNQIEKI----ENLENLVNLKKLYLGGNRISVVEGLENLT---NLEELHI 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A      431 SSNILTDT---IF-----RCLPPRIKVLDLHSNKIKSIpKQVVKLEALQELNVASNQLKSVPD--GIFDRLTSLQKIWLH 500
Cdd:cd21340  98 ENQRLPPGeklTFdprslAALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLT 176


                ...
6NIH_A      501 TNP 503
Cdd:cd21340 177 GNP 179
LRR_8 pfam13855
Leucine rich repeat;
445-503 5.54e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 5.54e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A        445 PRIKVLDLHSNKIKSIPKQV-VKLEALQELNVASNQLKSVPDGIFDRLTSLQKIWLHTNP 503
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
33-130 7.42e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.46  E-value: 7.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A        33 KNGLIHVPKDLSQKTTILNISQNYISELwtSDILSlSKLRILIISHNRIQYLDISVfkfNQELEYLDLSHNKLVKISCHP 112
Cdd:PRK15370 229 SNQLTSIPATLPDTIQEMELSINRITEL--PERLP-SALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAHL 302

                         90
                 ....*....|....*...
6NIH_A       113 TVNLKHLDLSFNAFDALP 130
Cdd:PRK15370 303 PSGITHLNVQSNSLTALP 320
LRRCT smart00082
Leucine rich repeat C-terminal domain;
502-544 2.82e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.95  E-value: 2.82e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
6NIH_A         502 NPWDCSCpRIDYLSRWLNKNSQ-KEQGSAKCSGSGK---PVR-----SIICP 544
Cdd:smart00082   1 NPFICDC-ELRWLLRWLQANEHlQDPVDLRCASPSSlrgPLLellhsEFKCP 51
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 474-535 4.26e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 43.53  E-value: 4.26e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
6NIH_A         474 NVASNQLKSVPDGIFDRLTSLQKIWLHTNPWDCSCpRIDYLSRWLNKNSQK--EQGSAKCSGSG 535
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDC-GLARLPRWAEEKGVKvrQPEAALCAGPG 63
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 43-109 2.50e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 2.50e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
6NIH_A       43 LSQKTTILNISQNYISELwtSDILSLSKLRILIISHNRIQYLD--ISVFKFNQELEYLDLSHNKLVKIS 109
Cdd:cd21340 118 LSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCKKP 184
 
Name Accession Description Interval E-value
DUF3439 pfam11921
Domain of unknown function (DUF3439); This presumed domain is functionally uncharacterized. ...
 507-545 4.79e-17

Domain of unknown function (DUF3439); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 46 to 94 amino acids in length. This domain is found associated with pfam01462, pfam00560.


Pssm-ID: 288750  Cd Length: 122  Bit Score: 77.30  E-value: 4.79e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
6NIH_A        507 SCPRIDYLSRWLNKNSQKEQG--------SAKCSGSGKPVRSIICPT 545
Cdd:pfam11921   1 TCPGIDYLSRWIQKNSGIVKDssgyvdpdSAKCSGSGKPVRSIICPT 47
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
369-502 6.18e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 6.18e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A      369 GHLTELETLILQMNQLKELSKIaemTTQMKSLQQLDISQNSVSY-DEKKGDCswtKSLLSLNMSSNILTD---TIFRClp 444
Cdd:COG4886 110 SNLTNLESLDLSGNQLTDLPEE---LANLTNLKELDLSNNQLTDlPEPLGNL---TNLKSLDLSNNQLTDlpeELGNL-- 181

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
6NIH_A      445 PRIKVLDLHSNKIKSIPKQVVKLEALQELNVASNQLKSVPDGIfDRLTSLQKIWLHTN 502
Cdd:COG4886 182 TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNN 238
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-152 1.34e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.41  E-value: 1.34e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A       29 VDRSKNGLIHVPKDLSQKT--TILNISQNYISELwTSDILSLSKLRILIISHNRIQYLDISVFKFNQeLEYLDLSHNKLV 106
Cdd:COG4886 118 LDLSGNQLTDLPEELANLTnlKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQIT 195

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
6NIH_A      107 KISCHPT--VNLKHLDLSFNAFDALPicKEFGNMSQLKFLGLSTTHLE 152
Cdd:COG4886 196 DLPEPLGnlTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLT 241
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
32-273 2.53e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.64  E-value: 2.53e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A       32 SKNGLIHVPKDLSQ--KTTILNISQNYISELwTSDILSLSKLRILIISHNRIQYLDISVFKFNQeLEYLDLSHNKLVKIs 109
Cdd:COG4886 167 SNNQLTDLPEELGNltNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTN-LETLDLSNNQLTDL- 243

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A      110 chPTV----NLKHLDLSFNAFDALPICKEFGNMSQLKFLG--LSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKEDPEG 183
Cdd:COG4886 244 --PELgnltNLEELDLSNNQLTDLPPLANLTNLKTLDLSNnqLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLT 321

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A      184 LQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIR 263
Cdd:COG4886 322 TLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVL 401

                       250
                ....*....|
6NIH_A      264 ILQLVWHTTV 273
Cdd:COG4886 402 LLTLALLDAV 411
LRR_8 pfam13855
Leucine rich repeat;
69-126 6.62e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 6.62e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
6NIH_A         69 SKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKIS---CHPTVNLKHLDLSFNAF 126
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 352-510 1.37e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.47  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A       352 HLDFSNNLLTDTVFENCGHLTELETLILQMNQLKelSKIAEMTTQMKSLQQLDISQNSVSyDEKKGDCSWTKSLLSLNMS 431
Cdd:PLN00113 240 HLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLS--GPIPPSIFSLQKLISLDLSDNSLS-GEIPELVIQLQNLEILHLF 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A       432 SNILTDTIFRCLP--PRIKVLDLHSNKIK-SIPKQVVKLEALQELNVASNQLKS-VPDGIFDRlTSLQKIWLHTNPWDCS 507
Cdd:PLN00113 317 SNNFTGKIPVALTslPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGeIPEGLCSS-GNLFKLILFSNSLEGE 395


                 ...
6NIH_A       508 CPR 510
Cdd:PLN00113 396 IPK 398
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 351-503 7.93e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.09  E-value: 7.93e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A      351 LHLdFSNNLltdTVFENCGHLTELETLILQMNQLKELskiaEMTTQMKSLQQLDISQNSVSYDEKKGDCSwtkSLLSLNM 430
Cdd:cd21340  29 LYL-YDNKI---TKIENLEFLTNLTHLYLQNNQIEKI----ENLENLVNLKKLYLGGNRISVVEGLENLT---NLEELHI 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A      431 SSNILTDT---IF-----RCLPPRIKVLDLHSNKIKSIpKQVVKLEALQELNVASNQLKSVPD--GIFDRLTSLQKIWLH 500
Cdd:cd21340  98 ENQRLPPGeklTFdprslAALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLT 176


                ...
6NIH_A      501 TNP 503
Cdd:cd21340 177 GNP 179
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 353-474 1.03e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 47.74  E-value: 1.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A      353 LDFSNNLLTD----TVFENCGHLTELETLILQMNQL--KELSKIAEMTTQMKSLQQLDISQNSVS----YDEKKGDCSWT 422
Cdd:cd00116 170 LNLANNGIGDagirALAEGLKANCNLEVLDLNNNGLtdEGASALAETLASLKSLEVLNLGDNNLTdagaAALASALLSPN 249

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
6NIH_A      423 KSLLSLNMSSNILTDTIFRCL------PPRIKVLDLHSNKIKSIPKQVVKLEALQELN 474
Cdd:cd00116 250 ISLLTLSLSCNDITDDGAKDLaevlaeKESLLELDLRGNKFGEEGAQLLAESLLEPGN 307
LRR_8 pfam13855
Leucine rich repeat;
48-105 4.33e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 4.33e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
6NIH_A         48 TILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKL 105
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
445-503 5.54e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 5.54e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A        445 PRIKVLDLHSNKIKSIPKQV-VKLEALQELNVASNQLKSVPDGIFDRLTSLQKIWLHTNP 503
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
33-130 7.42e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.46  E-value: 7.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A        33 KNGLIHVPKDLSQKTTILNISQNYISELwtSDILSlSKLRILIISHNRIQYLDISVfkfNQELEYLDLSHNKLVKISCHP 112
Cdd:PRK15370 229 SNQLTSIPATLPDTIQEMELSINRITEL--PERLP-SALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAHL 302

                         90
                 ....*....|....*...
6NIH_A       113 TVNLKHLDLSFNAFDALP 130
Cdd:PRK15370 303 PSGITHLNVQSNSLTALP 320
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 353-522 7.43e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 7.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A       353 LDFSNNLLTDTVFENCGHLTELETLILQMNQLkeLSKIAEMTTQMKSLQQLDISQNSVSyDEKKGDCSWTKSLLSLNMSS 432
Cdd:PLN00113 169 LDLGGNVLVGKIPNSLTNLTSLEFLTLASNQL--VGQIPRELGQMKSLKWIYLGYNNLS-GEIPYEIGGLTSLNHLDLVY 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A       433 NILTDTIfrclPP------RIKVLDLHSNKIK-SIPKQVVKLEALQELNVASNQLKSVPDGIFDRLTSLQKIWLHTNPWD 505
Cdd:PLN00113 246 NNLTGPI----PSslgnlkNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFT 321

                        170       180
                 ....*....|....*....|....
6NIH_A       506 -------CSCPRIDYLSRWLNKNS 522
Cdd:PLN00113 322 gkipvalTSLPRLQVLQLWSNKFS 345
LRRCT smart00082
Leucine rich repeat C-terminal domain;
502-544 2.82e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.95  E-value: 2.82e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
6NIH_A         502 NPWDCSCpRIDYLSRWLNKNSQ-KEQGSAKCSGSGK---PVR-----SIICP 544
Cdd:smart00082   1 NPFICDC-ELRWLLRWLQANEHlQDPVDLRCASPSSlrgPLLellhsEFKCP 51
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-152 3.20e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 3.20e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A        2 TSIFHFAIIFMLILQIRIQLSEESEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRI 81
Cdd:COG4886  29 LLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE 108

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
6NIH_A       82 qyldisvFKFNQELEYLDLSHNKLVKISCHPT--VNLKHLDLSFNAFDALPicKEFGNMSQLKFLGLSTTHLE 152
Cdd:COG4886 109 -------LSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP--EPLGNLTNLKSLDLSNNQLT 172
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 474-535 4.26e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 43.53  E-value: 4.26e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
6NIH_A         474 NVASNQLKSVPDGIFDRLTSLQKIWLHTNPWDCSCpRIDYLSRWLNKNSQK--EQGSAKCSGSG 535
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDC-GLARLPRWAEEKGVKvrQPEAALCAGPG 63
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 273-480 9.96e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 9.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A       273 VWYFSISNVKLQGQLDFRDFDYsgTSLKALSIhqVVSDVFG-FPQSyiyeiFSNMNIKNftvsgtrmvhmlcpskispfl 351
Cdd:PLN00113 430 VYFLDISNNNLQGRINSRKWDM--PSLQMLSL--ARNKFFGgLPDS-----FGSKRLEN--------------------- 479

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A       352 hLDFSNNLLTDTVFENCGHLTEletlilqmnqlkelskiaemttqmksLQQLDISQNSVSyDEKKGDCSWTKSLLSLNMS 431
Cdd:PLN00113 480 -LDLSRNQFSGAVPRKLGSLSE--------------------------LMQLKLSENKLS-GEIPDELSSCKKLVSLDLS 531

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
6NIH_A       432 SNILTDTIFRCLP--PRIKVLDLHSNKIK-SIPKQVVKLEALQELNVASNQL 480
Cdd:PLN00113 532 HNQLSGQIPASFSemPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHL 583
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 43-109 2.50e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 2.50e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
6NIH_A       43 LSQKTTILNISQNYISELwtSDILSLSKLRILIISHNRIQYLD--ISVFKFNQELEYLDLSHNKLVKIS 109
Cdd:cd21340 118 LSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCKKP 184
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 352-411 2.54e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 2.54e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A      352 HLDFSNNLLTDTvfENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVS 411
Cdd:cd21340 124 VLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPVC 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 389-502 4.94e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 4.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6NIH_A       389 KIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTIFRCLPPRIKVLDLHSNKIK-SIPKQVVKL 467
Cdd:PLN00113  84 KISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSgEIPNDIGSF 163

                         90       100       110
                 ....*....|....*....|....*....|....*
6NIH_A       468 EALQELNVASNQLKSVPDGIFDRLTSLQKIWLHTN 502
Cdd:PLN00113 164 SSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASN 198
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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