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Conserved domains on  [gi|1388258147|pdb|6CGB|A]
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Chain A, Cadherin-11, Cadherin-6 chimera

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10638917)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 110-207 7.82e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.15  E-value: 7.82e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6CGB_A      110 VYTATVPEMADVGTFVVQVTATDADDptyGNSAKVVYSILQGQP--YFSVESETGIIKTAlLNMDRENREQYQVVIQAKD 187
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|
6CGB_A      188 MGGQmgGLSGTTTVNITLTD 207
Cdd:cd11304  77 GGGP--PLSSTATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 26-104 5.81e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 5.81e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6CGB_A          26 SDIDSGD-GNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNrPLEPPSEFIVKVQDINDNEP 104
Cdd:smart00112   3 TDADSGEnGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 110-207 7.82e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.15  E-value: 7.82e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6CGB_A      110 VYTATVPEMADVGTFVVQVTATDADDptyGNSAKVVYSILQGQP--YFSVESETGIIKTAlLNMDRENREQYQVVIQAKD 187
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|
6CGB_A      188 MGGQmgGLSGTTTVNITLTD 207
Cdd:cd11304  77 GGGP--PLSSTATVTITVLD 94
Cadherin pfam00028
Cadherin domain;
111-206 7.95e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.04  E-value: 7.95e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6CGB_A        111 YTATVPEMADVGTFVVQVTATDADDPTygnSAKVVYSILQGQPY--FSVESETGIIKTAlLNMDRENREQYQVVIQAKDM 188
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP---NGRIFYSILGGGPGgnFRIDPDTGDISTT-KPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*...
6CGB_A        189 GGQmgGLSGTTTVNITLT 206
Cdd:pfam00028  77 GGP--PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 26-104 5.81e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 5.81e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6CGB_A          26 SDIDSGD-GNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNrPLEPPSEFIVKVQDINDNEP 104
Cdd:smart00112   3 TDADSGEnGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 16-102 1.30e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.97  E-value: 1.30e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6CGB_A       16 PDPVLVGRLH-SDIDSGD-GNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNrPLEPPSEFI 93
Cdd:cd11304  11 PPGTVVLTVSaTDPDSGEnGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP-PLSSTATVT 89


                ....*....
6CGB_A       94 VKVQDINDN 102
Cdd:cd11304  90 ITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 129-207 3.24e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.77  E-value: 3.24e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6CGB_A         129 TATDADDptyGNSAKVVYSILQG--QPYFSVESETGIIKTALlNMDRENREQYQVVIQAKDMGGQmgGLSGTTTVNITLT 206
Cdd:smart00112   1 SATDADS---GENGKVTYSILSGndDGLFSIDPETGEITTTK-PLDREEQPEYTLTVEATDGGGP--PLSSTATVTITVL 74


                   .
6CGB_A         207 D 207
Cdd:smart00112  75 D 75
Cadherin pfam00028
Cadherin domain;
8-97 1.42e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.47  E-value: 1.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6CGB_A          8 FVIEEyTGPDPVLVGRLH-SDIDSGD-GNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTnRP 85
Cdd:pfam00028   3 ASVPE-NAPVGTEVLTVTaTDPDLGPnGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG-PP 80

                          90
                  ....*....|..
6CGB_A         86 LEPPSEFIVKVQ 97
Cdd:pfam00028  81 LSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 110-207 7.82e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.15  E-value: 7.82e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6CGB_A      110 VYTATVPEMADVGTFVVQVTATDADDptyGNSAKVVYSILQGQP--YFSVESETGIIKTAlLNMDRENREQYQVVIQAKD 187
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|
6CGB_A      188 MGGQmgGLSGTTTVNITLTD 207
Cdd:cd11304  77 GGGP--PLSSTATVTITVLD 94
Cadherin pfam00028
Cadherin domain;
111-206 7.95e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.04  E-value: 7.95e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6CGB_A        111 YTATVPEMADVGTFVVQVTATDADDPTygnSAKVVYSILQGQPY--FSVESETGIIKTAlLNMDRENREQYQVVIQAKDM 188
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP---NGRIFYSILGGGPGgnFRIDPDTGDISTT-KPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*...
6CGB_A        189 GGQmgGLSGTTTVNITLT 206
Cdd:pfam00028  77 GGP--PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 26-104 5.81e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 5.81e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6CGB_A          26 SDIDSGD-GNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNrPLEPPSEFIVKVQDINDNEP 104
Cdd:smart00112   3 TDADSGEnGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 16-102 1.30e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.97  E-value: 1.30e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6CGB_A       16 PDPVLVGRLH-SDIDSGD-GNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNrPLEPPSEFI 93
Cdd:cd11304  11 PPGTVVLTVSaTDPDSGEnGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP-PLSSTATVT 89


                ....*....
6CGB_A       94 VKVQDINDN 102
Cdd:cd11304  90 ITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 129-207 3.24e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.77  E-value: 3.24e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6CGB_A         129 TATDADDptyGNSAKVVYSILQG--QPYFSVESETGIIKTALlNMDRENREQYQVVIQAKDMGGQmgGLSGTTTVNITLT 206
Cdd:smart00112   1 SATDADS---GENGKVTYSILSGndDGLFSIDPETGEITTTK-PLDREEQPEYTLTVEATDGGGP--PLSSTATVTITVL 74


                   .
6CGB_A         207 D 207
Cdd:smart00112  75 D 75
Cadherin pfam00028
Cadherin domain;
8-97 1.42e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.47  E-value: 1.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6CGB_A          8 FVIEEyTGPDPVLVGRLH-SDIDSGD-GNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTnRP 85
Cdd:pfam00028   3 ASVPE-NAPVGTEVLTVTaTDPDLGPnGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG-PP 80

                          90
                  ....*....|..
6CGB_A         86 LEPPSEFIVKVQ 97
Cdd:pfam00028  81 LSSTATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 9-102 1.71e-08

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 50.42  E-value: 1.71e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6CGB_A        9 VIEEYTGPDpvLVGRLHSDIDSGDGNIKYILS--GEGAGTIFVIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPl 86
Cdd:cd00031   6 AVEGRSRGS--FRVSIPTDLIASSGEIIKISAagKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVP- 82

                        90
                ....*....|....*.
6CGB_A       87 EPPSEFIVKVQDINDN 102
Cdd:cd00031  83 QTSSVFSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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