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Conserved domains on  [gi|1036305148|pdb|5EQX|A]
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Chain A, Desmoglein-3

Protein Classification

Cadherin_repeat domain-containing protein( domain architecture ID 11254398)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 116-214 1.96e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 1.96e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5EQX_A      116 EIEENSASNSLVMILNATDADEPNhlNSKIAFKIVSQEPAGtpMFLLSRNTGEVRTlTNSLDREQASSYRLVVSGADKDG 195
Cdd:cd11304   5 SVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNEDG--LFSIDPSTGEITT-AKPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
5EQX_A      196 EGLSTQCECNIKVKDVNDN 214
Cdd:cd11304  80 PPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
223-326 3.86e-17

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 3.86e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5EQX_A        223 YSARIEENILS-SELLRFQVTDLDEeyTDNWLAVYFFTSGNEGNWFEIQTDPrtneGILKVVKALDYEQLQSVKLSIAVK 301
Cdd:pfam00028   1 YSASVPENAPVgTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....*
5EQX_A        302 NKAEFHQSvisryrvQSTPVTIQVI 326
Cdd:pfam00028  75 DSGGPPLS-------STATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 33-106 5.36e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.29  E-value: 5.36e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
5EQX_A          33 KITYRISGvgidQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPP 106
Cdd:smart00112  12 KVTYSILS----GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 353-442 2.62e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 51.55  E-value: 2.62e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5EQX_A      353 VDYILGTYQAIDEDTNkAASNVKY-VMGRNDGGYLMIDSKTAEIKFVKNMNRDSTfivnKTITAEVLAIDEYT-GKTSTG 430
Cdd:cd11304  12 PGTVVLTVSATDPDSG-ENGEVTYsIVSGNEDGLFSIDPSTGEITTAKPLDREEQ----SSYTLTVTATDGGGpPLSSTA 86

                        90
                ....*....|..
5EQX_A      431 TVYVRVPDFNDN 442
Cdd:cd11304  87 TVTITVLDVNDN 98
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 116-214 1.96e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 1.96e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5EQX_A      116 EIEENSASNSLVMILNATDADEPNhlNSKIAFKIVSQEPAGtpMFLLSRNTGEVRTlTNSLDREQASSYRLVVSGADKDG 195
Cdd:cd11304   5 SVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNEDG--LFSIDPSTGEITT-AKPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
5EQX_A      196 EGLSTQCECNIKVKDVNDN 214
Cdd:cd11304  80 PPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
115-208 2.00e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.42  E-value: 2.00e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5EQX_A        115 GEIEENSASNSLVMILNATDADEPnhLNSKIAFKIVSQEPAGtpMFLLSRNTGEVRTlTNSLDREQASSYRLVVSGADKD 194
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGG--NFRIDPDTGDIST-TKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....
5EQX_A        195 GEGLSTQCECNIKV 208
Cdd:pfam00028  78 GPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 131-216 2.16e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 2.16e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5EQX_A         131 NATDADEPNhlNSKIAFKIVSQEPAGtpMFLLSRNTGEVRTlTNSLDREQASSYRLVVSGADKDGEGLSTQCECNIKVKD 210
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGNDDG--LFSIDPETGEITT-TKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
5EQX_A         211 VNDNFP 216
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
223-326 3.86e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 3.86e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5EQX_A        223 YSARIEENILS-SELLRFQVTDLDEeyTDNWLAVYFFTSGNEGNWFEIQTDPrtneGILKVVKALDYEQLQSVKLSIAVK 301
Cdd:pfam00028   1 YSASVPENAPVgTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....*
5EQX_A        302 NKAEFHQSvisryrvQSTPVTIQVI 326
Cdd:pfam00028  75 DSGGPPLS-------STATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 222-328 4.88e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.81  E-value: 4.88e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5EQX_A      222 QYSARIEENI-LSSELLRFQVTDLDEEytDNWLAVYFFTSGNEGNWFEIqtDPRTneGILKVVKALDYEQLQSVKLSIAV 300
Cdd:cd11304   1 SYEVSVPENApPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                        90       100
                ....*....|....*....|....*...
5EQX_A      301 KNKAEFHQSVisryrvqSTPVTIQVINV 328
Cdd:cd11304  75 TDGGGPPLSS-------TATVTITVLDV 95
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 33-106 5.36e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.29  E-value: 5.36e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
5EQX_A          33 KITYRISGvgidQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPP 106
Cdd:smart00112  12 KVTYSILS----GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 13-104 7.09e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.95  E-value: 7.09e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5EQX_A       13 EDNSKRNPIAKIT---SDYQATQKITYRISGvgidQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVE 89
Cdd:cd11304   8 ENAPPGTVVLTVSatdPDSGENGEVTYSIVS----GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                        90
                ....*....|....*
5EQX_A       90 KPLILTVKILDINDN 104
Cdd:cd11304  84 STATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
9-99 6.78e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.15  E-value: 6.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5EQX_A          9 CREGE-DNSKRNPIAKITSDYQATQKITYRISGvgidQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLD 87
Cdd:pfam00028   5 VPENApVGTEVLTVTATDPDLGPNGRIFYSILG----GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                          90
                  ....*....|..
5EQX_A         88 VEKPLILTVKIL 99
Cdd:pfam00028  81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 240-328 3.87e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 53.51  E-value: 3.87e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5EQX_A         240 QVTDLDEEytDNWLAVYFFTSGNEGNWFEIqtDPRTneGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVisryrvqST 319
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDGGGPPLSS-------TA 67


                   ....*....
5EQX_A         320 PVTIQVINV 328
Cdd:smart00112  68 TVTITVLDV 76
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 353-442 2.62e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 51.55  E-value: 2.62e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5EQX_A      353 VDYILGTYQAIDEDTNkAASNVKY-VMGRNDGGYLMIDSKTAEIKFVKNMNRDSTfivnKTITAEVLAIDEYT-GKTSTG 430
Cdd:cd11304  12 PGTVVLTVSATDPDSG-ENGEVTYsIVSGNEDGLFSIDPSTGEITTAKPLDREEQ----SSYTLTVTATDGGGpPLSSTA 86

                        90
                ....*....|..
5EQX_A      431 TVYVRVPDFNDN 442
Cdd:cd11304  87 TVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 361-444 1.30e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.27  E-value: 1.30e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5EQX_A         361 QAIDEDTNkAASNVKYVM-GRNDGGYLMIDSKTAEIKFVKNMNRDSTfivnKTITAEVLAIDEYT-GKTSTGTVYVRVPD 438
Cdd:smart00112   1 SATDADSG-ENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREEQ----PEYTLTVEATDGGGpPLSSTATVTITVLD 75


                   ....*.
5EQX_A         439 FNDNCP 444
Cdd:smart00112  76 VNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 116-214 1.96e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 1.96e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5EQX_A      116 EIEENSASNSLVMILNATDADEPNhlNSKIAFKIVSQEPAGtpMFLLSRNTGEVRTlTNSLDREQASSYRLVVSGADKDG 195
Cdd:cd11304   5 SVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNEDG--LFSIDPSTGEITT-AKPLDREEQSSYTLTVTATDGGG 79

                        90
                ....*....|....*....
5EQX_A      196 EGLSTQCECNIKVKDVNDN 214
Cdd:cd11304  80 PPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
115-208 2.00e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.42  E-value: 2.00e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5EQX_A        115 GEIEENSASNSLVMILNATDADEPnhLNSKIAFKIVSQEPAGtpMFLLSRNTGEVRTlTNSLDREQASSYRLVVSGADKD 194
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGG--NFRIDPDTGDIST-TKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....
5EQX_A        195 GEGLSTQCECNIKV 208
Cdd:pfam00028  78 GPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 131-216 2.16e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.00  E-value: 2.16e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5EQX_A         131 NATDADEPNhlNSKIAFKIVSQEPAGtpMFLLSRNTGEVRTlTNSLDREQASSYRLVVSGADKDGEGLSTQCECNIKVKD 210
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGNDDG--LFSIDPETGEITT-TKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
5EQX_A         211 VNDNFP 216
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
223-326 3.86e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 3.86e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5EQX_A        223 YSARIEENILS-SELLRFQVTDLDEeyTDNWLAVYFFTSGNEGNWFEIQTDPrtneGILKVVKALDYEQLQSVKLSIAVK 301
Cdd:pfam00028   1 YSASVPENAPVgTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....*
5EQX_A        302 NKAEFHQSvisryrvQSTPVTIQVI 326
Cdd:pfam00028  75 DSGGPPLS-------STATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 222-328 4.88e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 70.81  E-value: 4.88e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5EQX_A      222 QYSARIEENI-LSSELLRFQVTDLDEEytDNWLAVYFFTSGNEGNWFEIqtDPRTneGILKVVKALDYEQLQSVKLSIAV 300
Cdd:cd11304   1 SYEVSVPENApPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                        90       100
                ....*....|....*....|....*...
5EQX_A      301 KNKAEFHQSVisryrvqSTPVTIQVINV 328
Cdd:cd11304  75 TDGGGPPLSS-------TATVTITVLDV 95
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 33-106 5.36e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.29  E-value: 5.36e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
5EQX_A          33 KITYRISGvgidQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPP 106
Cdd:smart00112  12 KVTYSILS----GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 13-104 7.09e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 61.95  E-value: 7.09e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5EQX_A       13 EDNSKRNPIAKIT---SDYQATQKITYRISGvgidQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVE 89
Cdd:cd11304   8 ENAPPGTVVLTVSatdPDSGENGEVTYSIVS----GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                        90
                ....*....|....*
5EQX_A       90 KPLILTVKILDINDN 104
Cdd:cd11304  84 STATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
9-99 6.78e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.15  E-value: 6.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5EQX_A          9 CREGE-DNSKRNPIAKITSDYQATQKITYRISGvgidQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLD 87
Cdd:pfam00028   5 VPENApVGTEVLTVTATDPDLGPNGRIFYSILG----GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                          90
                  ....*....|..
5EQX_A         88 VEKPLILTVKIL 99
Cdd:pfam00028  81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 240-328 3.87e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 53.51  E-value: 3.87e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5EQX_A         240 QVTDLDEEytDNWLAVYFFTSGNEGNWFEIqtDPRTneGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVisryrvqST 319
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDGGGPPLSS-------TA 67


                   ....*....
5EQX_A         320 PVTIQVINV 328
Cdd:smart00112  68 TVTITVLDV 76
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 353-442 2.62e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 51.55  E-value: 2.62e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5EQX_A      353 VDYILGTYQAIDEDTNkAASNVKY-VMGRNDGGYLMIDSKTAEIKFVKNMNRDSTfivnKTITAEVLAIDEYT-GKTSTG 430
Cdd:cd11304  12 PGTVVLTVSATDPDSG-ENGEVTYsIVSGNEDGLFSIDPSTGEITTAKPLDREEQ----SSYTLTVTATDGGGpPLSSTA 86

                        90
                ....*....|..
5EQX_A      431 TVYVRVPDFNDN 442
Cdd:cd11304  87 TVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 361-444 1.30e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.27  E-value: 1.30e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5EQX_A         361 QAIDEDTNkAASNVKYVM-GRNDGGYLMIDSKTAEIKFVKNMNRDSTfivnKTITAEVLAIDEYT-GKTSTGTVYVRVPD 438
Cdd:smart00112   1 SATDADSG-ENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREEQ----PEYTLTVEATDGGGpPLSSTATVTITVLD 75


                   ....*.
5EQX_A         439 FNDNCP 444
Cdd:smart00112  76 VNDNAP 81
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 9-104 3.86e-06

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 45.41  E-value: 3.86e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
5EQX_A        9 CREGEDNSKRnpIAKITSDYQATQKITYRISGVGIDQPPfGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDV 88
Cdd:cd00031   6 AVEGRSRGSF--RVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVP 82

                        90
                ....*....|....*.
5EQX_A       89 EKPLILTVKILDINDN 104
Cdd:cd00031  83 QTSSVFSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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