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Conserved domains on  [gi|1321391647|pdb|4W2R|E]
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Chain E, Polycomb protein EED

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
30-360 1.11e-24

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.84  E-value: 1.11e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E       30 DPLVFATVGS-NRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshplLAVAGSRGIIRIINPITMQCIKHYV 108
Cdd:COG2319  89 DGRLLASASAdGTVRLWDLATGLLLRTLTGHTGA-----VRSVAFSPDGKT----LASGSADGTVRLWDLATGKLLRTLT 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E      109 GHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINS 188
Cdd:COG2319 160 GHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTL---TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E      189 KRMMnaikesydynpnktnrpfisqkihfpdfSTRDIHRNYVDCVRWL--GDLILSKSCENAIVCWkpgkmedDIDKIKP 266
Cdd:COG2319 236 GKLL----------------------------RTLTGHSGSVRSVAFSpdGRLLASGSADGTVRLW-------DLATGEL 280

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E      267 sesnvtiLGRFDYSQCDIWYMRFSMDfwQKMLALGNQVGKLYVWDLEVEDPHKakctTLTHHkcGAAIRQTSFSRDSSIL 346
Cdd:COG2319 281 -------LRTLTGHSGGVNSVAFSPD--GKLLASGSDDGTVRLWDLATGKLLR----TLTGH--TGAVRSVAFSPDGKTL 345

                       330
                ....*....|....
4W2R_E      347 IAVCDDASIWRWDR 360
Cdd:COG2319 346 ASGSDDGTVRLWDL 359
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
30-360 1.11e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.84  E-value: 1.11e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E       30 DPLVFATVGS-NRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshplLAVAGSRGIIRIINPITMQCIKHYV 108
Cdd:COG2319  89 DGRLLASASAdGTVRLWDLATGLLLRTLTGHTGA-----VRSVAFSPDGKT----LASGSADGTVRLWDLATGKLLRTLT 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E      109 GHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINS 188
Cdd:COG2319 160 GHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTL---TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E      189 KRMMnaikesydynpnktnrpfisqkihfpdfSTRDIHRNYVDCVRWL--GDLILSKSCENAIVCWkpgkmedDIDKIKP 266
Cdd:COG2319 236 GKLL----------------------------RTLTGHSGSVRSVAFSpdGRLLASGSADGTVRLW-------DLATGEL 280

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E      267 sesnvtiLGRFDYSQCDIWYMRFSMDfwQKMLALGNQVGKLYVWDLEVEDPHKakctTLTHHkcGAAIRQTSFSRDSSIL 346
Cdd:COG2319 281 -------LRTLTGHSGGVNSVAFSPD--GKLLASGSDDGTVRLWDLATGKLLR----TLTGH--TGAVRSVAFSPDGKTL 345

                       330
                ....*....|....
4W2R_E      347 IAVCDDASIWRWDR 360
Cdd:COG2319 346 ASGSDDGTVRLWDL 359
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 71-359 4.62e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.71  E-value: 4.62e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E       71 CAWTYDSNtshpLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDpNLLLSVSKDHALRLWNIQTDTLVAIF 150
Cdd:cd00200  15 VAFSPDGK----LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGECVRTL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E      151 ggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIK------ESYDYNPNKTnrpFIS-----QKIHFPD 219
Cdd:cd00200  90 ---TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRghtdwvNSVAFSPDGT---FVAsssqdGTIKLWD 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E      220 FS------TRDIHRNYVDCVRWLGD--LILSKSCENAIVCWkpgkmedDIDKIKPsesnvtiLGRFDYSQCDIWYMRFSm 291
Cdd:cd00200 164 LRtgkcvaTLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLW-------DLSTGKC-------LGTLRGHENGVNSVAFS- 228

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
4W2R_E      292 dFWQKMLALGNQVGKLYVWDLEVEDPHKakctTLTHHKcgAAIRQTSFSRDSSILIAVCDDASIWRWD 359
Cdd:cd00200 229 -PDGYLLASGSEDGTIRVWDLRTGECVQ----TLSGHT--NSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 100-140 1.14e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.14e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
4W2R_E         100 TMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 140
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
101-140 4.71e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 4.71e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
4W2R_E        101 MQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 140
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 88-190 7.40e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.47  E-value: 7.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E        88 GSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNI-QTDTLVAIFGG----VEGHRDEVLS 162
Cdd:PTZ00420  51 GLIGAIRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIpHNDESVKEIKDpqciLKGHKKKISI 130

                         90       100       110
                 ....*....|....*....|....*....|
4W2R_E       163 ADYDLLGEKIM-SCGMDHSLKLWRI-NSKR 190
Cdd:PTZ00420 131 IDWNPMNYYIMcSSGFDSFVNIWDIeNEKR 160
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
30-360 1.11e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.84  E-value: 1.11e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E       30 DPLVFATVGS-NRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshplLAVAGSRGIIRIINPITMQCIKHYV 108
Cdd:COG2319  89 DGRLLASASAdGTVRLWDLATGLLLRTLTGHTGA-----VRSVAFSPDGKT----LASGSADGTVRLWDLATGKLLRTLT 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E      109 GHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINS 188
Cdd:COG2319 160 GHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTL---TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E      189 KRMMnaikesydynpnktnrpfisqkihfpdfSTRDIHRNYVDCVRWL--GDLILSKSCENAIVCWkpgkmedDIDKIKP 266
Cdd:COG2319 236 GKLL----------------------------RTLTGHSGSVRSVAFSpdGRLLASGSADGTVRLW-------DLATGEL 280

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E      267 sesnvtiLGRFDYSQCDIWYMRFSMDfwQKMLALGNQVGKLYVWDLEVEDPHKakctTLTHHkcGAAIRQTSFSRDSSIL 346
Cdd:COG2319 281 -------LRTLTGHSGGVNSVAFSPD--GKLLASGSDDGTVRLWDLATGKLLR----TLTGH--TGAVRSVAFSPDGKTL 345

                       330
                ....*....|....
4W2R_E      347 IAVCDDASIWRWDR 360
Cdd:COG2319 346 ASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
83-359 8.21e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.14  E-value: 8.21e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E       83 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLS 162
Cdd:COG2319 176 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTL---TGHSGSVRS 251

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E      163 ADYDLLGEKIMSCGMDHSLKLWRINSKRMMnaikesydynpnktnrpfisqkihfpdfSTRDIHRNYVDCVRWL--GDLI 240
Cdd:COG2319 252 VAFSPDGRLLASGSADGTVRLWDLATGELL----------------------------RTLTGHSGGVNSVAFSpdGKLL 303

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E      241 LSKSCENAIVCWkpgkmedDIDKIKPsesnvtiLGRFDYSQCDIWYMRFSMDfwQKMLALGNQVGKLYVWDLEVedphKA 320
Cdd:COG2319 304 ASGSDDGTVRLW-------DLATGKL-------LRTLTGHTGAVRSVAFSPD--GKTLASGSDDGTVRLWDLAT----GE 363

                       250       260       270
                ....*....|....*....|....*....|....*....
4W2R_E      321 KCTTLTHHkcGAAIRQTSFSRDSSILIAVCDDASIWRWD 359
Cdd:COG2319 364 LLRTLTGH--TGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 71-359 4.62e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.71  E-value: 4.62e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E       71 CAWTYDSNtshpLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDpNLLLSVSKDHALRLWNIQTDTLVAIF 150
Cdd:cd00200  15 VAFSPDGK----LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGECVRTL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E      151 ggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIK------ESYDYNPNKTnrpFIS-----QKIHFPD 219
Cdd:cd00200  90 ---TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRghtdwvNSVAFSPDGT---FVAsssqdGTIKLWD 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E      220 FS------TRDIHRNYVDCVRWLGD--LILSKSCENAIVCWkpgkmedDIDKIKPsesnvtiLGRFDYSQCDIWYMRFSm 291
Cdd:cd00200 164 LRtgkcvaTLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLW-------DLSTGKC-------LGTLRGHENGVNSVAFS- 228

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
4W2R_E      292 dFWQKMLALGNQVGKLYVWDLEVEDPHKakctTLTHHKcgAAIRQTSFSRDSSILIAVCDDASIWRWD 359
Cdd:cd00200 229 -PDGYLLASGSEDGTIRVWDLRTGECVQ----TLSGHT--NSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
4-313 2.86e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.35  E-value: 2.86e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E        4 KCVNSLKEdHNQPLFGVQFnwhSKEGDPLvfATVGS-NRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshp 82
Cdd:COG2319 153 KLLRTLTG-HSGAVTSVAF---SPDGKLL--ASGSDdGTVRLWDLATGKLLRTLTGHTGA-----VRSVAFSPDGKL--- 218

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E       83 lLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFGgveGHRDEVLS 162
Cdd:COG2319 219 -LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLT---GHSGGVNS 293

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E      163 ADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKEsydynpnktnrpfisqkihfpdfstrdiHRNYVDCVRW--LGDLI 240
Cdd:COG2319 294 VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG----------------------------HTGAVRSVAFspDGKTL 345

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
4W2R_E      241 LSKSCENAIVCWkpgkmedDIDkikpsesNVTILGRFDYSQCDIWYMRFSMDfwQKMLALGNQVGKLYVWDLE 313
Cdd:COG2319 346 ASGSDDGTVRLW-------DLA-------TGELLRTLTGHTGAVTSVAFSPD--GRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
4-188 1.33e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.34  E-value: 1.33e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E        4 KCVNSLKeDHNQPLFGVQFnwhSKEGDPLVFATvGSNRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshpl 83
Cdd:COG2319 237 KLLRTLT-GHSGSVRSVAF---SPDGRLLASGS-ADGTVRLWDLATGELLRTLTGHSGG-----VNSVAFSPDGKL---- 302

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E       84 LAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLSA 163
Cdd:COG2319 303 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTL---TGHTGAVTSV 378

                       170       180
                ....*....|....*....|....*
4W2R_E      164 DYDLLGEKIMSCGMDHSLKLWRINS 188
Cdd:COG2319 379 AFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-185 4.21e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.76  E-value: 4.21e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E        2 SFKCVNSLKeDHNQPLFGVQFNWHSKegdplvFATVGS--NRVTLYECHSQGEIRLLQSYvdadaDENFYTCAWTYDSNT 79
Cdd:cd00200 124 TGKCLTTLR-GHTDWVNSVAFSPDGT------FVASSSqdGTIKLWDLRTGKCVATLTGH-----TGEVNSVAFSPDGEK 191

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E       80 shplLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDE 159
Cdd:cd00200 192 ----LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTL---SGHTNS 263

                       170       180
                ....*....|....*....|....*.
4W2R_E      160 VLSADYDLLGEKIMSCGMDHSLKLWR 185
Cdd:cd00200 264 VTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
83-359 2.08e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 2.08e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E       83 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLS 162
Cdd:COG2319  50 RLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTL---TGHTGAVRS 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E      163 ADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKEsydynpnktnrpfisqkihfpdfstrdiHRNYVDCVRWLGDlils 242
Cdd:COG2319 126 VAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG----------------------------HSGAVTSVAFSPD---- 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E      243 kscenaivcwkpgkmeddidkikpsesnvtilGRFdysqcdiwymrfsmdfwqkmLALGNQVGKLYVWDLEvedphKAKC 322
Cdd:COG2319 174 --------------------------------GKL--------------------LASGSDDGTVRLWDLA-----TGKL 196

                       250       260       270
                ....*....|....*....|....*....|....*...
4W2R_E      323 -TTLTHHKcgAAIRQTSFSRDSSILIAVCDDASIWRWD 359
Cdd:COG2319 197 lRTLTGHT--GAVRSVAFSPDGKLLASGSADGTVRLWD 232
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 153-359 8.54e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.94  E-value: 8.54e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E      153 VEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINskrmmnaikesydynpnkTNRPFISQKIHFPDFSTrdihrnyVDC 232
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE------------------TGELLRTLKGHTGPVRD-------VAA 59

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E      233 VRWlGDLILSKSCENAIVCWKPGKmeddidkikpSESNVTILGrfdySQCDIWYMRFSMDfwQKMLALGNQVGKLYVWDL 312
Cdd:cd00200  60 SAD-GTYLASGSSDKTIRLWDLET----------GECVRTLTG----HTSYVSSVAFSPD--GRILSSSSRDKTIKVWDV 122

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
4W2R_E      313 EVEDPhkakCTTLTHHKcgAAIRQTSFSRDSSILIAVCDDASIWRWD 359
Cdd:cd00200 123 ETGKC----LTTLRGHT--DWVNSVAFSPDGTFVASSSQDGTIKLWD 163
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 100-140 1.14e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.14e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
4W2R_E         100 TMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 140
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
101-140 4.71e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 4.71e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
4W2R_E        101 MQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 140
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 88-190 7.40e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.47  E-value: 7.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E        88 GSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNI-QTDTLVAIFGG----VEGHRDEVLS 162
Cdd:PTZ00420  51 GLIGAIRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIpHNDESVKEIKDpqciLKGHKKKISI 130

                         90       100       110
                 ....*....|....*....|....*....|
4W2R_E       163 ADYDLLGEKIM-SCGMDHSLKLWRI-NSKR 190
Cdd:PTZ00420 131 IDWNPMNYYIMcSSGFDSFVNIWDIeNEKR 160
PTZ00421 PTZ00421
coronin; Provisional
 104-330 2.52e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.49  E-value: 2.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E       104 IKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIfggVEGHRDEVLSADYDLLGEKIMSCGMDHSLkl 183
Cdd:PTZ00421 118 IVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEV---IKCHSDQITSLEWNLDGSLLCTTSKDKKL-- 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4W2R_E       184 wRINSKRMMNAIKESYDYNPNKTNRPFISQKihfpdfstrdihrnyVDCVRWLGdliLSKSCENAIVCWKPGKMEDDIDK 263
Cdd:PTZ00421 193 -NIIDPRDGTIVSSVEAHASAKSQRCLWAKR---------------KDLIITLG---CSKSQQRQIMLWDTRKMASPYST 253

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
4W2R_E       264 IKPSESNVTILGRFDySQCDIWYMRFSMDFWQKMLALGNQvGKLYVWDLEVEDPHKAKCT----TLTHHKC 330
Cdd:PTZ00421 254 VDLDQSSALFIPFFD-EDTNLLYIGSKGEGNIRCFELMNE-RLTFCSSYSSVEPHKGLCMmpkwSLDTRKC 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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