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Conserved domains on  [gi|586500476|pdb|4OLE|A]
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Chain A, Next to BRCA1 gene 1 protein

Protein Classification

next to BRCA1 gene 1 family protein; next to BRCA1 gene 1 protein( domain architecture ID 10202231)

next to BRCA1 gene 1 protein (NBR1) acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets; next to BRCA1 gene 1 protein (NBR1) acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NBR1_like cd14947
Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins; NBR1 has ...
 6-116 1.36e-44

Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins; NBR1 has been characterized as a specific late endosomal protein, which might play a role in receptor (RTK) trafficking. Specifically, NBR1 was shown to inhibit ligand-mediated receptor internalization from the cell surface. The region covered by this domain model may be involved in that function, as the C-terminus (which contains a UBA domain) was shown to be essential but not sufficient by itself. In an earlier yeast two-hybrid study, the region in mouse NBR1 covered by this domain has been shown to interact with CIB (calcium and integrin-binding protein) and FEZ1 (fasciculation and elongation protein zeta-1). Thus, NBR1 may play a role in cellular signalling pathways and possibly in neural development.


:

Pssm-ID: 271343 [Multi-domain]  Cd Length: 112  Bit Score: 140.89  E-value: 1.36e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4OLE_A        6 P*LSAAFV-DENLPDGTHLQPGTKFIKHWR*KNTGNVKWSADTKLKF*WGNLTLASTeKKDVLVPCLKAGHVGVVSVEFI 84
Cdd:cd14947   1 PGLSAAFVeDVTIPDGTVVPPGTEFTKTWRLRNTGTVPWPAGTLLRFVGGDPGLLSA-PERVPVPSTVPGEEVDVSVELR 79

                        90       100       110
                ....*....|....*....|....*....|...
4OLE_A       85 APALEGTYTSHWRLSHK-GQQFGPRVWCSIIVD 116
Cdd:cd14947  80 APSEPGRYISYWRLVTPdGLPFGDRLWVDITVE 112
 
Name Accession Description Interval E-value
NBR1_like cd14947
Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins; NBR1 has ...
 6-116 1.36e-44

Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins; NBR1 has been characterized as a specific late endosomal protein, which might play a role in receptor (RTK) trafficking. Specifically, NBR1 was shown to inhibit ligand-mediated receptor internalization from the cell surface. The region covered by this domain model may be involved in that function, as the C-terminus (which contains a UBA domain) was shown to be essential but not sufficient by itself. In an earlier yeast two-hybrid study, the region in mouse NBR1 covered by this domain has been shown to interact with CIB (calcium and integrin-binding protein) and FEZ1 (fasciculation and elongation protein zeta-1). Thus, NBR1 may play a role in cellular signalling pathways and possibly in neural development.


Pssm-ID: 271343 [Multi-domain]  Cd Length: 112  Bit Score: 140.89  E-value: 1.36e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4OLE_A        6 P*LSAAFV-DENLPDGTHLQPGTKFIKHWR*KNTGNVKWSADTKLKF*WGNLTLASTeKKDVLVPCLKAGHVGVVSVEFI 84
Cdd:cd14947   1 PGLSAAFVeDVTIPDGTVVPPGTEFTKTWRLRNTGTVPWPAGTLLRFVGGDPGLLSA-PERVPVPSTVPGEEVDVSVELR 79

                        90       100       110
                ....*....|....*....|....*....|...
4OLE_A       85 APALEGTYTSHWRLSHK-GQQFGPRVWCSIIVD 116
Cdd:cd14947  80 APSEPGRYISYWRLVTPdGLPFGDRLWVDITVE 112
N_BRCA1_IG pfam16158
Ig-like domain from next to BRCA1 gene; Domain present between positions 365-485 in the human ...
 16-115 8.35e-41

Ig-like domain from next to BRCA1 gene; Domain present between positions 365-485 in the human next to BRCA1 gene 1 protein Q14596 (NBR1_HUMAN) Distant homology and fold prediction analysis suggests this domain has an immunoglobulin like fold and is distantly homologous to domains involved in cell adhesion such as CARDB (PF07705). JCSG construct was crystalized confirming the domain boundaries


Pssm-ID: 465035  Cd Length: 98  Bit Score: 130.77  E-value: 8.35e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4OLE_A         16 NLPDGTHLQPGTKFIKHWR*KNTGNVKWSADTKLKF*WGNLTLASTekkDVLVPCLKAGHVGVVSVEFIAPALEGTYTSH 95
Cdd:pfam16158   1 TIPDGTVVPPGTEFTKTWRLRNSGNVAWPAGTSLRFVGGDNMGNVS---TVLVPPVAPGEEVDVSVELKAPSRPGRYISY 77

                          90       100
                  ....*....|....*....|.
4OLE_A         96 WRLSHK-GQQFGPRVWCSIIV 115
Cdd:pfam16158  78 WRLKTPdGTPFGDRLWVDITV 98
 
Name Accession Description Interval E-value
NBR1_like cd14947
Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins; NBR1 has ...
 6-116 1.36e-44

Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins; NBR1 has been characterized as a specific late endosomal protein, which might play a role in receptor (RTK) trafficking. Specifically, NBR1 was shown to inhibit ligand-mediated receptor internalization from the cell surface. The region covered by this domain model may be involved in that function, as the C-terminus (which contains a UBA domain) was shown to be essential but not sufficient by itself. In an earlier yeast two-hybrid study, the region in mouse NBR1 covered by this domain has been shown to interact with CIB (calcium and integrin-binding protein) and FEZ1 (fasciculation and elongation protein zeta-1). Thus, NBR1 may play a role in cellular signalling pathways and possibly in neural development.


Pssm-ID: 271343 [Multi-domain]  Cd Length: 112  Bit Score: 140.89  E-value: 1.36e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4OLE_A        6 P*LSAAFV-DENLPDGTHLQPGTKFIKHWR*KNTGNVKWSADTKLKF*WGNLTLASTeKKDVLVPCLKAGHVGVVSVEFI 84
Cdd:cd14947   1 PGLSAAFVeDVTIPDGTVVPPGTEFTKTWRLRNTGTVPWPAGTLLRFVGGDPGLLSA-PERVPVPSTVPGEEVDVSVELR 79

                        90       100       110
                ....*....|....*....|....*....|...
4OLE_A       85 APALEGTYTSHWRLSHK-GQQFGPRVWCSIIVD 116
Cdd:cd14947  80 APSEPGRYISYWRLVTPdGLPFGDRLWVDITVE 112
N_BRCA1_IG pfam16158
Ig-like domain from next to BRCA1 gene; Domain present between positions 365-485 in the human ...
 16-115 8.35e-41

Ig-like domain from next to BRCA1 gene; Domain present between positions 365-485 in the human next to BRCA1 gene 1 protein Q14596 (NBR1_HUMAN) Distant homology and fold prediction analysis suggests this domain has an immunoglobulin like fold and is distantly homologous to domains involved in cell adhesion such as CARDB (PF07705). JCSG construct was crystalized confirming the domain boundaries


Pssm-ID: 465035  Cd Length: 98  Bit Score: 130.77  E-value: 8.35e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4OLE_A         16 NLPDGTHLQPGTKFIKHWR*KNTGNVKWSADTKLKF*WGNLTLASTekkDVLVPCLKAGHVGVVSVEFIAPALEGTYTSH 95
Cdd:pfam16158   1 TIPDGTVVPPGTEFTKTWRLRNSGNVAWPAGTSLRFVGGDNMGNVS---TVLVPPVAPGEEVDVSVELKAPSRPGRYISY 77

                          90       100
                  ....*....|....*....|.
4OLE_A         96 WRLSHK-GQQFGPRVWCSIIV 115
Cdd:pfam16158  78 WRLKTPdGTPFGDRLWVDITV 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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