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Conserved domains on  [gi|422920133|pdb|4HQX|A]
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Chain A, Platelet-derived growth factor subunit B

Protein Classification

PDGF domain-containing protein( domain architecture ID 10448475)

PDGF domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDGF pfam00341
PDGF/VEGF domain;
16-99 1.25e-30

PDGF/VEGF domain;


:

Pssm-ID: 425620  Cd Length: 82  Bit Score: 103.52  E-value: 1.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HQX_A         16 CKTRTEVFEISRRLIDRTNANFLvwPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHL 95
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFK--PSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYAPRRPSPELVEVSFEEHV 78


                  ....
4HQX_A         96 ACKC 99
Cdd:pfam00341  79 QCEC 82
 
Name Accession Description Interval E-value
PDGF pfam00341
PDGF/VEGF domain;
16-99 1.25e-30

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 103.52  E-value: 1.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HQX_A         16 CKTRTEVFEISRRLIDRTNANFLvwPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHL 95
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFK--PSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYAPRRPSPELVEVSFEEHV 78


                  ....
4HQX_A         96 ACKC 99
Cdd:pfam00341  79 QCEC 82
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 14-101 3.05e-27

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 95.18  E-value: 3.05e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HQX_A          14 AECKTRTEVFEISRRLIDRTNanFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLrpVQVRKIEIVRKKPIfKKATVTLED 93
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETN--FLFKPPCVTVKRCGGCCNDEGLECVPTETSN--VTMQLLEISRPLSQ-HLVEVSFEE 75


                   ....*...
4HQX_A          94 HLACKCET 101
Cdd:smart00141  76 HTKCECRP 83
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 14-101 2.08e-25

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 90.51  E-value: 2.08e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HQX_A       14 AECKTRTEVFEISRRLIDRTNanFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRkKPIFKKATVTLED 93
Cdd:cd00135   1 SSCKPRETLVEISEELPDETN--TIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKR-KPRSKLVEISFEE 77


                ....*...
4HQX_A       94 HLACKCET 101
Cdd:cd00135  78 HTECECRP 85
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 12-100 1.96e-08

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 48.85  E-value: 1.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HQX_A        12 MIAECKTRTEVFEISRRLIDRTNANFLvwPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKK-ATVT 90
Cdd:PHA02661  44 DKSSCQPRDTVVQLSDEYPGNTNDRYN--PRCVTVRRCGGCCNDESQICTPTETSNVTVTVMLTSVSGSTGATSNfQTIS 121

                         90
                 ....*....|
4HQX_A        91 LEDHLACKCE 100
Cdd:PHA02661 122 VEEHTKCKCE 131
 
Name Accession Description Interval E-value
PDGF pfam00341
PDGF/VEGF domain;
16-99 1.25e-30

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 103.52  E-value: 1.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HQX_A         16 CKTRTEVFEISRRLIDRTNANFLvwPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHL 95
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFK--PSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYAPRRPSPELVEVSFEEHV 78


                  ....
4HQX_A         96 ACKC 99
Cdd:pfam00341  79 QCEC 82
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 14-101 3.05e-27

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 95.18  E-value: 3.05e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HQX_A          14 AECKTRTEVFEISRRLIDRTNanFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLrpVQVRKIEIVRKKPIfKKATVTLED 93
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETN--FLFKPPCVTVKRCGGCCNDEGLECVPTETSN--VTMQLLEISRPLSQ-HLVEVSFEE 75


                   ....*...
4HQX_A          94 HLACKCET 101
Cdd:smart00141  76 HTKCECRP 83
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 14-101 2.08e-25

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 90.51  E-value: 2.08e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HQX_A       14 AECKTRTEVFEISRRLIDRTNanFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRkKPIFKKATVTLED 93
Cdd:cd00135   1 SSCKPRETLVEISEELPDETN--TIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKR-KPRSKLVEISFEE 77


                ....*...
4HQX_A       94 HLACKCET 101
Cdd:cd00135  78 HTECECRP 85
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 12-100 1.96e-08

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 48.85  E-value: 1.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
4HQX_A        12 MIAECKTRTEVFEISRRLIDRTNANFLvwPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKK-ATVT 90
Cdd:PHA02661  44 DKSSCQPRDTVVQLSDEYPGNTNDRYN--PRCVTVRRCGGCCNDESQICTPTETSNVTVTVMLTSVSGSTGATSNfQTIS 121

                         90
                 ....*....|
4HQX_A        91 LEDHLACKCE 100
Cdd:PHA02661 122 VEEHTKCKCE 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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