NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|323714625|pdb|3Q2W|A]
View 

Chain A, Cadherin-2

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 114-219 3.83e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.87  E-value: 3.83e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A      114 NGSVPEGSKPGTYVMTVTAIDADDPNalNGMLRYRILSQapstPSPNMFTINNETGdIITVAAGLDREKVQQYTLIIQAT 193
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSG----NEDGLFSIDPSTG-EITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|....*.
3Q2W_A      194 DMEGNPtygLSNTATAVITVTDVNDN 219
Cdd:cd11304  76 DGGGPP---LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 349-442 4.78e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.84  E-value: 4.78e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A      349 EGLHAGTMLTTLTAQDPDRYMQQNIRYTKLS-DPANWLKIDPVNGQITTIAVLDRESPNVknniYNATFLASDNGIPPMS 427
Cdd:cd11304   8 ENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREEQSS----YTLTVTATDGGGPPLS 83

                        90
                ....*....|....*
3Q2W_A      428 GTGTLQIYLLDINDN 442
Cdd:cd11304  84 STATVTITVLDVNDN 98
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 4-104 3.25e-20

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member cd00031:

Pssm-ID: 481204  Cd Length: 98  Bit Score: 85.47  E-value: 3.25e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A        4 IPPINLPENSRGPfpQELVRIRSDRDKNLSLRYSVTGPGADQPPtGIFIINPISGQLSVTKPLDRELIARFHLRAHAVDI 83
Cdd:cd00031   1 IPDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                        90       100
                ....*....|....*....|.
3Q2W_A       84 NGNQVENPIDIVINVIDMNDN 104
Cdd:cd00031  78 GANVPQTSSVFSIEVYDENDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 227-335 3.53e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 3.53e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A      227 TFYGEVPEN-RVDVIVANLTVTDKDQPhtPAWNAAYRISGGDPTGRFAIltdpNSNDGLVTVVKPIDFETNRMFVLTVAA 305
Cdd:cd11304   1 SYEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTA 74

                        90       100       110
                ....*....|....*....|....*....|
3Q2W_A      306 ENqvplakGIQHPPQSTATVSVTVIDVNEN 335
Cdd:cd11304  75 TD------GGGPPLSSTATVTITVLDVNDN 98
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 449-542 6.44e-08

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member pfam00028:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 92  Bit Score: 50.38  E-value: 6.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A        449 QEAETCETPEPNS--INITALDYDIDPNAGPFAFDLPLSPvtiKRNWTINRLNGDfaqLNLK--IKFLEAGIYEVPIIIT 524
Cdd:pfam00028   1 YSASVPENAPVGTevLTVTATDPDLGPNGRIFYSILGGGP---GGNFRIDPDTGD---ISTTkpLDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
3Q2W_A        525 DSGNPPKSNISILRVKVC 542
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 114-219 3.83e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.87  E-value: 3.83e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A      114 NGSVPEGSKPGTYVMTVTAIDADDPNalNGMLRYRILSQapstPSPNMFTINNETGdIITVAAGLDREKVQQYTLIIQAT 193
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSG----NEDGLFSIDPSTG-EITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|....*.
3Q2W_A      194 DMEGNPtygLSNTATAVITVTDVNDN 219
Cdd:cd11304  76 DGGGPP---LSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
114-214 6.46e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 93.13  E-value: 6.46e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A        114 NGSVPEGSKPGTYVMTVTAIDADDPnaLNGMLRYRILSQapstPSPNMFTINNETGDiITVAAGLDREKVQQYTLIIQAT 193
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGG----GPGGNFRIDPDTGD-ISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|.
3Q2W_A        194 DmegNPTYGLSNTATAVITVT 214
Cdd:pfam00028  75 D---SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 131-221 9.44e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.03  E-value: 9.44e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A         131 TAIDADDPNalNGMLRYRILSQAPstpsPNMFTINNETGdIITVAAGLDREKVQQYTLIIQATDMEGNPtygLSNTATAV 210
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGND----DGLFSIDPETG-EITTTKPLDREEQPEYTLTVEATDGGGPP---LSSTATVT 70

                           90
                   ....*....|.
3Q2W_A         211 ITVTDVNDNPP 221
Cdd:smart00112  71 ITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 349-442 4.78e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.84  E-value: 4.78e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A      349 EGLHAGTMLTTLTAQDPDRYMQQNIRYTKLS-DPANWLKIDPVNGQITTIAVLDRESPNVknniYNATFLASDNGIPPMS 427
Cdd:cd11304   8 ENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREEQSS----YTLTVTATDGGGPPLS 83

                        90
                ....*....|....*
3Q2W_A      428 GTGTLQIYLLDINDN 442
Cdd:cd11304  84 STATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
345-437 2.34e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.51  E-value: 2.34e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A        345 IRQEEGLHAGTMLTTLTAQDPDRYMQQNIRYTKLSD-PANWLKIDPVNGQITTIAVLDRESpnvkNNIYNATFLASDNGI 423
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSGG 78

                          90
                  ....*....|....
3Q2W_A        424 PPMSGTGTLQIYLL 437
Cdd:pfam00028  79 PPLSSTATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 4-104 3.25e-20

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 85.47  E-value: 3.25e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A        4 IPPINLPENSRGPfpQELVRIRSDRDKNLSLRYSVTGPGADQPPtGIFIINPISGQLSVTKPLDRELIARFHLRAHAVDI 83
Cdd:cd00031   1 IPDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                        90       100
                ....*....|....*....|.
3Q2W_A       84 NGNQVENPIDIVINVIDMNDN 104
Cdd:cd00031  78 GANVPQTSSVFSIEVYDENDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 227-335 3.53e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 3.53e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A      227 TFYGEVPEN-RVDVIVANLTVTDKDQPhtPAWNAAYRISGGDPTGRFAIltdpNSNDGLVTVVKPIDFETNRMFVLTVAA 305
Cdd:cd11304   1 SYEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTA 74

                        90       100       110
                ....*....|....*....|....*....|
3Q2W_A      306 ENqvplakGIQHPPQSTATVSVTVIDVNEN 335
Cdd:cd11304  75 TD------GGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 361-444 9.34e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.86  E-value: 9.34e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A         361 TAQDPDRYMQQNIRYTKLS-DPANWLKIDPVNGQITTIAVLDREspnvKNNIYNATFLASDNGIPPMSGTGTLQIYLLDI 439
Cdd:smart00112   1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
3Q2W_A         440 NDNAP 444
Cdd:smart00112  77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
228-330 3.50e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 3.50e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A        228 FYGEVPEN-RVDVIVANLTVTDKDQPhtPAWNAAYRISGGDPTGRFAIltdpNSNDGLVTVVKPIDFETNRMFVLTVAAE 306
Cdd:pfam00028   1 YSASVPENaPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
3Q2W_A        307 NQVPlakgiqHPPQSTATVSVTVI 330
Cdd:pfam00028  75 DSGG------PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 26-106 4.78e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.15  E-value: 4.78e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A          26 SDRDKNLSLRYSVTGPGADqpptGIFIINPISGQLSVTKPLDRELIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNR 105
Cdd:smart00112   5 ADSGENGKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
3Q2W_A         106 P 106
Cdd:smart00112  81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 245-336 4.42e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.46  E-value: 4.42e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A         245 TVTDKDQPhtPAWNAAYRISGGDPTGRFAIltdpNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPlakgiqHPPQSTAT 324
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGG------PPLSSTAT 68

                           90
                   ....*....|..
3Q2W_A         325 VSVTVIDVNENP 336
Cdd:smart00112  69 VTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
5-99 6.70e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.33  E-value: 6.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A          5 PPINLPENSR-GPFPQELVRIRSDRDKNLSLRYSVTGPGADqpptGIFIINPISGQLSVTKPLDRELIARFHLRAHAVDI 83
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
3Q2W_A         84 NGNQVENPIDIVINVI 99
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
449-542 6.44e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.38  E-value: 6.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A        449 QEAETCETPEPNS--INITALDYDIDPNAGPFAFDLPLSPvtiKRNWTINRLNGDfaqLNLK--IKFLEAGIYEVPIIIT 524
Cdd:pfam00028   1 YSASVPENAPVGTevLTVTATDPDLGPNGRIFYSILGGGP---GGNFRIDPDTGD---ISTTkpLDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
3Q2W_A        525 DSGNPPKSNISILRVKVC 542
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 114-219 3.83e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.87  E-value: 3.83e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A      114 NGSVPEGSKPGTYVMTVTAIDADDPNalNGMLRYRILSQapstPSPNMFTINNETGdIITVAAGLDREKVQQYTLIIQAT 193
Cdd:cd11304   3 EVSVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSG----NEDGLFSIDPSTG-EITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|....*.
3Q2W_A      194 DMEGNPtygLSNTATAVITVTDVNDN 219
Cdd:cd11304  76 DGGGPP---LSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
114-214 6.46e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 93.13  E-value: 6.46e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A        114 NGSVPEGSKPGTYVMTVTAIDADDPnaLNGMLRYRILSQapstPSPNMFTINNETGDiITVAAGLDREKVQQYTLIIQAT 193
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGG----GPGGNFRIDPDTGD-ISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|.
3Q2W_A        194 DmegNPTYGLSNTATAVITVT 214
Cdd:pfam00028  75 D---SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 131-221 9.44e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.03  E-value: 9.44e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A         131 TAIDADDPNalNGMLRYRILSQAPstpsPNMFTINNETGdIITVAAGLDREKVQQYTLIIQATDMEGNPtygLSNTATAV 210
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGND----DGLFSIDPETG-EITTTKPLDREEQPEYTLTVEATDGGGPP---LSSTATVT 70

                           90
                   ....*....|.
3Q2W_A         211 ITVTDVNDNPP 221
Cdd:smart00112  71 ITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 349-442 4.78e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.84  E-value: 4.78e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A      349 EGLHAGTMLTTLTAQDPDRYMQQNIRYTKLS-DPANWLKIDPVNGQITTIAVLDRESPNVknniYNATFLASDNGIPPMS 427
Cdd:cd11304   8 ENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREEQSS----YTLTVTATDGGGPPLS 83

                        90
                ....*....|....*
3Q2W_A      428 GTGTLQIYLLDINDN 442
Cdd:cd11304  84 STATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
345-437 2.34e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.51  E-value: 2.34e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A        345 IRQEEGLHAGTMLTTLTAQDPDRYMQQNIRYTKLSD-PANWLKIDPVNGQITTIAVLDRESpnvkNNIYNATFLASDNGI 423
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSGG 78

                          90
                  ....*....|....
3Q2W_A        424 PPMSGTGTLQIYLL 437
Cdd:pfam00028  79 PPLSSTATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 4-104 3.25e-20

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 85.47  E-value: 3.25e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A        4 IPPINLPENSRGPfpQELVRIRSDRDKNLSLRYSVTGPGADQPPtGIFIINPISGQLSVTKPLDRELIARFHLRAHAVDI 83
Cdd:cd00031   1 IPDGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASL 77

                        90       100
                ....*....|....*....|.
3Q2W_A       84 NGNQVENPIDIVINVIDMNDN 104
Cdd:cd00031  78 GANVPQTSSVFSIEVYDENDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 227-335 3.53e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.75  E-value: 3.53e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A      227 TFYGEVPEN-RVDVIVANLTVTDKDQPhtPAWNAAYRISGGDPTGRFAIltdpNSNDGLVTVVKPIDFETNRMFVLTVAA 305
Cdd:cd11304   1 SYEVSVPENaPPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTA 74

                        90       100       110
                ....*....|....*....|....*....|
3Q2W_A      306 ENqvplakGIQHPPQSTATVSVTVIDVNEN 335
Cdd:cd11304  75 TD------GGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 361-444 9.34e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.86  E-value: 9.34e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A         361 TAQDPDRYMQQNIRYTKLS-DPANWLKIDPVNGQITTIAVLDREspnvKNNIYNATFLASDNGIPPMSGTGTLQIYLLDI 439
Cdd:smart00112   1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDRE----EQPEYTLTVEATDGGGPPLSSTATVTITVLDV 76


                   ....*
3Q2W_A         440 NDNAP 444
Cdd:smart00112  77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
228-330 3.50e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 3.50e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A        228 FYGEVPEN-RVDVIVANLTVTDKDQPhtPAWNAAYRISGGDPTGRFAIltdpNSNDGLVTVVKPIDFETNRMFVLTVAAE 306
Cdd:pfam00028   1 YSASVPENaPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....
3Q2W_A        307 NQVPlakgiqHPPQSTATVSVTVI 330
Cdd:pfam00028  75 DSGG------PPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 7-104 7.62e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 7.62e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A        7 INLPENSrgPFPQELVRIR-SDRDK--NLSLRYSVTGPGADqpptGIFIINPISGQLSVTKPLDRELIARFHLRAHAVDI 83
Cdd:cd11304   4 VSVPENA--PPGTVVLTVSaTDPDSgeNGEVTYSIVSGNED----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                        90       100
                ....*....|....*....|.
3Q2W_A       84 NGNQVENPIDIVINVIDMNDN 104
Cdd:cd11304  78 GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 26-106 4.78e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.15  E-value: 4.78e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A          26 SDRDKNLSLRYSVTGPGADqpptGIFIINPISGQLSVTKPLDRELIARFHLRAHAVDINGNQVENPIDIVINVIDMNDNR 105
Cdd:smart00112   5 ADSGENGKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
3Q2W_A         106 P 106
Cdd:smart00112  81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 245-336 4.42e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.46  E-value: 4.42e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A         245 TVTDKDQPhtPAWNAAYRISGGDPTGRFAIltdpNSNDGLVTVVKPIDFETNRMFVLTVAAENQVPlakgiqHPPQSTAT 324
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGG------PPLSSTAT 68

                           90
                   ....*....|..
3Q2W_A         325 VSVTVIDVNENP 336
Cdd:smart00112  69 VTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
5-99 6.70e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.33  E-value: 6.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A          5 PPINLPENSR-GPFPQELVRIRSDRDKNLSLRYSVTGPGADqpptGIFIINPISGQLSVTKPLDRELIARFHLRAHAVDI 83
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
3Q2W_A         84 NGNQVENPIDIVINVI 99
Cdd:pfam00028  77 GGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
449-542 6.44e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.38  E-value: 6.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3Q2W_A        449 QEAETCETPEPNS--INITALDYDIDPNAGPFAFDLPLSPvtiKRNWTINRLNGDfaqLNLK--IKFLEAGIYEVPIIIT 524
Cdd:pfam00028   1 YSASVPENAPVGTevLTVTATDPDLGPNGRIFYSILGGGP---GGNFRIDPDTGD---ISTTkpLDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
3Q2W_A        525 DSGNPPKSNISILRVKVC 542
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH