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Conserved domains on  [gi|304445724|pdb|3AD8|D]
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Chain D, SARCOSINE OXIDASE DELTA SUBUNIT

Protein Classification

sarcosine oxidase subunit delta( domain architecture ID 10018820)

sarcosine oxidase subunit delta (SoxD) is part of the heterotetrameric enzyme that catalyzes the oxidative demethylation of sarcosine to yield glycine, hydrogen peroxide and 5,10-methylenetetrahydrofolate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
soxD TIGR01374
sarcosine oxidase, delta subunit family, heterotetrameric form; This model describes the delta ...
 3-86 2.83e-54

sarcosine oxidase, delta subunit family, heterotetrameric form; This model describes the delta subunit of a family of known and putative heterotetrameric sarcosine oxidases. Five operons of such oxidases are found in Mesorhizobium loti and three in Agrobacterium tumefaciens, a high enough copy number to suggest that not all members are share the same function. The model is designated as subfamily rather than equivalog for this reason. Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) form [Energy metabolism, Amino acids and amines]


:

Pssm-ID: 130441  Cd Length: 84  Bit Score: 163.36  E-value: 2.83e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3AD8_D         3 LIECPNCGPRNENEFKYGGEAHVAYPEDPNALSDKEWSRYLFYRGNKKGIFAERWVHSGGCRKWFNALRDTVSYEFKAVY 82
Cdd:TIGR01374  1 LIPCPYCGPRPEEEFTYGGDAHIVRPADPAAASDEEWEDYLFLRDNPKGLHAERWVHSGGCRRWFNVVRDTVTHEILATY 80


                 ....
3AD8_D        83 RAGE 86
Cdd:TIGR01374 81 RAGE 84
 
Name Accession Description Interval E-value
soxD TIGR01374
sarcosine oxidase, delta subunit family, heterotetrameric form; This model describes the delta ...
 3-86 2.83e-54

sarcosine oxidase, delta subunit family, heterotetrameric form; This model describes the delta subunit of a family of known and putative heterotetrameric sarcosine oxidases. Five operons of such oxidases are found in Mesorhizobium loti and three in Agrobacterium tumefaciens, a high enough copy number to suggest that not all members are share the same function. The model is designated as subfamily rather than equivalog for this reason. Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) form [Energy metabolism, Amino acids and amines]


Pssm-ID: 130441  Cd Length: 84  Bit Score: 163.36  E-value: 2.83e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3AD8_D         3 LIECPNCGPRNENEFKYGGEAHVAYPEDPNALSDKEWSRYLFYRGNKKGIFAERWVHSGGCRKWFNALRDTVSYEFKAVY 82
Cdd:TIGR01374  1 LIPCPYCGPRPEEEFTYGGDAHIVRPADPAAASDEEWEDYLFLRDNPKGLHAERWVHSGGCRRWFNVVRDTVTHEILATY 80


                 ....
3AD8_D        83 RAGE 86
Cdd:TIGR01374 81 RAGE 84
SoxD COG4311
Sarcosine oxidase delta subunit [Amino acid transport and metabolism];
2-95 1.49e-52

Sarcosine oxidase delta subunit [Amino acid transport and metabolism];


Pssm-ID: 443452  Cd Length: 94  Bit Score: 159.27  E-value: 1.49e-52
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3AD8_D       2 MLIECPNCGPRNENEFKYGGEAHVAYPEDPNALSDKEWSRYLFYRGNKKGIFAERWVHSGGCRKWFNALRDTVSYEFKAV 81
Cdd:COG4311  1 LLITCPYCGPRDESEFTYGGEAHIARPDPPAAASDEEWADYLFLRDNPKGVHRERWYHAAGCRKWFNVERDTVTHEILGT 80

                       90
               ....*....|....
3AD8_D      82 YRAGEARPQLDSTE 95
Cdd:COG4311 81 YLAGEPRPAGAAEA 94
SoxD pfam04267
Sarcosine oxidase, delta subunit family; Sarcosine oxidase is a hetero-tetrameric enzyme that ...
 3-84 8.74e-50

Sarcosine oxidase, delta subunit family; Sarcosine oxidase is a hetero-tetrameric enzyme that contains both covalently bound FMN and non-covalently bound FAD and NAD(+). This enzyme catalyzes the oxidative demethylation of sarcosine to yield glycine, H2O2, and 5,10-CH2-tetrahydrofolate (H4folate) in a reaction requiring H4folate and O2.


Pssm-ID: 427830  Cd Length: 82  Bit Score: 151.93  E-value: 8.74e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3AD8_D         3 LIECPNCGPRNENEFKYGGEAHVAYPEDPNALSDKEWSRYLFYRGNKKGIFAERWVHSGGCRKWFNALRDTVSYEFKAVY 82
Cdd:pfam04267  1 LITCPYCGPRDESEFTYGGEAHIARPPDPAALSDEEWADYLFLRDNPKGVHRERWYHAAGCRRWFNAERDTVTHEILGTY 80


                 ..
3AD8_D        83 RA 84
Cdd:pfam04267 81 LA 82
 
Name Accession Description Interval E-value
soxD TIGR01374
sarcosine oxidase, delta subunit family, heterotetrameric form; This model describes the delta ...
 3-86 2.83e-54

sarcosine oxidase, delta subunit family, heterotetrameric form; This model describes the delta subunit of a family of known and putative heterotetrameric sarcosine oxidases. Five operons of such oxidases are found in Mesorhizobium loti and three in Agrobacterium tumefaciens, a high enough copy number to suggest that not all members are share the same function. The model is designated as subfamily rather than equivalog for this reason. Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) form [Energy metabolism, Amino acids and amines]


Pssm-ID: 130441  Cd Length: 84  Bit Score: 163.36  E-value: 2.83e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3AD8_D         3 LIECPNCGPRNENEFKYGGEAHVAYPEDPNALSDKEWSRYLFYRGNKKGIFAERWVHSGGCRKWFNALRDTVSYEFKAVY 82
Cdd:TIGR01374  1 LIPCPYCGPRPEEEFTYGGDAHIVRPADPAAASDEEWEDYLFLRDNPKGLHAERWVHSGGCRRWFNVVRDTVTHEILATY 80


                 ....
3AD8_D        83 RAGE 86
Cdd:TIGR01374 81 RAGE 84
SoxD COG4311
Sarcosine oxidase delta subunit [Amino acid transport and metabolism];
2-95 1.49e-52

Sarcosine oxidase delta subunit [Amino acid transport and metabolism];


Pssm-ID: 443452  Cd Length: 94  Bit Score: 159.27  E-value: 1.49e-52
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3AD8_D       2 MLIECPNCGPRNENEFKYGGEAHVAYPEDPNALSDKEWSRYLFYRGNKKGIFAERWVHSGGCRKWFNALRDTVSYEFKAV 81
Cdd:COG4311  1 LLITCPYCGPRDESEFTYGGEAHIARPDPPAAASDEEWADYLFLRDNPKGVHRERWYHAAGCRKWFNVERDTVTHEILGT 80

                       90
               ....*....|....
3AD8_D      82 YRAGEARPQLDSTE 95
Cdd:COG4311 81 YLAGEPRPAGAAEA 94
SoxD pfam04267
Sarcosine oxidase, delta subunit family; Sarcosine oxidase is a hetero-tetrameric enzyme that ...
 3-84 8.74e-50

Sarcosine oxidase, delta subunit family; Sarcosine oxidase is a hetero-tetrameric enzyme that contains both covalently bound FMN and non-covalently bound FAD and NAD(+). This enzyme catalyzes the oxidative demethylation of sarcosine to yield glycine, H2O2, and 5,10-CH2-tetrahydrofolate (H4folate) in a reaction requiring H4folate and O2.


Pssm-ID: 427830  Cd Length: 82  Bit Score: 151.93  E-value: 8.74e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3AD8_D         3 LIECPNCGPRNENEFKYGGEAHVAYPEDPNALSDKEWSRYLFYRGNKKGIFAERWVHSGGCRKWFNALRDTVSYEFKAVY 82
Cdd:pfam04267  1 LITCPYCGPRDESEFTYGGEAHIARPPDPAALSDEEWADYLFLRDNPKGVHRERWYHAAGCRRWFNAERDTVTHEILGTY 80


                 ..
3AD8_D        83 RA 84
Cdd:pfam04267 81 LA 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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