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Conserved domains on  [gi|301015750|pdb|2XJZ|L]
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Chain L, Lim Domain-binding Protein 1

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LID super family cl39379
LIM interaction domain (LID); LIM-homeodomain (LIM-HD) proteins are transcription factors that ...
 4-32 2.74e-08

LIM interaction domain (LID); LIM-homeodomain (LIM-HD) proteins are transcription factors that are critical in the development of many cell types and tissues. The activity of LIM-HD proteins is dependent on the essential cofactor LIM domain-binding protein 1 (Ldb1). This entry represents a 30-residue LIM interaction domain (LID) that binds to the LIM domains of all LIM-HD and closely related LIM-only (LMO) proteins. Isl1 (Insulin gene enhancer protein 1) and Isl2 each contain a LID-like sequence in their C-terminal regions, the Lhx3-binding domain (LBD), which binds the LIM domains Lhx3 and Lhx4.


The actual alignment was detected with superfamily member pfam17916:

Pssm-ID: 465564  Cd Length: 29  Bit Score: 43.23  E-value: 2.74e-08
                         10        20
                 ....*....|....*....|....*....
2XJZ_L         4 DVMVVGEPTLMGGEFGDEDERLITRLENT 32
Cdd:pfam17916  1 DVMVVGEPSMMGSDFGEGDERTISRVENT 29
 
Name Accession Description Interval E-value
LID pfam17916
LIM interaction domain (LID); LIM-homeodomain (LIM-HD) proteins are transcription factors that ...
 4-32 2.74e-08

LIM interaction domain (LID); LIM-homeodomain (LIM-HD) proteins are transcription factors that are critical in the development of many cell types and tissues. The activity of LIM-HD proteins is dependent on the essential cofactor LIM domain-binding protein 1 (Ldb1). This entry represents a 30-residue LIM interaction domain (LID) that binds to the LIM domains of all LIM-HD and closely related LIM-only (LMO) proteins. Isl1 (Insulin gene enhancer protein 1) and Isl2 each contain a LID-like sequence in their C-terminal regions, the Lhx3-binding domain (LBD), which binds the LIM domains Lhx3 and Lhx4.


Pssm-ID: 465564  Cd Length: 29  Bit Score: 43.23  E-value: 2.74e-08
                         10        20
                 ....*....|....*....|....*....
2XJZ_L         4 DVMVVGEPTLMGGEFGDEDERLITRLENT 32
Cdd:pfam17916  1 DVMVVGEPSMMGSDFGEGDERTISRVENT 29
 
Name Accession Description Interval E-value
LID pfam17916
LIM interaction domain (LID); LIM-homeodomain (LIM-HD) proteins are transcription factors that ...
 4-32 2.74e-08

LIM interaction domain (LID); LIM-homeodomain (LIM-HD) proteins are transcription factors that are critical in the development of many cell types and tissues. The activity of LIM-HD proteins is dependent on the essential cofactor LIM domain-binding protein 1 (Ldb1). This entry represents a 30-residue LIM interaction domain (LID) that binds to the LIM domains of all LIM-HD and closely related LIM-only (LMO) proteins. Isl1 (Insulin gene enhancer protein 1) and Isl2 each contain a LID-like sequence in their C-terminal regions, the Lhx3-binding domain (LBD), which binds the LIM domains Lhx3 and Lhx4.


Pssm-ID: 465564  Cd Length: 29  Bit Score: 43.23  E-value: 2.74e-08
                         10        20
                 ....*....|....*....|....*....
2XJZ_L         4 DVMVVGEPTLMGGEFGDEDERLITRLENT 32
Cdd:pfam17916  1 DVMVVGEPSMMGSDFGEGDERTISRVENT 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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