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Conserved domains on  [gi|192988265|pdb|2VSX|E]
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Chain E, EUKARYOTIC INITIATION FACTOR 4F SUBUNIT P150

Protein Classification

MIF4G domain-containing protein( domain architecture ID 10501351)

MIF4G (middle domain of eukaryotic initiation factor 4G) domain-containing protein may contain multiple alpha-helical repeats

CATH:  1.25.40.180
Gene Ontology:  GO:0005515|GO:0003723
SCOP:  4000569

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
37-280 2.75e-38

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


:

Pssm-ID: 397130  Cd Length: 203  Bit Score: 133.64  E-value: 2.75e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2VSX_E         37 ERKMKSLLNKLTLEMFDAISSEILAIANisvweTNGETLKAVIEQIFLKACDEPHWSSMYAQLCGKVVKELNPDITdetn 116
Cdd:pfam02854   1 LKKVKGILNKLSPENFEKLIKELLKLIM-----SDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLRNPTDFG---- 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2VSX_E        117 egktgpklvlHYLVARCHAEFDKGwtdklptnedgtplepemmSEEYYAAASAKRRGLGLVRFIGFLYRLNLLTGKMMFE 196
Cdd:pfam02854  72 ----------IHLLNRLQEEFEKR-------------------FELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFE 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2VSX_E        197 CFRRLMKDLTD---SPSEETLESVVELLNTVGEQFETDSfrtgqatleGSQLLDSLFGILDNIIQTAK---ISSRIKFKL 270
Cdd:pfam02854 123 CLKELLSSLTKedlKRDLFNLECLLTLLTTIGKLLENEK---------LPKLMDQFLDEIQKYVLSKDdpkLSSRLRFML 193
                         250
                  ....*....|
2VSX_E        271 IDIKELRHDK 280
Cdd:pfam02854 194 QDLIELRKNK 203
 
Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
37-280 2.75e-38

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 133.64  E-value: 2.75e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2VSX_E         37 ERKMKSLLNKLTLEMFDAISSEILAIANisvweTNGETLKAVIEQIFLKACDEPHWSSMYAQLCGKVVKELNPDITdetn 116
Cdd:pfam02854   1 LKKVKGILNKLSPENFEKLIKELLKLIM-----SDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLRNPTDFG---- 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2VSX_E        117 egktgpklvlHYLVARCHAEFDKGwtdklptnedgtplepemmSEEYYAAASAKRRGLGLVRFIGFLYRLNLLTGKMMFE 196
Cdd:pfam02854  72 ----------IHLLNRLQEEFEKR-------------------FELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFE 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2VSX_E        197 CFRRLMKDLTD---SPSEETLESVVELLNTVGEQFETDSfrtgqatleGSQLLDSLFGILDNIIQTAK---ISSRIKFKL 270
Cdd:pfam02854 123 CLKELLSSLTKedlKRDLFNLECLLTLLTTIGKLLENEK---------LPKLMDQFLDEIQKYVLSKDdpkLSSRLRFML 193
                         250
                  ....*....|
2VSX_E        271 IDIKELRHDK 280
Cdd:pfam02854 194 QDLIELRKNK 203
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
37-280 1.10e-28

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 108.60  E-value: 1.10e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2VSX_E          37 ERKMKSLLNKLTLEMFDAISSEILAIANisvweTNGETLKAVIEQIFLKACDEPHWSSMYAQLCGKvvkeLNPDITDetn 116
Cdd:smart00543   1 EKKVKGLINKLSPSNFESIIKELLKLNN-----SDKNLRKYILELIFEKAVEEPNFIPAYARLCAL----LNAKNPD--- 68
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2VSX_E         117 egktgpklVLHYLVARCHAEFdkgwtdklptnedgtplEPEMMSEEYyaaaSAKRRGLGLVRFIGFLYRLNLLTGKMMFE 196
Cdd:smart00543  69 --------FGSLLLERLQEEF-----------------EKGLESEEE----SDKQRRLGLVRFLGELYNFQVLTSKIILE 119
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2VSX_E         197 CFRRLMKDLT---DSPSEETLESVVELLNTVGEQFETDsfrtgqatlEGSQLLDSLFGILDNIIQTAK---ISSRIKFKL 270
Cdd:smart00543 120 LLKELLNDLTkldPPRSDFSVECLLSLLPTCGKDLERE---------KSPKLLDEILERLQDYLLKKDkteLSSRLRFML 190
                          250
                   ....*....|
2VSX_E         271 IDIKELRHDK 280
Cdd:smart00543 191 ELLIELRKNK 200
 
Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
37-280 2.75e-38

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 133.64  E-value: 2.75e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2VSX_E         37 ERKMKSLLNKLTLEMFDAISSEILAIANisvweTNGETLKAVIEQIFLKACDEPHWSSMYAQLCGKVVKELNPDITdetn 116
Cdd:pfam02854   1 LKKVKGILNKLSPENFEKLIKELLKLIM-----SDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLRNPTDFG---- 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2VSX_E        117 egktgpklvlHYLVARCHAEFDKGwtdklptnedgtplepemmSEEYYAAASAKRRGLGLVRFIGFLYRLNLLTGKMMFE 196
Cdd:pfam02854  72 ----------IHLLNRLQEEFEKR-------------------FELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFE 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2VSX_E        197 CFRRLMKDLTD---SPSEETLESVVELLNTVGEQFETDSfrtgqatleGSQLLDSLFGILDNIIQTAK---ISSRIKFKL 270
Cdd:pfam02854 123 CLKELLSSLTKedlKRDLFNLECLLTLLTTIGKLLENEK---------LPKLMDQFLDEIQKYVLSKDdpkLSSRLRFML 193
                         250
                  ....*....|
2VSX_E        271 IDIKELRHDK 280
Cdd:pfam02854 194 QDLIELRKNK 203
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
37-280 1.10e-28

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 108.60  E-value: 1.10e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2VSX_E          37 ERKMKSLLNKLTLEMFDAISSEILAIANisvweTNGETLKAVIEQIFLKACDEPHWSSMYAQLCGKvvkeLNPDITDetn 116
Cdd:smart00543   1 EKKVKGLINKLSPSNFESIIKELLKLNN-----SDKNLRKYILELIFEKAVEEPNFIPAYARLCAL----LNAKNPD--- 68
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2VSX_E         117 egktgpklVLHYLVARCHAEFdkgwtdklptnedgtplEPEMMSEEYyaaaSAKRRGLGLVRFIGFLYRLNLLTGKMMFE 196
Cdd:smart00543  69 --------FGSLLLERLQEEF-----------------EKGLESEEE----SDKQRRLGLVRFLGELYNFQVLTSKIILE 119
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2VSX_E         197 CFRRLMKDLT---DSPSEETLESVVELLNTVGEQFETDsfrtgqatlEGSQLLDSLFGILDNIIQTAK---ISSRIKFKL 270
Cdd:smart00543 120 LLKELLNDLTkldPPRSDFSVECLLSLLPTCGKDLERE---------KSPKLLDEILERLQDYLLKKDkteLSSRLRFML 190
                          250
                   ....*....|
2VSX_E         271 IDIKELRHDK 280
Cdd:smart00543 191 ELLIELRKNK 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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