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Conserved domains on  [gi|152149529|pdb|2UUI|A]
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Chain A, LEUKOTRIENE C4 SYNTHASE

Protein Classification

MAPEG family protein( domain architecture ID 10471516)

MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family protein is a membrane associated protein; similar to mammalian prostaglandin E synthase, leukotriene C4 synthase, arachidonate 5-lipoxygenase-activating protein, microsomal glutathione S-transferases, and mitochondrial glutathione S-transferase 3

CATH:  1.20.120.550
Gene Ontology:  GO:0016020
PubMed:  10091672|10673221

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MAPEG pfam01124
MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid ...
 14-106 1.72e-10

MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme catalyzes the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.


:

Pssm-ID: 460074  Cd Length: 127  Bit Score: 55.38  E-value: 1.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2UUI_A         14 LAAVTLLGVLLQAYFSLQVISARRAFRV--------SPPLTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIFFHE-GA 84
Cdd:pfam01124   1 VLLWAVLLALLLLLLSILVGKARKKAKVgdgganpeRALDDKLPPRVERAQRAHQNFLENLPLFLAAVLLAGLTGGSpGL 80

                          90       100
                  ....*....|....*....|..
2UUI_A         85 AALCGLVYLFARLRYFQGYARS 106
Cdd:pfam01124  81 AALLAWAYVVARVLHALGYATG 102
 
Name Accession Description Interval E-value
MAPEG pfam01124
MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid ...
 14-106 1.72e-10

MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme catalyzes the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.


Pssm-ID: 460074  Cd Length: 127  Bit Score: 55.38  E-value: 1.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2UUI_A         14 LAAVTLLGVLLQAYFSLQVISARRAFRV--------SPPLTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIFFHE-GA 84
Cdd:pfam01124   1 VLLWAVLLALLLLLLSILVGKARKKAKVgdgganpeRALDDKLPPRVERAQRAHQNFLENLPLFLAAVLLAGLTGGSpGL 80

                          90       100
                  ....*....|....*....|..
2UUI_A         85 AALCGLVYLFARLRYFQGYARS 106
Cdd:pfam01124  81 AALLAWAYVVARVLHALGYATG 102
YecN COG3788
Uncharacterized membrane protein YecN, MAPEG domain [Function unknown];
12-107 9.94e-10

Uncharacterized membrane protein YecN, MAPEG domain [Function unknown];


Pssm-ID: 443002  Cd Length: 131  Bit Score: 53.32  E-value: 9.94e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2UUI_A       12 ALLAAvtlLGVLLQAYFSLQVISARRAFRVSPPlTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIffhEGAAA----L 87
Cdd:COG3788   7 ALYAA---LLALLLLVLSLRVVRLRRKYRVALG-DGGDPELQRAIRAHGNFVEYVPLALILLLLLEL---NGAPAwwlhL 79

                        90       100
                ....*....|....*....|
2UUI_A       88 CGLVYLFARLRYFQGYARSA 107
Cdd:COG3788  80 LGIALLLGRLLHAYGLSRSK 99
 
Name Accession Description Interval E-value
MAPEG pfam01124
MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid ...
 14-106 1.72e-10

MAPEG family; This family is has been called MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism). It includes proteins such as Prostaglandin E synthase. This enzyme catalyzes the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). Because of structural similarities in the active sites of FLAP, LTC4 synthase and PGE synthase, substrates for each enzyme can compete with one another and modulate synthetic activity.


Pssm-ID: 460074  Cd Length: 127  Bit Score: 55.38  E-value: 1.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2UUI_A         14 LAAVTLLGVLLQAYFSLQVISARRAFRV--------SPPLTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIFFHE-GA 84
Cdd:pfam01124   1 VLLWAVLLALLLLLLSILVGKARKKAKVgdgganpeRALDDKLPPRVERAQRAHQNFLENLPLFLAAVLLAGLTGGSpGL 80

                          90       100
                  ....*....|....*....|..
2UUI_A         85 AALCGLVYLFARLRYFQGYARS 106
Cdd:pfam01124  81 AALLAWAYVVARVLHALGYATG 102
YecN COG3788
Uncharacterized membrane protein YecN, MAPEG domain [Function unknown];
12-107 9.94e-10

Uncharacterized membrane protein YecN, MAPEG domain [Function unknown];


Pssm-ID: 443002  Cd Length: 131  Bit Score: 53.32  E-value: 9.94e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2UUI_A       12 ALLAAvtlLGVLLQAYFSLQVISARRAFRVSPPlTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIffhEGAAA----L 87
Cdd:COG3788   7 ALYAA---LLALLLLVLSLRVVRLRRKYRVALG-DGGDPELQRAIRAHGNFVEYVPLALILLLLLEL---NGAPAwwlhL 79

                        90       100
                ....*....|....*....|
2UUI_A       88 CGLVYLFARLRYFQGYARSA 107
Cdd:COG3788  80 LGIALLLGRLLHAYGLSRSK 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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