|
Name |
Accession |
Description |
Interval |
E-value |
| Biopterin_H |
pfam00351 |
Biopterin-dependent aromatic amino acid hydroxylase; This family includes ... |
10-340 |
0e+00 |
|
Biopterin-dependent aromatic amino acid hydroxylase; This family includes phenylalanine-4-hydroxylase, the phenylketonuria disease protein.
Pssm-ID: 459776 Cd Length: 331 Bit Score: 715.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 10 PWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYKHGEPIPHVEYTAEEIATWKEVYVTLKGLY 89
Cdd:pfam00351 1 PWFPRKISDLDKCAHLVLKYGPELDADHPGFTDPVYRKRRKEIADIAFNYKHGDPIPRVEYTEEEIKTWGTVYKKLTSLY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 90 ATHACREHLEGFQLLERYCGYREDSIPQLEDVSRFLKERTGFQLRPVAGLLSARD*LASLAFRVFQCTQYIRHASSPMHS 169
Cdd:pfam00351 81 PTHACREYLENFPLLEKNCGYREDNIPQLEDVSNFLKERTGFTLRPVAGLLSARDFLAGLAFRVFHCTQYIRHHSSPMYT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 170 PEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTVYWFTVEFGLCKQNGELKAYGAGLLSSYGELLHSL 249
Cdd:pfam00351 161 PEPDCCHELLGHVPLLADPDFAQFSQEIGLASLGASDEDIEKLATCYWFTVEFGLCKQNGELKAYGAGLLSSFGELEYAL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 250 SEEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFNDAKDKLRNYASRIQRPFSVKFDPYTLAIDVLDSPHTIQRSLEGVQ 329
Cdd:pfam00351 241 SDKPEYKPFDPEVTAVQKYPITTYQPVYFVAESFEDAKEKLRKFASTIKRPFSVRYNPYTQSVEVLDSKDKLKNLLSQIK 320
|
330
....*....|.
2TOH_A 330 DELHTLAHALS 340
Cdd:pfam00351 321 GDLDILTDALE 331
|
|
| eu_TyrOH |
cd03345 |
Eukaryotic tyrosine hydroxylase (TyrOH); a member of the biopterin-dependent aromatic amino ... |
11-308 |
0e+00 |
|
Eukaryotic tyrosine hydroxylase (TyrOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH) and eukaryotic tryptophan hydroxylase (TrpOH). TyrOH catalyzes the conversion of tyrosine to L-dihydroxyphenylalanine (L-DOPA), the rate-limiting step in the biosynthesis of the catecholamines dopamine, noradrenaline, and adrenaline.
Pssm-ID: 239461 Cd Length: 298 Bit Score: 646.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 11 WFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYKHGEPIPHVEYTAEEIATWKEVYVTLKGLYA 90
Cdd:cd03345 1 WFPRHISELDKCHHLVTKYEPDLDLDHPGFSDKVYRERRKLIAEIAFQYKHGDPIPRVEYTAEEIATWKEVYKTLKDLHA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 91 THACREHLEGFQLLERYCGYREDSIPQLEDVSRFLKERTGFQLRPVAGLLSARD*LASLAFRVFQCTQYIRHASSPMHSP 170
Cdd:cd03345 81 THACKEYLDAFQLLEKECGYSEDRIPQLEDVSEFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 171 EPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTVYWFTVEFGLCKQNGELKAYGAGLLSSYGELLHSLS 250
Cdd:cd03345 161 EPDCCHELLGHVPMLADPTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKENGELKAYGAGLLSSYGELLHALS 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
2TOH_A 251 EEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFNDAKDKLRNYASRIQRPFSVKFDPY 308
Cdd:cd03345 241 DEPEHRPFDPAATAVQPYQDQTYQPIYFVSESFSDAKDKLRNYASTMKRPFSVRYDPY 298
|
|
| Tyr_3_monoox |
TIGR01269 |
tyrosine 3-monooxygenase, tetrameric; This model describes tyrosine 3-monooxygenase, a member ... |
1-340 |
0e+00 |
|
tyrosine 3-monooxygenase, tetrameric; This model describes tyrosine 3-monooxygenase, a member of the family of tetrameric, biopterin-dependent aromatic amino acid hydroxylases found in metazoans. It is closely related to tetrameric phenylalanine-4-hydroxylase and tryptophan 5-monooxygenase, and more distantly related to the monomeric phenylalanine-4-hydroxylase found in some Gram-negative bacteria.
Pssm-ID: 130336 [Multi-domain] Cd Length: 457 Bit Score: 589.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 1 VRSAREDKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYKHGEPIPHVEYTAEEIATWKE 80
Cdd:TIGR01269 115 LLNNQNVKEDWFPKHISELDKCQHLLTKFQPDLDTDHPGFHDKVYRQRREAIAEIAFQYKYGDPIPEVEYTKEEIETWRL 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 81 VYVTLKGLYATHACREHLEGFQLLERYCGYREDSIPQLEDVSRFLKERTGFQLRPVAGLLSARD*LASLAFRVFQCTQYI 160
Cdd:TIGR01269 195 VFTTMKDLHASHACREYIDAFQLLEKYCNYNSESIPQLQTISEFLHRTTGFRLRPVAGLLSARDFLASLAFRVFQCTQYI 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 161 RHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTVYWFTVEFGLCKQNGELKAYGAGLLS 240
Cdd:TIGR01269 275 RHHSSPMHTPEPDCIHELLGHMPMLADRQFAQFSQEIGLASLGASEEEIEKLSTLYWFTVEFGLCKENGETKAYGAGLLS 354
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 241 SYGELLHSLSEEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFNDAKDKLRNYASRIQRPFSVKFDPYTLAIDVLDSPHT 320
Cdd:TIGR01269 355 SYGELEHAFSDLSEKRPFNPNDAAVQPYQDQGYQKIYFVTESFEDAKRKLRNYINTSGRPFIVRFDPITETVEVLDRFSK 434
|
330 340
....*....|....*....|
2TOH_A 321 IQRSLEGVQDELHTLAHALS 340
Cdd:TIGR01269 435 RKELLKHVKEEIGQLTTALN 454
|
|
| phhA |
PRK11913 |
phenylalanine 4-monooxygenase; Reviewed |
42-285 |
7.36e-81 |
|
phenylalanine 4-monooxygenase; Reviewed
Pssm-ID: 237020 Cd Length: 275 Bit Score: 247.47 E-value: 7.36e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 42 DQVYRQRRKLIAEIAFQYKHGEPIphVEYTAEEIATWKEVYVTLKGLYATHACREHLEGFQLLerycGYREDSIPQLEDV 121
Cdd:PRK11913 1 DAAYRARRDAGMEKAADYTADQPW--IDYTAEEHAIWQTLYERQLALLPGRACDEFLEGLEAL----GLPKDRIPQLDEI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 122 SRFLKERTGFQLRPVAGLLSARD*LASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLAS 201
Cdd:PRK11913 75 NRVLQAATGWQVVPVPGLIPFDVFFELLANRRFPVATFIRRPEELDYLQEPDIFHDVFGHVPLLTNPVFADFMQAYGKLG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 202 LGASDEE-IEKLSTVYWFTVEFGLCKQNGELKAYGAGLLSSYGELLHSL-SEEPEVRAFDPDTAAVQPYQDQTYQPVYFV 279
Cdd:PRK11913 155 LRASKEGrLEFLARLYWFTVEFGLIRTPGGLRIYGAGILSSPGETLYALeSDSPNRRPFDLERVMRTPYRIDIFQPTYFV 234
|
....*.
2TOH_A 280 SESFND 285
Cdd:PRK11913 235 IDSFEQ 240
|
|
| PhhA |
COG3186 |
Phenylalanine-4-hydroxylase [Amino acid transport and metabolism]; |
64-285 |
3.81e-80 |
|
Phenylalanine-4-hydroxylase [Amino acid transport and metabolism];
Pssm-ID: 442419 Cd Length: 279 Bit Score: 245.49 E-value: 3.81e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 64 PIPHVEYTAEEIATWKEVYVTLKGLYATHACREHLEGFQLLerycGYREDSIPQLEDVSRFLKERTGFQLRPVAGLLSAR 143
Cdd:COG3186 20 PQGYIDYTAEEHAVWRRLYRRQVALLPGRACDEYLDGLEKL----GLPADRIPQLDEVNERLKALTGWRVVAVPGLIPPD 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 144 D*LASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGAS--DEEIEKLSTVYWFTVE 221
Cdd:COG3186 96 AFFELLANRRFPVATFIRTPEEIDYLPEPDIFHEVFGHVPLLTNPVFADFLQAYGEAGLKASklDSELALLARLYWFTVE 175
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
2TOH_A 222 FGLCKQNGELKAYGAGLLSSYGELLHSL-SEEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFND 285
Cdd:COG3186 176 FGLIGTPEGLRIYGAGILSSPGESEYALeSDEPNRIPFDLERVMRTPYRIDIYQPTYFVIDSFDQ 240
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Biopterin_H |
pfam00351 |
Biopterin-dependent aromatic amino acid hydroxylase; This family includes ... |
10-340 |
0e+00 |
|
Biopterin-dependent aromatic amino acid hydroxylase; This family includes phenylalanine-4-hydroxylase, the phenylketonuria disease protein.
Pssm-ID: 459776 Cd Length: 331 Bit Score: 715.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 10 PWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYKHGEPIPHVEYTAEEIATWKEVYVTLKGLY 89
Cdd:pfam00351 1 PWFPRKISDLDKCAHLVLKYGPELDADHPGFTDPVYRKRRKEIADIAFNYKHGDPIPRVEYTEEEIKTWGTVYKKLTSLY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 90 ATHACREHLEGFQLLERYCGYREDSIPQLEDVSRFLKERTGFQLRPVAGLLSARD*LASLAFRVFQCTQYIRHASSPMHS 169
Cdd:pfam00351 81 PTHACREYLENFPLLEKNCGYREDNIPQLEDVSNFLKERTGFTLRPVAGLLSARDFLAGLAFRVFHCTQYIRHHSSPMYT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 170 PEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTVYWFTVEFGLCKQNGELKAYGAGLLSSYGELLHSL 249
Cdd:pfam00351 161 PEPDCCHELLGHVPLLADPDFAQFSQEIGLASLGASDEDIEKLATCYWFTVEFGLCKQNGELKAYGAGLLSSFGELEYAL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 250 SEEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFNDAKDKLRNYASRIQRPFSVKFDPYTLAIDVLDSPHTIQRSLEGVQ 329
Cdd:pfam00351 241 SDKPEYKPFDPEVTAVQKYPITTYQPVYFVAESFEDAKEKLRKFASTIKRPFSVRYNPYTQSVEVLDSKDKLKNLLSQIK 320
|
330
....*....|.
2TOH_A 330 DELHTLAHALS 340
Cdd:pfam00351 321 GDLDILTDALE 331
|
|
| eu_TyrOH |
cd03345 |
Eukaryotic tyrosine hydroxylase (TyrOH); a member of the biopterin-dependent aromatic amino ... |
11-308 |
0e+00 |
|
Eukaryotic tyrosine hydroxylase (TyrOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH) and eukaryotic tryptophan hydroxylase (TrpOH). TyrOH catalyzes the conversion of tyrosine to L-dihydroxyphenylalanine (L-DOPA), the rate-limiting step in the biosynthesis of the catecholamines dopamine, noradrenaline, and adrenaline.
Pssm-ID: 239461 Cd Length: 298 Bit Score: 646.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 11 WFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYKHGEPIPHVEYTAEEIATWKEVYVTLKGLYA 90
Cdd:cd03345 1 WFPRHISELDKCHHLVTKYEPDLDLDHPGFSDKVYRERRKLIAEIAFQYKHGDPIPRVEYTAEEIATWKEVYKTLKDLHA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 91 THACREHLEGFQLLERYCGYREDSIPQLEDVSRFLKERTGFQLRPVAGLLSARD*LASLAFRVFQCTQYIRHASSPMHSP 170
Cdd:cd03345 81 THACKEYLDAFQLLEKECGYSEDRIPQLEDVSEFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 171 EPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTVYWFTVEFGLCKQNGELKAYGAGLLSSYGELLHSLS 250
Cdd:cd03345 161 EPDCCHELLGHVPMLADPTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKENGELKAYGAGLLSSYGELLHALS 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
2TOH_A 251 EEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFNDAKDKLRNYASRIQRPFSVKFDPY 308
Cdd:cd03345 241 DEPEHRPFDPAATAVQPYQDQTYQPIYFVSESFSDAKDKLRNYASTMKRPFSVRYDPY 298
|
|
| Tyr_3_monoox |
TIGR01269 |
tyrosine 3-monooxygenase, tetrameric; This model describes tyrosine 3-monooxygenase, a member ... |
1-340 |
0e+00 |
|
tyrosine 3-monooxygenase, tetrameric; This model describes tyrosine 3-monooxygenase, a member of the family of tetrameric, biopterin-dependent aromatic amino acid hydroxylases found in metazoans. It is closely related to tetrameric phenylalanine-4-hydroxylase and tryptophan 5-monooxygenase, and more distantly related to the monomeric phenylalanine-4-hydroxylase found in some Gram-negative bacteria.
Pssm-ID: 130336 [Multi-domain] Cd Length: 457 Bit Score: 589.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 1 VRSAREDKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYKHGEPIPHVEYTAEEIATWKE 80
Cdd:TIGR01269 115 LLNNQNVKEDWFPKHISELDKCQHLLTKFQPDLDTDHPGFHDKVYRQRREAIAEIAFQYKYGDPIPEVEYTKEEIETWRL 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 81 VYVTLKGLYATHACREHLEGFQLLERYCGYREDSIPQLEDVSRFLKERTGFQLRPVAGLLSARD*LASLAFRVFQCTQYI 160
Cdd:TIGR01269 195 VFTTMKDLHASHACREYIDAFQLLEKYCNYNSESIPQLQTISEFLHRTTGFRLRPVAGLLSARDFLASLAFRVFQCTQYI 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 161 RHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTVYWFTVEFGLCKQNGELKAYGAGLLS 240
Cdd:TIGR01269 275 RHHSSPMHTPEPDCIHELLGHMPMLADRQFAQFSQEIGLASLGASEEEIEKLSTLYWFTVEFGLCKENGETKAYGAGLLS 354
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 241 SYGELLHSLSEEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFNDAKDKLRNYASRIQRPFSVKFDPYTLAIDVLDSPHT 320
Cdd:TIGR01269 355 SYGELEHAFSDLSEKRPFNPNDAAVQPYQDQGYQKIYFVTESFEDAKRKLRNYINTSGRPFIVRFDPITETVEVLDRFSK 434
|
330 340
....*....|....*....|
2TOH_A 321 IQRSLEGVQDELHTLAHALS 340
Cdd:TIGR01269 435 RKELLKHVKEEIGQLTTALN 454
|
|
| eu_PheOH |
cd03347 |
Eukaryotic phenylalanine-4-hydroxylase (eu_PheOH); a member of the biopterin-dependent ... |
10-315 |
1.82e-180 |
|
Eukaryotic phenylalanine-4-hydroxylase (eu_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes prokaryotic phenylalanine-4-hydroxylase (pro_PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan hydroxylase (TrpOH). PheOH catalyzes the first and rate-limiting step in the metabolism of the amino acid L-phenylalanine (L-Phe), the hydroxylation of L-Phe to L-tyrosine (L-Tyr). It uses (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4) as the physiological electron donor. The catalytic activity of the tetrameric enzyme is tightly regulated by the binding of L-Phe and BH4 as well as by phosphorylation. Mutations in the human enzyme are linked to a severe variant of phenylketonuria.
Pssm-ID: 239463 Cd Length: 306 Bit Score: 501.59 E-value: 1.82e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 10 PWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYKHGEPIPHVEYTAEEIATWKEVYVTLKGLY 89
Cdd:cd03347 1 PWFPRTIQDLDRFANQILSYGAELDADHPGFKDPVYRARRKEFADIAYNYKHGQPIPRVEYTEEEKKTWGTVFRELKSLY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 90 ATHACREHLEGFQLLERYCGYREDSIPQLEDVSRFLKERTGFQLRPVAGLLSARD*LASLAFRVFQCTQYIRHASSPMHS 169
Cdd:cd03347 81 PTHACYEYNHVFPLLEKNCGFSEDNIPQLEDVSNFLQTCTGFRLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHPSKPMYT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 170 PEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTVYWFTVEFGLCKQNGELKAYGAGLLSSYGELLHSL 249
Cdd:cd03347 161 PEPDICHELLGHVPLFADPSFAQFSQEIGLASLGAPDEYIEKLATVYWFTVEFGLCKQGGSIKAYGAGLLSSFGELQYCL 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
2TOH_A 250 SEEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFNDAKDKLRNYASRIQRPFSVKFDPYTLAIDVL 315
Cdd:cd03347 241 SDKPELLPFEPEKTAVTKYPITEFQPLYYVAESFEDAKEKLRNFAATIPRPFSVRYNPYTQRIEVL 306
|
|
| Phe4hydrox_tetr |
TIGR01268 |
phenylalanine-4-hydroxylase, tetrameric form; This model describes the larger, tetrameric form ... |
6-342 |
4.02e-179 |
|
phenylalanine-4-hydroxylase, tetrameric form; This model describes the larger, tetrameric form of phenylalanine-4-hydroxylase, as found in metazoans. The enzyme irreversibly converts phenylalanine to tryosine and is known to be the rate-limiting step in phenylalanine catabolism in some systems. It is closely related to metazoan tyrosine 3-monooxygenase and tryptophan 5-monoxygenase, and more distantly to monomeric phenylalanine-4-hydroxylases of some Gram-negative bacteria. The member of this family from Drosophila has been described as having both phenylalanine-4-hydroxylase and tryptophan 5-monoxygenase activity (. However, a Drosophila member of the tryptophan 5-monoxygenase clade has subsequently been discovered.
Pssm-ID: 130335 [Multi-domain] Cd Length: 436 Bit Score: 503.21 E-value: 4.02e-179
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 6 EDKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYKHGEPIPHVEYTAEEIATWKEVYVTL 85
Cdd:TIGR01268 99 KDSVPWFPRKINDIDRFANQILSYGAELDADHPGFKDPVYRARRKQFADIAFNYKHGQPIPRVEYTDEEIATWRTVFNNL 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 86 KGLYATHACREHLEGFQLLERYCGYREDSIPQLEDVSRFLKERTGFQLRPVAGLLSARD*LASLAFRVFQCTQYIRHASS 165
Cdd:TIGR01268 179 TVLYPTHACQEYNHIFPLLQQNCGFREDNIPQLEDVSQFLQDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHHSK 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 166 PMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTVYWFTVEFGLCKQNGELKAYGAGLLSSYGEL 245
Cdd:TIGR01268 259 PMYTPEPDICHELLGHVPLFADVEFAQFSQEIGLASLGAPDDYIEKLATLYWFTIEFGLCKQDGEKKAYGAGLLSSFGEL 338
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 246 LHSLSEEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFNDAKDKLRNYASRIQRPFSVKFDPYTLAIDVLDSPHTIQRSL 325
Cdd:TIGR01268 339 QYCLSDKPEVVDFDPEVTCVTKYPITEFQPLYFLAESFEDAKEKLKSFAATIPRPFSVRYNAYTQRVEILDKKAQLQRLA 418
|
330
....*....|....*..
2TOH_A 326 EGVQDELHTLAHALSAI 342
Cdd:TIGR01268 419 DDIRSEISILQEALGKL 435
|
|
| Trp_5_monoox |
TIGR01270 |
tryptophan 5-monooxygenase, tetrameric; This model describes tryptophan 5-monooxygenase, a ... |
7-343 |
3.08e-169 |
|
tryptophan 5-monooxygenase, tetrameric; This model describes tryptophan 5-monooxygenase, a member of the family of tetrameric, biopterin-dependent aromatic amino acid hydroxylases found in metazoans. It is closely related to tetrameric phenylalanine-4-hydroxylase and tyrosine 3-monooxygenase, and more distantly related to the monomeric phenylalanine-4-hydroxylase found in some Gram-negative bacteria. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130337 [Multi-domain] Cd Length: 464 Bit Score: 479.35 E-value: 3.08e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 7 DKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYKHGEPIPHVEYTAEEIATWKEVYVTLK 86
Cdd:TIGR01270 127 TGVPWFPKKISDLDKCANRVLMYGSELDADHPGFKDTEYRKRRMMFADLALNYKHGEPIPRVEYTEEERKTWGTIYRELR 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 87 GLYATHACREHLEGFQLLERYCGYREDSIPQLEDVSRFLKERTGFQLRPVAGLLSARD*LASLAFRVFQCTQYIRHASSP 166
Cdd:TIGR01270 207 RLYKTHACKEFLDNLPLLEKYCGYREDNIPQLEDVSKFLKAKTGFRLRPVAGYLSARDFLSGLAFRVFHCTQYVRHSADP 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 167 MHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTVYWFTVEFGLCKQ-NGELKAYGAGLLSSYGEL 245
Cdd:TIGR01270 287 FYTPEPDTCHELLGHMPLLADPSFAQFSQEIGLASLGASEEDIKKLATLYFFTIEFGLCKQdDEQFKVYGAGLLSSVAEL 366
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 246 LHSLSEEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFNDAKDKLRNYASRIQRPFSVKFDPYTLAIDVLDSPHTIQRSL 325
Cdd:TIGR01270 367 QHALSGSAKIKPFDPDRVCEQECLITTFQNAYFYTRSFEEAKEKMREFTNTIKRPFGVRYNPYTESVEVLKNSKSITLAV 446
|
330
....*....|....*...
2TOH_A 326 EGVQDELHTLAHALSAIS 343
Cdd:TIGR01270 447 NELRSDLNLVAGALHKIS 464
|
|
| eu_TrpOH |
cd03346 |
Eukaryotic tryptophan hydroxylase (TrpOH); a member of the biopterin-dependent aromatic amino ... |
10-294 |
6.36e-164 |
|
Eukaryotic tryptophan hydroxylase (TrpOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH) and eukaryotic tyrosine hydroxylase (TyrOH). TrpOH oxidizes L-tryptophan to 5-hydroxy-L-tryptophan, the rate-limiting step in the biosynthesis of serotonin (5-hydroxytryptamine), a widely distributed hormone and neurotransmitter.
Pssm-ID: 239462 Cd Length: 287 Bit Score: 458.88 E-value: 6.36e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 10 PWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYKHGEPIPHVEYTAEEIATWKEVYVTLKGLY 89
Cdd:cd03346 1 PWFPKKISDLDKCANRVLMYGSELDADHPGFKDNVYRKRRKYFADVAMNYKHGDPIPRVEYTEEEIKTWGTVYRELNRLY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 90 ATHACREHLEGFQLLERYCGYREDSIPQLEDVSRFLKERTGFQLRPVAGLLSARD*LASLAFRVFQCTQYIRHASSPMHS 169
Cdd:cd03346 81 PTHACREYLKNLPLLEKHCGYREDNIPQLEDVSRFLKERTGFTIRPVAGYLSPRDFLAGLAFRVFHCTQYVRHSSDPFYT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 170 PEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTVYWFTVEFGLCKQNGELKAYGAGLLSSYGELLHSL 249
Cdd:cd03346 161 PEPDTCHELLGHVPLLADPSFAQFSQEIGLASLGASDEDIQKLATCYFFTVEFGLCKQDGQLKVYGAGLLSSIGELKHAL 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
2TOH_A 250 SEEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFNDAKDKLRNYA 294
Cdd:cd03346 241 SGEAKVKPFDPKVTCKQECLITTFQEAYFVSESFEEAKEKMREFA 285
|
|
| arom_aa_hydroxylase |
cd00361 |
Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent ... |
66-289 |
4.42e-136 |
|
Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan hydroxylase (TrpOH). PheOH converts L-phenylalanine to L-tyrosine, an important step in phenylalanine catabolism and neurotransmitter biosynthesis, and is linked to a severe variant of phenylketonuria in humans. TyrOH and TrpOH are involved in the biosynthesis of catecholamine and serotonin, respectively. The eukaryotic enzymes are all homotetramers.
Pssm-ID: 238215 Cd Length: 221 Bit Score: 385.75 E-value: 4.42e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 66 PHVEYTAEEIATWKEVYVTLKGLYATHACREHLEGFQLLerycGYREDSIPQLEDVSRFLKERTGFQLRPVAGLLSARD* 145
Cdd:cd00361 1 PRVDYTEEEHATWRTLYRRLKKLLPTHACREYLEGLELL----GLPEDRIPQLEDVSEFLKALTGWTLVPVAGLISPRDF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 146 LASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASD-EEIEKLSTVYWFTVEFGL 224
Cdd:cd00361 77 FALLAFRVFPVTQYIRHPEEPDYTPEPDIFHELFGHVPLLADPSFADFSQEYGLASLGASDlEEIEKLARLYWFTVEFGL 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
2TOH_A 225 CKQNGELKAYGAGLLSSYGELLHSLSEEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFNDAKDK 289
Cdd:cd00361 157 IKEDGELKAYGAGLLSSYGELQHALSDKPKRIPFDPERVARTPYDITSFQPTYFVIESFEQLKEK 221
|
|
| phhA |
PRK11913 |
phenylalanine 4-monooxygenase; Reviewed |
42-285 |
7.36e-81 |
|
phenylalanine 4-monooxygenase; Reviewed
Pssm-ID: 237020 Cd Length: 275 Bit Score: 247.47 E-value: 7.36e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 42 DQVYRQRRKLIAEIAFQYKHGEPIphVEYTAEEIATWKEVYVTLKGLYATHACREHLEGFQLLerycGYREDSIPQLEDV 121
Cdd:PRK11913 1 DAAYRARRDAGMEKAADYTADQPW--IDYTAEEHAIWQTLYERQLALLPGRACDEFLEGLEAL----GLPKDRIPQLDEI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 122 SRFLKERTGFQLRPVAGLLSARD*LASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLAS 201
Cdd:PRK11913 75 NRVLQAATGWQVVPVPGLIPFDVFFELLANRRFPVATFIRRPEELDYLQEPDIFHDVFGHVPLLTNPVFADFMQAYGKLG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 202 LGASDEE-IEKLSTVYWFTVEFGLCKQNGELKAYGAGLLSSYGELLHSL-SEEPEVRAFDPDTAAVQPYQDQTYQPVYFV 279
Cdd:PRK11913 155 LRASKEGrLEFLARLYWFTVEFGLIRTPGGLRIYGAGILSSPGETLYALeSDSPNRRPFDLERVMRTPYRIDIFQPTYFV 234
|
....*.
2TOH_A 280 SESFND 285
Cdd:PRK11913 235 IDSFEQ 240
|
|
| PhhA |
COG3186 |
Phenylalanine-4-hydroxylase [Amino acid transport and metabolism]; |
64-285 |
3.81e-80 |
|
Phenylalanine-4-hydroxylase [Amino acid transport and metabolism];
Pssm-ID: 442419 Cd Length: 279 Bit Score: 245.49 E-value: 3.81e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 64 PIPHVEYTAEEIATWKEVYVTLKGLYATHACREHLEGFQLLerycGYREDSIPQLEDVSRFLKERTGFQLRPVAGLLSAR 143
Cdd:COG3186 20 PQGYIDYTAEEHAVWRRLYRRQVALLPGRACDEYLDGLEKL----GLPADRIPQLDEVNERLKALTGWRVVAVPGLIPPD 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 144 D*LASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGAS--DEEIEKLSTVYWFTVE 221
Cdd:COG3186 96 AFFELLANRRFPVATFIRTPEEIDYLPEPDIFHEVFGHVPLLTNPVFADFLQAYGEAGLKASklDSELALLARLYWFTVE 175
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
2TOH_A 222 FGLCKQNGELKAYGAGLLSSYGELLHSL-SEEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFND 285
Cdd:COG3186 176 FGLIGTPEGLRIYGAGILSSPGESEYALeSDEPNRIPFDLERVMRTPYRIDIYQPTYFVIDSFDQ 240
|
|
| pro_PheOH |
cd03348 |
Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent ... |
60-285 |
2.78e-62 |
|
Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH), tyrosine hydroxylase (TyrOH) and tryptophan hydroxylase (TrpOH). PheOH catalyzes the hydroxylation of L-Phe to L-tyrosine (L-Tyr). It uses (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4) as the physiological electron donor.
Pssm-ID: 239464 Cd Length: 228 Bit Score: 198.26 E-value: 2.78e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 60 KHGEPIPHVEYTAEEIATWKEVYVTLKGLYATHACREHLEGFQLLERYcgyrEDSIPQLEDVSRFLKERTGFQLRPVAGL 139
Cdd:cd03348 1 DVPDEQGQIDYTPEEHAVWRTLYERQAKLLPGRACDAFLEGLEKLGLP----TDRIPDFADVSERLKAATGWTVVAVPGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 140 LSARD*LASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGAS-DEEIEKLSTVYWF 218
Cdd:cd03348 77 IPDDEFFEHLANRRFPVTNFIRRPEELDYLQEPDIFHDIFGHVPMLTNPVFADFMQAYGKGGLKATgLEDRALLARLYWY 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
2TOH_A 219 TVEFGLCKQNGELKAYGAGLLSSYGELLHSL-SEEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFND 285
Cdd:cd03348 157 TVEFGLIQEPGGLRIYGAGILSSPGETLYALeSPDPNRIPFDLERVMRTPYRIDSFQPTYFVIDSFEQ 224
|
|
| Phe4hydrox_mono |
TIGR01267 |
phenylalanine-4-hydroxylase, monomeric form; This model describes the smaller, monomeric form ... |
64-288 |
5.44e-44 |
|
phenylalanine-4-hydroxylase, monomeric form; This model describes the smaller, monomeric form of phenylalanine-4-hydroxylase, as found in a small number of Gram-negative bacteria. The enzyme irreversibly converts phenylalanine to tryosine and is known to be the rate-limiting step in phenylalanine catabolism in some systems. This family is of biopterin and metal-dependent hydroxylases is related to a family of longer, multimeric aromatic amino acid hydroxylases that have additional N-terminal regulatory sequences. These include tyrosine 3-monooxygenase, phenylalanine-4-hydroxylase, and tryptophan 5-monoxygenase. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130334 Cd Length: 248 Bit Score: 151.56 E-value: 5.44e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 64 PIPHVEYTAEEIATWKEVYVTLKGLYATHACREHLEGFQLLerycGYREDSIPQLEDVSRFLKERTGFQLRPVAGLLSAR 143
Cdd:TIGR01267 5 DQGFDHYSEEEHAVWNTLITRQLKLIEGRACQEYLDGIEQL----GLPHDRIPDFDEINRKLQATTGWRIAAVPGLIPFQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 144 D*LASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEE-IEKLSTVYWFTVEF 222
Cdd:TIGR01267 81 TFFEHLANRRFPVTTWLRTPEELDYLQEPDIFHDIFGHVPLLTNPVFADFTHTYGKLGLKASALGrVEMLARLYWYTIEF 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
2TOH_A 223 GLCKQNGELKAYGAGLLSSYGELLHSL-SEEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFNDAKD 288
Cdd:TIGR01267 161 GLVETDQGKRIYGAGILSSPKETVYSLeSDEPLHVAFDLLEAMRTPYRIDIFQPLYFVLPSFKRLFD 227
|
|
| PRK14056 |
PRK14056 |
aromatic amino acid hydroxylase; |
67-283 |
4.07e-20 |
|
aromatic amino acid hydroxylase;
Pssm-ID: 237598 Cd Length: 578 Bit Score: 91.27 E-value: 4.07e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 67 HVEYTAEEIATWKEVYVTLKGLYATHACREHLEGFQLleryCGYREDSIPQLEDVSRFLKeRTGFQLRPVAGLLSARD*L 146
Cdd:PRK14056 18 YDQYTPVDHAVWRYVMRQNHSFLKDVAHPAYLNGLQS----TGINIERIPKVEEMNECLA-EIGWGAVAVDGFIPPVAFF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 147 ASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGL-------------------------AS 201
Cdd:PRK14056 93 EFQGHGVLPIATDIRKVENIEYTPAPDIIHEAAGHAPILADPTYAEYLRRFGEigakaisskedhdvfeavrtlsivkES 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 202 LGASDEEIEK--------------------LSTVYWFTVEFGLCkqnGEL---KAYGAGLLSSYGELLHSLSEEPEVRAF 258
Cdd:PRK14056 173 PTSTPEEVAAaenrviekqnlvsglseaeqISRLFWWTVEYGLI---GTLdnpKIYGAGLLSSVGESKHCLTDAVEKVPF 249
|
250 260
....*....|....*....|....*
2TOH_A 259 DPDTAAVQPYQDQTYQPVYFVSESF 283
Cdd:PRK14056 250 SIEACTSTTYDITKMQPQLFVCPDF 274
|
|
| PRK14055 |
PRK14055 |
aromatic amino acid hydroxylase; Provisional |
96-285 |
1.56e-15 |
|
aromatic amino acid hydroxylase; Provisional
Pssm-ID: 172547 [Multi-domain] Cd Length: 362 Bit Score: 76.64 E-value: 1.56e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 96 EHLEGFQLLERYCGYREdsipqledVSRFLKERTGFQLRPVAGLLSARD*LASLAFRVFQCTQYIRHASSPMHSPEPDCC 175
Cdd:PRK14055 128 DYLEAFGLLSDFLDHQA--------VIKFFELETHFSYYPVSGFVAPHQYLSLLQDRYFPIASVMRTLDKDNFSLTPDLI 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2TOH_A 176 HELLGHVPMLADRTFAQFSQDIG---------LASLGASDEEIEKLST-------VYWFTVEFGLCKQNGELKAYGAGLL 239
Cdd:PRK14055 200 HDLLGHVPWLLHPSFSEFFINMGrlftkviekVQALPSKKQRIQTLQSnliaivrCFWFTVESGLIENHEGRKAYGAVLI 279
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
2TOH_A 240 SSYGELLHSLSEEPEVRAFDPDTAAVQPYQDQTYQPVYFVSESFND 285
Cdd:PRK14055 280 SSPQELGHAFIDNVRVLPLELDQIIRLPFNTSTPQETLFSIRHFDE 325
|
|
| |
