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Conserved domains on  [gi|859065910|pdb|2N4D|A]
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Chain A, Uncharacterized protein Atu1203

Protein Classification

heavy-metal-associated domain-containing protein( domain architecture ID 10006509)

heavy-metal-associated domain-containing protein may function as a heavy metal transporter and/or detoxification protein; similar to Synechocystis Pcc6803 copper chaperone Atx1, and to Salmonella enterica gold resistance metallochaperone GolB which exhibits selectivity toward the Au(I) cation

Gene Ontology:  GO:0046872
PubMed:  12443926|8905098

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CopZ COG2608
Copper chaperone CopZ [Inorganic ion transport and metabolism];
24-85 1.51e-11

Copper chaperone CopZ [Inorganic ion transport and metabolism];


:

Pssm-ID: 442020 [Multi-domain]  Cd Length: 71  Bit Score: 54.14  E-value: 1.51e-11
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|....*
2N4D_A      24 LSFHVEDMTCGHCAGVIKGAIEKTVPGAAVHADPASRTVVV---GGVSDAAHIAEIITAAGYTPE 85
Cdd:COG2608  4 VTLKVEGMTCGHCVARVEKALKALDGVASVEVDLATGTATVtydPEKVSLEDIKAAIEEAGYEVE 68
 
Name Accession Description Interval E-value
CopZ COG2608
Copper chaperone CopZ [Inorganic ion transport and metabolism];
24-85 1.51e-11

Copper chaperone CopZ [Inorganic ion transport and metabolism];


Pssm-ID: 442020 [Multi-domain]  Cd Length: 71  Bit Score: 54.14  E-value: 1.51e-11
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|....*
2N4D_A      24 LSFHVEDMTCGHCAGVIKGAIEKTVPGAAVHADPASRTVVV---GGVSDAAHIAEIITAAGYTPE 85
Cdd:COG2608  4 VTLKVEGMTCGHCVARVEKALKALDGVASVEVDLATGTATVtydPEKVSLEDIKAAIEEAGYEVE 68
HMA pfam00403
Heavy-metal-associated domain;
26-79 2.80e-08

Heavy-metal-associated domain;


Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 45.69  E-value: 2.80e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
2N4D_A        26 FHVEDMTCGHCAGVIKGAIEKtVPG-AAVHADPASRTVVVGGVSDAAHIAEIITA 79
Cdd:pfam00403  2 FRVSGMHCGGCAAKVEKALSE-LPGvLSVSVDLATKTVTVTGDAESTKLEKLVEA 55
HMA cd00371
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid ...
 28-85 1.71e-05

Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.


Pssm-ID: 238219 [Multi-domain]  Cd Length: 63  Bit Score: 38.74  E-value: 1.71e-05
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|.
2N4D_A      28 VEDMTCGHCAGVIKGAIEKtVPGAA-VHADPASRTVVVGGVS--DAAHIAEIITAAGYTPE 85
Cdd:cd00371  4 VEGMTCAGCVSKIEKALEK-LPGVEsVEVDLETGKATVEYDPevSPEELLEAIEDAGYKAR 63
PRK13748 PRK13748
putative mercuric reductase; Provisional
 26-85 7.58e-04

putative mercuric reductase; Provisional


Pssm-ID: 184298 [Multi-domain]  Cd Length: 561  Bit Score: 36.28  E-value: 7.58e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
2N4D_A        26 FHVEDMTCGHCAGVIKGAIEKtVPG---AAV-HADPASRTVVVGGVSDAAHIAEiITAAGYTPE 85
Cdd:PRK13748   4 LKITGMTCDSCAAHVKDALEK-VPGvqsADVsYPKGSAQLAIEVGTSPDALTAA-VAGLGYRAT 65
chaper_CopZ_Eh NF033794
copper chaperone CopZ; Copper chaperone CopZ, as the name is used in Enterococcus hirae and ...
 26-85 1.69e-03

copper chaperone CopZ; Copper chaperone CopZ, as the name is used in Enterococcus hirae and related species, is a small copper-binding protein with close homology to domains found, sometimes in multiple copies, in various copper-translocating copper-translocating P-type ATPases, and to distinct families of other small copper chaperones that also named CopZ.


Pssm-ID: 411374 [Multi-domain]  Cd Length: 68  Bit Score: 33.46  E-value: 1.69e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
2N4D_A       26 FHVEDMTCGHCAGVIKGAIeKTVPG---AAVHADPASRTVVVG-GVSDAAHIAEIITAAGYTPE 85
Cdd:NF033794  4 FSIKGMSCNHCVARVEKAV-NELPGvkkVKVNLKKENGVVKFDeTQVTAEKIAQAVNELGYQAE 66
 
Name Accession Description Interval E-value
CopZ COG2608
Copper chaperone CopZ [Inorganic ion transport and metabolism];
24-85 1.51e-11

Copper chaperone CopZ [Inorganic ion transport and metabolism];


Pssm-ID: 442020 [Multi-domain]  Cd Length: 71  Bit Score: 54.14  E-value: 1.51e-11
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|....*
2N4D_A      24 LSFHVEDMTCGHCAGVIKGAIEKTVPGAAVHADPASRTVVV---GGVSDAAHIAEIITAAGYTPE 85
Cdd:COG2608  4 VTLKVEGMTCGHCVARVEKALKALDGVASVEVDLATGTATVtydPEKVSLEDIKAAIEEAGYEVE 68
HMA pfam00403
Heavy-metal-associated domain;
26-79 2.80e-08

Heavy-metal-associated domain;


Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 45.69  E-value: 2.80e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
2N4D_A        26 FHVEDMTCGHCAGVIKGAIEKtVPG-AAVHADPASRTVVVGGVSDAAHIAEIITA 79
Cdd:pfam00403  2 FRVSGMHCGGCAAKVEKALSE-LPGvLSVSVDLATKTVTVTGDAESTKLEKLVEA 55
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
24-85 1.38e-06

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 43.98  E-value: 1.38e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
2N4D_A       24 LSFHVEDMTCGHCAGVIKGAIEKtVPG-AAVHADPASRTVVV---GGVSDAAHIAEIITAAGYTPE 85
Cdd:COG2217   3 VRLRIEGMTCAACAWLIEKALRK-LPGvLSARVNLATERARVeydPGKVSLEELIAAVEKAGYEAE 67
HMA cd00371
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid ...
 28-85 1.71e-05

Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.


Pssm-ID: 238219 [Multi-domain]  Cd Length: 63  Bit Score: 38.74  E-value: 1.71e-05
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|.
2N4D_A      28 VEDMTCGHCAGVIKGAIEKtVPGAA-VHADPASRTVVVGGVS--DAAHIAEIITAAGYTPE 85
Cdd:cd00371  4 VEGMTCAGCVSKIEKALEK-LPGVEsVEVDLETGKATVEYDPevSPEELLEAIEDAGYKAR 63
PRK13748 PRK13748
putative mercuric reductase; Provisional
 26-85 7.58e-04

putative mercuric reductase; Provisional


Pssm-ID: 184298 [Multi-domain]  Cd Length: 561  Bit Score: 36.28  E-value: 7.58e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
2N4D_A        26 FHVEDMTCGHCAGVIKGAIEKtVPG---AAV-HADPASRTVVVGGVSDAAHIAEiITAAGYTPE 85
Cdd:PRK13748   4 LKITGMTCDSCAAHVKDALEK-VPGvqsADVsYPKGSAQLAIEVGTSPDALTAA-VAGLGYRAT 65
chaper_CopZ_Eh NF033794
copper chaperone CopZ; Copper chaperone CopZ, as the name is used in Enterococcus hirae and ...
 26-85 1.69e-03

copper chaperone CopZ; Copper chaperone CopZ, as the name is used in Enterococcus hirae and related species, is a small copper-binding protein with close homology to domains found, sometimes in multiple copies, in various copper-translocating copper-translocating P-type ATPases, and to distinct families of other small copper chaperones that also named CopZ.


Pssm-ID: 411374 [Multi-domain]  Cd Length: 68  Bit Score: 33.46  E-value: 1.69e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
2N4D_A       26 FHVEDMTCGHCAGVIKGAIeKTVPG---AAVHADPASRTVVVG-GVSDAAHIAEIITAAGYTPE 85
Cdd:NF033794  4 FSIKGMSCNHCVARVEKAV-NELPGvkkVKVNLKKENGVVKFDeTQVTAEKIAQAVNELGYQAE 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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