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Conserved domains on  [gi|302565875|pdb|2KRA|A]
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Chain A, Prokineticin Bv8

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Prokineticin super family cl05897
Prokineticin; This family consists of several prokineticin proteins and related BM8 sequences. ...
 1-77 5.56e-35

Prokineticin; This family consists of several prokineticin proteins and related BM8 sequences. The suprachiasmatic nucleus (SCN) controls the circadian rhythm of physiological and behavioural processes in mammals. It has been shown that prokineticin 2 (PK2), a cysteine-rich secreted protein, functions as an output molecule from the SCN circadian clock. PK2 messenger RNA is rhythmically expressed in the SCN, and the phase of PK2 rhythm is responsive to light entrainment. Molecular and genetic studies have revealed that PK2 is a gene that is controlled by a circadian clock.


The actual alignment was detected with superfamily member pfam06607:

Pssm-ID: 148298  Cd Length: 97  Bit Score: 114.09  E-value: 5.56e-35
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
2KRA_A         1 AVITGACDKDVQCGSGTCCAASAWSRNIRFCIPLGNSGEDCHPASHKVPYDGKRLSSLCPCKSGLTCSK-SGEKFKCS 77
Cdd:pfam06607 20 AVITGACDKDVQCGGGMCCAVSLWLRGLRMCTPLGNEGDECHPLSHKVPFFGKRQHHTCPCLPNLTCSRfSDSKYRCL 97
 
Name Accession Description Interval E-value
Prokineticin pfam06607
Prokineticin; This family consists of several prokineticin proteins and related BM8 sequences. ...
 1-77 5.56e-35

Prokineticin; This family consists of several prokineticin proteins and related BM8 sequences. The suprachiasmatic nucleus (SCN) controls the circadian rhythm of physiological and behavioural processes in mammals. It has been shown that prokineticin 2 (PK2), a cysteine-rich secreted protein, functions as an output molecule from the SCN circadian clock. PK2 messenger RNA is rhythmically expressed in the SCN, and the phase of PK2 rhythm is responsive to light entrainment. Molecular and genetic studies have revealed that PK2 is a gene that is controlled by a circadian clock.


Pssm-ID: 148298  Cd Length: 97  Bit Score: 114.09  E-value: 5.56e-35
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
2KRA_A         1 AVITGACDKDVQCGSGTCCAASAWSRNIRFCIPLGNSGEDCHPASHKVPYDGKRLSSLCPCKSGLTCSK-SGEKFKCS 77
Cdd:pfam06607 20 AVITGACDKDVQCGGGMCCAVSLWLRGLRMCTPLGNEGDECHPLSHKVPFFGKRQHHTCPCLPNLTCSRfSDSKYRCL 97
 
Name Accession Description Interval E-value
Prokineticin pfam06607
Prokineticin; This family consists of several prokineticin proteins and related BM8 sequences. ...
 1-77 5.56e-35

Prokineticin; This family consists of several prokineticin proteins and related BM8 sequences. The suprachiasmatic nucleus (SCN) controls the circadian rhythm of physiological and behavioural processes in mammals. It has been shown that prokineticin 2 (PK2), a cysteine-rich secreted protein, functions as an output molecule from the SCN circadian clock. PK2 messenger RNA is rhythmically expressed in the SCN, and the phase of PK2 rhythm is responsive to light entrainment. Molecular and genetic studies have revealed that PK2 is a gene that is controlled by a circadian clock.


Pssm-ID: 148298  Cd Length: 97  Bit Score: 114.09  E-value: 5.56e-35
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
2KRA_A         1 AVITGACDKDVQCGSGTCCAASAWSRNIRFCIPLGNSGEDCHPASHKVPYDGKRLSSLCPCKSGLTCSK-SGEKFKCS 77
Cdd:pfam06607 20 AVITGACDKDVQCGGGMCCAVSLWLRGLRMCTPLGNEGDECHPLSHKVPFFGKRQHHTCPCLPNLTCSRfSDSKYRCL 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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