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Conserved domains on  [gi|134104512|pdb|2IFG|B]
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Chain B, High affinity nerve growth factor receptor

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig_TrkABC_d4 cd04972
Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; The members here ...
 160-247 4.64e-63

Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; The members here are composed of the fourth domain of Trk receptors TrkA, TrkB, and TrkC, an immunoglobulin (Ig)-like domain which binds to neurotrophin. The Trk family of receptors are tyrosine kinase receptors. They are activated by dimerization, leading to autophosphorylation of intracellular tyrosine residues, and triggering the signal transduction pathway. TrkA, TrkB, and TrkC share significant sequence homology and domain organization. The first three domains are leucine-rich domains while the fourth and fifth domains are Ig-like domains playing a part in ligand binding. TrkA, TrkB, and TrkC mediate the trophic effects of the neurotrophin Nerve Growth Factor (NGF) family. TrkA is recognized by NGF. TrKB is recognized by brain-derived neurotrophic factor (BDNF) and neurotrophin (NT)-4. TrkC is recognized by NT-3. NT-3 is promiscuous as in some cell systems it activates TrkA and TrkB receptors. TrkA is a receptor found in all major NGF targets, including the sympathetic, trigeminal, and dorsal root ganglia, cholinergic neurons of the basal forebrain, and the striatum. TrKB transcripts are found throughout multiple structures of the central and peripheral nervous systems. The TrkC gene is expressed throughout the mammalian nervous system.


:

Pssm-ID: 409361  Cd Length: 88  Bit Score: 195.27  E-value: 4.64e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IFG_B      160 TLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRA 239
Cdd:cd04972   1 TLKIQMPNASVDVGDDVLLQCQVEGQGLEQAGWILTELEQSATVMKSGSLPSLGLTLANVTSDLNRKNVTCWAENDVGRA 80


                ....*...
2IFG_B      240 EVSVQVNV 247
Cdd:cd04972  81 EVSVQVNV 88
IgI_TrKABC_d5 cd04971
Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set ...
 250-344 6.25e-54

Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the fifth domain of Trk receptors TrkA, TrkB, and TrkC, an immunoglobulin (Ig)-like domain which binds to neurotrophin. The Trk family of receptors are tyrosine kinase receptors. They are activated by dimerization, leading to autophosphorylation of intracellular tyrosine residues, and triggering the signal transduction pathway. TrkA, TrkB, and TrkC share significant sequence homology and domain organization. The first three domains are leucine-rich domains while the fourth and fifth domains are Ig-like domains playing a part in ligand binding. TrkA, TrkB, and TrkC mediate the trophic effects of the neurotrophin Nerve Growth Factor (NGF) family. TrkA is recognized by NGF. TrkB is recognized by brain-derived neurotrophic factor (BDNF) and neurotrophin (NT)-4. TrkC is recognized by NT-3. NT-3 is promiscuous as in some cell systems it activates TrkA and TrkB receptors. TrkA is a receptor found in all major NGF targets, including the sympathetic, trigeminal, and dorsal root ganglia, cholinergic neurons of the basal forebrain, and the striatum. TrKB transcripts are found throughout multiple structures of the central and peripheral nervous systems. The TrkC gene is expressed throughout the mammalian nervous system. This group belongs to the I-set of IgSF domains.


:

Pssm-ID: 409360  Cd Length: 96  Bit Score: 172.20  E-value: 6.25e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IFG_B      250 PASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAA 329
Cdd:cd04971   2 PVIVRLEEPELRHHWCIPFTVRGNPKPTLTWYHNGAVLNESDYIRTEIHYEAATPTEYHGCLKFDNPTHVNNGNYTLVAS 81

                        90
                ....*....|....*
2IFG_B      330 NPFGQASASIMAAFM 344
Cdd:cd04971  82 NEYGQDSKSISAHFM 96
LRRCT_2 pfam16920
Leucine rich repeat C-terminal motif; This entry represents the Leucine Rich Repeat C-terminal ...
 116-157 3.50e-13

Leucine rich repeat C-terminal motif; This entry represents the Leucine Rich Repeat C-terminal (LRRCT) capping motif from TRK receptors.


:

Pssm-ID: 465313  Cd Length: 45  Bit Score: 63.05  E-value: 3.50e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
2IFG_B        116 HCSCALRWLQRWEEEGLGGVPEQKLQCHGQG---PLAHMPNASCG 157
Cdd:pfam16920   1 RCSCDIRWLQLWQEEGLAGLGTQQLYCLNDGskiPLQSMNIPNCG 45
LRR_8 pfam13855
Leucine rich repeat;
57-115 2.67e-09

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 2.67e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
2IFG_B         57 ELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGL-SLQELVLSGNPL 115
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLpSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
Ig_TrkABC_d4 cd04972
Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; The members here ...
 160-247 4.64e-63

Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; The members here are composed of the fourth domain of Trk receptors TrkA, TrkB, and TrkC, an immunoglobulin (Ig)-like domain which binds to neurotrophin. The Trk family of receptors are tyrosine kinase receptors. They are activated by dimerization, leading to autophosphorylation of intracellular tyrosine residues, and triggering the signal transduction pathway. TrkA, TrkB, and TrkC share significant sequence homology and domain organization. The first three domains are leucine-rich domains while the fourth and fifth domains are Ig-like domains playing a part in ligand binding. TrkA, TrkB, and TrkC mediate the trophic effects of the neurotrophin Nerve Growth Factor (NGF) family. TrkA is recognized by NGF. TrKB is recognized by brain-derived neurotrophic factor (BDNF) and neurotrophin (NT)-4. TrkC is recognized by NT-3. NT-3 is promiscuous as in some cell systems it activates TrkA and TrkB receptors. TrkA is a receptor found in all major NGF targets, including the sympathetic, trigeminal, and dorsal root ganglia, cholinergic neurons of the basal forebrain, and the striatum. TrKB transcripts are found throughout multiple structures of the central and peripheral nervous systems. The TrkC gene is expressed throughout the mammalian nervous system.


Pssm-ID: 409361  Cd Length: 88  Bit Score: 195.27  E-value: 4.64e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IFG_B      160 TLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRA 239
Cdd:cd04972   1 TLKIQMPNASVDVGDDVLLQCQVEGQGLEQAGWILTELEQSATVMKSGSLPSLGLTLANVTSDLNRKNVTCWAENDVGRA 80


                ....*...
2IFG_B      240 EVSVQVNV 247
Cdd:cd04972  81 EVSVQVNV 88
IgI_TrKABC_d5 cd04971
Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set ...
 250-344 6.25e-54

Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the fifth domain of Trk receptors TrkA, TrkB, and TrkC, an immunoglobulin (Ig)-like domain which binds to neurotrophin. The Trk family of receptors are tyrosine kinase receptors. They are activated by dimerization, leading to autophosphorylation of intracellular tyrosine residues, and triggering the signal transduction pathway. TrkA, TrkB, and TrkC share significant sequence homology and domain organization. The first three domains are leucine-rich domains while the fourth and fifth domains are Ig-like domains playing a part in ligand binding. TrkA, TrkB, and TrkC mediate the trophic effects of the neurotrophin Nerve Growth Factor (NGF) family. TrkA is recognized by NGF. TrkB is recognized by brain-derived neurotrophic factor (BDNF) and neurotrophin (NT)-4. TrkC is recognized by NT-3. NT-3 is promiscuous as in some cell systems it activates TrkA and TrkB receptors. TrkA is a receptor found in all major NGF targets, including the sympathetic, trigeminal, and dorsal root ganglia, cholinergic neurons of the basal forebrain, and the striatum. TrKB transcripts are found throughout multiple structures of the central and peripheral nervous systems. The TrkC gene is expressed throughout the mammalian nervous system. This group belongs to the I-set of IgSF domains.


Pssm-ID: 409360  Cd Length: 96  Bit Score: 172.20  E-value: 6.25e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IFG_B      250 PASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAA 329
Cdd:cd04971   2 PVIVRLEEPELRHHWCIPFTVRGNPKPTLTWYHNGAVLNESDYIRTEIHYEAATPTEYHGCLKFDNPTHVNNGNYTLVAS 81

                        90
                ....*....|....*
2IFG_B      330 NPFGQASASIMAAFM 344
Cdd:cd04971  82 NEYGQDSKSISAHFM 96
LRRCT_2 pfam16920
Leucine rich repeat C-terminal motif; This entry represents the Leucine Rich Repeat C-terminal ...
 116-157 3.50e-13

Leucine rich repeat C-terminal motif; This entry represents the Leucine Rich Repeat C-terminal (LRRCT) capping motif from TRK receptors.


Pssm-ID: 465313  Cd Length: 45  Bit Score: 63.05  E-value: 3.50e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
2IFG_B        116 HCSCALRWLQRWEEEGLGGVPEQKLQCHGQG---PLAHMPNASCG 157
Cdd:pfam16920   1 RCSCDIRWLQLWQEEGLAGLGTQQLYCLNDGskiPLQSMNIPNCG 45
LRR_8 pfam13855
Leucine rich repeat;
57-115 2.67e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 2.67e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
2IFG_B         57 ELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGL-SLQELVLSGNPL 115
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLpSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 86-152 4.11e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 48.93  E-value: 4.11e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
2IFG_B          86 NLSFNALESLSWKTVQGL-SLQELVLSGNPLHCSCALRWLQRW-EEEGLGGVPEQKLQCHGQGPLAHMP 152
Cdd:TIGR00864    1 DISNNKISTIEEGICANLcNLSEIDLSGNPFECDCGLARLPRWaEEKGVKVRQPEAALCAGPGALAGQP 69
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 27-115 1.31e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 1.31e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IFG_B       27 LPGAENLTELYIENQQhLQ-----HLELRDLRGLGE-LRNLTIVKSGLRFVAPdaFHFTPRLSRLNLSFNALESLswKTV 100
Cdd:cd21340  86 LENLTNLEELHIENQR-LPpgeklTFDPRSLAALSNsLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDL--EEL 160

                        90       100
                ....*....|....*....|
2IFG_B      101 QGL-----SLQELVLSGNPL 115
Cdd:cd21340 161 LDLlsswpSLRELDLTGNPV 180
LRRCT smart00082
Leucine rich repeat C-terminal domain;
113-155 1.52e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 41.65  E-value: 1.52e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
2IFG_B         113 NPLHCSCALRWLQRWEEEGLGGVPEQKLQCHG----QGPLAHMPNAS 155
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASpsslRGPLLELLHSE 47
I-set pfam07679
Immunoglobulin I-set domain;
163-247 5.56e-05

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 41.47  E-value: 5.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IFG_B        163 VQVP-NASVDVGDDVLLRCQVEGRGLEQAGWIL--TELEQSATVM--KSGGLPSlgLTLANVTSDlNRKNVTCWAENDVG 237
Cdd:pfam07679   4 TQKPkDVEVQEGESARFTCTVTGTPDPEVSWFKdgQPLRSSDRFKvtYEGGTYT--LTISNVQPD-DSGKYTCVATNSAG 80

                          90
                  ....*....|
2IFG_B        238 RAEVSVQVNV 247
Cdd:pfam07679  81 EAEASAELTV 90
I-set pfam07679
Immunoglobulin I-set domain;
270-339 1.23e-04

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 40.32  E-value: 1.23e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IFG_B        270 VDGQPAPSLRWLFNGSVLNETSFIftEFLEPAANETvrhgcLRLNQPTHVNNGNYTLLAANPFGQASASI 339
Cdd:pfam07679  24 VTGTPDPEVSWFKDGQPLRSSDRF--KVTYEGGTYT-----LTISNVQPDDSGKYTCVATNSAGEAEASA 86
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 166-247 2.58e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.41  E-value: 2.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IFG_B         166 PNASVDVGDDVLLRCQVEGRGLEQAGWI---LTELEQSATVMKSGGLPSLGLTLANVTSDlNRKNVTCWAENDVGRAEVS 242
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPPEVTWYkqgGKLLAESGRFSVSRSGSTSTLTISNVTPE-DSGTYTCAATNSSGSASSG 80


                   ....*
2IFG_B         243 VQVNV 247
Cdd:smart00410  81 TTLTV 85
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
27-115 7.02e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.07  E-value: 7.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IFG_B       27 LPGAENLTELYIENQQ------------HLQHLELRD---------LRGLGELRNLTIVKSGLRFVaPDAFHFTPRLSRL 85
Cdd:COG4886 155 LGNLTNLKSLDLSNNQltdlpeelgnltNLKELDLSNnqitdlpepLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETL 233

                        90       100       110
                ....*....|....*....|....*....|.
2IFG_B       86 NLSFNALESLSWktVQGLS-LQELVLSGNPL 115
Cdd:COG4886 234 DLSNNQLTDLPE--LGNLTnLEELDLSNNQL 262
 
Name Accession Description Interval E-value
Ig_TrkABC_d4 cd04972
Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; The members here ...
 160-247 4.64e-63

Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; The members here are composed of the fourth domain of Trk receptors TrkA, TrkB, and TrkC, an immunoglobulin (Ig)-like domain which binds to neurotrophin. The Trk family of receptors are tyrosine kinase receptors. They are activated by dimerization, leading to autophosphorylation of intracellular tyrosine residues, and triggering the signal transduction pathway. TrkA, TrkB, and TrkC share significant sequence homology and domain organization. The first three domains are leucine-rich domains while the fourth and fifth domains are Ig-like domains playing a part in ligand binding. TrkA, TrkB, and TrkC mediate the trophic effects of the neurotrophin Nerve Growth Factor (NGF) family. TrkA is recognized by NGF. TrKB is recognized by brain-derived neurotrophic factor (BDNF) and neurotrophin (NT)-4. TrkC is recognized by NT-3. NT-3 is promiscuous as in some cell systems it activates TrkA and TrkB receptors. TrkA is a receptor found in all major NGF targets, including the sympathetic, trigeminal, and dorsal root ganglia, cholinergic neurons of the basal forebrain, and the striatum. TrKB transcripts are found throughout multiple structures of the central and peripheral nervous systems. The TrkC gene is expressed throughout the mammalian nervous system.


Pssm-ID: 409361  Cd Length: 88  Bit Score: 195.27  E-value: 4.64e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IFG_B      160 TLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRA 239
Cdd:cd04972   1 TLKIQMPNASVDVGDDVLLQCQVEGQGLEQAGWILTELEQSATVMKSGSLPSLGLTLANVTSDLNRKNVTCWAENDVGRA 80


                ....*...
2IFG_B      240 EVSVQVNV 247
Cdd:cd04972  81 EVSVQVNV 88
IgI_TrKABC_d5 cd04971
Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set ...
 250-344 6.25e-54

Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the fifth domain of Trk receptors TrkA, TrkB, and TrkC, an immunoglobulin (Ig)-like domain which binds to neurotrophin. The Trk family of receptors are tyrosine kinase receptors. They are activated by dimerization, leading to autophosphorylation of intracellular tyrosine residues, and triggering the signal transduction pathway. TrkA, TrkB, and TrkC share significant sequence homology and domain organization. The first three domains are leucine-rich domains while the fourth and fifth domains are Ig-like domains playing a part in ligand binding. TrkA, TrkB, and TrkC mediate the trophic effects of the neurotrophin Nerve Growth Factor (NGF) family. TrkA is recognized by NGF. TrkB is recognized by brain-derived neurotrophic factor (BDNF) and neurotrophin (NT)-4. TrkC is recognized by NT-3. NT-3 is promiscuous as in some cell systems it activates TrkA and TrkB receptors. TrkA is a receptor found in all major NGF targets, including the sympathetic, trigeminal, and dorsal root ganglia, cholinergic neurons of the basal forebrain, and the striatum. TrKB transcripts are found throughout multiple structures of the central and peripheral nervous systems. The TrkC gene is expressed throughout the mammalian nervous system. This group belongs to the I-set of IgSF domains.


Pssm-ID: 409360  Cd Length: 96  Bit Score: 172.20  E-value: 6.25e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IFG_B      250 PASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAA 329
Cdd:cd04971   2 PVIVRLEEPELRHHWCIPFTVRGNPKPTLTWYHNGAVLNESDYIRTEIHYEAATPTEYHGCLKFDNPTHVNNGNYTLVAS 81

                        90
                ....*....|....*
2IFG_B      330 NPFGQASASIMAAFM 344
Cdd:cd04971  82 NEYGQDSKSISAHFM 96
IgI_TrkB_d5 cd05855
Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig ...
 262-344 5.27e-31

Fifth domain (immunoglobulin-like) of Trk receptor TrkB; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the fifth domain of Trk receptor, TrkB, an immunoglobulin (Ig)-like domain which binds to neurotrophin. The Trk family of receptors are tyrosine kinase receptors, which mediate the trophic effects of the neurotrophin Nerve Growth Factor (NGF) family. Trks are activated by dimerization, leading to autophosphorylation of intracellular tyrosine residues, and triggering the signal transduction pathway. TrkB shares significant sequence homology and domain organization with TrkA and TrkC. The first three domains are leucine-rich domains while the fourth and fifth domains are Ig-like domains playing a part in ligand binding. TrKB is recognized by brain-derived neurotrophic factor (BDNF) and neurotrophin (NT)-4. In some cell systems NT-3 can activate TrkA and TrkB receptors. TrKB transcripts are found throughout multiple structures of the central and peripheral nervous systems. This group belongs to the I-set of IgSF domains


Pssm-ID: 409441  Cd Length: 94  Bit Score: 112.64  E-value: 5.27e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IFG_B      262 HHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEpaANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMA 341
Cdd:cd05855  14 HHWCIPFTVKGNPKPTLQWFHEGAILNESEYICTKIHV--INNTEYHGCLQLDNPTHLNNGIYTLVAKNEYGEDEKNVSA 91


                ...
2IFG_B      342 AFM 344
Cdd:cd05855  92 HFM 94
LRRCT_2 pfam16920
Leucine rich repeat C-terminal motif; This entry represents the Leucine Rich Repeat C-terminal ...
 116-157 3.50e-13

Leucine rich repeat C-terminal motif; This entry represents the Leucine Rich Repeat C-terminal (LRRCT) capping motif from TRK receptors.


Pssm-ID: 465313  Cd Length: 45  Bit Score: 63.05  E-value: 3.50e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
2IFG_B        116 HCSCALRWLQRWEEEGLGGVPEQKLQCHGQG---PLAHMPNASCG 157
Cdd:pfam16920   1 RCSCDIRWLQLWQEEGLAGLGTQQLYCLNDGskiPLQSMNIPNCG 45
LRR_8 pfam13855
Leucine rich repeat;
57-115 2.67e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 2.67e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
2IFG_B         57 ELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGL-SLQELVLSGNPL 115
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLpSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 86-152 4.11e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 48.93  E-value: 4.11e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
2IFG_B          86 NLSFNALESLSWKTVQGL-SLQELVLSGNPLHCSCALRWLQRW-EEEGLGGVPEQKLQCHGQGPLAHMP 152
Cdd:TIGR00864    1 DISNNKISTIEEGICANLcNLSEIDLSGNPFECDCGLARLPRWaEEKGVKVRQPEAALCAGPGALAGQP 69
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 27-115 1.31e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 1.31e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IFG_B       27 LPGAENLTELYIENQQhLQ-----HLELRDLRGLGE-LRNLTIVKSGLRFVAPdaFHFTPRLSRLNLSFNALESLswKTV 100
Cdd:cd21340  86 LENLTNLEELHIENQR-LPpgeklTFDPRSLAALSNsLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDL--EEL 160

                        90       100
                ....*....|....*....|
2IFG_B      101 QGL-----SLQELVLSGNPL 115
Cdd:cd21340 161 LDLlsswpSLRELDLTGNPV 180
LRRCT smart00082
Leucine rich repeat C-terminal domain;
113-155 1.52e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 41.65  E-value: 1.52e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
2IFG_B         113 NPLHCSCALRWLQRWEEEGLGGVPEQKLQCHG----QGPLAHMPNAS 155
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASpsslRGPLLELLHSE 47
I-set pfam07679
Immunoglobulin I-set domain;
163-247 5.56e-05

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 41.47  E-value: 5.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IFG_B        163 VQVP-NASVDVGDDVLLRCQVEGRGLEQAGWIL--TELEQSATVM--KSGGLPSlgLTLANVTSDlNRKNVTCWAENDVG 237
Cdd:pfam07679   4 TQKPkDVEVQEGESARFTCTVTGTPDPEVSWFKdgQPLRSSDRFKvtYEGGTYT--LTISNVQPD-DSGKYTCVATNSAG 80

                          90
                  ....*....|
2IFG_B        238 RAEVSVQVNV 247
Cdd:pfam07679  81 EAEASAELTV 90
I-set pfam07679
Immunoglobulin I-set domain;
270-339 1.23e-04

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 40.32  E-value: 1.23e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IFG_B        270 VDGQPAPSLRWLFNGSVLNETSFIftEFLEPAANETvrhgcLRLNQPTHVNNGNYTLLAANPFGQASASI 339
Cdd:pfam07679  24 VTGTPDPEVSWFKDGQPLRSSDRF--KVTYEGGTYT-----LTISNVQPDDSGKYTCVATNSAGEAEASA 86
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 266-339 1.43e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 39.62  E-value: 1.43e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
2IFG_B      266 IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPaanetvrHGCLRLNQPTHVNNGNYTLLAANPF-GQASASI 339
Cdd:cd00096   3 LTCSASGNPPPTITWYKNGKPLPPSSRDSRRSELG-------NGTLTISNVTLEDSGTYTCVASNSAgGSASASV 70
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 166-247 2.58e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.41  E-value: 2.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IFG_B         166 PNASVDVGDDVLLRCQVEGRGLEQAGWI---LTELEQSATVMKSGGLPSLGLTLANVTSDlNRKNVTCWAENDVGRAEVS 242
Cdd:smart00410   2 PSVTVKEGESVTLSCEASGSPPPEVTWYkqgGKLLAESGRFSVSRSGSTSTLTISNVTPE-DSGTYTCAATNSSGSASSG 80


                   ....*
2IFG_B         243 VQVNV 247
Cdd:smart00410  81 TTLTV 85
IgI_4_hemolin-like cd20978
Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set ...
 266-333 3.60e-04

Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin (Ig)-like domain of hemolin and similar proteins. Hemolin, an insect immunoglobulin superfamily (IgSF) member containing four Ig-like domains, is a lipopolysaccharide-binding immune protein induced during bacterial infection. Hemolin shares significant sequence similarity with the first four Ig-like domains of the transmembrane cell adhesion molecules (CAMs) of the L1 family. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The fourth Ig-like domain of hemolin is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409570 [Multi-domain]  Cd Length: 88  Bit Score: 38.91  E-value: 3.60e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
2IFG_B      266 IPFSVDGQPAPSLRWLFNGSVLNETSFIFteflepaaneTVRHGCLRLNQPTHVNNGNYTLLAANPFG 333
Cdd:cd20978  21 LPCQVTGVPQPKITWLHNGKPLQGPMERA----------TVEDGTLTIINVQPEDTGYYGCVATNEIG 78
IgI_4_MYLK-like cd20976
Fourth Ig-like domain from smooth muscle myosin light chain kinase and similar domains ; a ...
 257-338 6.74e-04

Fourth Ig-like domain from smooth muscle myosin light chain kinase and similar domains ; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin (Ig)-like domain from smooth muscle myosin light chain kinase (MYLK) and similar domains. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of this group shows that the fourth Ig-like domain from myosin light chain kinase lacks this strand and thus belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409568 [Multi-domain]  Cd Length: 90  Bit Score: 38.39  E-value: 6.74e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IFG_B      257 TAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTefLEPAANEtvrhgcLRLNQPTHVNNGNYTLLAANPFGQAS 336
Cdd:cd20976  12 EAVEGQDFVAQCSARGKPVPRITWIRNAQPLQYAADRST--CEAGVGE------LHIQDVLPEDHGTYTCLAKNAAGQVS 83


                ..
2IFG_B      337 AS 338
Cdd:cd20976  84 CS 85
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
27-115 7.02e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.07  E-value: 7.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IFG_B       27 LPGAENLTELYIENQQ------------HLQHLELRD---------LRGLGELRNLTIVKSGLRFVaPDAFHFTPRLSRL 85
Cdd:COG4886 155 LGNLTNLKSLDLSNNQltdlpeelgnltNLKELDLSNnqitdlpepLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETL 233

                        90       100       110
                ....*....|....*....|....*....|.
2IFG_B       86 NLSFNALESLSWktVQGLS-LQELVLSGNPL 115
Cdd:COG4886 234 DLSNNQLTDLPE--LGNLTnLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
21-115 7.27e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.07  E-value: 7.27e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IFG_B       21 LDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVK-SGLRFVA-PDAFHFTPRLSRLNLSFNALESLSwK 98
Cdd:COG4886  75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDlSGNQLTDlPEELANLTNLKELDLSNNQLTDLP-E 153

                        90
                ....*....|....*...
2IFG_B       99 TVQGLS-LQELVLSGNPL 115
Cdd:COG4886 154 PLGNLTnLKSLDLSNNQL 171
IgI_telokin-like cd20973
immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF ...
 270-338 1.01e-03

immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF domains; The members here are composed of the immunoglobulin (Ig) domain in telokin, the C-terminal domain of myosin light chain kinase which is identical to telokin, and similar proteins. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the telokin Ig domain lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409565 [Multi-domain]  Cd Length: 88  Bit Score: 37.94  E-value: 1.01e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IFG_B      270 VDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAAnetvrhgC-LRLNQPTHVNNGNYTLLAANPFGQASAS 338
Cdd:cd20973  21 VEGYPDPEVKWMKDDNPIVESRRFQIDQDEDGL-------CsLIISDVCGDDSGKYTCKAVNSLGEATCS 83
IgI_4_MYLK-like cd20976
Fourth Ig-like domain from smooth muscle myosin light chain kinase and similar domains ; a ...
 159-247 1.62e-03

Fourth Ig-like domain from smooth muscle myosin light chain kinase and similar domains ; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin (Ig)-like domain from smooth muscle myosin light chain kinase (MYLK) and similar domains. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of this group shows that the fourth Ig-like domain from myosin light chain kinase lacks this strand and thus belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409568 [Multi-domain]  Cd Length: 90  Bit Score: 37.23  E-value: 1.62e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2IFG_B      159 PTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLG-LTLANVTSDlNRKNVTCWAENDVG 237
Cdd:cd20976   2 PSFSSVPKDLEAVEGQDFVAQCSARGKPVPRITWIRNAQPLQYAADRSTCEAGVGeLHIQDVLPE-DHGTYTCLAKNAAG 80

                        90
                ....*....|
2IFG_B      238 RAEVSVQVNV 247
Cdd:cd20976  81 QVSCSAWVTV 90
LRR_8 pfam13855
Leucine rich repeat;
32-92 8.91e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.42  E-value: 8.91e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
2IFG_B         32 NLTELYIENQqHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNAL 92
Cdd:pfam13855   2 NLRSLDLSNN-RLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 269-330 9.42e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 34.85  E-value: 9.42e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
2IFG_B        269 SVDGQPAPSLRWLFNGSVLNETSFIFTEFLEpaanetvRHGCLRLNQPTHVNNGNYTLLAAN 330
Cdd:pfam13927  24 EATGSPPPTITWYKNGEPISSGSTRSRSLSG-------SNSTLTISNVTRSDAGTYTCVASN 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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