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Conserved domains on  [gi|73536318|pdb|2BWJ|A]
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Chain A, ADENYLATE KINASE 5

Protein Classification

nucleoside monophosphate kinase( domain architecture ID 11492279)

nucleoside monophosphate kinase catalyzes the transfer of the terminal phosphoryl group from a nucleoside triphosphate, usually ATP, to a nucleoside monophosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 10-197 1.16e-128

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


:

Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 359.51  E-value: 1.16e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A         10 RKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLG 89
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A         90 DTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQMSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYE 169
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
2BWJ_A        170 TKTQLHKINAEGTPEDVFLQLCTAIDSI 197
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
 
Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 10-197 1.16e-128

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 359.51  E-value: 1.16e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A         10 RKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLG 89
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A         90 DTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQMSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYE 169
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
2BWJ_A        170 TKTQLHKINAEGTPEDVFLQLCTAIDSI 197
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 14-186 5.78e-64

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 195.92  E-value: 5.78e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A       14 IIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMvASLGDTRG 93
Cdd:cd01428   1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERL-KKPDCKKG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A       94 FLIDGYPREVKQGEEFGRRI---GDPQLVICMDCSADTMTNRLLQ-------------------MSRSSLPVDDTTKTIA 151
Cdd:cd01428  80 FILDGFPRTVDQAEALDELLdegIKPDKVIELDVPDEVLIERILGrricpvsgrvyhlgkddvtGEPLSQRSDDNEETIK 159

                       170       180       190
                ....*....|....*....|....*....|....*
2BWJ_A      152 KRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDV 186
Cdd:cd01428 160 KRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
PLN02200 PLN02200
adenylate kinase family protein
 14-190 6.90e-52

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 166.61  E-value: 6.90e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        14 IIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASlgDTRG 93
Cdd:PLN02200  45 ITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEMESS--DNNK 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        94 FLIDGYPREVKQGEEFGRRIG-DPQLVICMDCSADTMTNRLLqmSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYETKT 172
Cdd:PLN02200 123 FLIDGFPRTEENRIAFERIIGaEPNVVLFFDCPEEEMVKRVL--NRNQGRVDDNIDTIKKRLKVFNALNLPVIDYYSKKG 200

                        170
                 ....*....|....*...
2BWJ_A       173 QLHKINAEGTPEDVFLQL 190
Cdd:PLN02200 201 KLYTINAVGTVDEIFEQV 218
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 13-194 3.17e-51

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 164.14  E-value: 3.17e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A       13 KIIFIiGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMvASLGDTR 92
Cdd:COG0563   2 RIILL-GPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERL-AQPDCAN 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A       93 GFLIDGYPREVKQGE-------EFGRRIgdpQLVICMDCSADTMTNRLlqMSRSSLPV---------------------- 143
Cdd:COG0563  80 GFILDGFPRTVAQAEaldellaELGIKL---DAVIELDVDDEELVERL--SGRRVCPNcgatyhvkfnppkvegvcdkcg 154

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
2BWJ_A      144 -------DDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDVFLQLCTAI 194
Cdd:COG0563 155 gelvqraDDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
ADK pfam00406
Adenylate kinase;
17-171 6.20e-51

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 162.48  E-value: 6.20e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A         17 IIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVAsLGDTRGFLI 96
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQ-NDCKNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A         97 DGYPREVKQGEEFGR---RIGDPQLVICMDCSADTMTNRLL------QMSRSSLPV---------------------DDT 146
Cdd:pfam00406  80 DGFPRTVPQAEALEElleRGIKLDYVIEFDVPDEVLVERLTgrrihpNSGRSYHLEfnppkvpgkddvtgeplvqrsDDN 159

                         170       180
                  ....*....|....*....|....*
2BWJ_A        147 TKTIAKRLEAYYRASIPVIAYYETK 171
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYYKKK 184
 
Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 10-197 1.16e-128

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 359.51  E-value: 1.16e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A         10 RKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLG 89
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A         90 DTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQMSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYE 169
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
2BWJ_A        170 TKTQLHKINAEGTPEDVFLQLCTAIDSI 197
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 14-186 5.78e-64

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 195.92  E-value: 5.78e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A       14 IIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMvASLGDTRG 93
Cdd:cd01428   1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERL-KKPDCKKG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A       94 FLIDGYPREVKQGEEFGRRI---GDPQLVICMDCSADTMTNRLLQ-------------------MSRSSLPVDDTTKTIA 151
Cdd:cd01428  80 FILDGFPRTVDQAEALDELLdegIKPDKVIELDVPDEVLIERILGrricpvsgrvyhlgkddvtGEPLSQRSDDNEETIK 159

                       170       180       190
                ....*....|....*....|....*....|....*
2BWJ_A      152 KRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDV 186
Cdd:cd01428 160 KRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 14-187 1.99e-61

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 189.12  E-value: 1.99e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A         14 IIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASE-SERSKLIRDIMERGDLVPSGIVLELLKEAMVASlGDTR 92
Cdd:TIGR01359   1 VVFVLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKREgSENGSLIESYIKEGKIVPSEVTVELLKKAIQED-GSSK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A         93 GFLIDGYPREVKQGEEFGRRIG---DPQLVICMDCSADTMTNRLLQMSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYE 169
Cdd:TIGR01359  80 KFLIDGFPRNEENLEAWEKLMDnkvNFKFVLFFDCPEETMIKRLLKRGQTSGRVDDNIETLKKRFRTYNEETLPIIEHFE 159

                         170
                  ....*....|....*...
2BWJ_A        170 TKTQLHKINAEGTPEDVF 187
Cdd:TIGR01359 160 NKGKVKEINAEGSVEEVF 177
PLN02200 PLN02200
adenylate kinase family protein
 14-190 6.90e-52

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 166.61  E-value: 6.90e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        14 IIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASlgDTRG 93
Cdd:PLN02200  45 ITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEMESS--DNNK 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        94 FLIDGYPREVKQGEEFGRRIG-DPQLVICMDCSADTMTNRLLqmSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYETKT 172
Cdd:PLN02200 123 FLIDGFPRTEENRIAFERIIGaEPNVVLFFDCPEEEMVKRVL--NRNQGRVDDNIDTIKKRLKVFNALNLPVIDYYSKKG 200

                        170
                 ....*....|....*...
2BWJ_A       173 QLHKINAEGTPEDVFLQL 190
Cdd:PLN02200 201 KLYTINAVGTVDEIFEQV 218
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 13-194 3.17e-51

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 164.14  E-value: 3.17e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A       13 KIIFIiGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMvASLGDTR 92
Cdd:COG0563   2 RIILL-GPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERL-AQPDCAN 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A       93 GFLIDGYPREVKQGE-------EFGRRIgdpQLVICMDCSADTMTNRLlqMSRSSLPV---------------------- 143
Cdd:COG0563  80 GFILDGFPRTVAQAEaldellaELGIKL---DAVIELDVDDEELVERL--SGRRVCPNcgatyhvkfnppkvegvcdkcg 154

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
2BWJ_A      144 -------DDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDVFLQLCTAI 194
Cdd:COG0563 155 gelvqraDDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
ADK pfam00406
Adenylate kinase;
17-171 6.20e-51

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 162.48  E-value: 6.20e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A         17 IIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVAsLGDTRGFLI 96
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQ-NDCKNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A         97 DGYPREVKQGEEFGR---RIGDPQLVICMDCSADTMTNRLL------QMSRSSLPV---------------------DDT 146
Cdd:pfam00406  80 DGFPRTVPQAEALEElleRGIKLDYVIEFDVPDEVLVERLTgrrihpNSGRSYHLEfnppkvpgkddvtgeplvqrsDDN 159

                         170       180
                  ....*....|....*....|....*
2BWJ_A        147 TKTIAKRLEAYYRASIPVIAYYETK 171
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYYKKK 184
adk PRK00279
adenylate kinase; Reviewed
 15-197 1.61e-47

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 154.54  E-value: 1.61e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        15 IFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMvASLGDTRGF 94
Cdd:PRK00279   3 LILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERL-AQPDCKNGF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        95 LIDGYPREVKQGEEFGRRIGDPQL----VICMDCSADTMTNRLLqmSRSSLPV--------------------------- 143
Cdd:PRK00279  82 LLDGFPRTIPQAEALDEMLKELGIkldaVIEIDVPDEELVERLS--GRRICPAcgrtyhvkfnppkvegkcdvcgeeliq 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
2BWJ_A       144 --DDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDVFLQLCTAIDSI 197
Cdd:PRK00279 160 raDDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKALGKL 215
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 13-195 1.88e-45

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 149.31  E-value: 1.88e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A         13 KIIFIiGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTR 92
Cdd:TIGR01351   1 RLVLL-GPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNEN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A         93 GFLIDGYPREVKQGEEF--------------------------GRRI------------GDPQLVICMDCSADTMTNRll 134
Cdd:TIGR01351  80 GFILDGFPRTLSQAEALdalleepidavieldvpdeelverlsGRRIcpscgrvyhlkfNPPKVPGCDDCTGELLVQR-- 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
2BWJ_A        135 qmsrsslpVDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDVFLQLCTAID 195
Cdd:TIGR01351 158 --------EDDTEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNGPIDEVWKRILEALK 210
PRK14527 PRK14527
adenylate kinase; Provisional
 11-187 1.28e-35

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 123.75  E-value: 1.28e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        11 KCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAmVASLGD 90
Cdd:PRK14527   5 KNKVVIFLGPPGAGKGTQAERLAQELGLKKLSTGDILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDE-LAGMEP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        91 TRgFLIDGYPREVKQGEEFGRRIGDPQL----VICMDCSADTMTNRLLQMSRSSLPVDDTTKTIAKRLEAYYRASIPVIA 166
Cdd:PRK14527  84 VR-VIFDGFPRTLAQAEALDRLLEELGArllaVVLLEVPDEELIRRIVERARQEGRSDDNEETVRRRQQVYREQTQPLVD 162

                        170       180
                 ....*....|....*....|.
2BWJ_A       167 YYETKTQLHKINAEGTPEDVF 187
Cdd:PRK14527 163 YYEARGHLKRVDGLGTPDEVY 183
PRK14531 PRK14531
adenylate kinase; Provisional
 11-195 3.76e-34

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 119.53  E-value: 3.76e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        11 KCKIIFIiGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGD 90
Cdd:PRK14531   2 KQRLLFL-GPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQLKALNSG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        91 trGFLIDGYPREVKQGEEFGRRIGD---P-QLVICMDCSADTMTNRLLQMSRSslpvDDTTKTIAKRLEAYYRASIPVIA 166
Cdd:PRK14531  81 --GWLLDGFPRTVAQAEALEPLLEElkqPiEAVVLLELDDAVLIERLLARGRA----DDNEAVIRNRLEVYREKTAPLID 154

                        170       180
                 ....*....|....*....|....*....
2BWJ_A       167 YYETKTQLHKINAEGTPEDVFLQLCTAID 195
Cdd:PRK14531 155 HYRQRGLLQSVEAQGSIEAITERIEKVLA 183
adk PRK02496
adenylate kinase; Provisional
 13-194 3.84e-33

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 117.16  E-value: 3.84e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        13 KIIFIiGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASlgDTR 92
Cdd:PRK02496   3 RLIFL-GPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQP--DAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        93 -GFLIDGYPREVKQG---EEFGRRIGDP-QLVICMDCSADTMTNRLLQMSRSslpvDDTTKTIAKRLEAYYRASIPVIAY 167
Cdd:PRK02496  80 nGWILDGFPRKVTQAaflDELLQEIGQSgERVVNLDVPDDVVVERLLARGRK----DDTEEVIRRRLEVYREQTAPLIDY 155

                        170       180
                 ....*....|....*....|....*..
2BWJ_A       168 YETKTQLHKINAEGTPEDVFLQLCTAI 194
Cdd:PRK02496 156 YRDRQKLLTIDGNQSVEAVTTELKAAL 182
PRK14532 PRK14532
adenylate kinase; Provisional
 15-196 1.05e-32

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 116.07  E-value: 1.05e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        15 IFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGdTRGF 94
Cdd:PRK14532   3 LILFGPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEERLPEAEA-AGGA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        95 LIDGYPREVKQGEEF-------GRRIgdpQLVICMDCSADTMTNRLLQMSRSSLPVDDTTKTIAKRLEAYYRASIPVIAY 167
Cdd:PRK14532  82 IFDGFPRTVAQAEALdkmlasrGQKI---DVVIRLKVDDEALIERIVKRFEEQGRPDDNPEVFVTRLDAYNAQTAPLLPY 158

                        170       180
                 ....*....|....*....|....*....
2BWJ_A       168 YETKTQLHKINAEGTPEDVflqlCTAIDS 196
Cdd:PRK14532 159 YAGQGKLTEVDGMGSIEAV----AASIDA 183
PRK14530 PRK14530
adenylate kinase; Provisional
 15-196 4.01e-32

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 115.27  E-value: 4.01e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        15 IFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLReelaseSERSKLIRDI----------MERGDLVPSGIVLELLKEAm 84
Cdd:PRK14530   6 ILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALR------ANKQMDISDMdteydtpgeyMDAGELVPDAVVNEIVEEA- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        85 vasLGDTRGFLIDGYPREVKQGEEFGR----------RIGDPQLV-------ICMDCSA---------------DTMTNR 132
Cdd:PRK14530  79 ---LSDADGFVLDGYPRNLEQAEYLESitdldvvlylDVSEEELVdrltgrrVCPDCGAnyhvefnqpeeegvcDECGGE 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
2BWJ_A       133 LLQMSrsslpvDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDVFLQLCTAIDS 196
Cdd:PRK14530 156 LIQRD------DDTEETVRERLDVFEENTEPVIEHYRDQGVLVEVDGEQTPDEVWADIQDAIDD 213
AAA_17 pfam13207
AAA domain;
19-150 6.07e-32

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 112.33  E-value: 6.07e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A         19 GGPGSGKGTQCEKLVEKYGFTHLSTGELLREElASESERSKlIRDIMERGDLVPSGIVLELLKEAMvASLGDTRGFLIDG 98
Cdd:pfam13207   2 GVPGSGKTTQLKKLAEKLGFPHISAGDLLREE-AKERGLVE-DRDEMRKLPLEPQKELQKLAAERI-AEEAGEGGVIVDG 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
2BWJ_A         99 YPREVKQGEEFGR------RIGDPQLVICMDCSADTMTNRLLQmSRSSLPVDDTTKTI 150
Cdd:pfam13207  79 HPRIKTPAGYLPGlpvevlRELKPDAIILLEADPEEILERRLK-DRTRGRDDDSEEEI 135
PRK14528 PRK14528
adenylate kinase; Provisional
 13-186 1.56e-27

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 102.78  E-value: 1.56e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        13 KIIFIiGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASlGDTR 92
Cdd:PRK14528   3 NIIFM-GPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIREA-DCKN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        93 GFLIDGYPREVKQGEEFGRRIGDPQL----VICMDCSADTMTNRLLQMSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYY 168
Cdd:PRK14528  81 GFLLDGFPRTVEQADALDALLKNEGKsidkAINLEVPDGELLKRLLGRAEIEGRADDNEATIKNRLDNYNKKTLPLLDFY 160

                        170
                 ....*....|....*...
2BWJ_A       169 ETKTQLHKINAEGTPEDV 186
Cdd:PRK14528 161 AAQKKLSQVNGVGSLEEV 178
PRK13808 PRK13808
adenylate kinase; Provisional
 15-186 3.57e-26

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 102.27  E-value: 3.57e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        15 IFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASlGDTRGF 94
Cdd:PRK13808   3 LILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISDRIEQP-DAANGF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        95 LIDGYPREVKQGEEFGRRIGDPQL----VICMDCSA----DTMTNRLLQMSRSSLPV--DDTTKTIAKRLEAYYRASIPV 164
Cdd:PRK13808  82 ILDGFPRTVPQAEALDALLKDKQLkldaVVELRVNEgallARVETRVAEMRARGEEVraDDTPEVLAKRLASYRAQTEPL 161

                        170       180
                 ....*....|....*....|..
2BWJ_A       165 IAYYETKTQLHKINAEGTPEDV 186
Cdd:PRK13808 162 VHYYSEKRKLLTVDGMMTIDEV 183
PLN02842 PLN02842
nucleotide kinase
 17-197 5.82e-26

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 103.79  E-value: 5.82e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        17 IIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLI 96
Cdd:PLN02842   2 ISGAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        97 DGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLqmSRSSLPV-------------------------DDTTKTIA 151
Cdd:PLN02842  82 DGYPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCV--GRRLDPVtgkiyhiknfppeseeikarlitrpDDTEEKVK 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
2BWJ_A       152 KRLEAYYRASIPVIAYYEtkTQLHKINAEGTPEDVFLQLCTAIDSI 197
Cdd:PLN02842 160 ARLQIYKKNAEAILSTYS--DIMVKIDGNRPKEVVFEEISSLLSQI 203
PLN02674 PLN02674
adenylate kinase
 13-186 7.90e-25

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 96.88  E-value: 7.90e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        13 KIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASlGDTR 92
Cdd:PLN02674  32 KRLILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVAAKTPLGIKAKEAMDKGELVSDDLVVGIIDEAMKKP-SCQK 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        93 GFLIDGYPREVKQGEEF-------GRRIgDPQLVICMDCS--ADTMTNRLLQMSR-------------------SSLPV- 143
Cdd:PLN02674 111 GFILDGFPRTVVQAQKLdemlakqGAKI-DKVLNFAIDDAilEERITGRWIHPSSgrtyhtkfappkvpgvddvTGEPLi 189

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
2BWJ_A       144 ---DDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDV 186
Cdd:PLN02674 190 qrkDDTAAVLKSRLEAFHKQTEPVIDYYAKKGVVANLHAEKPPKEV 235
PLN02459 PLN02459
probable adenylate kinase
 18-184 8.30e-23

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 92.22  E-value: 8.30e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        18 IGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGD-TRGFLI 96
Cdd:PLN02459  35 LGCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKSSGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLEAGEEEgESGFIL 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        97 DGYPREVKQGEEF------------------------GRRI----GDPQLVICMDCSADTMTNRLLQ---------MSRS 139
Cdd:PLN02459 115 DGFPRTVRQAEILegvtdidlvvnlklreevlvekclGRRIcsecGKNFNVADIDLKGEDGRPGIVMppllpppecASKL 194

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
2BWJ_A       140 SLPVDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKIN-AEGTPE 184
Cdd:PLN02459 195 ITRADDTEEVVKARLRVYKEESQPVEDFYRKRGKLLEFElPGGIPE 240
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 6-169 6.75e-22

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 89.09  E-value: 6.75e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A         6 MEDLRKCKIIFIiGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMV 85
Cdd:PTZ00088   1 MKLKGPLKIVLF-GAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        86 ASLGDT-RGFLIDGYPREVKQGEEFGrRIGDPQLV------------------ICMDCSADTMTNRLLQMSRSSLPV--- 143
Cdd:PTZ00088  80 KVTDDCfKGFILDGFPRNLKQCKELG-KITNIDLFvniylprnilikkllgrrICNTCNRNFNIAHIRSDPYDMPPIlpp 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
2BWJ_A       144 ----------------DDTTKTIAKRLEAYYRASIPVIAYYE 169
Cdd:PTZ00088 159 adcegckgnpklqkrsDDTEEIVAHRLNTYESTNSPIIQFFK 200
PRK14526 PRK14526
adenylate kinase; Provisional
 13-186 2.85e-20

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 84.13  E-value: 2.85e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        13 KIIFIiGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLkEAMVASLGDTR 92
Cdd:PRK14526   2 KLVFL-GPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIV-EDKINTIKNND 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        93 GFLIDGYPREVKQGEEFGRRIGDPQLV-----------------ICMDC-------SADTMTNRLLQMSRSSL--PVDDT 146
Cdd:PRK14526  80 NFILDGFPRNINQAKALDKFLPNIKIInflideellikrlsgrrICKSCnnifniyTLPTKEKGICDVCKGDLyqRKDDK 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
2BWJ_A       147 TKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDV 186
Cdd:PRK14526 160 EESLKTRLQEYKLQTKPLIEFYSKCNRLNNIDASKDIDEV 199
PRK14529 PRK14529
adenylate kinase; Provisional
 15-107 2.88e-15

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 71.29  E-value: 2.88e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A        15 IFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGI----VLELLKEAmvaslgD 90
Cdd:PRK14529   3 ILIFGPNGSGKGTQGALVKKKYDLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDDItipmILETLKQD------G 76

                         90
                 ....*....|....*..
2BWJ_A        91 TRGFLIDGYPREVKQGE 107
Cdd:PRK14529  77 KNGWLLDGFPRNKVQAE 93
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 14-78 2.72e-07

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 47.87  E-value: 2.72e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
2BWJ_A       14 IIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREE---LASESERSKLIRDIM---ERGDLVPSGIVLE 78
Cdd:cd02020   1 IIAIDGPAGSGKSTVAKLLAKKLGLPYLDTGGIRTEEvgkLASEVAAIPEVRKALderQRELAKKPGIVLE 71
PRK04182 PRK04182
cytidylate kinase; Provisional
 14-54 8.20e-06

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 44.41  E-value: 8.20e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
2BWJ_A        14 IIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLReELASE 54
Cdd:PRK04182   2 IITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFR-ELAKE 41
NK cd02019
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 14-64 3.13e-04

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


Pssm-ID: 238977 [Multi-domain]  Cd Length: 69  Bit Score: 37.70  E-value: 3.13e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
2BWJ_A       14 IIFIIGGPGSGKGTQCEKLVEKYG---FTHLSTGELLREELASESERSKLIRDI 64
Cdd:cd02019   1 IIAITGGSGSGKSTVAKKLAEQLGgrsVVVLDEIVILEGLYASYKSRDARIRDL 54
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
14-157 1.87e-03

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 37.59  E-value: 1.87e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2BWJ_A       14 IIFIIGGPGSGKGTQCEKLVEKYGFTHLStgellreelaSESERSKLIRDIMERGDLVP--SGIVLELLKEAMVASLGDT 91
Cdd:COG0645   1 LILVCGLPGSGKSTLARALAERLGAVRLR----------SDVVRKRLFGAGLAPLERSPeaTARTYARLLALARELLAAG 70

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
2BWJ_A       92 RGFLIDG---YPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQMSRSSLPVDDTTKTIAKRLEAY 157
Cdd:COG0645  71 RSVILDAtflRRAQREAFRALAEEAGAPFVLIWLDAPEEVLRERLEARNAEGGDSDATWEVLERQLAFE 139
TMPK cd01672
Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the ...
 13-80 2.26e-03

Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step in either de novo or salvage biosynthesis of thymidine triphosphate (TTP).


Pssm-ID: 238835  Cd Length: 200  Bit Score: 37.63  E-value: 2.26e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
2BWJ_A       13 KIIFIIGGPGSGKGTQCEKLVE---KYGFTHLSTGELlreelaSESERSKLIRDIMERGDLVPSGIVLELL 80
Cdd:cd01672   1 MFIVFEGIDGAGKTTLIELLAErleARGYEVVLTREP------GGTPIGEAIRELLLDPEDEKMDPRAELL 65
PRK01184 PRK01184
flagellar hook-basal body complex protein FliE;
13-50 6.25e-03

flagellar hook-basal body complex protein FliE;


Pssm-ID: 234914 [Multi-domain]  Cd Length: 184  Bit Score: 36.08  E-value: 6.25e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
2BWJ_A        13 KIIFIIGGPGSGKGtQCEKLVEKYGFTHLSTGELLREE 50
Cdd:PRK01184   2 KIIGVVGMPGSGKG-EFSKIAREMGIPVVVMGDVIREE 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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