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Conserved domains on  [gi|83754260|pdb|2B67|D]
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Chain D, COG0778: Nitroreductase

Protein Classification

nitroreductase family protein( domain architecture ID 10114825)

nitroreductase family protein may catalyze the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles, requiring NAD(P)H as an electron donor in an obligatory two-electron transfer and using FMN as cofactor

CATH:  3.40.109.10
EC:  1.7.1.-
Gene Ontology:  GO:0016491
PubMed:  25702712|7601851|29078300
SCOP:  3001947

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MhqN-like cd02137
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ...
 7-200 9.62e-52

nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


:

Pssm-ID: 380314 [Multi-domain]  Cd Length: 147  Bit Score: 163.57  E-value: 9.62e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D        7 LELNKKRHATKHFT-DKLVDPKDVRTAIEIATLAPSAHNSQPWKFVVVR--EKNAELAKLAYgsNFEQVSSAPVTIALFT 83
Cdd:cd02137   1 LEVIKSRRSVRNFDpDHKIPKEELKEILELATLAPSSFNLQPWRFVVVRdpELKAKLAEAAY--NQPQVTTASAVILVLG 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       84 DTdlakrarkiarvggannfseeqlqyf*knlpaefaryseqqvsdylalNAGLVA*NLVLALTDQGIGSNIILGFDKSK 163
Cdd:cd02137  79 DL------------------------------------------------NAGLAAMNLMLAAKAKGYDTCPMGGFDKEK 110

                       170       180       190
                ....*....|....*....|....*....|....*..
2B67_D      164 VNEVLEIEDRFRPELLITVGYTDEKLEPSYRLPVDEI 200
Cdd:cd02137 111 VAELLNLPDRYVPVLLIAIGKAADKAPRSGRLPVDEV 147
 
Name Accession Description Interval E-value
MhqN-like cd02137
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ...
 7-200 9.62e-52

nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380314 [Multi-domain]  Cd Length: 147  Bit Score: 163.57  E-value: 9.62e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D        7 LELNKKRHATKHFT-DKLVDPKDVRTAIEIATLAPSAHNSQPWKFVVVR--EKNAELAKLAYgsNFEQVSSAPVTIALFT 83
Cdd:cd02137   1 LEVIKSRRSVRNFDpDHKIPKEELKEILELATLAPSSFNLQPWRFVVVRdpELKAKLAEAAY--NQPQVTTASAVILVLG 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       84 DTdlakrarkiarvggannfseeqlqyf*knlpaefaryseqqvsdylalNAGLVA*NLVLALTDQGIGSNIILGFDKSK 163
Cdd:cd02137  79 DL------------------------------------------------NAGLAAMNLMLAAKAKGYDTCPMGGFDKEK 110

                       170       180       190
                ....*....|....*....|....*....|....*..
2B67_D      164 VNEVLEIEDRFRPELLITVGYTDEKLEPSYRLPVDEI 200
Cdd:cd02137 111 VAELLNLPDRYVPVLLIAIGKAADKAPRSGRLPVDEV 147
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 6-201 2.28e-46

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 150.39  E-value: 2.28e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D        6 FLELNKKRHATKHFTDKLVDPKDVRTAIEIATLAPSAHNSQPWKFVVVR--EKNAELAKLAYGSNFEQVSSAPVTIALFT 83
Cdd:COG0778   1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRdpELRERLAEALAEANQEWVADAPVLIVVCA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       84 DTDLAKRARKiarvggannfseeqlqyf*knlpaefaryseqqvsDYLALNAGLVA*NLVLALTDQGIGSNIILGFDKSK 163
Cdd:COG0778  81 DPDRSEKVPE-----------------------------------RYALLDAGIAAQNLLLAARALGLGTCWIGGFDPEK 125

                       170       180       190
                ....*....|....*....|....*....|....*...
2B67_D      164 VNEVLEIEDRFRPELLITVGYTDEKLEPSYRLPVDEII 201
Cdd:COG0778 126 VRELLGLPEGEEPVALLALGYPAEELNPRPRKPLEEVV 163
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 11-184 8.94e-32

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 113.26  E-value: 8.94e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D         11 KKRHATKHFTDKLVDPKDVRTAIEIATLAPSAHNSQPWKFVVVREKNA--ELAKLAYGSnfeqvssapVTIALFTDTDLA 88
Cdd:pfam00881   2 RQRRSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELryRLAEAALEL---------LLVEPAAALLLL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D         89 KRARKIARVGGANNFSEEQLQYF*KNLPAEFARYSEQQVSDYLALNAGLVA*NLVLALTDQGIGSNIILGFDKSKVNEVL 168
Cdd:pfam00881  73 LRRDANLKLLLQDFLRGAPVLIVITASLSTYLRKAAERAYREALLDAGAAAQNLLLAATSLGLGSCPIGGFDAAAVRELL 152

                         170
                  ....*....|....*.
2B67_D        169 EIEDRFRPELLITVGY 184
Cdd:pfam00881 153 GLPDDERLVGLIAVGY 168
PRK11053 PRK11053
oxygen-insensitive NAD(P)H nitroreductase;
7-201 1.88e-12

oxygen-insensitive NAD(P)H nitroreductase;


Pssm-ID: 182929 [Multi-domain]  Cd Length: 217  Bit Score: 63.45  E-value: 1.88e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D         7 LELNKKRHATKHFtdklvDPKDVRTAIEIATL------APSAHNSQPWKFVVV--REKNAELAKLA---YGSNFEQVSSA 75
Cdd:PRK11053   4 VSVAKKRYTTKAF-----DPSKKLPAEQIEQIktllrfSPSSVNSQPWHFIVAstEEGKARIAKAAagnYAFNERKILDA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D        76 PVTIALFTDTDL----------------------AKRARKIARVGGANnfseeqlqyF*KNLPAEFARYSEQQVsdYLAL 133
Cdd:PRK11053  79 SHVVVFCAKTDMddaylelvleqedadgrfateeAKAAQDKGRRFFAD---------MHRKELKDLQHWMEKQV--YLAL 147

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
2B67_D       134 Naglva*NLVLALTDQGIGSNIILGFDKSKVNEVLEIEDR-FRPELLITVGYTDE-----KLePSYRLPVDEII 201
Cdd:PRK11053 148 G------NLLLGAAALGIDATPIEGFDAAILDAEFGLREKgLTSSVVVPLGYHSEedfnaKL-PKSRLPQETIF 214
BluB TIGR02476
5,6-dimethylbenzimidazole synthase; A previously published hypothesis that BluB, involved in ...
 6-187 1.20e-11

5,6-dimethylbenzimidazole synthase; A previously published hypothesis that BluB, involved in cobalamin biosynthesis, is EC 1.16.8.1 (cob(II)yrinic acid a,c-diamide reductase) is now contradicted by newer work ascribing a role in 5,6-dimethylbenzimidazole (DMB) biosynthesis. The BluB protein is related to the nitroreductase family (pfam0881). [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 162875  Cd Length: 205  Bit Score: 61.30  E-value: 1.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D          6 FLELNKKRHATKHFTDKLVDPKDVRTAIEIATLAPSAHNSQPWKFVVVREK-------------NAELAKLAYGS----- 67
Cdd:TIGR02476   9 VYRLIRERRDVRHFRSDPVPEAVLERLLDAAHHAPSVGFSQPWRFVRVESPatreavhalftraNQAAAAIYDGErasqy 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D         68 ---NFEQVSSAPVTIALFTDTdlakrARKIARVGGANNFseeqlqyf*knlpAEFARYSeqqvsdylalnAGLVA*NLVL 144
Cdd:TIGR02476  89 hrlKLEGIREAPVQLAVFCDD-----ARGEGHGLGRHTM-------------PEMLRYS-----------VACAIQNLWL 139

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
2B67_D        145 ALTDQGIGSNIILGFDKSKVNEVLEIEDRFRPELLITVGYTDE 187
Cdd:TIGR02476 140 AARAEGLGVGWVSILDPDAVRRLLGVPEGWRLVAYLCLGWPDA 182
 
Name Accession Description Interval E-value
MhqN-like cd02137
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ...
 7-200 9.62e-52

nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380314 [Multi-domain]  Cd Length: 147  Bit Score: 163.57  E-value: 9.62e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D        7 LELNKKRHATKHFT-DKLVDPKDVRTAIEIATLAPSAHNSQPWKFVVVR--EKNAELAKLAYgsNFEQVSSAPVTIALFT 83
Cdd:cd02137   1 LEVIKSRRSVRNFDpDHKIPKEELKEILELATLAPSSFNLQPWRFVVVRdpELKAKLAEAAY--NQPQVTTASAVILVLG 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       84 DTdlakrarkiarvggannfseeqlqyf*knlpaefaryseqqvsdylalNAGLVA*NLVLALTDQGIGSNIILGFDKSK 163
Cdd:cd02137  79 DL------------------------------------------------NAGLAAMNLMLAAKAKGYDTCPMGGFDKEK 110

                       170       180       190
                ....*....|....*....|....*....|....*..
2B67_D      164 VNEVLEIEDRFRPELLITVGYTDEKLEPSYRLPVDEI 200
Cdd:cd02137 111 VAELLNLPDRYVPVLLIAIGKAADKAPRSGRLPVDEV 147
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 6-201 2.28e-46

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 150.39  E-value: 2.28e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D        6 FLELNKKRHATKHFTDKLVDPKDVRTAIEIATLAPSAHNSQPWKFVVVR--EKNAELAKLAYGSNFEQVSSAPVTIALFT 83
Cdd:COG0778   1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRdpELRERLAEALAEANQEWVADAPVLIVVCA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       84 DTDLAKRARKiarvggannfseeqlqyf*knlpaefaryseqqvsDYLALNAGLVA*NLVLALTDQGIGSNIILGFDKSK 163
Cdd:COG0778  81 DPDRSEKVPE-----------------------------------RYALLDAGIAAQNLLLAARALGLGTCWIGGFDPEK 125

                       170       180       190
                ....*....|....*....|....*....|....*...
2B67_D      164 VNEVLEIEDRFRPELLITVGYTDEKLEPSYRLPVDEII 201
Cdd:COG0778 126 VRELLGLPEGEEPVALLALGYPAEELNPRPRKPLEEVV 163
nitroreductase cd03370
uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus ...
 11-198 9.37e-34

uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus thermophilus NADH oxidase and other, uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380327 [Multi-domain]  Cd Length: 191  Bit Score: 118.96  E-value: 9.37e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       11 KKRHATKHFTDKLVDPKDVRTAIEIATLAPSAHNSQPWKFVVVR--EKNAELAKLAYGSnfEQVSSAPVTIALFTD-TDL 87
Cdd:cd03370   6 ESRRSIRKYTQEPVPDEDLREILRLAGLAPSAWNIQPWRFVVVRdaELKEQLQAAAYGQ--AQVTSAPAVIVIYSDmEDA 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       88 AKRARKIARVGgannFSEEQLQYF*KNLPAEFARYSEQQVSDYlALNAGLVA*N-LVLALTDQGIGSNIILGFDKSKVNE 166
Cdd:cd03370  84 LANLEETIHPG----LSEERRQREAAGLRGAFGKMSVEQRGQW-GLAQANIALGfLLLAAQSLGYDTSPMLGFDPEKVKA 158

                       170       180       190
                ....*....|....*....|....*....|..
2B67_D      167 VLEIEDRFRPELLITVGYTDEKLEPSYRLPVD 198
Cdd:cd03370 159 LLGLPEHVTIAALVALGKPAEEGYPHHRHSLE 190
Nitro_FMN_reductase cd02062
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 11-184 4.50e-33

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380311 [Multi-domain]  Cd Length: 139  Bit Score: 115.47  E-value: 4.50e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       11 KKRHATKHFTDKLVDPKDVRTAIEIATLAPSAHNSQPWKFVVV--REKNAELAKLAYGSNfEQVSSAPVTIALFTDTDla 88
Cdd:cd02062   2 KTRRSIRKFTDKPVPEEKLRKILEAARLAPSAGNLQPWRFIVVrdREKKEKLAKLAAPNQ-KFIAGAPVVIVVVADPD-- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       89 krarkiarvggannfseeqlqyf*knlpaefaryseqQVSDYLALNAGLVA*NLVLALTDQGIGSNIILGFDKS--KVNE 166
Cdd:cd02062  79 -------------------------------------KSRPWALEDAGAAAQNLLLAAAALGLGSCWIGGFDFRedKVRE 121

                       170
                ....*....|....*...
2B67_D      167 VLEIEDRFRPELLITVGY 184
Cdd:cd02062 122 LLGIPENLRPVALIAIGY 139
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 11-184 8.94e-32

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 113.26  E-value: 8.94e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D         11 KKRHATKHFTDKLVDPKDVRTAIEIATLAPSAHNSQPWKFVVVREKNA--ELAKLAYGSnfeqvssapVTIALFTDTDLA 88
Cdd:pfam00881   2 RQRRSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELryRLAEAALEL---------LLVEPAAALLLL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D         89 KRARKIARVGGANNFSEEQLQYF*KNLPAEFARYSEQQVSDYLALNAGLVA*NLVLALTDQGIGSNIILGFDKSKVNEVL 168
Cdd:pfam00881  73 LRRDANLKLLLQDFLRGAPVLIVITASLSTYLRKAAERAYREALLDAGAAAQNLLLAATSLGLGSCPIGGFDAAAVRELL 152

                         170
                  ....*....|....*.
2B67_D        169 EIEDRFRPELLITVGY 184
Cdd:pfam00881 153 GLPDDERLVGLIAVGY 168
nitroreductase cd02139
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 6-201 1.53e-26

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380316 [Multi-domain]  Cd Length: 165  Bit Score: 99.47  E-value: 1.53e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D        6 FLELNKKRHATKHFTDKLVDPKDVRTAIEIATLAPSAHNSQPWKFVVVR--EKNAELAKLAYGSNFeqVSSAPVTIALFT 83
Cdd:cd02139   1 VYEAIKKRRSIRKYKPTPVEEEKLLRILEAARLAPSAKNRQPWRFIVVKdkELKEKLAEAANGQKF--IAEAPVVIVACA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       84 DTDlakrarkiaRVGGANNfseeqlqyf*knlpaefaryseqqvSDYLALNAGLVA*NLVLALTDQGIGSNIILGFDKSK 163
Cdd:cd02139  79 DPS---------ESGMGCG-------------------------KPYYLVDVAIAMEHLVLAATEEGLGTCWIGAFDEDK 124

                       170       180       190
                ....*....|....*....|....*....|....*...
2B67_D      164 VNEVLEIEDRFRPELLITVGYTDEKLEPSYRLPVDEII 201
Cdd:cd02139 125 VKEILGIPEEYRVVALTPLGYPAEEPPPRPRKPLEEIV 162
nitroreductase cd20608
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 7-184 1.48e-25

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380329 [Multi-domain]  Cd Length: 145  Bit Score: 96.25  E-value: 1.48e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D        7 LELNKKRHATKHFTDKLVDPKDVRTAIEIATLAPSAHNSQPWKFVVVREKN--AELAKLAYGSNFeQVSSAPVTIALFTD 84
Cdd:cd20608   1 FEAIKTRRSVRRFSDKPVEEEKLEKILEAARLAPSWANKQCWRFIVVTDKEtlSELAKKESPSNG-WLKDAPVIIVVCAD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       85 tdlakrarkiarvggannfseeqlqyf*knlPAEFARYSEQQvsdYLALNAGLVA*NLVLALTDQGIGSNIILGFDKSKV 164
Cdd:cd20608  80 -------------------------------PKDSGWLNGQN---YYLVDAAIAMQNLMLAATDLGLGTCWIGAFDEKKV 125

                       170       180
                ....*....|....*....|
2B67_D      165 NEVLEIEDRFRPELLITVGY 184
Cdd:cd20608 126 KEILGIPENIRVVALTPLGY 145
TdsD-like cd02138
nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase ...
 11-201 7.83e-25

nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to Burkholderia pseudomallei TdsD, may be involved in the processing of organosulfur compounds. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380315 [Multi-domain]  Cd Length: 174  Bit Score: 95.30  E-value: 7.83e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       11 KKRHATKHFTDKLVDPKDVRTAIEIATLAPSAHNSQPWKFVVVREKNAELAKLA---YGSNFEQVSSAPVTIALFTDTDL 87
Cdd:cd02138   3 AERWSPRAFSPEPISEEDLLSLFEAARWAPSCFNEQPWRFVVARRDTEAFEKLLdllAEGNQSWAKNAPVLIVVLAKTEF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       88 AKRARkiarvggannfseeqlqyf*knlPAEFARYseqqvsdylalNAGLVA*NLVLALTDQGIGSNIILGFDKSKVNEV 167
Cdd:cd02138  83 DHNGK-----------------------PNRYALF-----------DTGAAVANLALQATALGLVVHQMAGFDPEKAKEA 128

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
2B67_D      168 LEIEDRFRPELLITVGYTDEK-----------LEPSYRLPVDEII 201
Cdd:cd02138 129 LGIPDEYEPITMIAIGYPGDPeslpekllereEAPRTRKPLSEIV 173
nitroreductase cd20609
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 6-184 4.30e-24

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380330 [Multi-domain]  Cd Length: 145  Bit Score: 92.45  E-value: 4.30e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D        6 FLELNKKRHATKHFTDKLVDPKDVRTAIEIATLAPSAHNSQPWKFVVVREKNAeLAKLAYGSNFeqVSSAPVTIALFTDT 85
Cdd:cd20609   2 FLELAKKRYSVRKFSDKPVEKEKLDKILEAGRLAPTAVNYQPQRILVVRSEEA-LEKLAKATPR--FFGAPLVIVVCYDK 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       86 DLA-KRarkiarvggannfseeqlQYF*KNlpaefarYSEQQVSdylalnagLVA*NLVLALTDQGIGSNIILGFDKSKV 164
Cdd:cd20609  79 DESwKR------------------PYDGKD-------SGDIDAA--------IVATHMMLAATELGLGTCWVGNFDPEKV 125

                       170       180
                ....*....|....*....|
2B67_D      165 NEVLEIEDRFRPELLITVGY 184
Cdd:cd20609 126 REAFNLPENLEPVAILPLGY 145
NfsB-like cd02149
nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This ...
 5-200 1.06e-22

nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family includes FRase I in Vibrio fischeri, wihich reduces FMN into FMNH2 as part of the bioluminescent reaction. The family also includes oxygen-insensitive nitroreductases that use NADH or NADPH as an electron donor in the ping pong bi bi mechanism. This type of nitroreductase can be used in cancer chemotherapy to activate a range of prodrugs.


Pssm-ID: 380324 [Multi-domain]  Cd Length: 156  Bit Score: 89.23  E-value: 1.06e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D        5 KFLELNKKRHATKHFTD-KLVDPKDVRTAIEIATLAPSAHNSQPWKFVVVR--EKNAELAKLAYGsNFEQVSSAPVTIAL 81
Cdd:cd02149   1 NILELLNFRYATKKFDPnKKISDEDLETILEALRLSPSSFGLEPWKFLVVEnpELKAKLAPAAWF-NQPQIKDASHVVVF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       82 FTDTDlakrarkiarvggannfseeqlqyf*knlpaefarYSEQQVsdYLALnaglva*NLVLALTDQGIGSNIILGFDK 161
Cdd:cd02149  80 LAKKD-----------------------------------WSAKQT--YIAL------GNMLLAAAMLGIDSCPIEGFDP 116

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
2B67_D      162 SKVNEVLEI-EDRFRPELLITVGYTDEKLEPSYRLPVDEI 200
Cdd:cd02149 117 AKLDEILGLdEKGYKISVMVAFGYRSEEKLPKSRKPLEDV 156
nitroreductase cd02151
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 8-191 1.01e-20

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers..


Pssm-ID: 380326 [Multi-domain]  Cd Length: 157  Bit Score: 84.12  E-value: 1.01e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D        8 ELNKKRHATKHFTDKLVDPKDVRTAIEIATLAPSAHNSQPWKFVVVREKnAELAKLA----YGSNFeqVSSAPVTIALFT 83
Cdd:cd02151   1 ELLKKRRSIRKYTDEPIEEEKLEEILEAALLAPSSRNSRPVEFIVVDDK-ETLKKLSeckpHGSAF--LKGAPAAIVVLA 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       84 DTDlakrarkiarvggannfseeqlqyf*knlpaefaryseqqVSDYLALNAGLVA*NLVLALTDQGIGS---NIILGFD 160
Cdd:cd02151  78 DTE----------------------------------------KSDTWIEDASIAATYIQLAAESLGLGScwiQIRNRET 117

                       170       180       190
                ....*....|....*....|....*....|....*..
2B67_D      161 KSK------VNEVLEIEDRFRPELLITVGYTDEKLEP 191
Cdd:cd02151 118 QDGktaeeyVRELLGIPENYRVLCIIALGYPDEEKPP 154
PnbA_NfnB-like cd02136
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as ...
 11-201 1.57e-20

nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.


Pssm-ID: 380313 [Multi-domain]  Cd Length: 152  Bit Score: 83.41  E-value: 1.57e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       11 KKRHATKHFTDKLVDPKDVRTAIEIATLAPSAHNSQPWKFVVVREKNAE-LAKLAYGsnfeqvssAPVTIALFTDTDLak 89
Cdd:cd02136   3 KSRRSVRAFKDKPVPKETIEKILEAARRAPSGKNTQPWRVYVVTGKARErLKKAFFG--------APVALFLTMDKVL-- 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       90 rarkiarvggannfseeqlqyf*knlpaefarySEQQVSDYlalnaGLVA*NLVLALTDQGIGSnIILGF---DKSKVNE 166
Cdd:cd02136  73 ---------------------------------GPWSWFDL-----GAFLQNLMLAAHALGLGT-CPQGAlagYPDVVRK 113

                       170       180       190
                ....*....|....*....|....*....|....*....
2B67_D      167 VLEIEDRFRPELLITVGYTDEKLEP----SYRLPVDEII 201
Cdd:cd02136 114 ELGIPDDEELVCGIALGYPDPDAPVnqfrTPREPLEEFV 152
nitroreductase cd02150
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 11-191 2.64e-17

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380325 [Multi-domain]  Cd Length: 156  Bit Score: 75.33  E-value: 2.64e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       11 KKRHATKHFTDKLVDPKDVRTAIEIATLAPSAHNSQPWKFVVVREKNAeLAKLAYGSNFEQ-VSSAPVTIALFTDTDLAK 89
Cdd:cd02150   2 LTRRSIRKYTDKPVEEEDIEKLLRAAMAAPSAGNQQPWHFIVVTDREK-LDKIAEAHPYGKmLKEAPLAIVVCGDPSKEK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       90 rarkiarvggannfseeqlqyf*knlpaefaryseqqVSDYLALNAGLVA*NLVLALTDQGIGSnIILGF--DKSKVN-- 165
Cdd:cd02150  81 -------------------------------------APGYWVQDCSAATENILLAAHALGLGA-VWLGVypFEERVKai 122

                       170       180
                ....*....|....*....|....*..
2B67_D      166 -EVLEIEDRFRPELLITVGYTDEKLEP 191
Cdd:cd02150 123 rEILNIPENIIPFCVIALGYPAEEKEP 149
RutE-like cd02148
nitroreductase similar to Escherichia coli RutE; A subfamily of the nitroreductase family ...
 14-196 1.71e-16

nitroreductase similar to Escherichia coli RutE; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. RutE is involved in the utilization of uracil as the sole nitrogen source; it appears to have the same function as YdfG, which reduces malonic semialdehyde to 3-hydroxypropionic acid.


Pssm-ID: 380323 [Multi-domain]  Cd Length: 186  Bit Score: 73.83  E-value: 1.71e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       14 HATKHFTDKLVDPKDVRTAIEIATLAPSAHNSQPWKFVVVR--EKNAELAKLAYGSNFEQVSSAPVTIALFTDTDLAKRA 91
Cdd:cd02148  10 RTHNAWEDKPVSDEELRAIYDLAKWGPTAANCSPARIVFVRsaEAKERLVPHLSEGNREKTMAAPVTAILAYDTEFYEHL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       92 RKIARVGGAnnfseeqlqyf*knlPAEFARYSEQQVSDYLALNAGLVA*NLVLALTDQGIGSNIILGFDKSKVNEVLEIE 171
Cdd:cd02148  90 PRLFPHGDA---------------RSWFFGSGPARAEETAFRNASLQAAYFILAARALGLDCGPMSGFDAAGVDAEFFAG 154

                       170       180
                ....*....|....*....|....*.
2B67_D      172 DRFRPELLITVGYTDE-KLEPsyRLP 196
Cdd:cd02148 155 TRWKSNLVVNLGYGDPsKLFP--RLP 178
BluB cd02145
5,6-dimethylbenzimidazole synthase; BluB catalyzes the O2-dependent conversion of FMNH2 to 5, ...
 8-187 9.65e-13

5,6-dimethylbenzimidazole synthase; BluB catalyzes the O2-dependent conversion of FMNH2 to 5,6-dimethylbenzimidazole (DMB), a component of vitamin B12; is is a subfamily of the nitroreductase family; nitroreductases typically reduce their substrates by using NAD(P)H as electron donor and often use FMN as a cofactor.


Pssm-ID: 380321  Cd Length: 196  Bit Score: 63.92  E-value: 9.65e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D        8 ELNKKRHATKHFTDKLVDPKDVRTAIEIATLAPSAHNSQPWKFVVVREK-------------NAELAKLAYGSNFEQVSS 74
Cdd:cd02145   2 RVIRWRRDVRHFRPDPVPEEVLERLLQAAHLAPSVGLMQPWRFVRVRSAatrkavhelfqraNAEAAEMYTGERAAQYRT 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       75 --------APVTIALFTDTDlakRARKIARVGGANNfseeqlqyf*knlpaEFARYSeqqvsdylalnAGLVA*NLVLAL 146
Cdd:cd02145  82 lklegieeAPLQLAVFCDRA---RAGGHGLGRTTMP---------------EMDLYS-----------SVCAVQNLWLAA 132

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
2B67_D      147 TDQGIGSNIILGFDKSKVNEVLEIEDRFRPELLITVGYTDE 187
Cdd:cd02145 133 RAEGLGVGWVSILDPDEVKRLLGIPEHWEPVAYLCIGYPEF 173
PRK11053 PRK11053
oxygen-insensitive NAD(P)H nitroreductase;
7-201 1.88e-12

oxygen-insensitive NAD(P)H nitroreductase;


Pssm-ID: 182929 [Multi-domain]  Cd Length: 217  Bit Score: 63.45  E-value: 1.88e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D         7 LELNKKRHATKHFtdklvDPKDVRTAIEIATL------APSAHNSQPWKFVVV--REKNAELAKLA---YGSNFEQVSSA 75
Cdd:PRK11053   4 VSVAKKRYTTKAF-----DPSKKLPAEQIEQIktllrfSPSSVNSQPWHFIVAstEEGKARIAKAAagnYAFNERKILDA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D        76 PVTIALFTDTDL----------------------AKRARKIARVGGANnfseeqlqyF*KNLPAEFARYSEQQVsdYLAL 133
Cdd:PRK11053  79 SHVVVFCAKTDMddaylelvleqedadgrfateeAKAAQDKGRRFFAD---------MHRKELKDLQHWMEKQV--YLAL 147

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
2B67_D       134 Naglva*NLVLALTDQGIGSNIILGFDKSKVNEVLEIEDR-FRPELLITVGYTDE-----KLePSYRLPVDEII 201
Cdd:PRK11053 148 G------NLLLGAAALGIDATPIEGFDAAILDAEFGLREKgLTSSVVVPLGYHSEedfnaKL-PKSRLPQETIF 214
nitroreductase cd20610
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 11-184 7.88e-12

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380331 [Multi-domain]  Cd Length: 167  Bit Score: 60.75  E-value: 7.88e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       11 KKRHATKHFTDKLVDPKDVRTAIEIATLAPSAHNSQPWKFVVV--REKNAELAKLAYGSNFEQVSSAPVTIALFTDTDlA 88
Cdd:cd20610   2 KKRRSIRKFKPDPVPKEDIEKILEAANWAPSGMNRQNWEFVVVkgGEKIEKIGISIKKKNEEIARLLEKVFAEKPIRF-R 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       89 KRARKIARVGGANNFSeeqLQYF*KNLPAEFARYSEQqvsdylalNAGLVA*NLVLALTDQGIGSNIILG--FDKSKVNE 166
Cdd:cd20610  81 KFRRFFTLFGGAPVLV---VVYTEPYKPPEERKPDLQ--------SVSAAIQNLLLAAHALGLGTCWMTGplYAEDEIEE 149

                       170
                ....*....|....*...
2B67_D      167 VLEIEDRFRPELLITVGY 184
Cdd:cd20610 150 ILEIPDDKELVAVTPLGY 167
NfsA-like cd02146
nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin ...
 18-201 9.22e-12

nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.


Pssm-ID: 380322 [Multi-domain]  Cd Length: 229  Bit Score: 61.87  E-value: 9.22e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       18 HFTDKLVDPKDVRTAIEIATLAPSAHNSQPWKFVVVR--EKNAELAKLAygSNFEQVSSAPVTIALFTDTdlaKRARKIA 95
Cdd:cd02146  13 KFTDEPLTDETLETLIAAAQSASTSSNLQAYSVIVVTdpELREKLAELA--GNQPYVAQAPVFLVFCADL---YRHQKIA 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       96 RvggANNFSEEQLQYF*KNLPAefaryseqqvsdylALNAGLVA*NLVLALTDQGIGSNIILGF--DKSKVNEVLEIEDR 173
Cdd:cd02146  88 E---EAGGKDVGLDYLESFLVG--------------VVDAALAAQNALVAAESLGLGIVYIGGIrnNPEEVIELLGLPEY 150

                       170       180
                ....*....|....*....|....*...
2B67_D      174 FRPELLITVGYTDEKLEPSYRLPVDEII 201
Cdd:cd02146 151 VFPLFGLTVGHPDPTPEVKPRLPLEAVV 178
iodotyrosine_dehalogenase cd02144
iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the ...
 6-200 9.52e-12

iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers.


Pssm-ID: 380320  Cd Length: 192  Bit Score: 61.01  E-value: 9.52e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D        6 FLELNKKRHATKHFTDKLVDPKDVRTAIEIATLAPSAHNSQPWKFVVVR--------------------------EKNAE 59
Cdd:cd02144   1 FYELMKKRRSVRDFSSEPVPREVIENAIRTAGTAPSGANTQPWTFVVVSdpeikrkireaaeeeekefyekrmgeEWVWD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       60 LAKLAYGSNFEQVSSAPVTIALFtdtdlakrarkiARVGGANNFSEEQLQYf*knlpaefarYSEQQVSdylaLNAGLva 139
Cdd:cd02144  81 LKPLGTNWEKPYLTEAPYLIVVF------------KQKYGVLPDGKKKKHY-----------YNEESVG----IAVGI-- 131

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
2B67_D      140 *nLVLALTDQGIG------SNIilgfdkSKVNEVLEIEDRFRPELLITVGY-TDEKLEPSY-RLPVDEI 200
Cdd:cd02144 132 --LLAALHNAGLVtlthtpSPM------PFLRDLLGRPKNEKPLLLLPVGYpAEDATVPDLkRKPLEEI 192
PRK05365 PRK05365
malonic semialdehyde reductase; Provisional
 13-199 9.88e-12

malonic semialdehyde reductase; Provisional


Pssm-ID: 180040 [Multi-domain]  Cd Length: 195  Bit Score: 60.98  E-value: 9.88e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D        13 RHATKH--FTDKLVDPKDVRTAIEIATLAPSAHNSQPWKFVVVR--EKNAELAKLAYGSNFEQVSSAPVTIALFTDTDla 88
Cdd:PRK05365  14 TEARTHngWLDEPVSDEQLRELYDLVKWGPTSANCSPARFVFVRsaEAKERLRPALSEGNLAKTLAAPVTAIVAYDTE-- 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D        89 krarkiarvggannFSEEQLQYF*knlPAEFAR---YSEQQVSDYLAL-NAGLVA*NLVLALTDQGIGSNIILGFDKSKV 164
Cdd:PRK05365  92 --------------FHEHLPKLF----PHADARswfAGNPALAEETAFrNSSLQGAYLILAARALGLDAGPMSGFDAAAV 153

                        170       180       190
                 ....*....|....*....|....*....|....*..
2B67_D       165 NEVLEIEDRFRPELLITVGYTDE-KLEP-SYRLPVDE 199
Cdd:PRK05365 154 DAEFFAGTTWKSNFLVNIGYGDPaKLFPrLPRLSFDE 190
BluB TIGR02476
5,6-dimethylbenzimidazole synthase; A previously published hypothesis that BluB, involved in ...
 6-187 1.20e-11

5,6-dimethylbenzimidazole synthase; A previously published hypothesis that BluB, involved in cobalamin biosynthesis, is EC 1.16.8.1 (cob(II)yrinic acid a,c-diamide reductase) is now contradicted by newer work ascribing a role in 5,6-dimethylbenzimidazole (DMB) biosynthesis. The BluB protein is related to the nitroreductase family (pfam0881). [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 162875  Cd Length: 205  Bit Score: 61.30  E-value: 1.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D          6 FLELNKKRHATKHFTDKLVDPKDVRTAIEIATLAPSAHNSQPWKFVVVREK-------------NAELAKLAYGS----- 67
Cdd:TIGR02476   9 VYRLIRERRDVRHFRSDPVPEAVLERLLDAAHHAPSVGFSQPWRFVRVESPatreavhalftraNQAAAAIYDGErasqy 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D         68 ---NFEQVSSAPVTIALFTDTdlakrARKIARVGGANNFseeqlqyf*knlpAEFARYSeqqvsdylalnAGLVA*NLVL 144
Cdd:TIGR02476  89 hrlKLEGIREAPVQLAVFCDD-----ARGEGHGLGRHTM-------------PEMLRYS-----------VACAIQNLWL 139

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
2B67_D        145 ALTDQGIGSNIILGFDKSKVNEVLEIEDRFRPELLITVGYTDE 187
Cdd:TIGR02476 140 AARAEGLGVGWVSILDPDAVRRLLGVPEGWRLVAYLCLGWPDA 182
nitroreductase_FeS-like cd02143
nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family ...
 18-65 2.66e-09

nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family utilize FMN as a cofactor. This family may be involved in the reduction of flavin or nitroaromatic compounds via an obligatory two-electron transfer. Nitroreductase is homodimer. Each subunit contains one FMN molecule.


Pssm-ID: 380319 [Multi-domain]  Cd Length: 187  Bit Score: 54.40  E-value: 2.66e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
2B67_D       18 HFTDKLVDPKDVRTAIEIATLAPSAHNSQPWKFVVV--REKNAELAKLAY 65
Cdd:cd02143  10 RYKDKPVPRETLEKLLDIARYAPTGHNSQPVHWLVVddPEKVRRLAELVI 59
PRK13294 PRK13294
F420-0--gamma-glutamyl ligase; Provisional
 13-204 5.80e-09

F420-0--gamma-glutamyl ligase; Provisional


Pssm-ID: 183957 [Multi-domain]  Cd Length: 448  Bit Score: 55.02  E-value: 5.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D        13 RHATKHFTDKLVDPKDVRTAIEIATLAPSAHNSQPWKFVVVRE-----------KNAELAKL-AYGSNFEQVS------- 73
Cdd:PRK13294 260 RRSVREFSDDPVDPEAVRRAVAAALTAPAPHHTRPVRFVWLRSaavrtrlldamRDAWRADLrADGLSEESIArrvrrgd 339

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D        74 ---SAPVTIALFTDTDLAKRARKIARVGgannfseeqlqyf*knlpAEFARYSeqqvsdyLALNAGLva*NLVLALTDQG 150
Cdd:PRK13294 340 ilyDAPELVVPFLVPDGAHSYPDARRTA------------------AERTMFT-------VAVGAAV--QNLLVALAVEG 392

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
2B67_D       151 IGSNIILG--FDKSKVNEVLEIEDRFRPELLITVGYTDEKLEPSYRLPVDEIIEKR 204
Cdd:PRK13294 393 LGSCWIGStiFAADVVRAVLDLPADWEPLGAVAIGHPAEPPGPRPPRDPGDFLVER 448
YdjA-like cd02135
nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the ...
 7-158 7.32e-08

nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.


Pssm-ID: 380312 [Multi-domain]  Cd Length: 162  Bit Score: 49.91  E-value: 7.32e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D        7 LELNKKRHATKHFTDKL-VDPKDVRTAIEIATLAPSAHNSQPWKFVVV----REKNAELAKLAYGSNFEQvssapvtial 81
Cdd:cd02135   1 LELIKTRRSIRKFKLTGaPPEEQLEELLEAAMWAPNHGKLEPWRFIVVtgegRERLAELLAAAAAARAPG---------- 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D       82 FTDTDLAKRARKIARVGG-----ANNFSEEQLQyf*knlpaefarYSEQQVSdylalnAGLVA*NLVLALTDQGIGSNII 156
Cdd:cd02135  71 ADPEKLEKAREKALRAPVviavvAKPDEDPKVP------------EWEQYAA------VGAAVQNLLLAAHALGLGAVWR 132


                ..
2B67_D      157 LG 158
Cdd:cd02135 133 TG 134
McbC_SagB-like_oxidoreductase cd02142
oxidase similar to the microcin B17 processing protein McbC; This family is the oxidase domain ...
 129-183 9.17e-05

oxidase similar to the microcin B17 processing protein McbC; This family is the oxidase domain of NRPS (non-ribosomal peptide synthetase) and other systems that modify polypeptides by cyclizing a thioester to form a ring. These include EpoB, part of the epothilone biosynthesis pathway; TubD, part of the tubulysin biosynthesis pathway, MtsD, part of the myxothiozol biosynthesis pathway; IndC, part of the indigoidine biosynthesis pathway and TfxB, part of the trifitoxin processing pathway. All are FMN-dependent and oxidize the product of the cyclization of thioesters in short polypeptides.


Pssm-ID: 380318  Cd Length: 200  Bit Score: 41.64  E-value: 9.17e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
2B67_D      129 DYLALNAGLVA*NLVLALTDQGIGSNIILGFDKSKVNEVLEIEDRFRPEL-LITVG 183
Cdd:cd02142 144 RYILLEAGHLAQNLYLAATALGLGLCAIGAFDDDALRELLGLDEVEEVVLyAFVVG 199
TM1586_NiRdase pfam14512
Putative TM nitroreductase; Compared with the more traditional NADH oxidase/flavin reductase ...
 101-202 2.66e-04

Putative TM nitroreductase; Compared with the more traditional NADH oxidase/flavin reductase family, this family is a duplication, consisting of two similar domains arranged as the subunits of the dimeric NADH oxidase/flavin reductase with one conserved active site.


Pssm-ID: 405236 [Multi-domain]  Cd Length: 214  Bit Score: 40.35  E-value: 2.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2B67_D        101 NNFSEEQLQYF*KNLPAEFARYSEQqvSDYLALNAGLVA*NLVLALTDQGIGSnIILGFDKSKVNEVLEIEDRFRPELLI 180
Cdd:pfam14512  51 DAFKGKAKYGKFKGVPNYIAAYGEK--DDDLLENAGYYGEQIVLYATALGLGT-CWVGGTYSKSKVKAKIKKGEKLVIVI 127

                          90       100
                  ....*....|....*....|..
2B67_D        181 TVGYTDEKLEPSYRLPVDEIIE 202
Cdd:pfam14512 128 AFGYGATKGVRAKRKPLDELCV 149
TM1586_NiRdase pfam14512
Putative TM nitroreductase; Compared with the more traditional NADH oxidase/flavin reductase ...
 26-53 4.90e-04

Putative TM nitroreductase; Compared with the more traditional NADH oxidase/flavin reductase family, this family is a duplication, consisting of two similar domains arranged as the subunits of the dimeric NADH oxidase/flavin reductase with one conserved active site.


Pssm-ID: 405236 [Multi-domain]  Cd Length: 214  Bit Score: 39.58  E-value: 4.90e-04
                          10        20
                  ....*....|....*....|....*...
2B67_D         26 PKDVRTAIEIATLAPSAHNSQPWKFVVV 53
Cdd:pfam14512 156 PEWFKEGMEAARLAPSAMNQQPWRFVLV 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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