NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|67464598|pdb|1ZHV|A]
View 

Chain A, X-ray Crystal Structure Protein Atu0741 from Agobacterium tumefaciens. Northeast Structural Genomics Consortium Target AtR8.

Protein Classification

ACT domain-containing protein( domain architecture ID 11466474)

ACT domain-containing protein similar to vertebrate GATS-like proteins 2 and 3, which function as regulators of TORC1 signaling pathway through the GATOR complex

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ACT-7 COG3603
ACT domain, ACT-7 family [Signal transduction mechanisms];
3-122 1.30e-61

ACT domain, ACT-7 family [Signal transduction mechanisms];


:

Pssm-ID: 442822 [Multi-domain]  Cd Length: 120  Bit Score: 184.64  E-value: 1.30e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZHV_A        3 RIKLKILNGSYGIARLSASEAIPAWADGGGFVSITRTDDELSIVCLIDRIPQDVRVDPGWSCFKFQGPFAFDETGIVLSV 82
Cdd:COG3603   1 KLTLKLLPGEYAVCRLPPDAPIPAWALGSGFVSITRTPDELSIVCPEERVPAGVRAERGWRALKVEGPLDFSLTGILASL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
1ZHV_A       83 ISPLSTNGIGIFVVSTFDGDHLLVRSNDLEKTADLLANAG 122
Cdd:COG3603  81 SSPLAEAGISIFAVSTFDTDYLLVKEADLDRAVAALRAAG 120
 
Name Accession Description Interval E-value
ACT-7 COG3603
ACT domain, ACT-7 family [Signal transduction mechanisms];
3-122 1.30e-61

ACT domain, ACT-7 family [Signal transduction mechanisms];


Pssm-ID: 442822 [Multi-domain]  Cd Length: 120  Bit Score: 184.64  E-value: 1.30e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZHV_A        3 RIKLKILNGSYGIARLSASEAIPAWADGGGFVSITRTDDELSIVCLIDRIPQDVRVDPGWSCFKFQGPFAFDETGIVLSV 82
Cdd:COG3603   1 KLTLKLLPGEYAVCRLPPDAPIPAWALGSGFVSITRTPDELSIVCPEERVPAGVRAERGWRALKVEGPLDFSLTGILASL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
1ZHV_A       83 ISPLSTNGIGIFVVSTFDGDHLLVRSNDLEKTADLLANAG 122
Cdd:COG3603  81 SSPLAEAGISIFAVSTFDTDYLLVKEADLDRAVAALRAAG 120
ACT_7 pfam13840
ACT domain; The ACT domain is a structural motif of 70-90 amino acids that functions in the ...
 57-118 4.30e-16

ACT domain; The ACT domain is a structural motif of 70-90 amino acids that functions in the control of metabolism, solute transport and signal transduction. They are thus found in a variety of different proteins in a variety of different arrangements. In mammalian phenylalanine hydroxylase the domain forms no contacts but promotes an allosteric effect despite the apparent lack of ligand binding.


Pssm-ID: 433519 [Multi-domain]  Cd Length: 65  Bit Score: 67.56  E-value: 4.30e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
1ZHV_A         57 RVDPGWSCFKFQGP-FAFDETGIVLSVISPLSTNGIGIFVVSTFDGDHLLVRSNDLEKTADLL 118
Cdd:pfam13840   1 ESEDGWAKLSVVGAgLDFDVPGVVAKLTSPLAEAGISIFQISSYTTDYVLVPEEDLEKAVRAL 63
 
Name Accession Description Interval E-value
ACT-7 COG3603
ACT domain, ACT-7 family [Signal transduction mechanisms];
3-122 1.30e-61

ACT domain, ACT-7 family [Signal transduction mechanisms];


Pssm-ID: 442822 [Multi-domain]  Cd Length: 120  Bit Score: 184.64  E-value: 1.30e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ZHV_A        3 RIKLKILNGSYGIARLSASEAIPAWADGGGFVSITRTDDELSIVCLIDRIPQDVRVDPGWSCFKFQGPFAFDETGIVLSV 82
Cdd:COG3603   1 KLTLKLLPGEYAVCRLPPDAPIPAWALGSGFVSITRTPDELSIVCPEERVPAGVRAERGWRALKVEGPLDFSLTGILASL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
1ZHV_A       83 ISPLSTNGIGIFVVSTFDGDHLLVRSNDLEKTADLLANAG 122
Cdd:COG3603  81 SSPLAEAGISIFAVSTFDTDYLLVKEADLDRAVAALRAAG 120
ACT_7 pfam13840
ACT domain; The ACT domain is a structural motif of 70-90 amino acids that functions in the ...
 57-118 4.30e-16

ACT domain; The ACT domain is a structural motif of 70-90 amino acids that functions in the control of metabolism, solute transport and signal transduction. They are thus found in a variety of different proteins in a variety of different arrangements. In mammalian phenylalanine hydroxylase the domain forms no contacts but promotes an allosteric effect despite the apparent lack of ligand binding.


Pssm-ID: 433519 [Multi-domain]  Cd Length: 65  Bit Score: 67.56  E-value: 4.30e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
1ZHV_A         57 RVDPGWSCFKFQGP-FAFDETGIVLSVISPLSTNGIGIFVVSTFDGDHLLVRSNDLEKTADLL 118
Cdd:pfam13840   1 ESEDGWAKLSVVGAgLDFDVPGVVAKLTSPLAEAGISIFQISSYTTDYVLVPEEDLEKAVRAL 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH