NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|66361330|pdb|1Z6A|A]
View 

Chain A, Helicase of the snf2/rad54 family

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 11425670)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA

CATH:  1.20.1320.20|3.40.50.300
EC:  3.6.4.-
Gene Ontology:  GO:0016887|GO:0003676|GO:0004386|GO:0005524
PubMed:  20206133|20225155

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 31-475 0e+00

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


:

Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 631.49  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       31 PYNIKANLRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKENELTPSLVICPLSVLKNWEEELSKFAP 110
Cdd:COG0553 235 PAGLKATLRPYQLEGAAWLLFLRRLGLGGLLADDMGLGKTIQALALLLELKERGLARPVLIVAPTSLVGNWQRELAKFAP 314

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      111 HLRFAVFHEDRSKIK----LEDYDIILTTYAVLLRD-TRLKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKSKYRIALTG 185
Cdd:COG0553 315 GLRVLVLDGTRERAKganpFEDADLVITSYGLLRRDiELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTG 394

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      186 TPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFATPIKKGDNMAKEELKAIISPFILRRTKYDkaIINDLPDKIETNVYCN 265
Cdd:COG0553 395 TPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIEKGDEEALERLRRLLRPFLLRRTKED--VLKDLPEKTEETLYVE 472

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      266 LTPEQAAMYKAEVENLFNNIDSVTGIKRKGMILSTLLKLKQIVDHPAL-LKGGEQSVRRSGKMIRTMEIIEEALDEGDKI 344
Cdd:COG0553 473 LTPEQRALYEAVLEYLRRELEGAEGIRRRGLILAALTRLRQICSHPALlLEEGAELSGRSAKLEALLELLEELLAEGEKV 552

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      345 AIFTQFVDMGKIIRNIIEKElNTEVPFLYGELSKKERDDIISKFQNNPSVKFIVLSVKAGGFGINLTSANRVIHFDRWWN 424
Cdd:COG0553 553 LVFSQFTDTLDLLEERLEER-GIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWN 631

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|.
1Z6A_A      425 PAVEDQATDRVYRIGQTRNVIVHKLISVGTLEEKIDQLLAFKRSLFKDIIS 475
Cdd:COG0553 632 PAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRALAESVLG 682
 
Name Accession Description Interval E-value
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 31-475 0e+00

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 631.49  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       31 PYNIKANLRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKENELTPSLVICPLSVLKNWEEELSKFAP 110
Cdd:COG0553 235 PAGLKATLRPYQLEGAAWLLFLRRLGLGGLLADDMGLGKTIQALALLLELKERGLARPVLIVAPTSLVGNWQRELAKFAP 314

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      111 HLRFAVFHEDRSKIK----LEDYDIILTTYAVLLRD-TRLKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKSKYRIALTG 185
Cdd:COG0553 315 GLRVLVLDGTRERAKganpFEDADLVITSYGLLRRDiELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTG 394

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      186 TPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFATPIKKGDNMAKEELKAIISPFILRRTKYDkaIINDLPDKIETNVYCN 265
Cdd:COG0553 395 TPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIEKGDEEALERLRRLLRPFLLRRTKED--VLKDLPEKTEETLYVE 472

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      266 LTPEQAAMYKAEVENLFNNIDSVTGIKRKGMILSTLLKLKQIVDHPAL-LKGGEQSVRRSGKMIRTMEIIEEALDEGDKI 344
Cdd:COG0553 473 LTPEQRALYEAVLEYLRRELEGAEGIRRRGLILAALTRLRQICSHPALlLEEGAELSGRSAKLEALLELLEELLAEGEKV 552

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      345 AIFTQFVDMGKIIRNIIEKElNTEVPFLYGELSKKERDDIISKFQNNPSVKFIVLSVKAGGFGINLTSANRVIHFDRWWN 424
Cdd:COG0553 553 LVFSQFTDTLDLLEERLEER-GIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWN 631

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|.
1Z6A_A      425 PAVEDQATDRVYRIGQTRNVIVHKLISVGTLEEKIDQLLAFKRSLFKDIIS 475
Cdd:COG0553 632 PAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRALAESVLG 682
DEXQc_arch_SWI2_SNF2 cd18012
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ...
 34-245 4.37e-124

DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350770 [Multi-domain]  Cd Length: 218  Bit Score: 361.11  E-value: 4.37e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       34 IKANLRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKENELTPSLVICPLSVLKNWEEELSKFAPHLR 113
Cdd:cd18012   1 LKATLRPYQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALLLSRKEEGRKGPSLVVAPTSLIYNWEEEAAKFAPELK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      114 FAVFHEDRSKIK----LEDYDIILTTYAVLLRDTR-LKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKSKYRIALTGTPI 188
Cdd:cd18012  81 VLVIHGTKRKREklraLEDYDLVITSYGLLRRDIElLKEVKFHYLVLDEAQNIKNPQTKTAKAVKALKADHRLALTGTPI 160

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
1Z6A_A      189 ENKVDDLWSIMTFLNPGLLGSYSEFKSKFATPIKK-GDNMAKEELKAIISPFILRRTK 245
Cdd:cd18012 161 ENHLGELWSIFDFLNPGLLGSYKRFKKRFAKPIEKdGDEEALEELKKLISPFILRRLK 218
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 28-483 5.62e-74

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 252.41  E-value: 5.62e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A         28 LLEPYNIKANLRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKENELT-PSLVICPLSVLKNWEEELS 106
Cdd:PLN03142  160 LVQPSCIKGKMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLHEYRGITgPHMVVAPKSTLGNWMNEIR 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A        107 KFAPHLRFAVFH---EDRSKIKLE-----DYDIILTTYAVLLRD-TRLKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKS 177
Cdd:PLN03142  240 RFCPVLRAVKFHgnpEERAHQREEllvagKFDVCVTSFEMAIKEkTALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFST 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A        178 KYRIALTGTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFATPIKKGDNMAKEELKAIISPFILRRTKYDkaIINDLPDK 257
Cdd:PLN03142  320 NYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQISGENDQQEVVQQLHKVLRPFLLRRLKSD--VEKGLPPK 397

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A        258 IETNVYCNLTPEQAAMYKAEVEnlfNNIDSVTGIKRKGMILSTLLKLKQIVDHPALLKG---------GEQSVRRSGKMI 328
Cdd:PLN03142  398 KETILKVGMSQMQKQYYKALLQ---KDLDVVNAGGERKRLLNIAMQLRKCCNHPYLFQGaepgppyttGEHLVENSGKMV 474

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A        329 RTMEIIEEALDEGDKIAIFTQfvdMGKIIrNIIEKELNTEvPFLY----GELSKKERDDIISKFQNNPSVKFI-VLSVKA 403
Cdd:PLN03142  475 LLDKLLPKLKERDSRVLIFSQ---MTRLL-DILEDYLMYR-GYQYcridGNTGGEDRDASIDAFNKPGSEKFVfLLSTRA 549

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A        404 GGFGINLTSANRVIHFDRWWNPAVEDQATDRVYRIGQTRNVIVHKLISVGTLEEKI----------DQL------LAFKR 467
Cdd:PLN03142  550 GGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVieraykklalDALviqqgrLAEQK 629

                         490       500
                  ....*....|....*....|....*...
1Z6A_A        468 SLFKD------------IISSGDSWITE 483
Cdd:PLN03142  630 TVNKDellqmvrygaemVFSSKDSTITD 657
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
 41-314 3.91e-72

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 230.65  E-value: 3.91e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A         41 YQIKGFSWM-RFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKENELT--PSLVICPLSVLKNWEEELSKFA--PHLRFA 115
Cdd:pfam00176   1 YQIEGVNWMlSLENNLGRGGILADEMGLGKTLQTISLLLYLKHVDKNWggPTLIVVPLSLLHNWMNEFERWVspPALRVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A        116 VFHED--------RSKIKLEDYDIILTTYAVLLRDTR-LKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKSKYRIALTGT 186
Cdd:pfam00176  81 VLHGNkrpqerwkNDPNFLADFDVVITTYETLRKHKElLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A        187 PIENKVDDLWSIMTFLNPGLLGSYSEFKSKFATPIKKGDNMAK-EELKAIISPFILRRTKYDKAIinDLPDKIETNVYCN 265
Cdd:pfam00176 161 PLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERGGGKKGvSRLHKLLKPFLLRRTKKDVEK--SLPPKVEYILFCR 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
1Z6A_A        266 LTPEQAAMYKAEV-ENLFNNIDSVTGIKRKGM-ILSTLLKLKQIVDHPALL 314
Cdd:pfam00176 239 LSKLQRKLYQTFLlKKDLNAIKTGEGGREIKAsLLNILMRLRKICNHPGLI 289
DEXDc smart00487
DEAD-like helicases superfamily;
37-199 1.16e-28

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 112.59  E-value: 1.16e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A          37 NLRPYQIKGFSWMRFMNKlgfGICLADDMGLGKTLQTIAVFSDAKKENELTPSLVICPLSVL-KNWEEELSKFAPHLRFA 115
Cdd:smart00487   8 PLRPYQKEAIEALLSGLR---DVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELaEQWAEELKKLGPSLGLK 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A         116 V--------FHEDRSKIKLEDYDIILTTYAVLLRD---TRLKEVEWKYIVIDEAQNIKNPQTK--IFKAVKEL-KSKYRI 181
Cdd:smart00487  85 VvglyggdsKREQLRKLESGKTDILVTTPGRLLDLlenDKLSLSNVDLVILDEAHRLLDGGFGdqLEKLLKLLpKNVQLL 164

                          170
                   ....*....|....*...
1Z6A_A         182 ALTGTPIENKVDDLWSIM 199
Cdd:smart00487 165 LLSATPPEEIENLLELFL 182
rad25 TIGR00603
DNA repair helicase rad25; All proteins in this family for which functions are known are ...
 36-417 2.32e-04

DNA repair helicase rad25; All proteins in this family for which functions are known are DNA-DNA helicases used for the initiation of nucleotide excision repair and transacription as part of the TFIIH complex.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273168 [Multi-domain]  Cd Length: 732  Bit Score: 44.02  E-value: 2.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A         36 ANLRPYQIKGFSWMrFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKEneltpSLVICPLSV-LKNWEEELSKF--APHL 112
Cdd:TIGR00603 254 TQIRPYQEKSLSKM-FGNGRARSGIIVLPCGAGKSLVGVTAACTVKKS-----CLVLCTSAVsVEQWKQQFKMWstIDDS 327

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A        113 RFAVFHEDRSKIKLEDYDIILTTYAVLLRDTR-----------LKEVEWKYIVIDEAQNIknPQTKIFKAVKELKSKYRI 181
Cdd:TIGR00603 328 QICRFTSDAKERFHGEAGVVVSTYSMVAHTGKrsyesekvmewLTNREWGLILLDEVHVV--PAAMFRRVLTIVQAHCKL 405

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A        182 ALTGTPI--ENKVDDLwsimTFL-NPGLlgsyseFKSKFATPIKKGdnmakeelkaiispFILRRTKydkaiindlpdki 258
Cdd:TIGR00603 406 GLTATLVreDDKITDL----NFLiGPKL------YEANWMELQKKG--------------FIANVQC------------- 448

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A        259 eTNVYCNLTPEqaaMYKaevENLFNNidsvtgiKRKGMILSTLLKLKqivdhpallkggeqsVRRSGKMIRTMEiieeal 338
Cdd:TIGR00603 449 -AEVWCPMTPE---FYR---EYLREN-------SRKRMLLYVMNPNK---------------FRACQFLIRFHE------ 493

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A        339 DEGDKIAIFTQFV--------DMGKiirniiekelntevPFLYGELSKKERDDIISKFQNNPSVKFIVLSvKAGGFGINL 410
Cdd:TIGR00603 494 QRGDKIIVFSDNVfalkeyaiKLGK--------------PFIYGPTSQQERMQILQNFQHNPKVNTIFLS-KVGDTSIDL 558


                  ....*..
1Z6A_A        411 TSANRVI 417
Cdd:TIGR00603 559 PEANVLI 565
 
Name Accession Description Interval E-value
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 31-475 0e+00

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 631.49  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       31 PYNIKANLRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKENELTPSLVICPLSVLKNWEEELSKFAP 110
Cdd:COG0553 235 PAGLKATLRPYQLEGAAWLLFLRRLGLGGLLADDMGLGKTIQALALLLELKERGLARPVLIVAPTSLVGNWQRELAKFAP 314

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      111 HLRFAVFHEDRSKIK----LEDYDIILTTYAVLLRD-TRLKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKSKYRIALTG 185
Cdd:COG0553 315 GLRVLVLDGTRERAKganpFEDADLVITSYGLLRRDiELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTG 394

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      186 TPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFATPIKKGDNMAKEELKAIISPFILRRTKYDkaIINDLPDKIETNVYCN 265
Cdd:COG0553 395 TPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIEKGDEEALERLRRLLRPFLLRRTKED--VLKDLPEKTEETLYVE 472

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      266 LTPEQAAMYKAEVENLFNNIDSVTGIKRKGMILSTLLKLKQIVDHPAL-LKGGEQSVRRSGKMIRTMEIIEEALDEGDKI 344
Cdd:COG0553 473 LTPEQRALYEAVLEYLRRELEGAEGIRRRGLILAALTRLRQICSHPALlLEEGAELSGRSAKLEALLELLEELLAEGEKV 552

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      345 AIFTQFVDMGKIIRNIIEKElNTEVPFLYGELSKKERDDIISKFQNNPSVKFIVLSVKAGGFGINLTSANRVIHFDRWWN 424
Cdd:COG0553 553 LVFSQFTDTLDLLEERLEER-GIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWN 631

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|.
1Z6A_A      425 PAVEDQATDRVYRIGQTRNVIVHKLISVGTLEEKIDQLLAFKRSLFKDIIS 475
Cdd:COG0553 632 PAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRALAESVLG 682
DEXQc_arch_SWI2_SNF2 cd18012
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ...
 34-245 4.37e-124

DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350770 [Multi-domain]  Cd Length: 218  Bit Score: 361.11  E-value: 4.37e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       34 IKANLRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKENELTPSLVICPLSVLKNWEEELSKFAPHLR 113
Cdd:cd18012   1 LKATLRPYQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALLLSRKEEGRKGPSLVVAPTSLIYNWEEEAAKFAPELK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      114 FAVFHEDRSKIK----LEDYDIILTTYAVLLRDTR-LKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKSKYRIALTGTPI 188
Cdd:cd18012  81 VLVIHGTKRKREklraLEDYDLVITSYGLLRRDIElLKEVKFHYLVLDEAQNIKNPQTKTAKAVKALKADHRLALTGTPI 160

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
1Z6A_A      189 ENKVDDLWSIMTFLNPGLLGSYSEFKSKFATPIKK-GDNMAKEELKAIISPFILRRTK 245
Cdd:cd18012 161 ENHLGELWSIFDFLNPGLLGSYKRFKKRFAKPIEKdGDEEALEELKKLISPFILRRLK 218
DEXHc_Snf cd17919
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ...
 38-204 6.37e-75

DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350677 [Multi-domain]  Cd Length: 182  Bit Score: 234.00  E-value: 6.37e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKE-NELTPSLVICPLSVLKNWEEELSKFAPHLRFAV 116
Cdd:cd17919   1 LRPYQLEGLNFLLELYENGPGGILADEMGLGKTLQAIAFLAYLLKEgKERGPVLVVCPLSVLENWEREFEKWTPDLRVVV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      117 FH---EDRSKI----KLEDYDIILTTYAVLLRDT-RLKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKSKYRIALTGTPI 188
Cdd:cd17919  81 YHgsqRERAQIrakeKLDKFDVVLTTYETLRRDKaSLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLTGTPL 160

                       170
                ....*....|....*.
1Z6A_A      189 ENKVDDLWSIMTFLNP 204
Cdd:cd17919 161 QNNLEELWALLDFLDP 176
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 28-483 5.62e-74

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 252.41  E-value: 5.62e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A         28 LLEPYNIKANLRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKENELT-PSLVICPLSVLKNWEEELS 106
Cdd:PLN03142  160 LVQPSCIKGKMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLHEYRGITgPHMVVAPKSTLGNWMNEIR 239

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A        107 KFAPHLRFAVFH---EDRSKIKLE-----DYDIILTTYAVLLRD-TRLKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKS 177
Cdd:PLN03142  240 RFCPVLRAVKFHgnpEERAHQREEllvagKFDVCVTSFEMAIKEkTALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFST 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A        178 KYRIALTGTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFATPIKKGDNMAKEELKAIISPFILRRTKYDkaIINDLPDK 257
Cdd:PLN03142  320 NYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQISGENDQQEVVQQLHKVLRPFLLRRLKSD--VEKGLPPK 397

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A        258 IETNVYCNLTPEQAAMYKAEVEnlfNNIDSVTGIKRKGMILSTLLKLKQIVDHPALLKG---------GEQSVRRSGKMI 328
Cdd:PLN03142  398 KETILKVGMSQMQKQYYKALLQ---KDLDVVNAGGERKRLLNIAMQLRKCCNHPYLFQGaepgppyttGEHLVENSGKMV 474

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A        329 RTMEIIEEALDEGDKIAIFTQfvdMGKIIrNIIEKELNTEvPFLY----GELSKKERDDIISKFQNNPSVKFI-VLSVKA 403
Cdd:PLN03142  475 LLDKLLPKLKERDSRVLIFSQ---MTRLL-DILEDYLMYR-GYQYcridGNTGGEDRDASIDAFNKPGSEKFVfLLSTRA 549

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A        404 GGFGINLTSANRVIHFDRWWNPAVEDQATDRVYRIGQTRNVIVHKLISVGTLEEKI----------DQL------LAFKR 467
Cdd:PLN03142  550 GGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVieraykklalDALviqqgrLAEQK 629

                         490       500
                  ....*....|....*....|....*...
1Z6A_A        468 SLFKD------------IISSGDSWITE 483
Cdd:PLN03142  630 TVNKDellqmvrygaemVFSSKDSTITD 657
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
 41-314 3.91e-72

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 230.65  E-value: 3.91e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A         41 YQIKGFSWM-RFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKENELT--PSLVICPLSVLKNWEEELSKFA--PHLRFA 115
Cdd:pfam00176   1 YQIEGVNWMlSLENNLGRGGILADEMGLGKTLQTISLLLYLKHVDKNWggPTLIVVPLSLLHNWMNEFERWVspPALRVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A        116 VFHED--------RSKIKLEDYDIILTTYAVLLRDTR-LKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKSKYRIALTGT 186
Cdd:pfam00176  81 VLHGNkrpqerwkNDPNFLADFDVVITTYETLRKHKElLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A        187 PIENKVDDLWSIMTFLNPGLLGSYSEFKSKFATPIKKGDNMAK-EELKAIISPFILRRTKYDKAIinDLPDKIETNVYCN 265
Cdd:pfam00176 161 PLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERGGGKKGvSRLHKLLKPFLLRRTKKDVEK--SLPPKVEYILFCR 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
1Z6A_A        266 LTPEQAAMYKAEV-ENLFNNIDSVTGIKRKGM-ILSTLLKLKQIVDHPALL 314
Cdd:pfam00176 239 LSKLQRKLYQTFLlKKDLNAIKTGEGGREIKAsLLNILMRLRKICNHPGLI 289
DEXHc_Mot1 cd17999
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ...
 38-243 1.12e-65

DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350757 [Multi-domain]  Cd Length: 232  Bit Score: 211.83  E-value: 1.12e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWMRFMNKLGF-GIcLADDMGLGKTLQTIAVF--SDAKKENELT----PSLVICPLSVLKNWEEELSKFAP 110
Cdd:cd17999   1 LRPYQQEGINWLAFLNKYNLhGI-LCDDMGLGKTLQTLCILasDHHKRANSFNsenlPSLVVCPPTLVGHWVAEIKKYFP 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      111 HLRFAVFHED-------RSKIKLEDYDIILTTYAVLLRDTR-LKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKSKYRIA 182
Cdd:cd17999  80 NAFLKPLAYVgppqerrRLREQGEKHNVIVASYDVLRNDIEvLTKIEWNYCVLDEGHIIKNSKTKLSKAVKQLKANHRLI 159

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
1Z6A_A      183 LTGTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFATPI-----KKGDNMAKEE-LKAI------ISPFILRR 243
Cdd:cd17999 160 LSGTPIQNNVLELWSLFDFLMPGYLGTEKQFQRRFLKPIlasrdSKASAKEQEAgALALealhkqVLPFLLRR 232
DEXDc_SHPRH-like cd18008
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ...
 38-243 1.01e-62

DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350766 [Multi-domain]  Cd Length: 241  Bit Score: 204.44  E-value: 1.01e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWMRFmnkLGfGIcLADDMGLGKTLQTIA------------------VFSDAKKENELTPSLVICPLSVLK 99
Cdd:cd18008   1 LLPYQKQGLAWMLP---RG-GI-LADEMGLGKTIQALAlilatrpqdpkipeeleeNSSDPKKLYLSKTTLIVVPLSLLS 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      100 NWEEELSKF--APHLRFAVFHED---RSKIKLEDYDIILTTYAVLLRDTR-----------------LKEVEWKYIVIDE 157
Cdd:cd18008  76 QWKDEIEKHtkPGSLKVYVYHGSkriKSIEELSDYDIVITTYGTLASEFPknkkgggrdskekeaspLHRIRWYRVILDE 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      158 AQNIKNPQTKIFKAVKELKSKYRIALTGTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFATPIKKGDNMAKEELKAIIS 237
Cdd:cd18008 156 AHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFNSDISKPFSKNDRKALERLQALLK 235


                ....*.
1Z6A_A      238 PFILRR 243
Cdd:cd18008 236 PILLRR 241
DEXHc_ERCC6L2 cd18005
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ...
 38-243 2.15e-61

DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350763 [Multi-domain]  Cd Length: 245  Bit Score: 201.07  E-value: 2.15e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFS----------DAK-----------KENELTPSLVICPLS 96
Cdd:cd18005   1 LRDYQREGVEFMYDLYKNGRGGILGDDMGLGKTVQVIAFLAavlgktgtrrDREnnrprfkkkppASSAKKPVLIVAPLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       97 VLKNWEEELSKFApHLRFAVFHEDR------SKIKLEDYDIILTTYAVLLRDT-RLKEVEWKYIVIDEAQNIKNPQTKIF 169
Cdd:cd18005  81 VLYNWKDELDTWG-HFEVGVYHGSRkddeleGRLKAGRLEVVVTTYDTLRRCIdSLNSINWSAVIADEAHRIKNPKSKLT 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      170 KAVKELKSKYRIALTGTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFATPIKKGDNM------------AKEELKAIIS 237
Cdd:cd18005 160 QAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRSQFKKHFSEPIKRGQRHtatarelrlgrkRKQELAVKLS 239


                ....*.
1Z6A_A      238 PFILRR 243
Cdd:cd18005 240 KFFLRR 245
DEXHc_SMARCA1_SMARCA5 cd17997
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ...
 38-245 2.15e-56

DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350755 [Multi-domain]  Cd Length: 222  Bit Score: 187.14  E-value: 2.15e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSDAKK-ENELTPSLVICPLSVLKNWEEELSKFAPHLRFAV 116
Cdd:cd17997   4 MRDYQIRGLNWLISLFENGINGILADEMGLGKTLQTISLLGYLKHyKNINGPHLIIVPKSTLDNWMREFKRWCPSLRVVV 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      117 FHED--------RSKIKLEDYDIILTTYAVLLRD-TRLKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKSKYRIALTGTP 187
Cdd:cd17997  84 LIGDkeeradiiRDVLLPGKFDVCITSYEMVIKEkTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNRLLLTGTP 163

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
1Z6A_A      188 IENKVDDLWSIMTFLNPGLLGSYSEFKSKFATPIKKGDNMAK-EELKAIISPFILRRTK 245
Cdd:cd17997 164 LQNNLHELWALLNFLLPDVFTSSEDFDEWFNVNNCDDDNQEVvQRLHKVLRPFLLRRIK 222
DEXHc_CHD1L cd18006
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ...
 38-243 2.07e-55

DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350764 [Multi-domain]  Cd Length: 216  Bit Score: 184.56  E-value: 2.07e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSD-AKKENELTPSLVICPLSVLKNWEEELSKFAPHLRFAV 116
Cdd:cd18006   1 LRPYQLEGVNWLLQCRAEQHGCILGDEMGLGKTCQTISLLWYlAGRLKLLGPFLVLCPLSVLDNWKEELNRFAPDLSVIT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      117 FHEDRSK-------IKLE-DYDIILTTYAVLLRDTR-LKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKSKYRIALTGTP 187
Cdd:cd18006  81 YMGDKEKrldlqqdIKSTnRFHVLLTTYEICLKDASfLKSFPWASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLLTGTP 160

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
1Z6A_A      188 IENKVDDLWSIMTFLNPGLLG--SYSEFKSKFATpIKKGDNMAkEELKAIISPFILRR 243
Cdd:cd18006 161 IQNSLQELYALLSFIEPNVFPkdKLDDFIKAYSE-TDDESETV-EELHLLLQPFLLRR 216
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 324-450 2.47e-53

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 176.13  E-value: 2.47e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      324 SGKMIRTMEIIEEALDEGDKIAIFTQFVDMGKIIRNIIEKElNTEVPFLYGELSKKERDDIISKFQNNPSVKFIVLSVKA 403
Cdd:cd18793  10 SGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRER-GIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTKA 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
1Z6A_A      404 GGFGINLTSANRVIHFDRWWNPAVEDQATDRVYRIGQTRNVIVHKLI 450
Cdd:cd18793  89 GGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
DEXQc_SRCAP cd18003
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ...
 38-243 2.00e-51

DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350761 [Multi-domain]  Cd Length: 223  Bit Score: 174.46  E-value: 2.00e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSD-AKKENELTPSLVICPLSVLKNWEEELSKFAPHLRFAV 116
Cdd:cd18003   1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAHlACEKGNWGPHLIVVPTSVMLNWEMEFKRWCPGFKILT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      117 F---HEDRSK-----IKLEDYDIILTTYAVLLRDTR-LKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKSKYRIALTGTP 187
Cdd:cd18003  81 YygsAKERKLkrqgwMKPNSFHVCITSYQLVVQDHQvFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLLTGTP 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
1Z6A_A      188 IENKVDDLWSIMTFLNPGLLGSYSEFKSKFATP----IKKGDNMAKE---ELKAIISPFILRR 243
Cdd:cd18003 161 LQNSLMELWSLMHFLMPHIFQSHQEFKEWFSNPltamSEGSQEENEElvrRLHKVLRPFLLRR 223
DEXHc_ERCC6L cd18001
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ...
 38-243 3.33e-51

DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350759 [Multi-domain]  Cd Length: 232  Bit Score: 174.10  E-value: 3.33e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKENELTPSLVICPLSVLKNWEEELSKFAPHLRFAVF 117
Cdd:cd18001   1 LYPHQREGVAWLWSLHDGGKGGILADDMGLGKTVQICAFLSGMFDSGLIKSVLVVMPTSLIPHWVKEFAKWTPGLRVKVF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      118 HEDRSKIKLEDYD-------IILTTYAVLLRDT------RLKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKSKYRIALT 184
Cdd:cd18001  81 HGTSKKERERNLEriqrgggVLLTTYGMVLSNTeqlsadDHDEFKWDYVILDEGHKIKNSKTKSAKSLREIPAKNRIILT 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
1Z6A_A      185 GTPIENKVDDLWSIMTFLNPG-LLGSYSEFKSKFATPI-------------KKGDNMAkEELKAIISPFILRR 243
Cdd:cd18001 161 GTPIQNNLKELWALFDFACNGsLLGTRKTFKMEFENPItrgrdkdatqgekALGSEVA-ENLRQIIKPYFLRR 232
DEXHc_HELLS_SMARCA6 cd18009
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ...
 38-245 4.68e-51

DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350767 [Multi-domain]  Cd Length: 236  Bit Score: 173.73  E-value: 4.68e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKENELTPSLVICPLSVLKNWEEELSKFAPHLRFAVF 117
Cdd:cd18009   4 MRPYQLEGMEWLRMLWENGINGILADEMGLGKTIQTIALLAHLRERGVWGPFLVIAPLSTLPNWVNEFARFTPSVPVLLY 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      118 H---EDRSKIK---------LEDYDIILTTYAVLLRDT-RLKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKSKYRIALT 184
Cdd:cd18009  84 HgtkEERERLRkkimkregtLQDFPVVVTSYEIAMRDRkALQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNSDNRLLLT 163

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
1Z6A_A      185 GTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKF---ATPIKKGDNMAKEE---------LKAIISPFILRRTK 245
Cdd:cd18009 164 GTPLQNNLSELWSLLNFLLPDVFDDLSSFESWFdfsSLSDNAADISNLSEereqnivhmLHAILKPFLLRRLK 236
DEXHc_SMARCA2_SMARCA4 cd17996
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ...
 38-245 6.74e-46

DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350754 [Multi-domain]  Cd Length: 233  Bit Score: 160.23  E-value: 6.74e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWM--RFMNKLGfGIcLADDMGLGKTLQTIAVFS---DAKKENelTPSLVICPLSVLKNWEEELSKFAPHL 112
Cdd:cd17996   4 LKEYQLKGLQWMvsLYNNNLN-GI-LADEMGLGKTIQTISLITylmEKKKNN--GPYLVIVPLSTLSNWVSEFEKWAPSV 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      113 RFAVF-------HEDRSKIKLEDYDIILTTYAVLLRD-TRLKEVEWKYIVIDEAQNIKNPQTKIFKAVKE-LKSKYRIAL 183
Cdd:cd17996  80 SKIVYkgtpdvrKKLQSQIRAGKFNVLLTTYEYIIKDkPLLSKIKWKYMIIDEGHRMKNAQSKLTQTLNTyYHARYRLLL 159

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
1Z6A_A      184 TGTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFATPI-----KKGDNMAKEE-------LKAIISPFILRRTK 245
Cdd:cd17996 160 TGTPLQNNLPELWALLNFLLPKIFKSCKTFEQWFNTPFantgeQVKIELNEEEtlliirrLHKVLRPFLLRRLK 233
DEXHc_CHD6_7_8_9 cd17995
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ...
 38-243 4.29e-45

DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350753 [Multi-domain]  Cd Length: 223  Bit Score: 157.41  E-value: 4.29e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSD-AKKENELTPSLVICPLSVLKNWEEELSKFAPhLRFAV 116
Cdd:cd17995   1 LRDYQLEGVNWLLFNWYNRRNCILADEMGLGKTIQSIAFLEHlYQVEGIRGPFLVIAPLSTIPNWQREFETWTD-MNVVV 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      117 FH---EDRSKIKLEDY----------------DIILTTYAVLLRD-TRLKEVEWKYIVIDEAQNIKNPQTKIFKAVKELK 176
Cdd:cd17995  80 YHgsgESRQIIQQYEMyfkdaqgrkkkgvykfDVLITTYEMVIADaEELRKIPWRVVVVDEAHRLKNRNSKLLQGLKKLT 159

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
1Z6A_A      177 SKYRIALTGTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFatpikkGDnMAKEE----LKAIISPFILRR 243
Cdd:cd17995 160 LEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEF------GD-LKTAEqvekLQALLKPYMLRR 223
DEXHc_HLTF1_SMARC3 cd18071
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ...
 55-243 5.36e-45

DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350829 [Multi-domain]  Cd Length: 239  Bit Score: 158.02  E-value: 5.36e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       55 LGFGICLADDMGLGKTLQTIAVFSdakkeneLTPSLVICPLSVLKNWEEELSKFAP--HLRFAVFH---EDRSKIKLEDY 129
Cdd:cd18071  47 LVRGGILADDMGLGKTLTTISLIL-------ANFTLIVCPLSVLSNWETQFEEHVKpgQLKVYTYHggeRNRDPKLLSKY 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      130 DIILTTYAVLLRD------TRLKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKSKYRIALTGTPIENKVDDLWSIMTFLN 203
Cdd:cd18071 120 DIVLTTYNTLASDfgakgdSPLHTINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSLLSFLH 199

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
1Z6A_A      204 PGLLGSYSEFKSKFATPIKKGDNMAKEELKAIISPFILRR 243
Cdd:cd18071 200 LKPFSNPEYWRRLIQRPLTMGDPTGLKRLQVLMKQITLRR 239
DEXHc_RAD54 cd18004
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ...
 38-243 1.40e-43

DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350762 [Multi-domain]  Cd Length: 240  Bit Score: 153.98  E-value: 1.40e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWM-----RFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKEN-----ELTPSLVICPLSVLKNWEEELSK 107
Cdd:cd18004   1 LRPHQREGVQFLydcltGRRGYGGGGAILADEMGLGKTLQAIALVWTLLKQGpygkpTAKKALIVCPSSLVGNWKAEFDK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      108 FAPHLRFAVF-------HEDRSKIKL---EDYDIILTTYAVLLRDT-RLKEVEWKYIVI-DEAQNIKNPQTKIFKAVKEL 175
Cdd:cd18004  81 WLGLRRIKVVtadgnakDVKASLDFFssaSTYPVLIISYETLRRHAeKLSKKISIDLLIcDEGHRLKNSESKTTKALNSL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      176 KSKYRIALTGTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFATPIKKGDNMAK------------EELKAIISPFILRR 243
Cdd:cd18004 161 PCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPILRSRDPDAseedkelgaersQELSELTSRFILRR 240
DEXHc_SMARCA1 cd18065
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ...
 26-245 5.68e-43

DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350823 [Multi-domain]  Cd Length: 233  Bit Score: 152.48  E-value: 5.68e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       26 FQLLEPYNIKANLRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSDAKK-ENELTPSLVICPLSVLKNWEEE 104
Cdd:cd18065   4 FEESPSYVKGGTLRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLGYLKHyRNIPGPHMVLVPKSTLHNWMNE 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      105 LSKFAPHLRFAVFHED--------RSKIKLEDYDIILTTYAVLLRDTRL-KEVEWKYIVIDEAQNIKNPQTKIFKAVKEL 175
Cdd:cd18065  84 FKRWVPSLRAVCLIGDkdaraafiRDVMMPGEWDVCVTSYEMVIKEKSVfKKFNWRYLVIDEAHRIKNEKSKLSEIVREF 163

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      176 KSKYRIALTGTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFATPIKKGDNMAKEELKAIISPFILRRTK 245
Cdd:cd18065 164 KTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWFDTKNCLGDQKLVERLHAVLKPFLLRRIK 233
DEXHc_CHD1_2 cd17993
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ...
 38-243 8.74e-43

DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350751 [Multi-domain]  Cd Length: 218  Bit Score: 151.35  E-value: 8.74e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKENELT-PSLVICPLSVLKNWEEELSKFAPHLRFAV 116
Cdd:cd17993   2 LRDYQLTGLNWLAHSWCKGNNGILADEMGLGKTVQTISFLSYLFHSQQQYgPFLVVVPLSTMPAWQREFAKWAPDMNVIV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      117 ----------------FHEDRSKIKledYDIILTTYAVLLRD-TRLKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKSKY 179
Cdd:cd17993  82 ylgdiksrdtireyefYFSQTKKLK---FNVLLTTYEIILKDkAFLGSIKWQYLAVDEAHRLKNDESLLYEALKEFKTNN 158

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
1Z6A_A      180 RIALTGTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFATPIKKGDNMAKEELKaiisPFILRR 243
Cdd:cd17993 159 RLLITGTPLQNSLKELWALLHFLMPGKFDIWEEFEEEHDEEQEKGIADLHKELE----PFILRR 218
DEXHc_SMARCA5 cd18064
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ...
 38-257 2.13e-42

DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350822 [Multi-domain]  Cd Length: 244  Bit Score: 150.97  E-value: 2.13e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSDAKK-ENELTPSLVICPLSVLKNWEEELSKFAPHLRFAV 116
Cdd:cd18064  16 LRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHyRNIPGPHMVLVPKSTLHNWMAEFKRWVPTLRAVC 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      117 FHEDRSK--------IKLEDYDIILTTYAVLLRDTRL-KEVEWKYIVIDEAQNIKNPQTKIFKAVKELKSKYRIALTGTP 187
Cdd:cd18064  96 LIGDKDQraafvrdvLLPGEWDVCVTSYEMLIKEKSVfKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTP 175

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      188 IENKVDDLWSIMTFLNPGLLGSYSEFKSKFATPIKKGDNMAKEELKAIISPFILRRTKYDkaIINDLPDK 257
Cdd:cd18064 176 LQNNLHELWALLNFLLPDVFNSAEDFDSWFDTNNCLGDQKLVERLHMVLRPFLLRRIKAD--VEKSLPPK 243
DEXQc_INO80 cd18002
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ...
 38-243 9.03e-42

DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350760 [Multi-domain]  Cd Length: 229  Bit Score: 148.81  E-value: 9.03e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSD-AKKENELTPSLVICPLSVLKNWEEELSKFAPHLRFAV 116
Cdd:cd18002   1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLAHlAEEHNIWGPFLVIAPASTLHNWQQEISRFVPQFKVLP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      117 F----HE--------DRSKIKLED--YDIILTTYAVLLRDTR-LKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKSKYRI 181
Cdd:cd18002  81 YwgnpKDrkvlrkfwDRKNLYTRDapFHVVITSYQLVVQDEKyFQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCRNRL 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
1Z6A_A      182 ALTGTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFATPIKK----GDNMAKEELK---AIISPFILRR 243
Cdd:cd18002 161 LLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIEShaenKTGLNEHQLKrlhMILKPFMLRR 229
DEXHc_CHD2 cd18054
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ...
 38-243 1.31e-40

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350812 [Multi-domain]  Cd Length: 237  Bit Score: 146.30  E-value: 1.31e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKENEL-TPSLVICPLSVLKNWEEELSKFAPHLRFAV 116
Cdd:cd18054  21 LRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLyGPFLLVVPLSTLTSWQREFEIWAPEINVVV 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      117 FHED-RSKIKLEDYD------------IILTTYAVLLRD-TRLKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKSKYRIA 182
Cdd:cd18054 101 YIGDlMSRNTIREYEwihsqtkrlkfnALITTYEILLKDkTVLGSINWAFLGVDEAHRLKNDDSLLYKTLIDFKSNHRLL 180

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
1Z6A_A      183 LTGTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFAtpikKGDNMAKEELKAIISPFILRR 243
Cdd:cd18054 181 ITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHG----KGRENGYQSLHKVLEPFLLRR 237
DEXHc_ERCC6 cd18000
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ...
 38-207 1.34e-40

DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350758 [Multi-domain]  Cd Length: 193  Bit Score: 144.39  E-value: 1.34e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKENELT-PSLVICPLSVLKNWEEELSKFAPHLRFAV 116
Cdd:cd18000   1 LFKYQQTGVQWLWELHCQRVGGILGDEMGLGKTIQIIAFLAALHHSKLGLgPSLIVCPATVLKQWVKEFHRWWPPFRVVV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      117 FH------------------EDRSKIKLEDYDIILTTYAVLLRDTR-LKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKS 177
Cdd:cd18000  81 LHssgsgtgseeklgsierkSQLIRKVVGDGGILITTYEGFRKHKDlLLNHNWQYVILDEGHKIRNPDAEITLACKQLRT 160

                       170       180       190
                ....*....|....*....|....*....|
1Z6A_A      178 KYRIALTGTPIENKVDDLWSIMTFLNPGLL 207
Cdd:cd18000 161 PHRLILSGTPIQNNLKELWSLFDFVFPPYL 190
DEXHc_ATRX-like cd18007
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ...
 38-226 2.13e-38

DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350765 [Multi-domain]  Cd Length: 239  Bit Score: 140.12  E-value: 2.13e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFswmRFM----------NKLGFGICLADDMGLGKTLQTIAVF-SDAKKENELTPSLVICPLSVLKNWEEELS 106
Cdd:cd18007   1 LKPHQVEGV---RFLwsnlvgtdvgSDEGGGCILAHTMGLGKTLQVITFLhTYLAAAPRRSRPLVLCPASTLYNWEDEFK 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      107 KFAP--HLRFAVFHE-DRSKIKLEDYDII----------LTTYAVLLRDTRLKEVEWKY---------------IVIDEA 158
Cdd:cd18007  78 KWLPpdLRPLLVLVSlSASKRADARLRKInkwhkeggvlLIGYELFRNLASNATTDPRLkqefiaalldpgpdlLVLDEG 157

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
1Z6A_A      159 QNIKNPQTKIFKAVKELKSKYRIALTGTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFATPIKKGDN 226
Cdd:cd18007 158 HRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGTLKEFKKKFVKPIEAGQC 225
DEXHc_CHD3_4_5 cd17994
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ...
 38-243 3.12e-38

DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350752 [Multi-domain]  Cd Length: 196  Bit Score: 138.34  E-value: 3.12e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKENELT-PSLVICPLSVLKNWEEELSKFAPHLRFAV 116
Cdd:cd17994   1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHSKgPFLVSAPLSTIINWEREFEMWAPDFYVVT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      117 FHEDRskikledydIILTTYAVLLRDTR-LKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKSKYRIALTGTPIENKVDDL 195
Cdd:cd17994  81 YVGDH---------VLLTSYELISIDQAiLGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKIGYKLLLTGTPLQNNLEEL 151

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
1Z6A_A      196 WSIMTFLNPGLLGSYSEFKSKFATpIKKGDNMAKeeLKAIISPFILRR 243
Cdd:cd17994 152 FHLLNFLTPERFNNLQGFLEEFAD-ISKEDQIKK--LHDLLGPHMLRR 196
DEXHc_SMARCAD1 cd17998
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ...
 38-204 7.68e-37

DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350756 [Multi-domain]  Cd Length: 187  Bit Score: 134.44  E-value: 7.68e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKENELTPSLVICPLSVLKNWEEELSKFAPHLRFAVF 117
Cdd:cd17998   1 LKDYQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLAYLKEIGIPGPHLVVVPSSTLDNWLREFKRWCPSLKVEPY 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      118 H---EDRSKI------KLEDYDIILTTY--AVLLRDTR--LKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKSKYRIALT 184
Cdd:cd17998  81 YgsqEERKHLrydilkGLEDFDVIVTTYnlATSNPDDRsfFKRLKLNYVVYDEGHMLKNMTSERYRHLMTINANFRLLLT 160

                       170       180
                ....*....|....*....|
1Z6A_A      185 GTPIENKVDDLWSIMTFLNP 204
Cdd:cd17998 161 GTPLQNNLLELMSLLNFIMP 180
DEXHc_CHD8 cd18060
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ...
 38-243 2.12e-36

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350818 [Multi-domain]  Cd Length: 222  Bit Score: 134.41  E-value: 2.12e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKENELTPSLVICPLSVLKNWEEELSKFApHLRFAVF 117
Cdd:cd18060   1 LREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEVYNVGIHGPFLVIAPLSTITNWEREFNTWT-EMNTIVY 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      118 H---EDRSKIKLED----------------YDIILTTYAVLLRDT-RLKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKS 177
Cdd:cd18060  80 HgslASRQMIQQYEmyckdsrgrlipgaykFDALITTFEMILSDCpELREIEWRCVIIDEAHRLKNRNCKLLDSLKHMDL 159

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
1Z6A_A      178 KYRIALTGTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFatpikkGDNMAKEE---LKAIISPFILRR 243
Cdd:cd18060 160 EHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDF------GDLKTEEQvqkLQAILKPMMLRR 222
DEXHc_CHD1 cd18053
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ...
 38-243 4.05e-36

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350811 [Multi-domain]  Cd Length: 237  Bit Score: 134.02  E-value: 4.05e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKENEL-TPSLVICPLSVLKNWEEELSKFAPHLRFAV 116
Cdd:cd18053  21 LRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLyGPFLLVVPLSTLTSWQREIQTWAPQMNAVV 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      117 FHED---RSKIKLEDY----------DIILTTYAVLLRDTR-LKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKSKYRIA 182
Cdd:cd18053 101 YLGDinsRNMIRTHEWmhpqtkrlkfNILLTTYEILLKDKSfLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLL 180

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
1Z6A_A      183 LTGTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFAtpikKGDNMAKEELKAIISPFILRR 243
Cdd:cd18053 181 ITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEEHG----KGREYGYASLHKELEPFLLRR 237
DEXHc_TTF2 cd18072
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ...
 38-243 9.66e-36

DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350830 [Multi-domain]  Cd Length: 241  Bit Score: 132.99  E-value: 9.66e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWMRFM-NKLGFGICLADDMGLGKTLQTIAV--------------------FSDAKKENELTPS---LVIC 93
Cdd:cd18072   1 LLLHQKQALAWLLWReRQKPRGGILADDMGLGKTLTMIALilaqkntqnrkeeekekaltEWESKKDSTLVPSagtLVVC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       94 PLSVLKNWEEEL-SKFAPH-LRFAVFH---EDRSKIKLEDYDIILTTYAVLLRD-TRLKE---------VEWKYIVIDEA 158
Cdd:cd18072  81 PASLVHQWKNEVeSRVASNkLRVCLYHgpnRERIGEVLRDYDIVITTYSLVAKEiPTYKEesrssplfrIAWARIILDEA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      159 QNIKNPQTKIFKAVKELKSKYRIALTGTPIENKVDDLWSIMTFLNpglLGSYSEFKSkFATPIKKGDNMAKEELKAIISP 238
Cdd:cd18072 161 HNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFLR---CSPFDDLKV-WKKQVDNKSRKGGERLNILTKS 236


                ....*
1Z6A_A      239 FILRR 243
Cdd:cd18072 237 LLLRR 241
DEXHc_RAD54B cd18066
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ...
 38-243 6.03e-35

DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350824 [Multi-domain]  Cd Length: 235  Bit Score: 130.74  E-value: 6.03e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKG--FSWMRFMNKL---GFGICLADDMGLGKTLQTIAVFSDAKKENE------LTPSLVICPLSVLKNWEEELS 106
Cdd:cd18066   1 LRPHQREGieFLYECVMGMRvneRFGAILADEMGLGKTLQCISLIWTLLRQGPyggkpvIKRALIVTPGSLVKNWKKEFQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      107 KFAPHLRFAVF-----HEDRSKIKLEDYDIILTTYAVLLRD-TRLKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKSKYR 180
Cdd:cd18066  81 KWLGSERIKVFtvdqdHKVEEFIASPLYSVLIISYEMLLRSlDQISKLNFDLVICDEGHRLKNTSIKTTTALTSLSCERR 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
1Z6A_A      181 IALTGTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFATPI-------------KKGDNMAKeELKAIISPFILRR 243
Cdd:cd18066 161 IILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVYEEPIvrsreptatpeekKLGEARAA-ELTRLTGLFILRR 235
DEXHc_CHD5 cd18057
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ...
 38-243 6.27e-34

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350815 [Multi-domain]  Cd Length: 232  Bit Score: 127.87  E-value: 6.27e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIA-VFSDAKKENELTPSLVICPLSVLKNWEEELSKFAPHLRFAV 116
Cdd:cd18057   1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVfLYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      117 F---HEDRSKIK-----LED-------------------YDIILTTYAVLLRDTR-LKEVEWKYIVIDEAQNIKNPQTKI 168
Cdd:cd18057  81 YtgdKESRSVIRenefsFEDnairsgkkvfrmkkeaqikFHVLLTSYELITIDQAiLGSIEWACLVVDEAHRLKNNQSKF 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
1Z6A_A      169 FKAVKELKSKYRIALTGTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFATpIKKGDNMAKeeLKAIISPFILRR 243
Cdd:cd18057 161 FRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFAD-ISKEDQIKK--LHDLLGPHMLRR 232
DEXHc_SMARCA2 cd18063
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ...
 19-245 6.99e-34

DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350821 [Multi-domain]  Cd Length: 251  Bit Score: 128.26  E-value: 6.99e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       19 SHMASKSFQLLEPYNIKANLRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKENELT-PSLVICPLSV 97
Cdd:cd18063   5 AHAITERVEKQSSLLINGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNgPYLIIVPLST 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       98 LKNWEEELSKFAPH-----------LRFAVFHEDRSKikleDYDIILTTYAVLLRDTR-LKEVEWKYIVIDEAQNIKNPQ 165
Cdd:cd18063  85 LSNWTYEFDKWAPSvvkisykgtpaMRRSLVPQLRSG----KFNVLLTTYEYIIKDKHiLAKIRWKYMIVDEGHRMKNHH 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      166 TKIFKAVK-ELKSKYRIALTGTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFATPIK-KGD--NMAKEE-------LKA 234
Cdd:cd18063 161 CKLTQVLNtHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAmTGErvDLNEEEtiliirrLHK 240

                       250
                ....*....|.
1Z6A_A      235 IISPFILRRTK 245
Cdd:cd18063 241 VLRPFLLRRLK 251
DEXHc_CHD6 cd18058
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ...
 38-243 2.15e-32

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350816 [Multi-domain]  Cd Length: 222  Bit Score: 123.23  E-value: 2.15e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKENELTPSLVICPLSVLKNWEEELSKFAPH------ 111
Cdd:cd18058   1 LREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLSEIFLMGIRGPFLIIAPLSTITNWEREFRTWTEMnaivyh 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      112 ---------LRFAVFHEDRSKIKLE---DYDIILTTYAVLLRDT-RLKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKSK 178
Cdd:cd18058  81 gsqisrqmiQQYEMYYRDEQGNPLSgifKFQVVITTFEMILADCpELKKINWSCVIIDEAHRLKNRNCKLLEGLKLMALE 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
1Z6A_A      179 YRIALTGTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFatpikkGDNMAKEELK---AIISPFILRR 243
Cdd:cd18058 161 HKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEF------GDLKTEEQVKklqSILKPMMLRR 222
DEXHc_SMARCA4 cd18062
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ...
 34-245 6.39e-32

DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350820 [Multi-domain]  Cd Length: 251  Bit Score: 122.85  E-value: 6.39e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       34 IKANLRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKENELT-PSLVICPLSVLKNWEEELSKFAPHL 112
Cdd:cd18062  20 VNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINgPFLIIVPLSTLSNWVYEFDKWAPSV 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      113 RFAVFHEDRS-------KIKLEDYDIILTTYAVLLRDTR-LKEVEWKYIVIDEAQNIKNPQTKIFKAVK-ELKSKYRIAL 183
Cdd:cd18062 100 VKVSYKGSPAarrafvpQLRSGKFNVLLTTYEYIIKDKQiLAKIRWKYMIVDEGHRMKNHHCKLTQVLNtHYVAPRRLLL 179

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
1Z6A_A      184 TGTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFATPIK---KGDNMAKEE-------LKAIISPFILRRTK 245
Cdd:cd18062 180 TGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAmtgEKVDLNEEEtiliirrLHKVLRPFLLRRLK 251
DEXHc_CHD7 cd18059
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ...
 38-243 8.73e-32

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350817 [Multi-domain]  Cd Length: 222  Bit Score: 121.68  E-value: 8.73e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKENELTPSLVICPLSVLKNWEEELSKFApHLRFAVF 117
Cdd:cd18059   1 LREYQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFLVIAPLSTIPNWEREFRTWT-ELNVVVY 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      118 HEDR-SKIKLEDYDI------------------ILTTYAVLLRDT-RLKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKS 177
Cdd:cd18059  80 HGSQaSRRTIQLYEMyfkdpqgrvikgsykfhaIITTFEMILTDCpELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDL 159

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
1Z6A_A      178 KYRIALTGTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFatpikkGDNMAKEE---LKAIISPFILRR 243
Cdd:cd18059 160 EHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEF------GDLKTEEQvqkLQAILKPMMLRR 222
DEXHc_CHD3 cd18055
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ...
 38-243 2.61e-31

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350813 [Multi-domain]  Cd Length: 232  Bit Score: 120.89  E-value: 2.61e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIA-VFSDAKKENELTPSLVICPLSVLKNWEEELSKFAPHLRFAV 116
Cdd:cd18055   1 LHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVfLYSLYKEGHTKGPFLVSAPLSTIINWEREFQMWAPDFYVVT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      117 FHEDRS------------------------KIKLE---DYDIILTTYAVLLRDTR-LKEVEWKYIVIDEAQNIKNPQTKI 168
Cdd:cd18055  81 YTGDKDsraiirenefsfddnavkggkkafKMKREaqvKFHVLLTSYELVTIDQAaLGSIRWACLVVDEAHRLKNNQSKF 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
1Z6A_A      169 FKAVKELKSKYRIALTGTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFATpIKKGDNMAKeeLKAIISPFILRR 243
Cdd:cd18055 161 FRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFAD-ISKEDQIKK--LHDLLGPHMLRR 232
DEXQc_SHPRH cd18070
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ...
 38-242 5.04e-31

DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350828 [Multi-domain]  Cd Length: 257  Bit Score: 120.53  E-value: 5.04e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWMRFmnkLGfGIcLADDMGLGKTLQTIA-VFSDAKKENELTPS-------------------------LV 91
Cdd:cd18070   1 LLPYQRRAVNWMLV---PG-GI-LADEMGLGKTVEVLAlILLHPRPDNDLDAAdddsdemvccpdclvaetpvsskatLI 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       92 ICPLSVLKNWEEELSKFAP-HLRFAVFH--EDRSKIK------LEDYDIILTTYAVL-------------LRDTR----- 144
Cdd:cd18070  76 VCPSAILAQWLDEINRHVPsSLKVLTYQgvKKDGALAspapeiLAEYDIVVTTYDVLrtelhyaeanrsnRRRRRqkrye 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      145 -----LKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKSKYRIALTGTPIENKVDDLWSIMTFL--NPGllgsYSEFKSKF 217
Cdd:cd18070 156 appspLVLVEWWRVCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSFLgvEPF----CDSDWWAR 231

                       250       260
                ....*....|....*....|....*
1Z6A_A      218 ATPIKKGDNMAKEELKAIISPFILR 242
Cdd:cd18070 232 VLIRPQGRNKAREPLAALLKELLWR 256
DEXHc_CHD4 cd18056
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ...
 38-243 5.73e-31

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350814 [Multi-domain]  Cd Length: 232  Bit Score: 119.78  E-value: 5.73e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQT-IAVFSDAKKENELTPSLVICPLSVLKNWEEELSKFAPHLRFAV 116
Cdd:cd18056   1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTaVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      117 FHEDR------------------------SKIKLE---DYDIILTTYAVLLRDTR-LKEVEWKYIVIDEAQNIKNPQTKI 168
Cdd:cd18056  81 YVGDKdsraiirenefsfednairggkkaSRMKKEasvKFHVLLTSYELITIDMAiLGSIDWACLIVDEAHRLKNNQSKF 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
1Z6A_A      169 FKAVKELKSKYRIALTGTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFATpIKKGDNMAKeeLKAIISPFILRR 243
Cdd:cd18056 161 FRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFAD-IAKEDQIKK--LHDMLGPHMLRR 232
DEXHc_CHD9 cd18061
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ...
 38-243 3.11e-29

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350819 [Multi-domain]  Cd Length: 222  Bit Score: 114.72  E-value: 3.11e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWMRFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKENELTPSLVICPLSVLKNWEEELSKFApHLRFAVF 117
Cdd:cd18061   1 LREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFLYEILLTGIRGPFLIIAPLSTIANWEREFRTWT-DLNVVVY 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      118 HEDR-SKIKLEDYDI------------------ILTTYAVLLRDT-RLKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKS 177
Cdd:cd18061  80 HGSLiSRQMIQQYEMyfrdsqgriirgayrfqaIITTFEMILGGCpELNAIDWRCVIIDEAHRLKNKNCKLLEGLKLMNL 159

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
1Z6A_A      178 KYRIALTGTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFatpikkGDNMAKEE---LKAIISPFILRR 243
Cdd:cd18061 160 EHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEF------GDLKTEEQvqkLQAILKPMMLRR 222
DEXDc smart00487
DEAD-like helicases superfamily;
37-199 1.16e-28

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 112.59  E-value: 1.16e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A          37 NLRPYQIKGFSWMRFMNKlgfGICLADDMGLGKTLQTIAVFSDAKKENELTPSLVICPLSVL-KNWEEELSKFAPHLRFA 115
Cdd:smart00487   8 PLRPYQKEAIEALLSGLR---DVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELaEQWAEELKKLGPSLGLK 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A         116 V--------FHEDRSKIKLEDYDIILTTYAVLLRD---TRLKEVEWKYIVIDEAQNIKNPQTK--IFKAVKEL-KSKYRI 181
Cdd:smart00487  85 VvglyggdsKREQLRKLESGKTDILVTTPGRLLDLlenDKLSLSNVDLVILDEAHRLLDGGFGdqLEKLLKLLpKNVQLL 164

                          170
                   ....*....|....*...
1Z6A_A         182 ALTGTPIENKVDDLWSIM 199
Cdd:smart00487 165 LLSATPPEEIENLLELFL 182
DEXHc_HARP_SMARCAL1 cd18010
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ...
 38-213 1.78e-28

DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350768 [Multi-domain]  Cd Length: 213  Bit Score: 112.30  E-value: 1.78e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGfswmrfmnkLGFGI-----CL-ADDMGLGKTLQTIAVfSDAKKENelTPSLVICPLSVLKNWEEELSKFAPH 111
Cdd:cd18010   1 LLPFQREG---------VCFALrrggrVLiADEMGLGKTVQAIAI-AAYYREE--WPLLIVCPSSLRLTWADEIERWLPS 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      112 L---RFAVFHEDRSKIKLEDYDIILTTYAVLLR-DTRLKEVEWKYIVIDEAQNIKNPQTKIFKAVKEL--KSKYRIALTG 185
Cdd:cd18010  69 LppdDIQVIVKSKDGLRDGDAKVVIVSYDLLRRlEKQLLARKFKVVICDESHYLKNSKAKRTKAALPLlkRAKRVILLSG 148

                       170       180
                ....*....|....*....|....*...
1Z6A_A      186 TPIENKVDDLWSIMTFLNPGLLGSYSEF 213
Cdd:cd18010 149 TPALSRPIELFTQLDALDPKLFGRFHDF 176
DEXHc_ARIP4 cd18069
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ...
 38-227 1.83e-28

DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350827 [Multi-domain]  Cd Length: 227  Bit Score: 112.60  E-value: 1.83e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWM---------RFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKENELTPSLVICPLSVLKNWEEELSKF 108
Cdd:cd18069   1 LKPHQIGGIRFLydniiesleRYKGSSGFGCILAHSMGLGKTLQVISFLDVLLRHTGAKTVLAIVPVNTLQNWLSEFNKW 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      109 APHlrfavfHEDRSKIKLEDYDIILTTYAVLLRDTRLKEVE-WKY--------------------IVIDEAQNIKNPQTK 167
Cdd:cd18069  81 LPP------PEALPNVRPRPFKVFILNDEHKTTAARAKVIEdWVKdggvllmgyemfrlrpgpdvVICDEGHRIKNCHAS 154

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      168 IFKAVKELKSKYRIALTGTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFATPIKKGDNM 227
Cdd:cd18069 155 TSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCV 214
DEXHc_RAD54A cd18067
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ...
 38-243 2.76e-28

DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350825 [Multi-domain]  Cd Length: 243  Bit Score: 112.56  E-value: 2.76e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGfswMRFM--------NKLGFGICLADDMGLGKTLQTIAVFSDAKKEN-----ELTPSLVICPLSVLKNWEEE 104
Cdd:cd18067   1 LRPHQREG---VKFLyrcvtgrrIRGSHGCIMADEMGLGKTLQCITLMWTLLRQSpqckpEIDKAIVVSPSSLVKNWANE 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      105 LSKFApHLRFAVFHEDRSKIKLEDYD---------------IILTTYAVLLRDTR-LKEVEWKYIVIDEAQNIKNPQTKI 168
Cdd:cd18067  78 LGKWL-GGRLQPLAIDGGSKKEIDRKlvqwasqqgrrvstpVLIISYETFRLHVEvLQKGEVGLVICDEGHRLKNSDNQT 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      169 FKAVKELKSKYRIALTGTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFATPIKKG---DNMAKE---------ELKAII 236
Cdd:cd18067 157 YQALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNFELPILKGrdaDASEKErqlgeeklqELISIV 236


                ....*..
1Z6A_A      237 SPFILRR 243
Cdd:cd18067 237 NRCIIRR 243
DEXDc_RapA cd18011
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ...
 38-243 3.32e-25

DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350769 [Multi-domain]  Cd Length: 207  Bit Score: 102.75  E-value: 3.32e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFswMRFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKENELTPSLVICPLSVLKNWEEEL-SKFapHLRFAV 116
Cdd:cd18011   1 PLPHQIDAV--LRALRKPPVRLLLADEVGLGKTIEAGLIIKELLLRGDAKRVLILCPASLVEQWQDELqDKF--GLPFLI 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      117 FheDRSKIK---------LEDYDIILTTYAVLLRDTR----LKEVEWKYIVIDEAQNIKN----PQTKIFKAVKEL--KS 177
Cdd:cd18011  77 L--DRETAAqlrrlignpFEEFPIVIVSLDLLKRSEErrglLLSEEWDLVVVDEAHKLRNsgggKETKRYKLGRLLakRA 154

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
1Z6A_A      178 KYRIALTGTPIENKVDDLWSIMTFLNPGLLGSysefkskfatpikKGDNMAKEELKAIISPFILRR 243
Cdd:cd18011 155 RHVLLLTATPHNGKEEDFRALLSLLDPGRFAV-------------LGRFLRLDGLREVLAKVLLRR 207
DEXHc_ATRX cd18068
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ...
 38-224 3.81e-25

DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350826 [Multi-domain]  Cd Length: 246  Bit Score: 103.81  E-value: 3.81e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWM---------RFMNKLGFGICLADDMGLGKTLQTIA----VFSDAKKENeLTPSLVICPLSVLKNWEEE 104
Cdd:cd18068   1 LKPHQVDGVQFMwdccceslkKTKKSPGSGCILAHCMGLGKTLQVVTflhtVLLCEKLEN-FSRVLVVCPLNTVLNWLNE 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      105 LSKFAPHLR----FAVFHEDRSKIKLE-----------------DYDI--ILTTYAVLLRDTRLKEVEWKY--------I 153
Cdd:cd18068  80 FEKWQEGLKdeekIEVNELATYKRPQErsyklqrwqeeggvmiiGYDMyrILAQERNVKSREKLKEIFNKAlvdpgpdfV 159

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
1Z6A_A      154 VIDEAQNIKNPQTKIFKAVKELKSKYRIALTGTPIENKVDDLWSIMTFLNPGLLGSYSEFKSKFATPIKKG 224
Cdd:cd18068 160 VCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRFVNPIQNG 230
DEXQc_bact_SNF2 cd18013
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ...
 38-226 3.75e-23

DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350771 [Multi-domain]  Cd Length: 218  Bit Score: 97.42  E-value: 3.75e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFSWMrfMNKLGFGICLadDMGLGKTLQTIAVFSDAKKENELTPSLVICPLSVLKN-WEEELSKFA--PHLRF 114
Cdd:cd18013   1 PHPYQKVAINFI--IEHPYCGLFL--DMGLGKTVTTLTALSDLQLDDFTRRVLVIAPLRVARStWPDEVEKWNhlRNLTV 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      115 AVFHE---DRSKIKLEDYDIILTTYAVL--LRDTRLKEVEWKYIVIDEAQNIKNPQTKIFKAVKELKSKYR--IALTGTP 187
Cdd:cd18013  77 SVAVGterQRSKAANTPADLYVINRENLkwLVNKSGDPWPFDMVVIDELSSFKSPRSKRFKALRKVRPVIKrlIGLTGTP 156

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
1Z6A_A      188 IENKVDDLWSIMTFLNPG-LLG-SYSEFKSKFATPIKKGDN 226
Cdd:cd18013 157 SPNGLMDLWAQIALLDQGeRLGrSITAYRERWFDPDKRNGQ 197
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 325-439 8.85e-22

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 89.96  E-value: 8.85e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A        325 GKMIRTMEIIEEAldEGDKIAIFTQFVDMgkIIRNIIEKELNTEVPFLYGELSKKERDDIISKFQNNPSvkFIVLSVKAG 404
Cdd:pfam00271   1 EKLEALLELLKKE--RGGKVLIFSQTKKT--LEAELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKI--DVLVATDVA 74

                          90       100       110
                  ....*....|....*....|....*....|....*
1Z6A_A        405 GFGINLTSANRVIHFDRWWNPAVEDQATDRVYRIG 439
Cdd:pfam00271  75 ERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
38-417 1.67e-20

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 94.71  E-value: 1.67e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKGFS--WMRFMNKLGFGICLADdMGLGKTLqtIAVFsDAKKENELTPSLVICPLSVLKN-WEEELSKFaphLRF 114
Cdd:COG1061  81 LRPYQQEALEalLAALERGGGRGLVVAP-TGTGKTV--LALA-LAAELLRGKRVLVLVPRRELLEqWAEELRRF---LGD 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      115 AVFHEDRSKIkleDYDIILTTYAVLLRDTRLKEV--EWKYIVIDEAQNIKNPQTKifKAVKELKSKYRIALTGTPIENkv 192
Cdd:COG1061 154 PLAGGGKKDS---DAPITVATYQSLARRAHLDELgdRFGLVIIDEAHHAGAPSYR--RILEAFPAAYRLGLTATPFRS-- 226

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      193 DDLWSIMTFLNpGLLGSYSefkskfatpikkgdnmAKEELKA-IISPFILRRtkydkaiindlpdkietnVYCNLTPEQA 271
Cdd:COG1061 227 DGREILLFLFD-GIVYEYS----------------LKEAIEDgYLAPPEYYG------------------IRVDLTDERA 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      272 AmYKAEVENLFNNIDSVTgiKRKGMILSTLLklkqivdhpallkggeqsvRRSGKMIRTMeiieealdegdkiaIFTQFV 351
Cdd:COG1061 272 E-YDALSERLREALAADA--ERKDKILRELL-------------------REHPDDRKTL--------------VFCSSV 315

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
1Z6A_A      352 DMGKIIRNIIeKELNTEVPFLYGELSKKERDDIISKFQNNPSVkfIVLSVKAGGFGINLTSANRVI 417
Cdd:COG1061 316 DHAEALAELL-NEAGIRAAVVTGDTPKKEREEILEAFRDGELR--ILVTVDVLNEGVDVPRLDVAI 378
HELICc smart00490
helicase superfamily c-terminal domain;
363-439 2.91e-18

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 79.18  E-value: 2.91e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
1Z6A_A         363 KELNTEVPFLYGELSKKERDDIISKFQNNPSVkfIVLSVKAGGFGINLTSANRVIHFDRWWNPAVEDQATDRVYRIG 439
Cdd:smart00490   8 KELGIKVARLHGGLSQEEREEILDKFNNGKIK--VLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
DEXHc_RE cd17926
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ...
 38-187 2.73e-11

DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350684 [Multi-domain]  Cd Length: 146  Bit Score: 61.55  E-value: 2.73e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       38 LRPYQIKG-FSWMRFMNKLGFGICLAddMGLGKTLQTIAVFSDAKKEneltPSLVICP-LSVLKNWEEELSKFAPHLRFA 115
Cdd:cd17926   1 LRPYQEEAlEAWLAHKNNRRGILVLP--TGSGKTLTALALIAYLKEL----RTLIVVPtDALLDQWKERFEDFLGDSSIG 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
1Z6A_A      116 VFHEDRSKiKLEDYDIILTTYAVLLRDtrLKEV-----EWKYIVIDEAQNIknPQTKIFKAVKELKSKYRIALTGTP 187
Cdd:cd17926  75 LIGGGKKK-DFDDANVVVATYQSLSNL--AEEEkdlfdQFGLLIVDEAHHL--PAKTFSEILKELNAKYRLGLTATP 146
ResIII pfam04851
Type III restriction enzyme, res subunit;
37-189 3.53e-11

Type III restriction enzyme, res subunit;


Pssm-ID: 398492 [Multi-domain]  Cd Length: 162  Bit Score: 61.53  E-value: 3.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A         37 NLRPYQIKGF-SWMRFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKENELTPSLVICP-LSVLKNWEEELSKFAPHLRF 114
Cdd:pfam04851   3 ELRPYQIEAIeNLLESIKNGQKRGLIVMATGSGKTLTAAKLIARLFKKGPIKKVLFLVPrKDLLEQALEEFKKFLPNYVE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A        115 A--VFHEDRSKIKLEDYDIILTTYAVLLRDTRLKEVE-----WKYIVIDEAQNIknpQTKIFKAVKE-LKSKYRIALTGT 186
Cdd:pfam04851  83 IgeIISGDKKDESVDDNKIVVTTIQSLYKALELASLEllpdfFDVIIIDEAHRS---GASSYRNILEyFKPAFLLGLTAT 159


                  ...
1Z6A_A        187 PIE 189
Cdd:pfam04851 160 PER 162
SF2_C_XPB cd18789
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ...
 332-417 1.04e-09

C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350176 [Multi-domain]  Cd Length: 153  Bit Score: 56.87  E-value: 1.04e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      332 EIIEEALD---EGDKIAIFTQFVDMGKIIrniiEKELNteVPFLYGELSKKERDDIISKFQNNPsVKFIVLSvKAGGFGI 408
Cdd:cd18789  37 RALEELLKrheQGDKIIVFTDNVEALYRY----AKRLL--KPFITGETPQSEREEILQNFREGE-YNTLVVS-KVGDEGI 108


                ....*....
1Z6A_A      409 NLTSANRVI 417
Cdd:cd18789 109 DLPEANVAI 117
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 56-161 7.63e-09

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 54.33  E-value: 7.63e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       56 GFGICLADDMGLGKTL--QTIAVFSDAKKEnelTPSLVICPLSVL-KNWEEELSK-FAPHLRFAVFH-----EDRSKIKL 126
Cdd:cd00046   1 GENVLITAPTGSGKTLaaLLAALLLLLKKG---KKVLVLVPTKALaLQTAERLRElFGPGIRVAVLVggssaEEREKNKL 77

                        90       100       110
                ....*....|....*....|....*....|....*....
1Z6A_A      127 EDYDIILTTYAVL----LRDTRLKEVEWKYIVIDEAQNI 161
Cdd:cd00046  78 GDADIIIATPDMLlnllLREDRLFLKDLKLIIVDEAHAL 116
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 342-450 5.33e-08

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 50.01  E-value: 5.33e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      342 DKIAIFTQFVDMGKIIRNIIEkelntevpflygelskkerddiiskfqnnpsvkfIVLSVKAGGFGINLTSANRVIHFDR 421
Cdd:cd18785   4 VKIIVFTNSIEHAEEIASSLE----------------------------------ILVATNVLGEGIDVPSLDTVIFFDP 49

                        90       100
                ....*....|....*....|....*....
1Z6A_A      422 WWNPAVEDQATDRVYRIGQtRNVIVHKLI 450
Cdd:cd18785  50 PSSAASYIQRVGRAGRGGK-DEGEVILFV 77
DEXHc_XPB cd18029
DEXH-box helicase domain of TFIIH XPB subunit and similar proteins; TFIIH basal transcription ...
 35-186 1.59e-07

DEXH-box helicase domain of TFIIH XPB subunit and similar proteins; TFIIH basal transcription factor complex helicase XPB subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350787 [Multi-domain]  Cd Length: 169  Bit Score: 51.15  E-value: 1.59e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       35 KANLRPYQIKGFSWMrFMN-KLGFGI----CladdmGLGKTLQTIAVFSDAKKEneltpSLVICPLSV-LKNWEEELSKF 108
Cdd:cd18029   6 STQLRPYQEKALSKM-FGNgRARSGVivlpC-----GAGKTLVGITAACTIKKS-----TLVLCTSAVsVEQWRRQFLDW 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A      109 --APHLRFAVFHEDRsKIKLEDYDIILTTYAVLLRDTR-----------LKEVEWKYIVIDEAQNIKNPqtkIFKAVKEL 175
Cdd:cd18029  75 ttIDDEQIGRFTSDK-KEIFPEAGVTVSTYSMLANTRKrspesekfmefITEREWGLIILDEVHVVPAP---MFRRVLTL 150

                       170
                ....*....|..
1Z6A_A      176 -KSKYRIALTGT 186
Cdd:cd18029 151 qKAHCKLGLTAT 162
DEXHc_Hrq1-like cd17923
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ...
 68-158 3.22e-06

DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350681 [Multi-domain]  Cd Length: 182  Bit Score: 47.58  E-value: 3.22e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       68 GKTLQ-TIAVFSDAKKENELTpSLVICPLSVLKN-WEEELSKFA----PHLRFAVF-----HEDRSKIKLEDYDIILTT- 135
Cdd:cd17923  27 GKSLCyQLPILEALLRDPGSR-ALYLYPTKALAQdQLRSLRELLeqlgLGIRVATYdgdtpREERRAIIRNPPRILLTNp 105

                        90       100
                ....*....|....*....|....*....
1Z6A_A      136 ----YAVLLRDTRLKEV--EWKYIVIDEA 158
Cdd:cd17923 106 dmlhYALLPHHDRWARFlrNLRYVVLDEA 134
ERCC3_RAD25_C pfam16203
ERCC3/RAD25/XPB C-terminal helicase; This is the C-terminal helicase domain of ERCC3, RAD25 ...
 341-419 2.76e-05

ERCC3/RAD25/XPB C-terminal helicase; This is the C-terminal helicase domain of ERCC3, RAD25 and XPB helicases.


Pssm-ID: 406585  Cd Length: 248  Bit Score: 45.67  E-value: 2.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A        341 GDKIAIFTQfvdmgkiirNI-----IEKELNteVPFLYGELSKKERDDIISKFQNNPSVKFIVLSvKAGGFGINLTSANR 415
Cdd:pfam16203  60 GDKIIVFSD---------NVfalkeYAKKLN--KPYIYGGTSQAERMRILQNFKHNPNVNTIFLS-KVGDTSIDLPEANV 127


                  ....*...
1Z6A_A        416 VI----HF 419
Cdd:pfam16203 128 LIqissHF 135
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 66-195 3.83e-05

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 44.16  E-value: 3.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A         66 GLGKTLQT-IAVFSDAKKENELTPSLVICPLSVL-KNWEEELSKFAPHLRFAV--------FHEDRSKIKleDYDIILTT 135
Cdd:pfam00270  24 GSGKTLAFlLPALEALDKLDNGPQALVLAPTRELaEQIYEELKKLGKGLGLKVasllggdsRKEQLEKLK--GPDILVGT 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
1Z6A_A        136 YAVLL----RDTRLKEVewKYIVIDEAQNIKN----PQtkIFKAVKELKSKYRI-ALTGTPIENkVDDL 195
Cdd:pfam00270 102 PGRLLdllqERKLLKNL--KLLVLDEAHRLLDmgfgPD--LEEILRRLPKKRQIlLLSATLPRN-LEDL 165
rad25 TIGR00603
DNA repair helicase rad25; All proteins in this family for which functions are known are ...
 36-417 2.32e-04

DNA repair helicase rad25; All proteins in this family for which functions are known are DNA-DNA helicases used for the initiation of nucleotide excision repair and transacription as part of the TFIIH complex.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273168 [Multi-domain]  Cd Length: 732  Bit Score: 44.02  E-value: 2.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A         36 ANLRPYQIKGFSWMrFMNKLGFGICLADDMGLGKTLQTIAVFSDAKKEneltpSLVICPLSV-LKNWEEELSKF--APHL 112
Cdd:TIGR00603 254 TQIRPYQEKSLSKM-FGNGRARSGIIVLPCGAGKSLVGVTAACTVKKS-----CLVLCTSAVsVEQWKQQFKMWstIDDS 327

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A        113 RFAVFHEDRSKIKLEDYDIILTTYAVLLRDTR-----------LKEVEWKYIVIDEAQNIknPQTKIFKAVKELKSKYRI 181
Cdd:TIGR00603 328 QICRFTSDAKERFHGEAGVVVSTYSMVAHTGKrsyesekvmewLTNREWGLILLDEVHVV--PAAMFRRVLTIVQAHCKL 405

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A        182 ALTGTPI--ENKVDDLwsimTFL-NPGLlgsyseFKSKFATPIKKGdnmakeelkaiispFILRRTKydkaiindlpdki 258
Cdd:TIGR00603 406 GLTATLVreDDKITDL----NFLiGPKL------YEANWMELQKKG--------------FIANVQC------------- 448

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A        259 eTNVYCNLTPEqaaMYKaevENLFNNidsvtgiKRKGMILSTLLKLKqivdhpallkggeqsVRRSGKMIRTMEiieeal 338
Cdd:TIGR00603 449 -AEVWCPMTPE---FYR---EYLREN-------SRKRMLLYVMNPNK---------------FRACQFLIRFHE------ 493

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A        339 DEGDKIAIFTQFV--------DMGKiirniiekelntevPFLYGELSKKERDDIISKFQNNPSVKFIVLSvKAGGFGINL 410
Cdd:TIGR00603 494 QRGDKIIVFSDNVfalkeyaiKLGK--------------PFIYGPTSQQERMQILQNFQHNPKVNTIFLS-KVGDTSIDL 558


                  ....*..
1Z6A_A        411 TSANRVI 417
Cdd:TIGR00603 559 PEANVLI 565
YprA COG1205
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ...
 68-158 2.43e-03

ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];


Pssm-ID: 440818 [Multi-domain]  Cd Length: 758  Bit Score: 40.59  E-value: 2.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       68 GKTLQ-TIAVFSDAKKENELTpSLVICPLSVL-----KNWEEELSKFAPHLRFAVFH-----EDRSKIkLEDYDIILTT- 135
Cdd:COG1205  83 GKSLAyLLPVLEALLEDPGAT-ALYLYPTKALardqlRRLRELAEALGLGVRVATYDgdtppEERRWI-REHPDIVLTNp 160

                        90       100       110
                ....*....|....*....|....*....|....
1Z6A_A      136 ----YAVLLRDTRlkeveW-------KYIVIDEA 158
Cdd:COG1205 161 dmlhYGLLPHHTR-----WarffrnlRYVVIDEA 189
DEXHc_RE_I_III_res cd18032
DEXH-box helicase domain of type III restriction enzyme res subunit; Members of this model ...
 66-187 7.24e-03

DEXH-box helicase domain of type III restriction enzyme res subunit; Members of this model includes both type I and type III restriction enzymes. Both are hetero-oligomeric proteins. Type I REs are encoded by three closely linked genes: a specificity subunit (HsdS or S) for recognizing a DNA sequence, a methylation subunit (HsdM or M) for methylating the recognized target bases, and a restriction subunit (HsdR or R) for the translocation and random cleavage of non-methylated DNA. They show diverse catalytic activities, including methyltransferase (MTase), ATP hydrolase (ATPase), DNA translocation and restriction activities. These enzymes cut at a site that differs, and is a random distance (at least 1000 bp) away, from their recognition site. Cleavage at these random sites follows a process of DNA translocation, which shows that these enzymes are also molecular motors. The recognition site is asymmetrical and is composed of two specific portions: one containing 3-4 nucleotides, and another containing 4-5 nucleotides, separated by a non-specific spacer of about 6-8 nucleotides. Type III enzymes are composed of two subunits, Res and Mod. The Mod subunit recognizes the DNA sequence specific for the system and is a modification methyltransferase; as such, it is functionally equivalent to the M and S subunits of type I restriction endonucleases. Res is required for restriction, although it has no enzymatic activity on its own. Type III enzymes recognize short 5-6 bp-long asymmetric DNA sequences and cleave 25-27 bp downstream to leave short, single-stranded 5' protrusions. They require the presence of two inversely oriented unmethylated recognition sites for restriction to occur. These enzymes methylate only one strand of the DNA, at the N-6 position of adenosyl residues, so newly replicated DNA will have only one strand methylated, which is sufficient to protect against restriction. Both type I and type III REs are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350790 [Multi-domain]  Cd Length: 163  Bit Score: 37.16  E-value: 7.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z6A_A       66 GLGKTlqTIAVFsDAKKENELTPS---LVICPLSVLKnwEEELSKFAPHLRFAVFHE-DRSKIKLEDYDIILTTYAVLLR 141
Cdd:cd18032  30 GTGKT--YTAAF-LIKRLLEANRKkriLFLAHREELL--EQAERSFKEVLPDGSFGNlKGGKKKPDDARVVFATVQTLNK 104

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
1Z6A_A      142 DTRLKEV---EWKYIVIDEA-QNIKNPQTKIFkavKELKSKYRIALTGTP 187
Cdd:cd18032 105 RKRLEKFppdYFDLIIIDEAhHAIASSYRKIL---EYFEPAFLLGLTATP 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH