5KO9,6OE7,6KCQ,2BDV


Conserved Protein Domain Family
SRAP

?
pfam02586: SRAP 
SOS response associated peptidase (SRAP)
The SRAP family functions as a DNA-associated autoproteolytic switch that recruits diverse repair enzymes onto DNA damage. We propose that the human protein Q96FZ2:UniProtKB, the eukaryotic member of the SRAP family, which has been recently shown to bind specifically to DNA with 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxycytosine, is a sensor for these oxidized bases generated by the TET (tetrahedral aminopeptidase of the M42 family) enzymes from methylcytosine. Hence, its autoproteolytic activity might help it act as a switch that recruits DNA repair enzymes to remove these oxidized methylcytosine species as part of the DNA demethylation pathway downstream of the TET enzymes.
Statistics
?
PSSM-Id: 460605
Aligned: 407 rows
Threshold Bit Score: 144.206
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
5KO9_A         1 MCGRTSCHLPRDVLTR----ACAY---------QDRrgqqrlpewrDp-------------------------------- 35 
WP_038532150   1 MCFHTATTSKTKRLDK----HFGV---------KLS----------Aedv------------------------------ 27  Formosa agariphila
WP_013870909   1 MCFHKSLTKKQEEFKE----RFDA---------AMK----------El-------------------------------- 25  Lacinutrix sp. ...
WP_015481161   1 MCVHTSLTKSAKAIEK----KTKK---------EFT----------Tp-------------------------------- 25  Polaribacter sp...
WP_012772487   1 MIERYSITADVGDMIE----AFK----------VEQ----------Li-------------------------------- 24  Paenibacillus s...
EOR01532       1 MCGRFSLHVPPTEYSRriaiDYGLn-------iQQN----------Ss-------------------------------- 31 
EGV66891       1 MCGRYAMTVDVQQLPS----QFTRtalrredpgSSN----------Tddvkkvtentystteth----fngseenvkifv 62 
Q6BHR8         1 MCGRYALGININELPQ----QFNEtvln-rsntNVQ----------Ysikqlsdtnyeavdesndeatsnhanrieimil 65  Debaryomyces ha...
CCE40826       1 MCGRFAQRINPNSIPS----EFYEtvf---geeTSD----------Inepstgvyetdvhea--------ndkvekvqld 55 
EPB88444       1 MCGRFCCSLNTDDIRTe---LYEEn--------VLP----------Qrdve----------------------------- 30 
5KO9_A        36 ----DKYCPS--YNK-SPQSNSPVL-LsrLHF-EkdadssErIIAPM----RWGLVP---------SWF------KESdp 87 
WP_038532150  28 --rsIFDTPQ--YHLnGFTHPNMLViPqqKPE----------VLAPG----VWGIVPytktpdqinPYY------KEAv- 82  Formosa agariphila
WP_013870909  26 ----DVYEPYfhRSG-FEDNYIYII-KanEPY----------DIVPS----YWGIMP---------ENY------NIYq- 69  Lacinutrix sp. ...
WP_015481161  26 ----QLFQPYfhFNG-WESKNLAIT-TqeAST----------QIAFA----KWGVLP---------THY------DVSy- 69  Polaribacter sp...
WP_012772487  25 ----NCYTNR--FNV-APTQTVSIV-M--NDRwG------LrTMHDA----RWGLFP---------FWA------KDS-- 67  Paenibacillus s...
EOR01532      32 ----STWNQS--YNV-SPTSNVPVI-Nqs------------lVVRVC----RWGVIP---------HFSkesqlhGSNy- 77 
EGV66891      63 mnglEGYRQS--YNV-APTKNELII-Y--KQYsa------anNVEYImetsGFGLVP---------NWSk----pGNTd- 116
Q6BHR8        66 nlsnQTFQSS--YNI-PPTRTALII-Y--QAKnsd----atfKNRYVieslTFGLVP---------SWAk----pKDPt- 121 Debaryomyces ha...
CCE40826      56 ltrvSQWTPS--CNI-APTDTALMV-Y--MTEptk-----diTQNYViepsKFGLVP---------SWAk----pVDSt- 110
EPB88444      31 wideSSHRPS--YNV-CPSRSIPAI-Ve-KGQsQ------SkALQSM----QWGFIP---------AWL------KSN-- 78 
5KO9_A        88 sKLq------------------FNTTNCRSDTVM-E-KRSFKVPLGKgRRCVVLADGFYEW-QRcqGT-NQr--QPYFIY 143
WP_038532150  83 -KY-------------------GGGLNARAEKLF-N-HFIYKNAIHE-QRCIIPVTGFYEP-HE--FE-KKk--YPFFIQ 133 Formosa agariphila
WP_013870909  70 -RKgfl--------------tkTNTLNARSENLF-T-SPLFKEHIKT-QRCLILADGFFEP-H---TRnKIs--YPHYIK 125 Lacinutrix sp. ...
WP_015481161  70 -RTdfl--------------akTNTLNATRERLF-E-SDLYSQFIEG-QRCIIYADGFFEPheA--AGvQKk--IPYFFK 127 Polaribacter sp...
WP_012772487  68 -------------------------VNADSSMLS-N-KPFFERMLRK-QRCVVPCSGFFGW-QK--GQ-KEkdsRAMHIV 115 Paenibacillus s...
EOR01532      78 -TAs------------------LKTINARSESLEdGsSPLWNSLKSS-KRCIIPVDGFFEWlQ---SG-REk--IPHFTK 131
EGV66891     117 -PLkevr------------kqqAMHFNCRRETLL-QtSSIWNASKKT--RCVVPIQGYYEW-MK--IK-TQk--VPYYVF 174
Q6BHR8       122 -PIerkgkpgpr-ysrelqkyqGKHFNCRKESLA-NkTPVWNSAKRT--RCVVPIQGYFEWiK---SG-KNk--TPYFVH 190 Debaryomyces ha...
CCE40826     111 -PVnkgkqnegekfsrelgkheSKYFNCRRESLA-QhRAVWSSCKKH--RCVIPIQGYFEW-LK--TK-NAk--VPYFIH 180
EPB88444      79 -Ph-------------------NKPINARVETLT-E-KPSMFDKSKNvHRCIIAAEGFFEW-N------KKr--QPFFIK 127
5KO9_A       144 FpqikteksgsigaadspenwekvWDNwRLLTMAGIFD-------CW-EP-PEGg-------DVLYSYTIITVDSCK--- 204
WP_038532150 134 N-----------------------GNR-EPLSLAGIYT-------II-----GT----------YVTFSVITKVASP--- 164 Formosa agariphila
WP_013870909 126 Y-----------------------RDS-NLFAFAGIYS-------EL----DDG----------LYTASIITTIAND--- 157 Lacinutrix sp. ...
WP_015481161 128 E-----------------------KNH-ELFAFAGIYS-------KV-IEnNST----------TYAASIITTEAND--- 162 Polaribacter sp...
WP_012772487 116 V-----------------------PNH-RVFGIAGFFD-------VW-RN-YSG--------QEVRAFTMITAPATG--- 151 Paenibacillus s...
EOR01532     132 R-----------------------KDG-KMMMFAGLYD-------TKnSKnGNE--------QNIQSFTIITTRASS--- 169
EGV66891     175 S-----------------------KDQ-PLIYLAGFYS----------H--NKNftdnfnndQYLSTFTIITGPATKeds 218
Q6BHR8       191 S-----------------------SKA-PLIYLAALYS----------H--NPNysnldshaKYLSSFTIITGPATKeds 234 Debaryomyces ha...
CCE40826     181 S-----------------------KTT-PLIFLAGLYShnynykeNF-N--VNN--------EYLSSFTVITAPAEKsdk 225
EPB88444     128 R-----------------------KDS-KMMLFAGLYSt------AY----VDG--------QPVTTCTIITTAASE--- 162
5KO9_A       205 -GLSDIHH--------RMPAILDgE--EAVSKWLDFGEVSTQE--ALK-L--I-HPTE-----NITFHAVSSVVNNS 259
WP_038532150 165 -LFAKIHNvk-----kRQPLILD-A--EHVKAWLSS-SVSDTQ--IKE-L--VnFNYSe---dKLHTYTVSKDVFSP 223 Formosa agariphila
WP_013870909 158 -FMKGIHNkpsrqgdyRMPLILD-K--SNEDDWLNG--NLSIDs-IRE-L--L-FTFTs---nDLVSYPVTKNVMNS 220 Lacinutrix sp. 5H-...
WP_015481161 163 -FFKAIHNkpnalgsyRMPLILD-P--STYETWLMA--TTTAE--VKT-V--L-DSFTq---qELVSYAVSTDVFSS 224 Polaribacter sp. M...
WP_012772487 152 -TMSQWQP--------NVPVIMD-E--EGMEDWLNPSISDFRS--LRKhLepM-DSY------RMRAYPVTNAVNDE 207 Paenibacillus sp. ...
EOR01532     170 -QFSSVHS--------RMPVILT-Q--QGAVKWLDKSKKWDTE--LAR-L--L-EPFNd----DLDIYAVTKEMSKP 224
EGV66891     219 nDLSWLHS--------RKPIFLK-PgtQQWDDWLDPKVPWSHElqIAC-LdtLtNPAFe----SITCHKVSRDVGNT 281
Q6BHR8       235 kDLSWLHP--------RKPLMLM-PstNEWHEWLDPEKDWSDS--LLDtS--L-NTIDnkaymNIEYHTVSSDVGKP 297 Debaryomyces hansenii
CCE40826     226 yDLSWLHT--------RKTLIIE-PgsKAWFRWLDPTTDWDDS--LIEeV--LnSKTnea-yaNIEGYQVSNDVGNP 288
EPB88444     163 -FFSKIHN--------RMPVILE-S--KDVDTWINHKVLWTQD--VIK-L--L-KPFDg----ELSCFQVTDKVGPI 217
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap