6ION,6IOM


Conserved Protein Domain Family
TFP_LU_ECD_LYPD3_rpt1
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cd23562: TFP_LU_ECD_LYPD3_rpt1 
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first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and similar proteins
LYPD3 (also called GPI-anchored metastasis-associated protein C4.4A homolog, or matrigel-induced gene C4 protein (MIG-C4)) supports cell migration. It may be involved in urothelial cell-matrix interactions as well as in tumor progression. LYPD3 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.
Links
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Statistics
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PSSM-Id: 467092
Aligned: 15 rows
Threshold Bit Score: 85.1
Created: 27-Nov-2018
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
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trimer
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:trimer interface [polypeptide binding site]
Evidence:
  • Structure:6ION; Homo sapiens LYPD3 in complex with antibody 11H10 Fab light/heavy chains, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                             # ###                       ####  # # # #  
6ION_A         1 LECYSCVQkaDDGCSPnkMKTVKCAPg-vDVCTEAVGAVETIHg--qFSLAVRGCGs-GLPGKNDRGLDlhGLLAFIQLQ 76  human
OCT57124       6 LECYSCVDynDGSCSEdkAAKTSCSPd--QNCIETNATLETSHn--ySYLMVKGCGnrSIEDMLELVPFy-GINLYFHLS 80  African clawed ...
XP_018410102  33 TECYTCTDrgDGGCSPdkAVNVSCPLd-hDMCLETITAIKTSHa--nHVVLKKGCGy-GVPTMLKQSIIsyGISIYMQLN 108 Nanorana parkeri
XP_025043789  35 LECHSCVErgDGGCSPekMKTILCPDn-tHVCAETVAAVKWSEcnfsLSRTIKGCV--QDEDCTKETRG--STAVSLGGS 109 Chinese soft-sh...
XP_029432840 126 LECYSCTEegDGGCSPanITAVQCAPp-mKICTEYWQTLAVGAt--tVTIHKRGCNs-GPPESMSGWFThlVLESNYKMR 201 two-lined caeci...
XP_029433383  33 LECYSCIDqgDHGCSMekAMKVKCQEgqeNVCMEAVYTVQASHg--tHTITMKACGa-STSGQLNKTESyhGLTLFIQVK 109 two-lined caeci...
XP_030067371  31 LECYSCIEegDNGCSPanITIVQCVLp-mNICIEYMQTVGTGSf--mVTRRKKGCSl-GLEVGIAGNTTneAMYHISNIQ 106 Microcaecilia u...
XP_030067938  31 LDCYSCTEegDSRCSAkdTNIIQCGPa-mNICIDYLYVASTANl--tLTLWKKGCSs-GPTMKWNDEILdeHLQHKVEAR 106 Microcaecilia u...
XP_030068956  55 LRCYSCIEegDSGCSPanTPVVLCVPp-mNICTEYIQTISTDSf--tVTRRKKGCSl-GLDKDYSTVTSndVIYHTIHIR 130 Microcaecilia u...
XP_030069336  46 LECYSCTEegDAGCSAdkIVKVSCAQa-mNVCMDYTHTIKTDAl--nMTIRKKGCSs-GLTKTYDSEGSfvQHCYVTHIN 121 Microcaecilia u...

Feature 1                   
6ION_A        77 QCAQDRCNAKL 87  human
OCT57124      81 QCNSSLCNNLN 91  African clawed frog
XP_018410102 109 QCNTSLCNTNM 119 Nanorana parkeri
XP_025043789 110 CCSGSLCNRDL 120 Chinese soft-shelled turtle
XP_029432840 202 ACTTDLCNLEL 212 two-lined caecilian
XP_029433383 110 QCNTSLCNAEA 120 two-lined caecilian
XP_030067371 107 GCSTNLCNNKL 117 Microcaecilia unicolor
XP_030067938 107 ACSTSLCNNDV 117 Microcaecilia unicolor
XP_030068956 131 ACSTDYCNTQL 141 Microcaecilia unicolor
XP_030069336 122 ACNTSLCNNDL 132 Microcaecilia unicolor

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