Conserved Protein Domain Family
IRK_C

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pfam17655: IRK_C 
Inward rectifier potassium channel C-terminal domain
This cytoplasmic C-terminal domain has an Ig fold.
Statistics
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PSSM-Id: 465439
Aligned: 31 rows
Threshold Bit Score: 240.186
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011660845 226 LKFSRKAAIAQRDGKLCFMFRVGDIRNSHLFEAHLRVYMIKPKVTKEGEiIPLCHHNMDLGydtgEDRIFLVWPIIVSHT 305
EKC39442     186 IMFSKVACVAQEEGDLCLQIRIGDMRQSHLIDAKVHGILIKRHVTREGVsYPLFQHDVHFQankmGDTIMLMWPLILSHR 265
XP_522246    192 ITFSKNAVISKRGGKLCLLIRVANLRKSLLISSHIYGKLLKTTVTPEGEtIILDQININFVvdagNENLFFISPLTIYHV 271
Q1L8I6       173 ITFSESAVICPKKGTLCLQIRVANLRKTLMIGSQIYGKLLRTTVTG-GEtVILDQVSIDFMvdagKDNLFFVCPLTLYHI 251 zebrafish
XP_005458317 179 VTFSHTAVICLKKGSLCLLIRVANLRKTLLIGSQIYGKLLRTTTTADGEtIILDQVDIDFMvdagKDNLFFVCPLTLYHV 258
XP_006002585 182 VKFSHNAVITRHNGKICLMIRVANLRKSLLIQCQLLGKFLHTYETKEGEkILLNQTNVQFQvdssSESPFLVLPLTFYHV 261
XP_004919636 185 IKFSNKAVITKHNGKLCLVVQVANMRKSLLIQCQLYGKLLHSYETKEGEkILLQQVNMNFNvdssSESPFLILPLTFYHV 264
XP_005202134 178 IKFSHCAVITKQNGKLCLVIQVANMRKSLLIQCQLSGKLLQTHVTKEGEqILLNQATVKFHvdssSESPFLILPMTFYHV 257
P49655       179 IRFSQHAVVAYHNGKLCLMIRVANMRKSLLIGCQVTGKLLQTHQTKEGEnIRLNQVNVTFQvdtaSDSPFLILPLTFYHV 258 Norway rat
XP_005999398 179 IKFSHNAVVSQQEGKLCLMIRVANMRKSLLIGCQVSGKLLQTYVTKEGEsIGLNQNNVDFQvdtsSDSPFLILPLTFYHV 258
XP_011660845 306 IDEDSPLYEYSCNTIDTADFEIVVILEGIVEQTGLTTQARTSYMPGEIQWGSRFCSSVLCLRSefdkQYDIDYSKFEETY 385
EKC39442     266 ITQESPFWDIRPSDLSSEAYELVVCIEGTLETTGEFCQARTSYLPSEILWGHRFDRIEEFDAGn--gRWEIDFSGFNDVV 343
XP_522246    272 IDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEg---KYRVDFHNFSKTV 348
Q1L8I6       252 IDKSSPFFDMAVDTLHQQDFELVVFLDGMAETTSSSCQVRTSYIPQEIMWGYDFLSIISRSEEg---RYQVDFSNFAKVV 328 zebrafish
XP_005458317 259 INRSSPFFDLSADTLPQQDFELVVFLDGTAESTSSSCQVRTSYIPQEIQWGYSFLPIISRTKTg---KYHVDFSNFSKSV 335
XP_006002585 262 IDDKSPLKDFTPDNPQENNFELVVILNAMVESTSAVCQSRSSYLPEEILWGYKFMPIIYISPSg---KYVADFSCYDQVT 338
XP_004919636 265 LDDNSPLKDLTADNIKTKDFELVVLLNATVESTSTVCQSRTSYLPDEIYWGYEFVPVVSLSPQg---KYVADFSNFDKIR 341
XP_005202134 258 LDETSPLRDLTPQNLKEKEFELVVLLNATVESTSAVCQSRTSYIPEEIYWGFEFVPVVSLSKTg---KYVADFSQFEQIR 334
P49655       259 VDETSPLKDLPLRS-GEGDFELVLILSGTVESTSATCQVRTSYLPEEILWGYEFTPAISLSASg---KYVADFSLFDQVV 334 Norway rat
XP_005999398 259 IDSNSPFRDISFSS-RDTDFELVVILSGTVESTSATCQVRTSYLPEEILWGYEFPPVISISPSg---KYVADFSCFDKVV 334
XP_011660845 386 TVPgHPRK----SAKELDEIEQ 403
EKC39442     344 YITnIRH-----SAKELNPYRE 360
XP_522246    349 EVE-TPHC----AMCLYNEKDV 365
Q1L8I6       329 PVP-TAHC----SRCYHNEPGN 345 zebrafish
XP_005458317 336 RVT-TPHC----VHCFEADVDQ 352
XP_006002585 339 Q---STDF----PLHWANSEKL 353
XP_004919636 342 KCK-VIE-----TIYLVNFEKR 357
XP_005202134 335 K---SPDC----TFYCADSEKQ 349
P49655       335 KVA-SPGGlrdsTVRYGDPEKL 355 Norway rat
XP_005999398 335 KVH-TPHClh-eSLKYGDPEKM 354
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