Conserved Protein Domain Family
CC2D2AN-C2

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pfam15625: CC2D2AN-C2 
CC2D2A N-terminal C2 domain
Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition zone of cilia. This is the first C2 domain of ciliary CC2D2A proteins which also have another C2 domain (CC2D2AC-C2) and a new inactive transglutaminase-like peptidase domain (CC2D2A-TGL).
Statistics
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PSSM-Id: 464780
Aligned: 36 rows
Threshold Bit Score: 115.574
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CBJ30489      624 LGgrsggtEEGSHvLRLSNDGIVTPDVGCGRLERARREEA------RELRFRVAVFVNGSKV-STTRAVSLe-WPEFACS 695 
XP_001316922  461 PG------DPLWR-PVLTENEDVTPLVNCPEKEKQRRQRL------QAAKIYVRVKIGAETN-ITSLQVPL--SRDFVAL 524 
XP_001323414  428 PG------DPKWF-AVFSSDAAITPNDQVPAEEQQRRSDI------QNTQTSVRIIIPNQSV-FNTQYAKL--TSNFESL 491 
EAX95198      389 PG------ETTW--EPVLKKIEIPSVQRLTMEENNRRKMI------DETNLWIQANISDKKA-ISSEF-----KMNYSLY 448 
XP_001581530  389 AG------DTEWN-PKLTT-VETTEDSKIPNSEVQRLNQA------SETYNYVKIIVGGQQA-ISMA-SSL--DSDFTSQ 450 
EAU76045      239 PG------EPLVD--------------IVLRRDQERRSDPsgvpsgRDLLFKMKLFIDNNHV-ASTKARHFetEDRTMID 297 
A1ZAV1        421 PE------EPYVEvFRLHADEATARLSIPGGDQLP-----------KARNYFLKIFLDGQFV-GQSRTYRL--EPDLQIS 480  fruit fly
XP_002500417  358 KG------NGESE-PVLLAGAARDEGAHVPKPEQQRRAKA------TSTRFCVALEVNGQQVpGTSRPVTLrsSGGFSTE 424 
EFJ49224      774 PG------GGPF--PVAPFQPPPPQLPPKPNLKQG-----------SKGRYYVKLFVNDYYV-DSSEVASL--GDNFAGD 831 
EFC50285      558 PG------EPIVV-PEI-LKMEITKESELPPMEVERRKQI------SMLSYHINLLVNGNYV-CKTTNQQL--RSDFTIN 620 
CBJ30489      696 FNHLVRLR-L-VRRPESVMVAIYSCSg--lPWWPDQEVAS-VWVPVPGgqdnrfgdsvgagpqtthafaprtQWTQFSSr 770 
XP_001316922  525 PDLAIEVE-V-TKVPENVICEIWETGyvrpRQIAVVNLATsVGMPVVD------------------------DVYEFTAr 578 
XP_001323414  492 INKQFEIQ-T-TRLPSSIILEVWEMD----TKKKERAVAR-VSIPVYVgtp------------------pefFSYEFSSd 546 
EAX95198      449 AESGIGIRfLcTRVPKAVPVEIWQD-----GPTGKTVIAT-VNIPVVNgvp------------------yqpMKIQFTSs 504 
XP_001581530  451 VNFGAKFI-I-TRIPKYINIEIWE-Q----SKNGVFKVCD-TTLPVFNgep------------------akyYENHFTS- 503 
EAU76045      298 FNTSFSIK-LtTKIPETIALHLYEKN----RMMMKNKRAE-LFLPLPSseely--------------edvdfVDYQFSSg 357 
A1ZAV1        481 INECIGVL-LeRSLPENLNIWLYEKStltpK---SRRLAQ-ISTPLVLsskd----------------davqEKLSFQA- 538  fruit fly
XP_002500417  425 VAHAFSLS-V-QRWPDSVRLALYEK-----GTIVDTFLAV-VPIAVPGsnpgep------------lqdpapRQYQFSAe 484 
EFJ49224      832 FKDTFTIQ-V-SRFPESISAMLFER-----HTLRDSYIGQ-VYIAIPGlagsah-------------vdaqaRPYQFTAl 890 
EFC50285      621 FNEIVSVS-V-FKWPESISLQISQSG------WFEKPLTN-VFVPVPGlersgk------------tdtesvKQISFTSp 679 
CBJ30489      771 RPMats---------------------gpLADRRTCGSVLVGTewstsrdsaedttsggvvaeGDNAS 817 
XP_001316922  579 PPS--------------------------GKGRMTIGTVYARS--------------------FVMPC 600 
XP_001323414  547 FQL--------------------------PNGNLITGTVEARI--------------------YIKPE 568 
EAX95198      505 QP---------------------------IHGCLVQGTISAQG--------------------FVEPD 525 
XP_001581530  504 DTPl-------------------------SNGKLVEGNILGAAficvnpn------asitrirQNKPH 540 
EAU76045      358 KPY--------------------------QAQTYTNGTVELRIgwmep-----------sdgsFPSPS 388 
A1ZAV1        539 -----------------------------LSSTQLAGDVYLYYeyrstegwg---salhlddvQRLPD 574  fruit fly
XP_002500417  485 SPHaptwrg---------------aqpgaSQVQYTSGSLFVTCa--------------------wTPN 517 
EFJ49224      891 tplrprlptqgpgpvplmpdtqfqdssynFNTIFPAGVMYVRCgwvsdrtp-----pgsrladTVQPN 953 
EFC50285      680 EPHvpvwdlqatgsf--ppsifqifkpvlSPSHHTYGSIKLSIswvkps--------eertveAPKPP 737 
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