2DWG


Conserved Protein Domain Family
RUN

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pfam02759: RUN 
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RUN domain
This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signalling pathways. The domain is comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.
Statistics
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PSSM-Id: 460679
Aligned: 36 rows
Threshold Bit Score: 93.1085
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2DWG_A     46 QFFVVMEHCLKHGLKA---------------------------------------------------------------- 61  
Q54LN3   1015 RLATAIANLVSHGFIVsptnmvgsifrnvinga----------------------------------------------- 1047 Dictyostelium dis...
CAG07791 1074 yLCPALHEVLQDGLKPyv-------------------------------------------------------------- 1091
Q94222    607 RLANSFRQIMDHGIREnalytsma-------------------------------------------------------- 630  Caenorhabditis el...
Q17FM5    615 TLAPTIKQVLEHGMKRpsflggpc-------------------------------------------------------- 638  yellow fever mosq...
PNJ37530    8 TLCPALKALFEHGLKKpsllggac-------------------------------------------------------- 31  
Q96C34    429 ELTVAVRDLLAHGLYAsspgmslvmapiacll------------------------------------------------ 460  human
Q9W5C1    516 NFARTLQQLIQHGLRIpaesaasslmvpfmrclhpgppvv---------------------------------------- 555  fruit fly
Q17Q22    446 QLAKTIQGLMQHGLRGitessgslvpfisgcfsgggyhsqgpsknsaeerfyrgdsrrkstggmtka------attppkr 519  yellow fever mosq...
Q7QH55    369 RLAKTIQRLMQHGLRSisesashslvpfisgcfsttgsghsgtnhssmsgranesfyrsevrrkstgatttapkkqssyv 448  Anopheles gambiae...
2DWG_A     62 --------------------------------------------K-KTFLGQNKSFWGPLELV-----------EKLVPE 85  
Q54LN3   1048 ----------------------------tgsggggsgggnslssSlGNIVTGKRHLWEFIENY-----------KKTTQH 1088 Dictyostelium dis...
CAG07791 1092 -------------------------------------------lD-LIIGQRRCQPWSLAEAS-----------TQLGPS 1116
Q94222    631 ------------------------------------yhpwsfieD-IAYYSVEKNFNSVYSRLtlcntfnldedGKILTP 673  Caenorhabditis el...
Q17FM5    639 -------------------------------------hpwlfieE-AATREVEKDFESVYSRLvlcktyrldedGKVLTP 680  yellow fever mosq...
PNJ37530   32 -------------------------------------hpwlfieE-AAGREVERDFASVYSRLvlcktfrldedGKVLTP 73  
Q96C34    461 ----------------------------pafssapeamhpwelfVkYYHAKNGRAYVESPARKlsqsfalpvtgGTVVTP 512  human
Q9W5C1    556 --------------------ppavggdsqflglgramhawelvlA-YYRLKHGEEYNNTPARKlsqsfqldivdAQAVTA 614  fruit fly
Q17Q22    520 nsssleeeepiemnlftqleededeeveycdgdesemhawelllL-YYNIKNGDRYNSAPARKlsesfnldlveGRPQSN 598  yellow fever mosq...
Q7QH55    449 eedtsnaavteenlfsqldddeeedmepqfdsnnkdemhvwellLvYYNIKNGDRYNSTPARKlsesfnldivdGRPLSN 528  Anopheles gambiae...
2DWG_A     86 AAEI---TASVKDLPGLKT----------PVGRGRAWLRLALMQKKLSEYMKALINKKE---LLSEFYEVNALMMEEEGA 149 
Q54LN3   1089 GTIAg--ISLIQTINTINSfenissawkdPNIKFRTLICVGLNQHVLDQWFALLQTDTN---GISHYFHPNAIINSLDHW 1163 Dictyostelium dis...
CAG07791 1117 TRVLhslFSKVSQYSELTNh----------SLRLNSFIFGLLNLKSLEFWFSHLYTHDD---IIAAHYNPWGFLPLSQGV 1183
Q94222    674 EELL---FRSVQLINDSHNavs-----ahSDVKLRSLLVVGVNEQCIHLWFDLLCSATQhehIRNKYYHSWAFIRSPAWR 745  Caenorhabditis el...
Q17FM5    681 EELL---YRCVQAVNQSHDaah-----aqMDVKLRSLICLGLNEQVLHLWMEVLCSCSE---IVHKWYQPWSFIYSPGWV 749  yellow fever mosq...
PNJ37530   74 EELL---YRAVQSVNVTHDavh-----aqMDVKLRSLICVGLNEQVLHLWLEVLCSSLP---TVEKWYQPWSFLRSPGWV 142 
Q96C34    513 KQSL---LTAIHMVLTEHDpfk-----rsADSELKALVCMALNEQRLVSWVNLICKSGS---LIEPHYQPWSYMAHTGFE 581  human
Q9W5C1    615 KQSL---LSAVGMILAMHRpyk-----rsNNAHFKAFVCAGLNSHLLVEWLNLILSCHE---LVDTYYSADSYVARTGFR 683  fruit fly
Q17Q22    599 KQSL---LSAIGTIIALHSpyk-----rsYNSQFKAFICAALNAQKLTQWLHLIYQCKE---LVSSYYTSWSYVANTGFR 667  yellow fever mosq...
Q7QH55    529 KQSL---LSAIGSIIALHSpyk-----rsYDSQFKAFVCAGLNAQKLTQWLYLIFQCKE---LVSSHYASWSYVANTGFR 597  Anopheles gambiae...
2DWG_A    150 ------IIAGLLVGLNVIDANFCMKG 169 
Q54LN3   1164 r-----LFCQCFAPILNLPFKLSLDY 1184 Dictyostelium discoideum AX4
CAG07791 1184 cqplfeELLLLLQPLSLLPFDLDLlf 1209
Q94222    746 ------QIKCDLRLLSQFSFNLSMSF 765  Caenorhabditis elegans
Q17FM5    750 ------QIKCELRLLSQFAFNLNPDW 769  yellow fever mosquito
PNJ37530  143 ------QIKCELRVLCCFAFSLSQDw 162 
Q96C34    582 ------SALNLLSRLSSLKFSLPVDL 601  human
Q9W5C1    684 ------DSLRSIDALSRFDFDLPVDL 703  fruit fly
Q17Q22    668 ------DALKTLDRLTQYRFDLPVDL 687  yellow fever mosquito
Q7QH55    598 ------DALKTLDCLTQYRFDLPVDL 617  Anopheles gambiae str. PEST
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