Conserved Protein Domain Family
FAST_2
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pfam08368: FAST_2 (this model, PSSM-Id:429950 is obsolete and has been replaced by 462448)
FAST kinase-like protein, subdomain 2
This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.
Links
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Statistics
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PSSM-Id: 429950
Aligned: 77 rows
Threshold Bit Score: 72.6131
Created: 27-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_800329    530 YKHLYCLDCSIAIECPDYKGPRLPKSIASRSklVPHGSSkvvgdeKQAYAEIIPILARVLGSKDALKVHPILDHIRTpVD 609 purple sea urchin
2_pfamImport   1 CQKLVHINATAQLEHPKYIGPYLPLALPTGL--PPPNLHrk---mTPMQKDLQDIMKGWLGSEDKVRFGETTQYGWE-LD 74 
EHB09129     450 FQKLLHVNATAQLEHPEYRGPLLPATAVAPT-----SPGrk---vTPLQQELREALQAVLGSADQGSLEVATQYGWV-LD 520 naked mole-rat
XP_003465836 451 FLKLMNINATAQLEHPEYQGPFLPATAVGPT---PSSPDqk---vTLLQQELRETLQELLGNASQGSFNVVTQYGWV-LD 523 domestic guinea...
XP_005319311 452 LQKLLHINATALLEHPDYKGPLLPASALASK---PSAPDkk---mTPLQKELQETLKVLLGSSERGCLEVATRYGWV-LD 524 thirteen-lined ...
Q5M9G9       449 FQKLVHINSTALLEYPEYKGPFLPASAVAPS---PSPSNkk---mTPLQKELQDALKALLGNNDTGSLEVATQYGWV-LD 521 Norway rat
XP_016821946 449 FQKLVHINTTALLEHPEYKGPFLPASAVALC---PSSSSkq---mTPLQKELQETLKELLGSTDQGRLDVVTQYGWV-LD 521 Chinese hamster
XP_003982637 450 FQKLLHISATAQLEHPEYTGPLLPASDWAPW---LLACDgk---aTPLQKELRDTLRGLLGSPSRGSFAVATQYGWV-LD 522 domestic cat
XP_012665438 452 FQKLLHINATAQLEHPEYTGPFLPASAVAPR---SLALDkt---vTPLQKELQGILKGLLGSANEGSFEVATQYGWV-LD 524 small-eared galago
Q3SZK4       452 FQKLLHINATAQLEHPEYTGPLLPTSALVPS---PSALEqk---mTPLQKELQETLKGLLGSADKGSFMVPTQYGWV-LD 524 cattle

XP_800329    610 IEIHLDDNNKPIN 622 purple sea urchin
2_pfamImport  75 AELVLDVENQPLP 87 
EHB09129     521 AEVLLDADGQFLP 533 naked mole-rat
XP_003465836 524 AEVLLDTDGQFLP 536 domestic guinea pig
XP_005319311 525 AEVLLDADGQFLP 537 thirteen-lined ground squirrel
Q5M9G9       522 AEVLLDAEGHFLP 534 Norway rat
XP_016821946 522 AEVLLDTDGHFLP 534 Chinese hamster
XP_003982637 523 AEVLLDTDGQFLP 535 domestic cat
XP_012665438 525 AEVLLDADGQFLP 537 small-eared galago
Q3SZK4       525 AEVLLDTESQLLP 537 cattle
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