Conserved Protein Domain Family
Neurexophilin

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pfam06312: Neurexophilin 
Neurexophilin
This family consists of mammalian neurexophilin proteins. Mammalian brains contain four different neurexophilin proteins. Neurexophilins form a family of related glycoproteins that are proteolytically processed after synthesis and bind to alpha-neurexins. The structure and characteriztics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins.
Statistics
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PSSM-Id: 428882
Aligned: 6 rows
Threshold Bit Score: 262.108
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003442170  62 KSRAANATSLELPY-----HSPVPfskqeFSKQEFWEML--GSDLLKpdasnprVKRRPIVK---TGKFKKMFGwGDF-Y 130
XP_004002940  73 RERLEEDSLLAALQwqepdVGPVPflkstDPSSSYFVILnsAAFFRVg------SQLEVLVHvqdFQRKPKKYG-GDYlQ 145
Q9Z2N5        57 SRPLANSTLLGLLA----------------PPGEVWGILgqp---------pnrPKQSPLPS----TKVKKIFGwGDF-Y 106 Norway rat
XP_008111720  62 SSNLQNTSLLELTS---------------NNNQEFWDVLenLSKQGQgpq-plrGRRDSAAS---PSRLKKIFGwGDF-Y 121
OBS69243      45 FRGKENDTDLDLRY-----DTPEP-----YSEQDLWDWLrnSTDLQEpr---prAKRRPIVK---TGKFKKMFGwGDF-H 107
XP_005463951  65 HTKLSRNPFVPL------------------SKQGFWEILggNSQLHSnps--lkIKLQPIMKvhgTSKWSGTFIwGDF-Y 123
XP_003442170 131 SNIKTVRLNLLITGKIVDHGNGTFSVYFRHNSTGQGNISVSLVPPVKAVEFdleRQSVVYPKDSKI-FNCRVDYEKVDRS 209
XP_004002940 146 ARIHSPKLQAGAVGRVVDYQNGFYKVFFTLLWPGQVKVSISLVHPSEGIRV---LQYLQEKKPDRVyFKSLFRSGRISET 222
Q9Z2N5       107 SNIKTVALNLLVTGKIVDHGNGTFSVHFRHNATGQGNISISLVPPSKAVEFhqeQQIFIEAKASKI-FNCRMEWEKVERG 185 Norway rat
XP_008111720 122 SNIKTVKLNLLITGKVVDHGNGTVNVFFRHNSTGHGNISVSLVPPNKAVEFdleQQIFIEAKESKI-FNCRVEYEKVDKA 200
OBS69243     108 SNIKTVKLNLLITGKIVDHGNGTFSVYFRHNSTGQGNVSVSLVPPTKIVEFdlaQQTVIDAKDSKS-FNCRIEYEKVDKA 186
XP_005463951 124 SNIKTVKLNLLILGKIVDHGNGSLGVFFRHNSTGVGNVSVSLVPPTKEVEFdleRQSVIHPKDSKT-FNCRVDSEKTERN 202
XP_003442170 210 KRTSLCNYDPSKTCFQEQIQSHVSWICSKPFKVIC-IYISFYSTDY--RLVQKvcpdynYHNemPYLPSG 276
XP_004002940 223 TECNVCLPGSLPLCNFTDLYTGEPWFCFKPKKLPCsSRINHFKGGYlkGLLTA------TEN--AFFQSG 284
Q9Z2N5       186 RRTSLCTHDPAKICSRDHAQSSATWSCSQPFKIVC-VYIAFYSTDY--RLVQKvcpdynYHSdtPYYPSG 252 Norway rat
XP_008111720 201 KKTTLCTYDPSKTCFLNHTQSQVSWVCSKPFKVIC-IYITFYSIDY--RLVQKvcpdynYHNnvPYYPSG 267
OBS69243     187 TKNTLCNYDPSKTCYQEQTQSHVSWLCSKPFKVIC-IYISFYSTDY--KLVQKvcpdynYHSdtPYFPSG 253
XP_005463951 203 KKVMLCNYDPSKTCDQEHTQSHVTWMCSRPFQVIC-IYVSFYSTDY--RLVQKvcpdysLQS--PAYLPA 267
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