2DNG


Conserved Protein Domain Family
RRM_eIF4H
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cd12401: RRM_eIF4H 
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RNA recognition motif (RRM) found in eukaryotic translation initiation factor 4H (eIF-4H) and similar proteins
This subfamily corresponds to the RRM of eIF-4H, also termed Williams-Beuren syndrome chromosomal region 1 protein, which, together with elf-4B/eIF-4G, serves as the accessory protein of RNA helicase eIF-4A. eIF-4H contains a well conserved RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain). It stimulates protein synthesis by enhancing the helicase activity of eIF-4A in the initiation step of mRNA translation.
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Statistics
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PSSM-Id: 409835
Aligned: 21 rows
Threshold Bit Score: 137.417
Created: 21-Dec-2011
Updated: 25-Oct-2021
Structure
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Program:
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2DNG_A     11 PTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDG---ALLGDRSLRV 87  house mouse
XP_788335  48 PTEPPFTAFVGNLPDDTVQGDLDHIFADMQIQSTRLVHDKETGKFKGFSYVEFEDTQSLKDALKLNG---AIYDDRQLKV 124 purple urchin
EFX85352   22 PEEPPYTAYVGNLPDGTVQGDLENMFENLTVKNVRMVRDRETDRFKGFCYVEFDSQKDLIHALDLDG---VLCEGKTLRV 98  common water flea
CBY23069   10 PTEPPFTAYVGNLPDSLVQGDFDHIFPDQQVKQIRMVRDRETAAFRGYAYVEFETVEDLKNALAVDGa--QIENGKKIRI 87  Oikopleura dioica
ABC86252   24 PTEPPFIAFVGNLPQGLVQGDVIKIFQDFEVKYVRLVKDRETDQFKGFCYVEFETLDNLERALECDGrikLDDLSAPLRI 103 fruit fly
AEO34015   28 PTEPPFTAFVGNLPDGVVQSDIDEIFHGIKIKSTRLVRDKETDKFKGYCYVEFFDLDSLKEALEFDS---ADLQGRSLRV 104 Amblyomma maculatum
ADY47308   45 PEEGPYKAFVGNLPFDSVQGDIDAIFKDLSIRETRMMRDHESDRFKGFAYVEFATREHLERALELDG---CEFDNRRLRI 121 pig roundworm
ELU01797    2 PDEPPFTAYVGNLPHNLIQGDIDQIFKNMSIKGIRMVRDRETDKFKGYAYVEFADRESLEEALSFND---ALFEDRYLRV 78  Capitella teleta
PAA49397   12 EEEPQTTVYIGNLPSDSIQGDVEHIFSACKIRSIRMVRDRETDAFRGFAYVEFEDTVSVKKALELNG---ALYDGKELKI 88  Macrostomum lignano
RDD42855   43 PEEPPYTAYVGNLPFNCVQRDLEQIFKHLDVVSVRLVRDRETDKFRGFCYVEFSSPEGLKEALEYNG---SEFENRNIKV 119 Trichoplax sp. H2

2DNG_A     88 DIAEGRK 94  house mouse
XP_788335 125 DIAQGRN 131 purple urchin
EFX85352   99 DIAEGRK 105 common water flea
CBY23069   88 DIAENRD 94  Oikopleura dioica
ABC86252  104 DIADRRK 110 fruit fly
AEO34015  105 DIAEGRR 111 Amblyomma maculatum
ADY47308  122 DVADAPR 128 pig roundworm
ELU01797   79 DIANGRR 85  Capitella teleta
PAA49397   89 DVAQNRN 95  Macrostomum lignano
RDD42855  120 DIAGGKR 126 Trichoplax sp. H2
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