Conserved Protein Domain Family
PL48
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pfam15903: PL48 (this model, PSSM-Id:406354 is obsolete and has been replaced by 464930)
Filopodia upregulated, FAM65
PL48 is associated with cytotrophoblast and lineage-specific HL-60 cell differentiation. The N-terminal part of the family is found to induce the formation of filopodia. It is found in vertebrates.
Links
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Statistics
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PSSM-Id: 406354
Aligned: 15 rows
Threshold Bit Score: 614.018
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003224034   16 INRSCSFAGFSNAHN--RKLTKSISKGSTRSKTSL--KSAKMY-PSLQKgTVIWDPKPQQVKRIFEALKKGLNDYLEMKQ 90   green anole
Q96MK2         19 VGRSASFAGFSSAQS--RRIAKSINRNSVRSRMPA--KSSKMY-GTLRKgSVCADPKPQQVKKIFEALKRGLKEYLCVQQ 93   human
XP_021244499   45 IIRSQSFAGFSGLQErrSRCNSFIENSSALKKPQA--KVKKMHnLGHKNsTTPKEPQPKRMEEVYRALKNGLDEYLEVHQ 122  helmeted guin...
XP_004074425   49 IIRSQSFAGFSTLQErrSRCNSFMGNSAVPKKPQS--KPKKPHlSGHKGgSSSREPQPKRLEEVYNALKQGLDEYLEVHQ 126  Japanese medaka
Q4FZU8         17 VSRSQSFAGVLGSQErgPRNFTVFSPPGPQRKPLVlsRVSRMFsVAH---PAPKVPQPERLDLVYAALKRGLTAYLEVHQ 93   Norway rat
Q1LXK2         16 ITRSQSFAGVNSYDKs-YRSLSVFSTPGCVRKTPs--RASRMFtLSTKS-PPPKVPQPERLDEVYEALKRGLQSYLQVHQ 91   zebrafish
XP_006639810   16 VRRSRSFAGFGTPLS--RHARVSSVRSSVRSRGFSg-KSPRMP----HSsRSPVASQPEQVERVFQTLRRGLKEYLEGHQ 88   spotted gar
XP_018534112   16 ITRSQSFTGVNTYDKpy-rNLSVFSTPGLSRKPs---RASRMFtMSTKSnPPPKVPQPERLDQVYEALKKGLQSYLQVHQ 91   barramundi perch
KAE8576278     17 VGRSRSFAGFSTLQV--RKTSQSLRRSSVRSKVLA--KSDKLY-PSLRKgSIPLDPHPHQVKKIFEALRKGLNEYLEEHQ 91   tropical claw...
XP_007475802   16 mGRSSSFAGFSSMQR--RNIVKSLNRNSMRSKVPM--KSSKIY-ATLRRgTPCLDPKPQQVKKIFEALKKGLKEYLCAQQ 90   gray short-ta...

XP_003224034   91 AELDYLLECHKDTRRNSRLAFYYDLDKQIRYVERYIRKLEFHISKVEELYEAYSIQCRLRDGASNMKHAF-SLSPSTKAS 169  green anole
Q96MK2         94 AELDHLSGRHKDTRRNSRLAFYYDLDKQTRCVERHIRKMEFHISKVDELYEDYCIQCRLRDGASSMQRAF-ARCPPSRAA 172  human
XP_021244499  123 TELDKLTAQLKDMRRNSRLGVLYDLDKQIKAVERYMRRLEFHISKVDELYEAYCIQRRLCDGASKMKQAF-AMSPASKAA 201  helmeted guin...
XP_004074425  127 TELDKLMCLMKDMKRNSRLGVLYDLDKQIKSIERYMRRLEFHISKVDELYEAFCIQSRLRDGASRMKQAF-SSSPSTKGT 205  Japanese medaka
Q4FZU8         94 QEQEKLQRQIKESKRNSRLGFLYDLDKQVKSIERFLRRLEFHASKIDELYEAYCVQRRLRDGAYNMVRAYsTGSPGSREA 173  Norway rat
Q1LXK2         92 MELDGLNRQMKESKRNSRLGFLYELDKQVKVIERFMRRLEFHLSKIDELYEAYCMQRRLRDGADKMVKAY-TASPGSREA 170  zebrafish
XP_006639810   89 AELDFLTAQQRDSKRISRLAFLYDLEKEIRALERYIRRLEFHISKVEELHEAYAIQWRLCTGAANMKRAF-ALSPSTRAS 167  spotted gar
XP_018534112   92 MDLDNLSRQMKESKRNSRLGFLYELDKQVKVTERYIRRLEFHLSKIEELYEAYCLKRRLRDGANKMVKAY-TASPGSKEA 170  barramundi perch
KAE8576278     92 TQLDFLAGQQKDIKRNSRLAYFYDLDKEIRLIERHIRKLEFHISKIEELYETYCIQWRLRVGACNMKHAF-SLSPSTKAS 170  tropical claw...
XP_007475802   91 AELDYLSGRHKDTRRNSRLAFYYDLDKQTRSVERHIRKMEFHISKVEELYEGYCIQWRLRDGASNMQQAF-SLSPLTKAS 169  gray short-ta...

XP_003224034  170 RESLVELYKNLQDCTEDMCLIEGTLEVHLGEFHLKMKGLVGYARLCPGDQYEVFVRLGRQKWKLRGKILTDDSQTWDEEE 249  green anole
Q96MK2        173 RESLQELGRSLHECAEDMWLIEGALEVHLGEFHIRMKGLVGYARLCPGDHYEVLMRLGRQRWKLKGRIESDDSQTWDEEE 252  human
XP_021244499  202 RESLTEINRSYKEYTENMCTIEAELENLLGEFCIKMKGLAGFARLCPGDQYEIFMRYGRQRWKLKGKIEVNGKQSWDGEE 281  helmeted guin...
XP_004074425  206 KESIAEVNRRYKEYTENMSTFEVELENLLGEFHIKMKGLAGFARLCPGDQYEIFMRYGRQRWKLKGRIEVNSRQSWDGDE 285  Japanese medaka
Q4FZU8        174 RDSLAEATRGHREYTESMCLLENELEAQLGEFHLRMKGLAGFARLCVGDQYEICMKYGRQRWKLRGRIESSGKQVWDSEE 253  Norway rat
Q1LXK2        171 RESLSEANKSFKEYTENMCMLESELENQLGEFHIKMKGLAGFARLCAGDQYEIFMKYGRQRWKLRGRIEINGKQVWDSEE 250  zebrafish
XP_006639810  168 RESLLQLGRSQRQCLEDMFMMEGELELLLGELHIKMKGLIGFARLCPGDQYEVLIRLGRQRWKLKGKIEADDRQSWDEEE 247  spotted gar
XP_018534112  171 RESLTEANKGYKEYTENMCVLENELENQLGEFHIKMKGLAGFARLCAGDQYEIFMKYGRQRWKLRGRIEINAKQVWDSEE 250  barramundi perch
KAE8576278    171 RESLLELYKNFQECTEDMCTIEGELEVHLGEFLIKMKGLVGYARLCPGDHYEVLIKLGRQRWRLKGKIETDDSQMWDEEE 250  tropical claw...
XP_007475802  170 RESLVELYRNLQECTEDMCLIEGALEVHLGEFHVKMKGLVGYARICPGDQYEVFIRLGRQRWKLKGKIETDNSQTWDEEE 249  gray short-ta...

XP_003224034  250 KVFIPNLHEKFEIKVTELRGLST-LLVGVVTCDSIDFFTTRPQIIVVDITELGTIKLQLEVLWNPFDNESVILSPGSTAK 328  green anole
Q96MK2        253 KAFIPTLHENLDIKVTELRGLGS-LAVGAVTCDIADFFTTRPQVIVVDITELGTIKLQLEVQWNPFDTESFLVSPSPTGK 331  human
XP_021244499  282 MVFLPLIVGLISIKVTEVKGLAThILVGSVTCETKDLFAARPQVVAVDINDLGTIKLNLEITWYPFDVEDLTPSTGNVSK 361  helmeted guin...
XP_004074425  286 MIFMPLISDLINIKVTELKGLAThMLVGSVICETKELFTAMPQVVAVDVNDLGTIKLNLEVTWYPFDVEDLTLSSGNLSK 365  Japanese medaka
Q4FZU8        254 TVFLPLLTEFLSIKVTELKGLANhVVVGSVSCETKDLFAALPQVVAVDINDLGTIKLSLEVIWSPFDKDDQPSAASTVNK 333  Norway rat
Q1LXK2        251 MVFLPLITEFLSIKVTELKSLANhVVVGSVSCETKDLFAALPQTVAVDINDLGTIKLSLEVTWNPFDKDDQSSSASTVNK 330  zebrafish
XP_006639810  248 MVFLPHIQENFEIKVTEVKGLGS-VLVGVVTCESLDFFQARPHIMVVDITELGTIKLQMEVMWdPFDSGETRPMSTSTSK 326  spotted gar
XP_018534112  251 MVFLPLINEFLTVKVTELKSLANhVVVGSVSCETKDLFAALPQTVAVDINDLGTIKLSLEVTWNPFDKDDQVSVASTVNK 330  barramundi perch
KAE8576278    251 RMFIPNLCENFEIKVVELRGLTT-IVVGLVTCHSADFFTTRPRIIIVDITELGTIKLQLEVIWNPFNTSKLLSTPGTTTK 329  tropical claw...
XP_007475802  250 KVFIPILHEHFEIKVIELRGLST-LLVGTVTCQLEDFFTTRPQIIVVDITELGTIKLQLEVIWNPFDTESFLVSPG-ISK 327  gray short-ta...

XP_003224034  329 FSVGSRKNSI-YSWTPPNTPSFREKYYLSVLQP 360  green anole
Q96MK2        332 FSMGSRKGSL-YNWTPPSTPSFRERYYLSVLQQ 363  human
XP_021244499  362 ASALQRRMSM-YSQGTPETPTFKDHSFFKWLHP 393  helmeted guineafowl
XP_004074425  366 ATALQRRVSV-YSQGTPETPTFQDNSFfmqpyp 397  Japanese medaka
Q4FZU8        334 ASTVTKRFST-YSQSPPDTPSLREQAFYNMLRR 365  Norway rat
Q1LXK2        331 APTVNKRFST-YNQSPPDTPSLREQAFYNMLRR 362  zebrafish
XP_006639810  327 LSVPSRKGSL-YSWTPPSTPSFTEKYFISVARR 358  spotted gar
XP_018534112  331 APTVSKRFSTiFNQTPPDTPSLREQAFYNMLRr 363  barramundi perch
KAE8576278    330 FSTSGRKASL-YHWTPPNTPSFREKFYLqndld 361  tropical clawed frog
XP_007475802  328 FSVGSRKGSL-YNWTPPSTPSFREKYYLSLFQQ 359  gray short-tailed opossum
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