6WHR


Conserved Protein Domain Family
CaM_bdg_C0
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pfam10562: CaM_bdg_C0 
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Calmodulin-binding domain C0 of NMDA receptor NR1 subunit
This is a very short highly conserved domain that is C-terminal to the cytosolic transmembrane region IV of the NMDA-receptor 1. It has been shown to bind Calmodulin-Calcium with high affinity. The ionotropic N-methyl-D-aspartate receptor (NMDAR) is a major source of calcium flux into neurons in the brain and plays a critical role in learning, memory, neural development, and synaptic plasticity. Calmodulin (CaM) regulates NMDARs by binding tightly to the C0 and C1 regions of their NR1 subunit. The conserved tryptophan is considered to be the anchor residue.
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Statistics
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PSSM-Id: 402271
Aligned: 9 rows
Threshold Bit Score: 37.8807
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6WHR_A        856 IAYKRHKDARRKQMQLAFAAVNVWRKNLQ 884 
XP_028025350  844 VVYKRHQIRKQKRLEIARHAADRWRGAVE 872 
Q7PXM3        853 VVYKKHQIKKQKKMEIARHAADKWRGTIE 881  Anopheles gambiae str. PEST
XP_002424050  847 MAYKKHQIKKQKRLELARHAADKWRGAIE 875 
EFN89750      892 IAYKKHHMRRQKKLDTMRNVIDKWRGMIQ 920 
EDO35545      819 ILYHKHRGWKEEQKELAKKTTDKWRANIL 847 
EKC19122      837 IAYKRHRGLKDKELELARNAADRWRGNIE 865 
XP_005161117  851 IAYKRHKDARRKQMQLAFAAVNVWRKNLQ 879 
EEC15663      512 IVYKKHQTRKQRRLELARHAADKWRGAVE 540
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