Conserved Protein Domain Family
Vps23_core
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pfam09454: Vps23_core (this model, PSSM-Id:401418 is obsolete and has been replaced by 462803)
Vps23 core domain
ESCRT complexes form the main machinery driving protein sorting from endosomes to lysosomes. The core domain of the Vps23 subunit of the heterotrimeric ESCRT-I complex is a helical hairpin sandwiched in a fan-like formation between two other helical hairpins from Vps28 (pfam03997) and Vps37. Vps23 gives ESCRT-I complex its stability.
Links
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Statistics
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PSSM-Id: 401418
Aligned: 103 rows
Threshold Bit Score: 53.6208
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CCE79523                      410 NIIIADSPLVNQVYELSGEIRAIRDSLDLLSGKFQgeNEVINdvtLNQCVKLARNLGRELFWLQM 474 Millerozyma f...
CBZ05870                      268 NCLVPADPLQARALELLAEIHAADDTLALLEEGLK--RELMT---CDEYVKNVSDVGREQFVSRH 327 Leishmania ma...
Q4DWG4                        282 TCIEPVDDLQTHALELLSEIHALDDALELLERSLK--AGQLS---CEEYVRRVSDMGRKQFEARF 341 Trypanosoma c...
Q59WF8                        408 EIVIADSPMIDTLYKVSAEINSITDTINLISGNFHneQEIVNeksFDSCLKTTRKMGRELFWLhf 472 Candida albicans
XP_006689532                  412 EVVISDSVLTNQLYEISSEIKANNDCMSLIGGSFDneNELIDdasFDTCVKTVRGIGRDIFWLKL 476 Yamadazyma te...
A0BPW4                        218 lqhisTTPYQDQLIELDAKIKGIRDTLRLIQHNFQ--NNHLN---FLELNQFTRNLAKEEFDAFL 277 Paramecium te...
A0BV93                        339 qniRENDQFSTSILELYSDIQACRETLHFIVTKFK--NFNLP---FETVIKMTRKYSEEQFNNIL 398 Paramecium te...
A0CR15                        375 eelmQTDPLSNQIIDLTSEIQAQKEGLYYVQKKFR--HQNLD---YDQLIKITRQMSQQMFDQYL 434 Paramecium te...
WGS:AAGF:cds.TTHERM_00486330A 261 kyMTAQSPVHNQILQLIAELDAIKETFLFTDEWFK--RSK-D---FDQYSSQIKLLAEREFECKI 319 Tetrahymena t...
Q24HU3                        343 NFIKEQNPLQNQILELTSEQEAIKETIIYIEEAFK--QKKID---FETLIKSIQYYSELEFNTKL 402 Tetrahymena t...
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