Conserved Protein Domain Family
CCDC106

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pfam15794: CCDC106 (this model, PSSM-Id:318088 is obsolete and has been replaced by 464874)
Coiled-coil domain-containing protein 106
CCDC106, coiled-coil domain-containing protein 106, is a family of eukaryote proteins. Yeast two-hybrid screening has identified CCDC106 as a p53-interacting partner. CCDC106 is a negative regulator of p53 and may be involved in tumorigenesis in some cancers by promoting the degradation of p53 protein and inhibiting its transactivity.
Statistics
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PSSM-Id: 318088
Aligned: 10 rows
Threshold Bit Score: 206.542
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007239305  26 MLTITKLQCLLESKQEKIESLERQVEDLQQDRKFLRQQIENLTSSRS-------Gp-aPEAS------------------ 79  Mexican tetra
XP_003969145  79 FILVSNLRAHLYVALEKNAWLQKRIEELEEERNFLRCQLDRFIVSMRs-----sEdwcGDSQ------------------ 135 torafugu
XP_017270744  71 YMVITNLRTQLQISLEKNSWLQKRIEDLEEERDFLRCQLDRFIFSTKs---------qGQEQsqnqysngyesrrftwra 141 mangrove rivulus
ETE73069      76 LTLVTSMKTQLHMALERNSWLQKRIEDLEEERDFLRCQLDKFISSARl-----dA---DDHC------------------ 129 king cobra
NP_037433     55 LALMNSVKTQLHMALERNSWLQKRIEDLEEERDFLRCQLDKFISSARm-----eA---EDHC------------------ 108 human
XP_004916271  55 IILMNSMKTQLHMALERNSWLQKRIEDLEEERDFLRCQLDKFISCTKs-----dS---EEHS------------------ 108 western clawed ...
XP_006005149  81 QMFMTNLRNQLNLTLEKNSWLQKRIEDLEEERDFLRCQLDKFISSTKs-----dAv-sEYES------------------ 136 coelacanth
XP_005474778  56 TALLNKEQEELTFLKEKLEWQKMRIEELEGERDFLRRQLSSFTK------------------------------------ 99  Nile tilapia
XP_017214581 216 qlSLEQAKKTIEIQKEKILHLQEKVDFLMDDRNYLRSRLEDAL---------------RLRC------------------ 262 zebrafish
XP_011606398  82 llTITKLQCMLESKQERIAALEKQVEDLMQDRKFLRTQVENLTSSRSmqafappTe-aPKPS------------------ 142 torafugu
XP_007239305  80 --------KSVYTE--------------PKAHKR---------------------------------------------- 91  Mexican tetra
XP_003969145 136 --------RSVKGQpagspsppspmttrSGMTLK---------------------------------------------- 161 torafugu
XP_017270744 142 rreddrpaEQQKAD--------------SQHFPSrqfiqrrpgpptmvssknhissplstqltsmnalfnstqsqallqg 207 mangrove rivulus
ETE73069     130 --------CKKKLP--------------RRAEIM---------------------------------------------- 141 king cobra
NP_037433    109 --------RMKPGP--------------RRME-G---------------------------------------------- 119 human
XP_004916271 109 --------RIKQTN--------------WR---S---------------------------------------------- 117 western clawed ...
XP_006005149 137 --------RMKQNL--------------R--------------------------------------------------- 143 coelacanth
XP_005474778 100 ------------QP--------------KDQPFN---------------------------------------------- 107 Nile tilapia
XP_017214581 263 --------ETVNSP--------------ALTASS---------------------------------------------- 274 zebrafish
XP_011606398 143 --------KGQHSD--------------GKSRKR---------------------------------------------- 154 torafugu
XP_007239305  92 -----Q------------------------------------RTASSSS----SLCNESGSdGSFSSAss---------- 116 Mexican tetra
XP_003969145 162 -----HiqgagsrsrrsaaitaavkqefhleeekfftedeyvEEEEDDD----DEEEDEAS-SSEKGLkk---------- 221 torafugu
XP_017270744 208 hshstP------------------------------------STTAGSGcsksGSVTRSSI-NEMSGHsgpdslsllges 250 mangrove rivulus
ETE73069     142 -----E------------------------------------SR---NG----EVTDDDSMaSWLTASpeeg-------- 165 king cobra
NP_037433    120 -----D------------------------------------SRGGAGG----EASDPESAaSSLSGAseeg-------- 146 human
XP_004916271 118 -----E------------------------------------GKECCNE----DLTDNDSMlS-VSAYseeg-------- 143 western clawed ...
XP_006005149 144 -----------------------------------------------NG----NISDDEDGlGTQSPSsdag-------- 164 coelacanth
XP_005474778 108 -----D------------------------------------PFSLKAS----ENSDSSSAfSSVSSVwsss-------- 134 Nile tilapia
XP_017214581 275 -----S------------------------------------TIVTSQK----NQSTDTSSdSSESTDssds-------- 301 zebrafish
XP_011606398 155 -----E------------------------------------RASCSSS----DGS-PSGSeASDSSEasaa-------- 180 torafugu
XP_007239305 117 -------------------------aASERKRRh---KEKKKGKKGKDYGRKRATGVQYVIHRYKQVLSAFNKKKSMSGA 168 Mexican tetra
XP_003969145 222 ------------------------kgRGRANSEpr-mKMRRIFRITHGRERQRVKDPDGVLIRYKKILTTYQRVRSMSRA 276 torafugu
XP_017270744 251 ddyleqdgfieeeeiisgedvmpdtiSTNRHQL----KRRRLFRAP--RERQRVKDAAGVLFRYKKILLTYQRLKNMSKA 324 mangrove rivulus
ETE73069     166 ----------------------gsveHKKLIAG----LNRRCFAKPKIRERQRVKDVDGVLCRYKKILYTFQKMQSMSRA 219 king cobra
NP_037433    147 ----------------------saseRRRQKQKg--gASRRRFGKPKARERQRVKDADGVLCRYKKILGTFQKLKSMSRA 202 human
XP_004916271 144 ----------------------dtlaDTKRQRQkg-sCNKRGFCKPKIRERQRVKDADGVLCRYKKILSTFQKLKSMSRA 200 western clawed ...
XP_006005149 165 ----------------------cselDRKKLRGr--gARGKQPLRVKVRDRQRVKDAEDVLCRYKKILTSFQKLKSMSRA 220 coelacanth
XP_005474778 135 ----------------------ssfpKKRKQKYkkkhSRAKKPKKEQKKLRQHVQTPNDIVQRCKSPLKTFPRTKTMTKA 192 Nile tilapia
XP_017214581 302 ----------------------eptaKKKKKGKk---SKRQKKSKTKMIDIKRVRTPEDSINRYNKVLQLVRDGLSKAEA 356 zebrafish
XP_011606398 181 ----------------------ssehRRKKHH-----KEKKRSKKTKDYSRKRATGVQYVIHRYKQVLTAFVKKKNMSEA 233 torafugu
XP_007239305 169 FRHHGIDRNTIANTAPIAELHLAAKEAVPLVGQFRPREETLVNYAQRCALAIetDEELSRKIEQMKANGELLPISA 244 Mexican tetra
XP_003969145 277 FQIHGVDRNTMASTSPIAELLLVAPEKMTEVGEFEASREKLLDYARRCYKTM--DEQTHTKVQAMKKTHKLLPISY 350 torafugu
XP_017270744 325 FQIHGVDRNTVASTTPIAELLLVAPEKVAEVGEFDPSKEKLLDYARRCYIAL--DEETLSRVQALKKNNLLLPISY 398 mangrove rivulus
ETE73069     220 FEHHRVDRNTVALTTPIAELLIVAPEKLAEVGEFDPSKERLLEYSRRCFMAL--DDETLKKVQALKKSKLLLPITY 293 king cobra
NP_037433    203 FEHHRVDRNTVALTTPIAELLIVAPEKLAEVGEFDPSKERLLEYSRRCFLAL--DDETLKKVQALKKSKLLLPITY 276 human
XP_004916271 201 FEHHRVDRNTVALSTPIAELLIVAPEKIAEVGEFDPSKERLLEYSRRCFLAL--DEETLEKVQTLKKNKLLLPITY 274 western clawed frog
XP_006005149 221 FEYHGVDRNTVALTTPIAELLIVAPEKVAEIGEFDSSKERLLEYSKRCFMAL--DEETLMKVQALKRNKLLLPISY 294 coelacanth
XP_005474778 193 FQKHGLDRNTVVSTSSVGELAIAVPNVYQELLSNRSSGETVLAFAKRCEAAIqgSDEV--KKQNRkyegrwyfasi 266 Nile tilapia
XP_017214581 357 YNKVKIDRNTIVKQAPIAELATANPTEFKSLRATFKKGESVQEFANLCLTRClaQSNM-EILKQLKESNALLDIfk 431 zebrafish
XP_011606398 234 FRHLGIDRNTIANTASIAELHLAGVDFVHLVGRFRQGEETLVNYAQRCTMVIdsDSDLSQKIDQMKANGELLPISg 309 torafugu
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