Conserved Protein Domain Family
GREB1
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pfam15782: GREB1 (this model, PSSM-Id:318077 is obsolete and has been replaced by 464866)
Gene regulated by oestrogen in breast cancer
GREB1 (gene regulated by estrogen in breast cancer 1) was first identified as an oestrogen-regulated gene expressed in breast cancer. Its exact function is not known but its expression is regulated by the coordinated binding of oestrogen-receptors to distal sites interacting with Pol II to activate gene transcription from core promoters located at a considerable distance from the greb1 gene.
Links
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Statistics
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PSSM-Id: 318077
Aligned: 8 rows
Threshold Bit Score: 3109.85
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_004935823    1 MGNSYAGQLKTTRFEEVLHNSIEASLRSNNLVPRPIFSQLYLEAEQQ---------------------LSS------LE- 52   chicken
XP_005995991    1 MGNSYAGQLKTTRFEEVLHNSIEASLRSNNLVPRPVFSQLYLEAEQQ---------------------LTS------VE- 52   coelacanth
XP_003924837    1 MGNSYAGQLKSARFEEALHNSIEASLRCNSVVPRPIFSQLYLDPDQHpf--------------------------ssADv 54   Bolivian squi...
XP_010707123    1 MGNSYAGQLKSARFEEALHNSIEASLRCSSVVPRPIFSQLYLDPDQPpflpedvkpkveeldkelvhrFSQngnsdfST- 79   turkey
XP_002609592   57 MGNTH-GQLKSSRFEAALHSSIEQSLRSQDVAPRPVFSQLYLDKQQGhvrppgpenidvkpnikeleaAPRdrhssaSS- 134  Florida lancelet
XP_011490902    1 MGNSYAGQLRSARFEEVLHNSIEASLRSNTLVPRPVFSQLYLETEQS---------------------F----------- 48   Japanese medaka
XP_005459036    1 MGNSYAGQLRTTRFEEVLHNSIEASLRSNTIIPRPVFSQLYLETEQP---------------------LAR--------- 50   Nile tilapia
XP_011616889    1 MGNSYAGQMRTTRFEEVLHNSIEASLRSNVAVPPPVFSQLYLEIEKS---------------------LSFlcc------ 53   torafugu

XP_004935823   53 -------------------------AGS--------RADNEEEEEeeEEEGS-ESSSPVSYQMKPPPEGCCTTDGFCQAG 98   chicken
XP_005995991   53 -------------------------AGS--------RPENEEEEE--DDGSE-SNSPPIPYQMKPPPDGCCTTDGFCQAG 96   coelacanth
XP_003924837   55 kpkvedldkdlvhrytqngsldfsnSLT--------VNEMEDDEDd-EEMSD-SNSPPIPYSQKPAPEGSCTTDGFCQAG 124  Bolivian squi...
XP_010707123   80 -------------------------NQT--------VNEMEDEEEd-EDMSD-SSSPPIPYSQKPAPEGSCTTDGFCQAG 124  turkey
XP_002609592  135 -------------------------TSGyrgnppaeQPSVDQSYEd-EEKEDpPGSPQQPYRFPTPPEGACQTPGYCQAG 188  Florida lancelet
XP_011490902   49 ---------------------------G--------RAENDDEDD--EDGSE-SNSPPIPYQMKPPPEGCCTADGFCQAG 90   Japanese medaka
XP_005459036   51 ----------------------------------------DDEDD--EDGSE-SNSPPIPYQMKPPPEGCCTTDGFCQAG 87   Nile tilapia
XP_011616889   54 -----------------------vsSKG--------HAEVDD-DD--EDASE-DTSPHIPYQMKPPPEGCCTTEGFCQAG 98   torafugu

XP_004935823   99 KDLRLVSISNEHIDVPSGFLLVGAKSPNLPDHLLVCAVDKRFLPDDNGRNALLGFSGNCVGCGKKGFCYFTEFSNHINLK 178  chicken
XP_005995991   97 KDLRLASISNEQIELPAGFLLVGAKSPNLLDHLLVCAVDKRFLPDDNGRNALLGFSGNCVGCGEKGFRYFTEFSNHINLK 176  coelacanth
XP_003924837  125 KDLRLVSLCMEQIDIPAGFLLVGAKSPNLPEHILVCAVDKRFLPDDNGKNALLGFSGNCIGCGERGFRYFTEFSNHINLK 204  Bolivian squi...
XP_010707123  125 KDLRLVSLCTEQIDIPAGFLLVGAKSPNLPEHILVCAVDKRFLPDDHGKNALLGFSGNCIGCGERGFRYFTEFSNHINLK 204  turkey
XP_002609592  189 KDIRLTSLREVKLTLPEGFVLVGAKSPNLTNNILVAAVDARFLPNPKTNLALLGFSGNCIGCGEQGFRYFTEFSAHINMR 268  Florida lancelet
XP_011490902   91 KDLRLSSLASDTLDVPAGFMLVGVKSPSLPDNLLVCAVDHRFLPDERGRNALLGFSGNCMGCGEKGFRYFTEFSNHINLK 170  Japanese medaka
XP_005459036   88 RDLRLSSLASDPLDVPPGFMLVGVKSPSLPENLLVCAVDRRFLPDERGRYALLGFSGNCMGCGEKGFRYFTEFSNHINLK 167  Nile tilapia
XP_011616889   99 RDLRLSSLALDTFDVPPGFLLVGVKSHTLPEDLLVCTVDCRFLPDERGHDALLGFSGNCVGCGEKGFRYFTDFANHINLK 178  torafugu

XP_004935823  179 LTTQPKKQKHLKYYLVRNAQGALTKGSVICWKG--AELRGRQSSSSTCSGTVCQLPESAGLSGSTTSEPP---------- 246  chicken
XP_005995991  177 LTTQPKKQKHLKYYLVRNAQGVLTKGPLICWKG--TECRGQQSTSSTCSSAPSQPPESPSPLMMAATESVslvn------ 248  coelacanth
XP_003924837  205 LTTQPKKQKHLKYYLVRSSQGVLSKGPLICWK----ECRSRQSSASCQTIKPSSSVSSTVTPENGTANGYkagf------ 274  Bolivian squi...
XP_010707123  205 LTTQPKKQKHLKYYLVRSSQGVLSKGPLICW----KECRSRQSSAASLSAKPNSAVSPSTTPEGGSANGYksgftqtdss 280  turkey
XP_002609592  269 LTTQPKKQKHLKYYIVRNNLGLLVRGPLVPWKVvsPEVRKRGFPMAPQVVSPLLSAAQGAQQATISYHANrvpa------ 342  Florida lancelet
XP_011490902  171 LSTQPKKQKHLKYHLYRNKQGILVKGAPICWRV--N------DGRIRPIRPTHSESTLTSHEQP----PNmalt------ 232  Japanese medaka
XP_005459036  168 LHTQPKKQKHLKYYLYRNSQGLLVKGAPICWRG--NDGRMRQLGPTLSEGQSTPDAQPPNLTL---SQPShtpg------ 236  Nile tilapia
XP_011616889  179 LSTQPKKQKHLKYLLYRNNQSVLVKGAPICWRG--HDtrt----kknGSSHVSSDEQPSNMPL---NHPShttg------ 243  torafugu

XP_004935823  247 --------------------------------------------PGTPQAATAIDH-IPSTAAFGSAAYNGKESPK-Q-- 278  chicken
XP_005995991  249 ----------------------------------------qnasAGSQQTGIPTDQaLPVLTSGTPTTLNGKDSPKhQ-- 286  coelacanth
XP_003924837  275 -------------------------------------------tqtdAANGN-------------SSHGGKGSASSsTpa 298  Bolivian squi...
XP_010707123  281 vfspaksssainlsgtqdpsrnknvvkplalsvqlvgktfasaplslHATDGT-----------NGNTNGGRNNVLsS-- 347  turkey
XP_002609592      --------------------------------------------------------------------------------      Florida lancelet
XP_011490902  233 -----------------------------------------------yrtAVAGPHvDQQTTDLAHTLINGNHSAPsS-- 263  Japanese medaka
XP_005459036  237 --------------------------------------------------shsaSHaEPQTADVSHNLINDNQAVPsN-- 264  Nile tilapia
XP_011616889  244 ---------------------------------------------shtgGSHVDSAaGPQVNDAPQSITNCNLAVSsN-- 276  torafugu

XP_004935823  279 ---QLVK-NNLSALTRPSV-----------L----GTLTNSGPPKKRHKGWSPES-----PSSTETwnlPLNPQAP---N 331  chicken
XP_005995991  287 ---HSVKsSNLSMQMRPSV-----------I----GTLANSGPPKKRHKGWSPES-----PSATEAgglQSNQAVPfhgN 343  coelacanth
XP_003924837  299 hpgNY------SLSPRPSY-----------AsgdqATMFISGPPKKRHRGWYPGSp---lPQPGLVvpvPTVRPLSr-tE 357  Bolivian squi...
XP_010707123  348 ---TVSRpMPHSTSPSPAC-----------AagdqASMSNSGPPKKRHRGWSPGSp---vPPPGLVvpvPTIRPSTr-tE 409  turkey
XP_002609592  343 -sllaAQqQHPSPQPRPSTikyggggspplPngpsPPDGSAQPPKKRHKGWGPGR-----PDT----------------- 399  Florida lancelet
XP_011490902  264 ---AQSS-LNQ--PGRSSA-----------P----ATHTNAGPPKKRHKGWSPDLsanslQESTVKsppASLSLSTlsvS 322  Japanese medaka
XP_005459036  265 ---THPP-LNQSGPGRPSA-----------T----GVHLNTGPPKKRHKGWSPESstsnlPESTAKtppSSLASSTlsvS 325  Nile tilapia
XP_011616889  277 ---VQLP-LNQSVARRPSV-----------T----APHSNSGPPKKRHKGWSPESaansvPDGTMKtptSSSSLPTlsvS 337  torafugu

XP_004935823  332 RIKn---------------dGGSL-SSLPHSALVGPASSpmvGSGEPVSVPDNLLKICKAKPVIFKGHGNFPYLCGNIND 395  chicken
XP_005995991  344 KAD-----------------GIGL-TCLSQPVPAGLLPSplaATGEPVSVPDNLLKISRTRPVILKGHGNFPYFCGNLND 405  coelacanth
XP_003924837  358 SPLs---------------aPVPQ-TPLTGILQPRPIPA-----GETVIVPENLLSNSGVRPVILIGYGTLPYFYGNVSD 416  Bolivian squi...
XP_010707123  410 PLLs---------------vPVPQ-SMLTGILQPQPIPA-----GETVIVPENLLNNSGVRPVILIGYGTLPYFYGNVGD 468  turkey
XP_002609592  400 -----------------------M-SNLNLVMPPHPAMQ-----AESVFIQPGLLNICCTKPVVLACHGNLPYLHGNVND 450  Florida lancelet
XP_011490902  323 SVVtngnrseipslqsssqpSAAIf----------------pPLQLSVTVPDQLLHTCRLQPVILKGHGPLPQLTGNVRD 386  Japanese medaka
XP_005459036  326 SVAt---------------nGSRA-ETTAQQGSSQWISTplsPPEVPVIVPDQLLQTCRLQPVIFKGHGPLPQLTGSVSD 389  Nile tilapia
XP_011616889  338 SVIt---------------nGARSdGAAPGITStps------ppGLSVTVPDQLLHTCRLRPVIFTGHGTLPQLTGNVSE 396  torafugu

XP_004935823  396 VIVSPLLYTCYRNSQSLSRAYEQYGAPTIQPISEEMQLLLTVYYLVQLASDQVPLIEDLEQIFMRSWRESHLSEIRQYQQ 475  chicken
XP_005995991  406 IIVSPLLQTCYKNAQSLPRAYEQYGASPIQPLSVEMQILLTVYYLVQLAPDQAPLIEDLEQIFMRSWRESHLAEIRQYQQ 485  coelacanth
XP_003924837  417 IVVSPLLVNCYKIPQLENKDLEQLGLTGSQYLSVENMILLTIQYLVRLGPDQIPLREEFEQIMLKAMQEFTLRE--RALQ 494  Bolivian squi...
XP_010707123  469 IVVSPLLVNCYKIPQLENKDLELLSLTSSQLLSVENMILLTIQYLVQLGPDQIPLREEFEQIMLKAMQEFTLRE--RSLQ 546  turkey
XP_002609592  451 VVVSTLLVDCYKPVQMPPKLLEGLGLTNAPPLSVETMALLTVQYLVQLGNEKVPLREEFDAILLQARQESAIKD--KNMQ 528  Florida lancelet
XP_011490902  387 ILVSSLLHSCYMSSQTLPRIYQHYGPSPIQPLSTEMQILLTIYYLVQLGPEQVPLVEDLEQIFMRSWRESHLSEIRQFQQ 466  Japanese medaka
XP_005459036  390 VLVSSLLQSCYLSSQTLPRVYQHYGPSPIQPLSTEMQILLTVYYLVQLGSDQVPLVEDLEQIFMRSWRESHLSEIRQYQQ 469  Nile tilapia
XP_011616889  397 VLVSSLLQSCYLSSQTLPRVYQHYGPSPIQPLSAEMQILLTVYYLVQLGPVQVPLIEDLEQILMRSWRESHLSEIRQYQQ 476  torafugu

XP_004935823  476 MIPQTFPQVP----S--------------------------QIAPVTSAQLPWLAGLAASSCNDSVHII-ECSYSLAEGL 524  chicken
XP_005995991  486 AHPQMLPQVR----V--------------------------QIPPVTSAQLPWLTRLAASSCNNSVHII-ESTNSLAEGL 534  coelacanth
XP_003924837  495 LGAQCVP--------------------------------------VSPGQLPWLARLIASVSQDLVHVI-VTQNSLAEGI 535  Bolivian squi...
XP_010707123  547 MSAQCIS--------------------------------------VSPAQLPWLARLIASVSRDLVHVV-VTQNSLAEGI 587  turkey
XP_002609592  529 QHAQFLS--------------------------------------VAPAQLPWLAKVAASASNGLVRIV-NAQASLAEGI 569  Florida lancelet
XP_011490902  467 ------PQAP----Avqgrhytletpv--slpghlqqislqSQQTLTPSQLPWLAQLAASSSGEGVVVLgEDVRSLAQGL 534  Japanese medaka
XP_005459036  470 ------PQTT----GtpgrhygieippvlpglpqylslpsqSPQPLTPNQLPWLAQLAASSYGEGVVVLgKDVGSLAQGL 539  Nile tilapia
XP_011616889  477 ------PQPQhlpvPp------------------------qSQQPLSPSQLPWLAQLATSSCGEGVVVLgEHIKSLARGI 526  torafugu

XP_004935823  525 SEMFKLLIEGKLIKT--NYVVIICASRNRAIDSCIVITGKYQARVLSEGMLTPSDYQKEVNYQLVTGKVESLGSFFST-- 600  chicken
XP_005995991  535 SELFRSLAKGKLQQT--NFVVIIYSPKNRSTESCVAVIGKHQARALAESMFSPSESLKEINYELVTGKVASLGAFFST-- 610  coelacanth
XP_003924837  536 SETLRTLSEMRHYQRlpDYVVAICASKIRGNEFCVVVLGPHQSRALAESMLTTSEFLKEISYELITGKVSFLASHFKT-- 613  Bolivian squi...
XP_010707123  588 SETLRTLNEMKHQQKlpDYVVAICASKIRGNEFCVVVLGQYQSRALAESMLTSSEFLKEISYELITGKVSFLASHFKN-- 665  turkey
XP_002609592  570 SETLQMICMPQPYTRypSFVLVIHVSRHRGTEFCVLVTGVHQARVVAESMLSASDCFKEISYEIITGKFNLLTSHFKEpn 649  Florida lancelet
XP_011490902  535 DQTFSRLIEGKLQNT--NYVVILVTTPGHETQSCVVVTGKHQCRALSESMFSPSEGLKEINLQLSSGVAEELIHFCKS-- 610  Japanese medaka
XP_005459036  540 QLTFSRLMEGRLENT--NYVVIIVTAPGQETQSCVVVTGKHQCRALAESMFSPSQGLKEIAHQLSTGVAQELIHYCNS-- 615  Nile tilapia
XP_011616889  527 QQTFNRLMEGQLENT--NYVVIIVSSPGEQTQSCVIVTGKHQCRALAESMYSPIEGLREISRQLSTDITQELLQYCHC-- 602  torafugu

XP_004935823  601 -LCP------------E------GDIDLLL----------------------------------EKFYQENQGHISSSLS 627  chicken
XP_005995991  611 -LCP------------D------GDINTLL----------------------------------DKFHQERSGKTSSPFS 637  coelacanth
XP_003924837  614 -TSL------------G------DDLDKLL----------------------------------EKMQQRRGDSVVIPFN 640  Bolivian squi...
XP_010707123  666 -TSL------------G------DDLDKLL----------------------------------EKMLQQRGESVIIPFN 692  turkey
XP_002609592  650 tAMSvpvkkhaahipgN------SELDKLL----------------------------------DDFVGPMSGEVMVPYH 689  Florida lancelet
XP_011490902  611 -LGS------------D------GDIDKLLesnpansnealplsrnqecpeenmsspkkepnskDSQTQSSKDEV-SPKE 670  Japanese medaka
XP_005459036  616 -LGQ------------D------GDIDSLL----------------------------------DNAILDS-NEP-SPLS 640  Nile tilapia
XP_011616889  603 -LGD------------GvadmcyGDMDSLLdlaavdtkep---------------salsrnspkDSNIHISKDLP-SPKV 653  torafugu

XP_004935823  628 ASA-NKSTALNGTGAAV-------------------------CTS--YEIERHQIRPFQLAVAQKLLSHICSIADSSTQN 679  chicken
XP_005995991  638 ISFnKAVSSEGVATKATt-----------------------aCTS--YNTEWHQIRSIQLAVARKLLSHVCAIADSSTQN 692  coelacanth
XP_003924837  641 GDLnECVSPQEAAAMMP-------------------------TQNldLDSETFQIYQPQLTVARKLLSQVCAIADSGSQS 695  Bolivian squi...
XP_010707123  693 GDVsECVSSQEAIAMVSt-----------------------qEPD--LDVDTFQIYQPQLTVARKLLSQVCAIADSGNQT 747  turkey
XP_002609592  690 GGElHRVREDVAKDMVPd-----------------------kQPD--VSTDHQELHPVQIAVAMKILSQVCAIADSGTQS 744  Florida lancelet
XP_011490902  671 SKHsCS--------------------------------------E--YSAEWREVRPIQLAVARKLLSHVCAIADSSTQN 710  Japanese medaka
XP_005459036  641 SSQeSAEERSNKSPRVThspkdphthlskdspkdtasstkdtCSE--YSVDWREVRPIQLAVARKLLSHVCAIADSSTQN 718  Nile tilapia
XP_011616889  654 QSAsLKDSCS--VSMSA---------------------------E--YLVEWCEVRPIQLAVARKLLSHVCAIADSSTQN 702  torafugu

XP_004935823  680 LDLGSFEKIDFLICVPPSEVTYQQTLFHLWHSGILLELG-LEKQHLTKQKVEQYVLKLDA--EAQIKFKVFLQNSMQNPH 756  chicken
XP_005995991  693 LDLGSFEKVDFLIFVPPSEVTYQQIVLHLWQSGILLEIG-LEKKSVIKQRAEQYVVKMDA--EAQTKFKAFLQKSLQNPY 769  coelacanth
XP_003924837  696 LDLGHFSKVDFIIIVPRSEVLVQQTLQRIRQSGVLVDLG-LEENGTAHQRAEKYVVRLDN--EIQTKFEVFMRRVKQNPY 772  Bolivian squi...
XP_010707123  748 LDLGHFSKVDFIVIVPRSEVLVQQTLQRIRQSGVLVDLG-LEDNGTAYQRAEKYVVRLDN--EIQTKFEVFMKRVKQNPY 824  turkey
XP_002609592  745 LDLGRFSKVDILVMVPPSNILYNQTVERLKQSGVLVDLG-METASSIDQKVDQYVMKCDSvaENQAKFESFVKHVRQHPY 823  Florida lancelet
XP_011490902  711 LDLGSFDRISFLILVPPSEVTFQQTVFHLRNSGVLQDLVsSDQECMSKLEPEQYVVKMDR--KAQARIDNLTQEAHRNPY 788  Japanese medaka
XP_005459036  719 LDLGSFDRVSFLILVPPSEVTFQQTILHLWSSGVLQELGsLDQACVSHREAERYVVKMDH--SAQARIDNLIREAYSNSY 796  Nile tilapia
XP_011616889  703 LDLGSFDRVSFLILVPPSEVTFQQTVLHLWSSGVL---GgLDQGCASKQEAERYVVKMDH--GAQARIESLIHEAHSNSY 777  torafugu

XP_004935823  757 TLFVLIHDHAHWDLMsa-mHSLYPQTELPTGLVDRLLNCREVKEAPNIVTLHVTSFPYALQTQHTHISPYNEIHWPSSYS 835  chicken
XP_005995991  770 TLFVLIHDHAHWDLVssgaPGPYPQTESYVGLIDRLLNCRQVTEAPNILILHVTSFPYALQTQQTRISPYNEIHWPSACN 849  coelacanth
XP_003924837  773 TLFVLVHDNSHVELTsv-iSGSLSHGEPSHGLADRVINCREVLEAFNLLVLQVSSFPYTLQTQQSRISSNNEVHWIQL-D 850  Bolivian squi...
XP_010707123  825 TLFVLVHDNAHVDLTsa-iSSSLSHGEPSHGLADRVINCREVLEAFNLLVLQVSSFPYALQTQQSRISSSNEVHWIQF-D 902  turkey
XP_002609592  824 TLHVLIQDQAHVDVN--------RHSSGNMGLADKYINCKDFADAPNLLTLQVSASPFSLQTQKSRVTPHNEVFWPSNIK 895  Florida lancelet
XP_011490902  789 TLYILVHDHAHWDIS----SSSCSSPDSGLGLVDLLLNSQQVKDAANILILHVTSFPFALQTQCTRVSPYNEIHWPPAFS 864  Japanese medaka
XP_005459036  797 TLYILVHDHAHWDIS----SATYSSSDSGLGLVDQLLNSRQVKDATNILILHVTSFPFALQTQCTRISPYNEIHWPSAFS 872  Nile tilapia
XP_011616889  778 TLYILVHDHAHWDIH----NASCRSSDNGLGLVDQLLNSGLIRDAPNILILHVTSFPFALQTQCTRISPYNEIHWPSAFS 853  torafugu

XP_004935823  836 NGVDLYHENKKYFGLSEFIESTLSGHSIPLLRYDSSFEAMVMALGKRFPRLHSAVIRTFVLIQHYSAAMMAVCG----LS 911  chicken
XP_005995991  850 NGVDLYHENKKYFGLSEFIESTHTGHSLPLLRYDSSFEAMVMAVGERFPKLHSAVIRTYVLIQHYAAAMMAVSG----LS 925  coelacanth
XP_003924837  851 TGEDVGCEEKLYFGLNEYSKSLQWGVTSPLLRCDEAFEKMVNTLLERYPRLHSMVVRCYLLIQQYSEALMALTT----MA 926  Bolivian squi...
XP_010707123  903 AVDDTASEDKLYFGLNEYSKSLQWGVTSPLLRCDETFEKMVTTLLERYPRLHSMVVRCYLLIQQYSQALMSLTT----MA 978  turkey
XP_002609592  896 QNPNVPPEDTVYFGVSDYCRTADWSNHMPALRSDDSFEQMSTSLLAKYPKLHSMVIRTYILVRHYSAALMTIAG----VP 971  Florida lancelet
XP_011490902  865 NDVDLYHERTRYFGVSELLETTRSGGCLPLLRYDSSFESMSSALEERFPKLHSAVIRTMVLIQHYCMALVALSGrissSH 944  Japanese medaka
XP_005459036  873 NDVDLYHERTRYFGVSELLESTHSGSSLPLMRYDPSFESMAATLEERFPKLHSAVIRTTVLIQHYCVALMAVSGrfnrSH 952  Nile tilapia
XP_011616889  854 NDVDLYHERTRYFGVSELLESTHSGSSLPLMRYDSSFESMASALEERFLMLHSAVIRTTVLIQHYCVALMAVSGrigdSD 933  torafugu

XP_004935823  912 QMKNYTSVETLEITQNLINSSRQCPSGHGLMVVLRIPCTPLAAVAYERLYNVRERLALEDNFEIILGNPNSGITIGKHFV 991  chicken
XP_005995991  926 QMKNYTSVETLEIIQNLINSPGQCSSSHGHMVLLRIPSVPLAAVAYERLCQVRERLGLEHHFEVILGNPNTGITIGKHFV 1005 coelacanth
XP_003924837  927 SLRDHSTPETLSIMDDLISSPGRNKSGRGHMLIIRVPSVQLAMLAKERLQEVRNKLGLQYRFEIILGNPASELSVATHFV 1006 Bolivian squi...
XP_010707123  979 SLRDHSTPETLSIMDDLITSPGKDKNGCGHMLVIRVPSVQLAMLAKERLQEVRDKLGLQYRFEILLGNPASELTVAKHFV 1058 turkey
XP_002609592  972 GAQEKTTTETLNMLQDVVNAPLTSPGGQGSMLLLRVPSIQLAMVAYDKLHSVRDKLGLQYRFDVILSSANTDLTLEEYFL 1051 Florida lancelet
XP_011490902  945 NLHKHTSVETMEIVQALLTAAQQCPSHHGHMVLLRIPSLALAEWAHRRLCRVRKQLDLENCFEIILGNPSQTLTIRQHFT 1024 Japanese medaka
XP_005459036  953 NLQKHTSVETMEIVQSLVNAAQQCPAHHGHMVLVRIPSLALAAWAHQRLSRVRKQLGLEENFEIILGNPKQDLNIGQSFT 1032 Nile tilapia
XP_011616889  934 HLHKHTSVETLEITQSLFTAAQQCPSRHGHMVLLRIPSPALAEWAFRQLCRVRRQLGLEHSFEIILGNPNQPLNIGQSFV 1013 torafugu

XP_004935823  992 EQLKVWQKIED-----VDWRPQTYLELEGLPCILIFSGMDPQGESLP----------------RSLRYCDLRLINSSSLV 1050 chicken
XP_005995991 1006 EQLKMWQKIED-----TEWMPHTYLELEALPCILIFTGMDPQGESLP----------------RSLRYCDLRLINSAYLE 1064 coelacanth
XP_003924837 1007 ARLKTWRGNEP-----EEWIPRTYQDLDGLPCIVILTGKDPLGESFP----------------RSLKYCDLRLIDSSYLT 1065 Bolivian squi...
XP_010707123 1059 TRLKAWRGNEQ-----DDWIPRTYQDLEGLPCIVILTGKDPLGETFP----------------RSLKYCDLRLIDSSYLT 1117 turkey
XP_002609592 1052 KRMQAWRGELDnperkSSWVPRTYCDLDGLPCILILCGKDPLGETMPrsgchepfidvslpmfRSLKYCDLRLVNHGHVT 1131 Florida lancelet
XP_011490902 1025 NQIKTWLKDQD-----CDWVPHTYLELEALPCILILSGAEPLGESLP----------------RSLKYCDLRVISCSYLH 1083 Japanese medaka
XP_005459036 1033 DQIKKWLKIQD-----ADWVPRTYLELEALPCILILSGAEPLGESLP----------------RSLKYCDLRVISCSYLQ 1091 Nile tilapia
XP_011616889 1014 DQIKKWLKIQE-----ADWVPRTYLELEALPCILILSGAEPLGESLP----------------RSLKHCDLRVISSSYLQ 1072 torafugu

XP_004935823 1051 RTTLEQELGLAAYFVSSEI--HTEKAVVNDVIESD--PEKLSSTDNEDEEIATEGST----------------------S 1104 chicken
XP_005995991 1065 RTALEQELGLAAYLLRSDL--SREMVVVSDLSESD--PEKLSSTDFEDEEIVIEDHA----------------------S 1118 coelacanth
XP_003924837 1066 RTALEQEVGLACCYVSKEV--IRGPTVALDLSGKE--QERAAVSENDSDELLIDLERpqsnssavtgtsgsimengvsss 1141 Bolivian squi...
XP_010707123 1118 RTALEQEVGLACCYVSKEV--IRGPIVALDLSEKE--HEKANGSENDADELLIDLDRpqsn------------------- 1174 turkey
XP_002609592 1132 RASLEQEISLGCRYISRDV--VNEPITVCDMSDED--SQSDSEMDNDDGDLQIDTDRprsnssdvqqtspgfsgnqaqhN 1207 Florida lancelet
XP_011490902 1084 RTTLEQELGLAAYLVKAESrpPHKPGPGSDVIESDpePEKLSSTDNEEEEAQENGETllqstqpvlsc-qksaaecvpaQ 1162 Japanese medaka
XP_005459036 1092 RTTLEQELGLAAYLVKKESrpPQNLGSGSDLLESD--AEKLSSTDNEEEEGQDNGEPsqplqacpd----sgaldlnpaQ 1165 Nile tilapia
XP_011616889 1073 RTNLEQELGLAAYLVRAEPrlQHNPSSGSDTLESD--AEKLSSTDNEEEEEQ-NDDSplsssqqlq----scsdtgaadA 1145 torafugu

XP_004935823 1105 EK---RSP------MKRERSHSHDSASSSLSSKASITAFCS--Ep---SPPLVTAGDRAKSPHQVlsNSTEETTNNHE-- 1168 chicken
XP_005995991 1119 AK---RSP------IKRQRSHSNDSASSSLSSKASNSAFSS--K----SSSASATENTTKSPHPSlvNSTEGSVHNKG-- 1181 coelacanth
XP_003924837 1142 stadkskK------QSLTPSFQSPATSLGMDEGVSAST-----P-----------GTGARETL--------------K-- 1183 Bolivian squi...
XP_010707123 1175 --------------ssavTGTSGSLADNGVSSSSAADKSQKqaPslnfQMVAHSSVDEGTYPG-------FTAGDTLK-- 1231 turkey
XP_002609592 1208 GS---VSdstrnpnDNVGRSSPDSAQDSGKESQGNSVPEMS--P---------------QQPQASvtSLQGMVENSIDmi 1267 Florida lancelet
XP_011490902 1163 ST---TSP-------NVQK-GAFDTLPFLSKAQAQPQPS----SqsfpYAPTAPQNQAQ--------------------- 1206 Japanese medaka
XP_005459036 1166 ST---TSP-------NVEK-VALDAIQSSSQSQTQLQPQFS--SqsfpCPQTAPESQTQ--PYAPcySQSQQISQLQS-- 1228 Nile tilapia
XP_011616889 1146 ST---TAP-------NVLK-GTVDNV------QSQTPPA----Sqs-fpHPTPPVHQTH--PHMHsySQEQPTSQLPP-- 1199 torafugu

XP_004935823 1169 --RQKQKVDKGAQTTISKHLPPGNEQLDTkqniksaqiSITSSSSSPFSSSSSSSA---Pthns---filqTSQCSMTKS 1240 chicken
XP_005995991 1182 --SKKNQVDRKTQRIYNVNHSLAKEPIDCis-----tiNKSARKPPKSTSSASSST---Ptynif--vsqpSSQCSMAKA 1249 coelacanth
XP_003924837 1184 --QECDSLG----PQM-----------------------ASSTISKPSSSSSGPRTlpwP-----------GQPIRGYQG 1223 Bolivian squi...
XP_010707123 1232 --QECDSLG----NQM-----------------------ASSTTSKLSSLSSVSQTfrwP-----------GHSTKDSKA 1271 turkey
XP_002609592 1268 ygKEKNSNSHEGDADLPNEPFEQREAAAA---------RDRSGTSPMASVKSSVSKdnvPttstssvgqhkPPASRIAGS 1338 Florida lancelet
XP_011490902 1207 -----------------------QAPVSH---------QMPPKSTSSDSSSPRASS---P-----------HQNCSWARG 1240 Japanese medaka
XP_005459036 1229 --QTQIQLLSQTNPQPYLQIPPQQPLLSQm--------QIRSKSTSSGSSSPRASS---P-----------HPSCSWARG 1284 Nile tilapia
XP_011616889 1200 --QPPVQ----------------------------------------------SSS---P-----------HRSCSWARG 1217 torafugu

XP_004935823 1241 SKQ--PPIVFLPKLVYDIITSTDSSGLPKSSSLLPYHSVMWASSFRPLMSKMMTCTEQSLYYRQWTVPKPIHMDYNNRNE 1318 chicken
XP_005995991 1250 LQQ--PPIVFLPKAIYDIVTSIDSSGLPKSASFLPYHSVSWVSSFRPLLSKMMTCTEQSLYYRQWTVPKQIHMDYNNRVE 1327 coelacanth
XP_003924837 1224 PHTalPPVVILSKAAYSLLGSQKSGKLPSSSSLLPHADVAWVSSLRPFLNRDMSSEEQSLYYRQWTSARQHHADYSNQPD 1303 Bolivian squi...
XP_010707123 1272 LRAalPRIVILSKAAYCLLSSQKSGNLPSSSSLLPHADVSWLSSLRPLLHKDMSSEEQSLYYRQWTTARQHHADFSNQGE 1351 turkey
XP_002609592 1339 SLL--PVTIIVSKTAYDILRP-DPQGKQRHISLQPHPDVGWICPLRPMLLGEVTNEVQSAYYRQWTEPLQHHMDTDNKGE 1415 Florida lancelet
XP_011490902 1241 VGR--PPSVLLPRALYDIITVSDSSGLPRCTSFLPHIYVAWASSFRPLLSKMMTCTEQSLYYRQWTVPQSNHMDSSNRTE 1318 Japanese medaka
XP_005459036 1285 ASR--PPSVLLPHALYNVITASDSSGLPRCTSFLPHMSVAWASSFRPLLSKMMTCTEQSLYYRQWTVPRSYHMDSSNRTE 1362 Nile tilapia
XP_011616889 1218 VRR--PPSVLLPRTLYNVITASDSSGLPRCTSFLPHMSVAWASSFRPLLSKMMTCTEQSLYYRQWTVPRSYHMDSNNRTE 1295 torafugu

XP_004935823 1319 --GRMDTFHPRRLLLSGPPQIGKTGAYLQFLSILSRMLIRLTEVDVYDEEEININIKEESDQCYHQPGDT------WPDL 1390 chicken
XP_005995991 1328 --GRTDNFHPRRLLLSGPPQVGKTGAYLQFLSILSRMLIRLMEVDVYDEQEISINMQEESAHHYHQPGAL------WPDL 1399 coelacanth
XP_003924837 1304 paSGTRTFHPRRLLLTGPPKVGKTGSYLQFLRILFRMLIRLLEVDVYDEEEINTD-HSESTEVSQSEGEP------WPDI 1376 Bolivian squi...
XP_010707123 1352 a-SSSRSFHPRRLLLTGPPQVGKTGSYLQFLRILFRMLIRLLEVDVYDEEEINAN-HTESSEIAQSSNDH------WPDI 1423 turkey
XP_002609592 1416 --NSLPVFHPRRLLLSGPPQVGKTGAYLQFLRVLFRMLIRLLEVEVYNEEEINMDRESPAVSLVYNDNQTthltakWPDY 1493 Florida lancelet
XP_011490902 1319 --GRSDNFHPRRLLLSGPPQVGKTGAYLHFLGILSRMLIRLMEVDIYDEEDINNSVQAECVQ-FHPPNAP------WPKM 1389 Japanese medaka
XP_005459036 1363 --GRSDNFHPRRLLLSGPPQVGKTGAYLHFLGILSRMLIRLMEVDIYDEEDINCNSQTEGVQ-YHPASAP------WPNP 1433 Nile tilapia
XP_011616889 1296 --GRSDNFHPRRLLLSGPPQVGKTGAYLHFLGILSRMLIRLMEVDIYDEEETNCSVQLQEVQ-YHPPNTS------WPNP 1366 torafugu

XP_004935823 1391 ETFKKIPFDYTIHDPKYEDASLICSK-LQTVNSEDRP--ISRRQEDMYTHRQTTRMRLSKYAAYNTYHHCEQCHQYMGFN 1467 chicken
XP_005995991 1400 ERFKKMPFDYTVHDPNYEDASPVFSK-LCNLESKEKV--SGRKQEDIYLRRHTTRMRLSKYAAYNTYHHCEQCHQYMGFS 1476 coelacanth
XP_003924837 1377 ESFSKMPFDVSVHDPKYSLMSLVYTEkLAGVKQEVIK--E--SKVEEPRKRETVSIMLTKYAAYNTFHHCEQCRQYMDFT 1452 Bolivian squi...
XP_010707123 1424 EIFSKMSFDLSVHDPKYRNISPVYTEqLSRIKQETSKemKSEEP----KKRETVSMMLTKYAAYNTFHHCEQCHQYMDIN 1499 turkey
XP_002609592 1494 EFVRSMPFDANLHEGKYMSCSPVYTG-------AEKKdnSPAVNKD--SRRPTMSIMLSKFSAHNSFHHCEHCHHYMESV 1564 Florida lancelet
XP_011490902 1390 DIMKRMPFDYIIHDAKYDDISSIYCP-GYKPVAER----NPLRQEDVYLRRRTSRIKLSKYAAYNTYHHCEQCHQYLGFN 1464 Japanese medaka
XP_005459036 1434 EIVRTMPFDYTIHDSKYDDISTIYCP-GYKSNSEG----NPVRKEDVYLRRRTARIKLSKYAAYNTYHHCEQCHQYLGFN 1508 Nile tilapia
XP_011616889 1367 EIMKTIPFDYTVHDPKYDDISSVYNP-AYKLSDEG----NPVCQEEVFLRRRTCRIKLSKYAAYNTYHHCEQCHQYLGFN 1441 torafugu

XP_004935823 1468 PRYQLYESTLHAFAFSYSMLGEEIQLHFIIPKSKEHHFVFSQPGRQLESMRLPLVTDKSEDFIKSPTFTPTTGRHEHGLF 1547 chicken
XP_005995991 1477 PRYQPYESTLHAFAFSYSMLGEEIQLHFIIPKSKEHHFVFSQPGGQLESMRLPLVTDKNPDYIKTPIFTPTSGRHEHGLF 1556 coelacanth
XP_003924837 1453 SASQMSDSTLHAFTFSSSMLGEEVQLYFIIPKSKESHFVFSKQGKHLESMRLPLVSDKNLNAVKSPIFTPSSGRHEHGLL 1532 Bolivian squi...
XP_010707123 1500 PAAQVSDSTLHAFTFSSSMLGEEVQLHFIIPKSKESHFVFSKQGKHLESMRLPLVSDKNLNAVKSPIFTPSSGRHEHGLL 1579 turkey
XP_002609592 1565 APQQTRESSLYSFTFPSAVYGEEVRLHFIIPQTQEKHFVFSKQGHHLESLRLPSLEDAGHNDIKTPIFTPTCSRQEHGLL 1644 Florida lancelet
XP_011490902 1465 PRYQIYESTLHAFTFTHLLLGEDIQLYFIIPKSKEHYFSFSQQGGQLESMRLPLASEQNPDCIKTPIFTPTTGRHEHGLF 1544 Japanese medaka
XP_005459036 1509 SRYQMCESTLHAFTFTHLLLGEEIQLYFIIPKSKEHYFSFSQPGGQLESMRLPLTSDWSPDCIKSPIFTPTTGRHEHGLF 1588 Nile tilapia
XP_011616889 1442 HRYQMCESTLHTFTFTHLLLGEEIQLYFIIPKSKERYFSFNQSGGQLEGMHLPLTSDRSPDCIKSPIFTPTTGRHEHGLF 1521 torafugu

XP_004935823 1548 NLYHAMDGASHLHVLVVKEYEMAIYKKYWPNHIMLVLPSIFNSAGVGAAHFLIKELSYHNLELERNRQEELGIKPQDIWP 1627 chicken
XP_005995991 1557 NLYHAMDGATHLHILVVKEYEMAVYKKYWPNHIMLVLPSIFNTAGVGAAHFLIKELSYHNLELERNRQEELGVKPQDIWP 1636 coelacanth
XP_003924837 1533 NLFHAMEGINHLHLLVVKEYEMPLYRKYWPNHIMLVLPGMFNNAGVGAARFLIKELSYHNLELERNRLEELGIKRQCVWP 1612 Bolivian squi...
XP_010707123 1580 NLYHAMEGISHLHLLVVKEYEMPLYRKYWPNHIMLVLPGMFNNAGVGAARFLIKELSYHNLELERNRLEELGVKRQCVWP 1659 turkey
XP_002609592 1645 NLFHAMEGGRHTHMVVVKQCEMALYQKFWPNHIILVLPVVCNDAGIGAARFLVKELAYYNLELERNRQEELGVRRQDVWP 1724 Florida lancelet
XP_011490902 1545 NLYHAMDGASHLHILVVKEYEMAVYKKYWPNHIMLVLPTIFNGAGIGAAHFLIKELSYHNLELERTRRLEGGSPA-DVWP 1623 Japanese medaka
XP_005459036 1589 NLYHAMDGASHLHILVVKEYEMAVYKKYWPNHIMLVLPTVFNGAGIGAAHFLIKELSYHNLELERSRRLEGGGPAGDVWP 1668 Nile tilapia
XP_011616889 1522 NLFHALDGASHLHILVVKEYEMAVYKKYWPNHIMLVLPSVFNGAGIGAAHFLIKELSYHNLEMERSRRLEGGGPAGDVWP 1601 torafugu

XP_004935823 1628 FIVISDDSCVMWNAVEVDCSG--DRKSD-YTWTERNVSLKHILQRIEATPNVTHYALIGMRKWSSKTNT-AEIKEPFSCC 1703 chicken
XP_005995991 1637 FIAIADDSCVMWNVVDFNRNR--EASSE-DIWTERNVSLKHVMQRIEETPNVIHYALLGMRKWSNKESS-KRIQEPFSRC 1712 coelacanth
XP_003924837 1613 FIVMMDDSCVLWNIHSVQEPS--SQPME-VGVSSKNVSLKTVLQHIEATPKIVHYAILGIQKWSSKLTS-QSLKAPFSRC 1688 Bolivian squi...
XP_010707123 1660 FIVVMDDSCVLWNMHSAHEQS--SQSLE-PGGTSKNVSLKNVLQHIEATPKIVHYAILGVQKWNSKLNA-KKTKAPFSRC 1735 turkey
XP_002609592 1725 YVIIMDDSLVMWNMHDSTQED--KQT--------QNISLKSVIQHLEATPKITHFSMLGARQWSGKSTV-DVSMQPFSRC 1793 Florida lancelet
XP_011490902 1624 FIILADDSCVMWNAVDLDARS---------GPVEHAVSLKQVLQHMEACPELAQYSLCGIRKWSSRGLKgSKRWEPFFRG 1694 Japanese medaka
XP_005459036 1669 FIILADDSCVMWNTLDLEARN---------GPVEHAVSLKQVLQHMEACPDLSHYGLCGIRKWSR--LTgNVLREPFSRG 1737 Nile tilapia
XP_011616889 1602 FIILADDSCVMWNVVDLDTRNffLLSATfSGPAEQAISLKQVLLHMEGCPDLAHYGLCGIRKWTSRTLTgNKHREPFSRG 1681 torafugu

XP_004935823 1704 HVHDFIMLNVDLTQNVQYNQNRFTCDDVDFNLRVHSAGLLICRFNHFSVMKKQIAVGGQRSFHIKSKVSD--IPVSISPA 1781 chicken
XP_005995991 1713 HLHDFILLNVDLTQNVQYKQNRFTCDDVDFNLRAHSAGLLICRFNCFSVMKKQIAIGGHRTFHIKSKVPD--VSTSVSPS 1790 coelacanth
XP_003924837 1689 HVHDFLLLNIDLTQNVQYDFNRYFCEDVDFNLRTNSSGLLICRFNNFSLMKKHVQVGGQRDFIIKPKIMVseNLAPILPL 1768 Bolivian squi...
XP_010707123 1736 HVRDFILLNIDLTQNVQYDLNRYFCEDIDFNLRTNSSGLLICRFNNFSVMKKHIQVGGQKDFVVKPKIVVsdSPAPIMPL 1815 turkey
XP_002609592 1794 HLHSFIMLNVDATQNVQYDQNRYNCEDIDFNMRISSGNGLLCRFNRFSFMKKAIHVGGGMDFPMKPKVANa-NTQNITTR 1872 Florida lancelet
XP_011490902 1695 HLYDFLLLNVDRSQNVQYDQNRFTCHDVDFTLRLHSAGLIVCRFNNFSVMKKQITIGGYKTFIIKTKMTD--VPTSVGPS 1772 Japanese medaka
XP_005459036 1738 HLHDFFLLNVDRSQNVQYDQNRFTCHDVDFTLRLHSAGLLVCRFNNFSVMKKQIAIGGYRTFIIKTKMTD--VPTSVSPS 1815 Nile tilapia
XP_011616889 1682 HLHDFLLLNVDQSQNVQYDQNRFSCHDVDFGLRLHSAGMLVCRFNGFSVMKKQISIGGYRTFVIKTKVSDdpVPTSVGPS 1761 torafugu

XP_004935823 1782 QYICAPDSKHTF-LAAPAQLLLEKYLQYHSHRFFPLSLKNYRHPVLSVDCYLNLGPQIAVCYVSSRPHSLNISSSGLTFS 1860 chicken
XP_005995991 1791 QYICAPDSKHTF-LAAPAQLLLEKHLQYTSHCFFPLSLKNYNHPVLCVDCYLNLGAEISVCYVSSRPHSLNINCSGLEFS 1869 coelacanth
XP_003924837 1769 QYICAPDSEHTL-LAAPAQFLLEKFLQHASYKLFPKAIRNFKSPVLAIDCYLNIGPEVAICYISSRPHSSNVNCEGVFFS 1847 Bolivian squi...
XP_010707123 1816 QYVCAPDSEHTL-LAAPSQFLLEKFLQHATYKLFPKAIHNFKNPVLAIDCYLNIGLEVAICYVSSRPHSVNVNCEGVFFS 1894 turkey
XP_002609592 1873 QFVAAPDSEDLVpLVAPPQFLLEKYLAHESKALFPMAMDNHLTPVLAIDCYLNLGAQISVAYMSSRPHSVNTDTD-CRFS 1951 Florida lancelet
XP_011490902 1773 QYICAPDSKHLF-LATPAQLLLEKYLQHTSQKLFPLSIKNYANPVLSVDCYLNLGPEVTVCFMSSRPHSVNISTTGLLFS 1851 Japanese medaka
XP_005459036 1816 QYICAPDSKHLF-LATPAQLLLEKYLQHNSHKLFPLSTKNYTHPVLSVDCYLNLGPEVTVCFVSSRPHSVNISTAGLLFS 1894 Nile tilapia
XP_011616889 1762 QYVCAPDTKHLF-LATPAQLLLEKYLQHTSQKLFPLSTRNYTHPVLSVDCYLNLGPEVTVCFVSSRPHSVNINTTGLLFS 1840 torafugu

XP_004935823 1861 GLLLYLCDSFVVASFLKKFHFLKGATLCVICQDRNSLRQTVVRLELEDEWQFRLRDEFQTANAKEDRPLFFLTGRHI 1937 chicken
XP_005995991 1870 GLLLYLCDSFVTASFLKNFHFMKDATLCVICQDRSSLRQTVVRLELEDEWQFRLRDEFQTANSKEDRPLFLLTGRHI 1946 coelacanth
XP_003924837 1848 GLLLYLCDSFVGADLLKNFKFLKGATLCVICQDRSSLRQTIVRLELEDEWQFRLRDEFQTANSSDDKPLYFLTGRHV 1924 Bolivian squirre...
XP_010707123 1895 GLLLYLCDSFVGADLLKRFRFLKGATLCVICQDRSSLRQTIVRLELEDEWQFRLRDEFQTANSSDDRPLYFLTGRHI 1971 turkey
XP_002609592 1952 GLLLYLCDSFVMADFLKKFNFVPGATLCVICPDRNTLRRQIARLELEDQWRFRLRDEFQTANTAEDKPLYFLTGQHI 2028 Florida lancelet
XP_011490902 1852 GLLLCFADAFVTSGFLKKFTFLKGATLCVISADRSSLRQTVGRLELEEEWRFRLSDEFQTANAKEDRPLFFLTGKHI 1928 Japanese medaka
XP_005459036 1895 GLLLCFADSFVTPGFLKKFTFLKGATLCVISADRSSLRETVGRLELEEEWRFRLSDEFQTANAKEDRPLFFLTGKHI 1971 Nile tilapia
XP_011616889 1841 GLLLSFADSFVTPGFLKKFSFLKGATLCVISADRSSLRKTVSRLELEEEWRFRLSDEFQTANAKEDRPLFFLTGKHI 1917 torafugu
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