Conserved Protein Domain Family
PCNP
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pfam15473: PCNP (this model, PSSM-Id:317824 is obsolete and has been replaced by 464736)
PEST, proteolytic signal-containing nuclear protein family
PCNP is a PEST-containing nuclear protein that is ubiquitinated by NIRF, a Np95/ICBP90-like RING finger protein. PEST sequences, which are rich in proline (P), glutamic acid (E), serine (S) and threonine (T), are found in a number of short-lived proteins, such as transcription factors and cell cycle-associated proteins. Their function is generally controlled by proteolysis, mostly via ubiquitin-mediated degradation. Thus, NIRF and PCNP are a ubiquitin ligase and its substrate, respectively, that may constitute a novel signalling pathway with some relation to cell proliferation.
Links
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Statistics
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PSSM-Id: 317824
Aligned: 12 rows
Threshold Bit Score: 149.983
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q17H13        54 QLQKHNP-LrplpGGRKDSGSSSDDSGDDDNGSQSKT---APPKPSVMPKIGFSfqKPAANAKtsstlstsfnlqkaKPM 129 yellow fever mo...
XP_006639248  25 VKTKTVS-S----SNGGGSNTRSADKRSAEEAAGDSM---VQPAPPKVSKIGLS--SQALKKP--------------API 80  spotted gar
XP_004911769  44 VNTKNVS-Ssn-gGESSSRS---AEKRAAEDSK-------NAPHPFKVSKIGFAigNQNLKKS--------------QPI 97  western clawed ...
XP_015457216  25 AKSNTVS-Sst-gPGGG------LGKRPAEGSSTAGDqrrKQAVPFKISKPSISttSPILKKP--------------API 82  Mexican tetra
XP_001847943  52 AQLRKAAeSqr-kYDHRRSSSSSGSSSSDGSDNEGPV---APPAPPVISKVGFSfqKPPSAKPtstgf-----qlqqKPS 122 southern house ...
XP_004067142  24 VKTKPVS-Cst-vGGDGAAYKRTSQHLSAEEEDESSE---DPPAPRKVSKLGFSmsSQAATKS--------------NAI 84  Japanese medaka
CAF99796      24 VKTKPIS-Cst-vGGKGTAFKRTSQHLAPEDDDEDEAs-qIPPAHCKISKIGLKmsSQMGKKS--------------NPI 86  spotted green p...
NP_001313646  25 VKTKTVS-S-------SKASGDSLRKRPAREIDPEDEs-kSTSAPPKMFKSGFSm---TAKKP--------------MAI 78  zebrafish
XP_006743063  27 eareTAA-SwsrrSNGGESSSRSAEKRSAEEEAAD-----LPTKPTKISKFGFAigSQTTKKA--------------SAI 86  Weddell seal
XP_001363703  31 VKTKTVS-S----SNGGENSSRSAEKRSAEEEAEDFS---SKPVPAKIAKFGFAigSQTAKKA--------------PVI 88  gray short-tail...
XP_001122504  15 SVYRAED-SrgddRGRDRSPLRSDDRCEEANYNQSDA---------KKQKLAFGfgKKSGTEQk-------------KGI 71  honey bee
EHJ68405      44 SGHRGSP-Srp-gRSRERNLENADKRRYSESWEESDEevpAPPPPPRISKISIDfsKPK------------------API 103 monarch butterfly

Q17H13       130 AIQMK-LGt--APKKETPKL--LKPVANAFAGSD-SDEEPEEMPAECRMRMRNIGRDTPTSSGPNSFGKTKHGFCDSKKI 203 yellow fever mo...
XP_006639248  81 SIKLG-AS---KPKESAPVLpaKKPALAAVFNED-EDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDHQKL 155 spotted gar
XP_004911769  98 SIKLG-AS---KPKEVAPAVvkKKTAVASVFNDD-DDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDSQKL 172 western clawed ...
XP_015457216  83 SIKLG-AS---KPKEAAPPPavKKP--ASVFNEDsDDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKQGFSDHQKL 156 Mexican tetra
XP_001847943 123 AVQLKlAS---GPKKEQPKL--LKPTANA-FADD-SDDEPEEMPAECRMRMRNIGRETPTSSGPNSFGKTKHGFCDSKKM 195 southern house ...
XP_004067142  85 SIKLG-AT---KPKEPVPSLppKKPALASVFNDS-DDSEPEEMPPEAKMRMKNIGRETPTSAGPNSFNKGKQGFSDHQKL 159 Japanese medaka
CAF99796      87 SIKLG-ATvsvKPKEPVPSVppKKPGLASVFNED-DDSEPEEMPPEAKMRMKNIGRETPTSAGPNSFNKGKHGFSDNQRL 164 spotted green p...
NP_001313646  79 SIKLG-AN---KPKEPPPAIppKKSGLASVFNED-DDSEPEEMPPEAKMRMKNIGRETPTSAGPNSFNKGKQGFSDHQKL 153 zebrafish
XP_006743063  87 SIKLG-SS---KPKETVATLapKTLSVAAAFNED-EDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDNQKL 161 Weddell seal
XP_001363703  89 SIKLG-AS---KPKETVPTLapKTLSVAAVFNED-DDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDNQKL 163 gray short-tail...
XP_001122504  72 QIKLG-STs--KPTVKATPI--QRPTVASVFNAD-EEDEPEEMPAEARMRMRNIGRETPTSAGPNSFGKTKQGFCDSKKI 145 honey bee
EHJ68405     104 KMTLG-ATs--KPA--------PKPTVASVFNAD-DDDEPEEMPAEARMRMRNIGRETPTSAGPNSFGKTKQGFCDAKKV 171 monarch butterfly

Q17H13       204 FEKKLNTMTD 213 yellow fever mosquito
XP_006639248 156 WERKLKTHTD 165 spotted gar
XP_004911769 173 WERNMKAQLD 182 western clawed frog
XP_015457216 157 WERKLKAQTD 166 Mexican tetra
XP_001847943 196 LEKKLNSLHD 205 southern house mosquito
XP_004067142 160 WERKIKAQgd 169 Japanese medaka
CAF99796     165 WERKIKTQ-- 172 spotted green pufferfish
NP_001313646 154 WERKLKSHTD 163 zebrafish
XP_006743063 162 WERNIKSHLG 171 Weddell seal
XP_001363703 164 WERNIKSHLG 173 gray short-tailed opossum
XP_001122504 146 FEKTLKKAME 155 honey bee
EHJ68405     172 FEKNLKQALE 181 monarch butterfly
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