Conserved Protein Domain Family
NT-C2
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pfam10358: NT-C2 (this model, PSSM-Id:313563 is obsolete and has been replaced by 463058)
N-terminal C2 in EEIG1 and EHBP1 proteins
This version of the C2 domain was initally identified in the vertebrate estrogen early-induced gene 1 (EEIG1), and its Drosophila ortholog required for uptake of dsRNA via the endocytotic machinery to induce RNAi silencing. It is also in C.elegans ortholog Sym-3 (SYnthetic lethal with Mec-3) and the mammalian protein EHBP1 (EH domain Binding Protein-1) that regulates endocytotic recycling and two plant proteins, RPG that regulates Rhizobium-directed polar growth and PMI1 (Plastid Movement Impaired 1) that is essential for intracellular movement of chloroplasts in response to blue light.
Links
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Statistics
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PSSM-Id: 313563
Aligned: 58 rows
Threshold Bit Score: 59.6113
Created: 20-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9FMC4         17 LFAVKFDVIVVVHQMDGLLDsdgggddstdqsqrgggtttrK--RPVVEIKWKGPKSVtlkr-svvrNLTEEGGFRGDGV 93   thale cress
Q9C8E6        136 MQKLSCLLSVEVVAAQNLPAs-------------------mN--GLRLGVCVRKKETKd-------gAVQTMPCRVSQGS 187  thale cress
Q7Y219         86 QRRFDVCFLLHVHSIEGLPLn-------------------lD--GTKLVVQWKRKDE----------VMTTQPSKVLQGT 134  thale cress
Q86IC6         16 GEQGKFQFDFKLISVENLPV------------------------TGNCFVSWKRGTKSas------nGKTKAVTINSNKS 65   Dictyostelium...
Q54CQ9          7 KDVLKVKVEILVKKVGNLKEl--------------------N--GGSVFVYWRRGTSKq--------SGETHHMIVRNGE 56   Dictyostelium...
XP_001312419    6 YKSTPHHCFILIEKITFSKK---------------------V--DVPVFIRVARKKSSggvfktaysSETSFQLADQSNI 62   Trichomonas v...
XP_001324177    6 VQSLKCYCILHIESIKFEKD---------------------I--KFPVFIRVARVRKSgifervafnSETNYSMLDANLV 62   Trichomonas v...
NP_197561      74 NRRFNCCFSAQVHSIEGLPPi-------------------fQ--DLSLTVHWKRRDE----------SLSTRPAKVSNGR 122  thale cress
XP_001326174    4 EQVMNYIAFILVEKVQFPEK---------------------Y--NKPLFIRVQRKKTAggqtklafsSETSYKNLDNNLI 60   Trichomonas v...
XP_006660954  139 MNRLGCLFSVEVVAAQGLPP---------------------SmnGLRLAVAVRKKETRd-------gAVQTMPSRVQQGA 190  malo sina

Q9FMC4         94 VEWNEEFKRVCEFSVY-----KegS-----FLPWFVSLTVFSGlnqGSKEKvrSFGKASLNIAEYFSL-------M---- 152  thale cress
Q9C8E6        188 ADFEETLFIKCHVYYSpa--nG--KgspakFEARPFLFYLFAV---DAKEL--EFGRHVVDLSELIQE-------Svekm 251  thale cress
Q7Y219        135 AEFEETLTHRCSVYGSkh-gpHrsAk----YQVKLFLIYVSPV---DAPWL--VLGKHWIDLTRILPL-------Sleem 197  thale cress
Q86IC6         66 ASFNHSFSMVTTLYK------EkpPk----KTYESKTIAISIK---DEKNKk-SIAKTMIDLADFTNf------------ 119  Dictyostelium...
Q54CQ9         57 AIFEEKISFESKFFID-----AksQ-----KPDEKKLSLQLKEe--KKKSQgkVLGKIELDLTSYMNS-------Kh--- 114  Dictyostelium...
XP_001312419   63 VQFNNEFQIPITIF-T-----KkgEe----PQKKMLEVSCLAIm-sKKEPEh-QVCTWKFDAANLLD------------- 117  Trichomonas v...
XP_001324177   63 AQFDCEFIIPITLYQ------KegHk----LEKKILDIEIFSLd--KNQGQn-CISKVRMDIANLTD--------P---- 117  Trichomonas v...
NP_197561     123 AEFKDKLTHTCSVYGSrs-gpHhsAk----YEAKHFLLYVSLV----GSPEi-DLGKHRMDLTKLLPLtleelqdE---- 188  thale cress
XP_001326174   61 AHFDNEFSLPFT--TV-----KkgDk----YVKKVVEIQLVSVs-nKKKEEv-EICKWRFDASNMPD------------- 114  Trichomonas v...
XP_006660954  191 ADFEETLFVRCHLYCSggagtGkpLk----FEPRPFLLSAVAVd----APEl-DFGRSAVNLSLLVKE-------Stdks 254  malo sina

Q9FMC4        153 ----KEDDVQVKVPLKDc-D-SS-SVRSPHVHISLQFS 183  thale cress
Q9C8E6        252 nyegARVRQWDMNWGLSgkA-KG-GELALKLGFQIMEK 287  thale cress
Q7Y219        198 -egtRSTRKWNTSFKLSglA-ES-AVLNLSFDYSVVTS 232  thale cress
Q86IC6        120 ----KDEQFKSIQIKQK--K-GG-PIVIAMNIKSKEME 149  Dictyostelium discoideum
Q54CQ9        115 ---nQPITLSFTKGLKP--E-PQ-IFCSFNTIPLKHNN 145  Dictyostelium discoideum AX4
XP_001312419  118 ----PKDSSVQTSMTKCe-F-GI-ATLYLRIVVLPESD 148  Trichomonas vaginalis G3
XP_001324177  118 ----RSTARQTSNFQTNk-F-GT-AQLNFRLCVLPIDE 148  Trichomonas vaginalis G3
NP_197561     189 ----KSSGKWSTTFQLSg-K-ANgATLSMSFGYTVVGD 220  thale cress
XP_001326174  115 ----PRDPSVHFSVASSd-F-GN-VNLYVRFCVIPAEE 145  Trichomonas vaginalis G3
XP_006660954  255 -hqgERVRQWDMALPLAg-KaKG-GELVVKLSFQIMDD 289  malo sina
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