Conserved Protein Domain Family
Zwilch

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pfam09817: Zwilch (this model, PSSM-Id:313105 is obsolete and has been replaced by 401684)
RZZ complex, subunit zwilch
The protein Zwilch is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. It is required for the assembly of the dynein-dynactin, Mad2 complexes and spindly/CG15415 onto kinetochores.
Statistics
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PSSM-Id: 313105
Aligned: 15 rows
Threshold Bit Score: 595.6
Created: 27-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8R060        31 PFIYEADVQVqliskgq-----psllktiL--NENDSVFLV------------------------------EKVVLEKEE 73  house mouse
A6QM04        31 PFIYEADIQVqliskgq-----pnplkniL--HENETIFIV------------------------------EKVPLEKEE 73  cattle
Q95XP9        27 PVLLLDKYRVrvlpltsipfvmnhssvsqLslSSEDVLVVDfpskgtgsgag---------kaekkmifkkKIEPMEDSF 97  Caenorhabditis ...
P0C664        27 PVLLLDKYRVrlvpitelplvsnysntsqLglNSEEVLVIDspiesaekqktssllnrrenkktiksekedESMDMETAE 106 Caenorhabditis ...
Q29CE6        26 PPTYLGSIAG-------------------AgeVGKKIVLVFkedrna-------------------aaskiKTTPTKLLQ 67  Drosophila pseu...
Q9VA00        29 PPTYLVSMVG-------------------AaeAGKKIVLVFkedrng-------------------avarlRTTPTRAAP 70  fruit fly
NP_080783     38 PFIYEADVQVqliskg-------qpsllkTilNENDSVFLV------------------------------EKVVLEKEE 80  house mouse
XP_003098253  27 PVLLLNKYRIrllplsslpfvqnysnisqLslNSDDVLVIDspigat-------------------ekyskKS--IENSK 85  Caenorhabditis ...
XP_314811      6 dlanvyqlfrskfedndfqyyyppsyirsLteCDDKIIFAFrkvqnh------------------ilssemDAVRPKQSP 67  Anopheles gambi...
XP_001954734  27 PPTYLASIAG-------------------VseTGKKVVLVFkedrsg------------------saykiqHITPKKALP 69  Drosophila anan...
Q8R060        74 TS--------------QVEE-----------------------LQSEETAISDLSAGE-NIRPL---------ALPVGRA 106 house mouse
A6QM04        74 PS--------------PIEE-----------------------LQSEDTAISDLSTGE-NVGLL---------ALPIGRA 106 cattle
Q95XP9        98 ED--------------KENVneggplmtsf---ltleklrkgmVGDVEIIGYECETSFfDANPI---------PLSDGVS 151 Caenorhabditis ...
P0C664       107 GD--------------KENTvsetgggplvtsfltldklekdgVNDVEIVGLDCEIQFfDANPI---------PFEDGIS 163 Caenorhabditis ...
Q29CE6        68 KI--------------EGTSeldltgs---------plkddciVDAIADLSLDLQLVSsHPWKLeee---fqrGMTVDKA 121 Drosophila pseu...
Q9VA00        71 KK--------------EGSAdldltgs---------plkddclVDAIADLSIDLQLDHsNPWKLeee---yqrGIPVDKA 124 fruit fly
NP_080783     81 TS--------------QVEE-----------------------LQSEETAISDLSAGE-NIRPL---------ALPVGRA 113 house mouse
XP_003098253  86 KSmikeedesmemeedKENEggengplvtsf-ltleklqkgapLNDIEIVGLDCEVQFfDANPI---------PFEDGVS 155 Caenorhabditis ...
XP_314811     68 NS--------------NGSAsldltgs----------plrdvsFEQFEEMNLSKEYHEsSVQNLwtideetyaPLSTEKA 123 Anopheles gambi...
XP_001954734  70 KL--------------EGTSemdltgs---------plkddclVDAIADLSLDLQLEHsNPWKLeee---fqrGVPVDQA 123 Drosophila anan...
Q8R060       107 -RQLIGLYTMAH-NPNMTHLkikqpvtalpplWVRCDGSDPEGTCWLGAELITTNdiiagVILYVLTCK-ADKNYSEDLE 183 house mouse
A6QM04       107 -RQLIGFYTMAH-NPNMTHLkinrpvtalpplWVRCDGSDPEGISWLGAELISTSsnitgIVLYMVTCK-VDKNYSVNLE 183 cattle
Q95XP9       152 lQRYIRLNCSEHfSPSISTLp----------vWISTTSSKFPSICWLAAGRTNRN----------VQFAaATR----VLG 207 Caenorhabditis ...
P0C664       164 lQRFLRLESSKNfSAAVDKLp----------iWISTIGHHFPSVCWLAAGRTNKN----------VQVSgATR----ILG 219 Caenorhabditis ...
Q29CE6       122 -RGIICTEHFQH-ADGLGSV------------WFLCDGSDHGQTQLLQYEFNKTH-----FSRGILSYQgVLPAFMVTSQ 182 Drosophila pseu...
Q9VA00       125 -RSIVCSEFLQL-AEGLGSV------------WFLCDGSDLGQTQLLQYEFNPTH-----FSRGILSYQgVRPAYLVTSQ 185 fruit fly
NP_080783    114 -RQLIGLYTMAH-NPNMTHLkikqpvtalpplWVRCDGSDPEGTCWLGAELITTNdiiagVILYVLTCK-ADKNYSEDLE 190 house mouse
XP_003098253 156 lQRFLRLESSAHfSPAVDKLp----------iWISTISQNIPSVCWIASGRTQKN----------IQFSgVTR----VIG 211 Caenorhabditis ...
XP_314811    124 -RSLLQAFISLEcRIGRGSi------------WVLCCGTDSEQKVLLQLSVNAASnnqrhFTRGVVRFSgVQPSNSITLG 190 Anopheles gambi...
XP_001954734 124 -RGIISTEPFQQ-SEGTGSV------------WFLCDGTDLGQTQLLQYEFNKSH-----FSRGILSYHgVVPAYMVTSQ 184 Drosophila anan...
Q8R060       184 NLKTSHKKRHHVSAVTArgfAQYELFKSDDlddtv-----apsqtTVTLDLSWSPV---DEMLQTPPLSSTAALNIRVQs 255 house mouse
A6QM04       184 DLKKSHKKRHHLSTLTAsgfARYELFKSTAlddtv-----aasqtTITLDISWSPV---DEILQTPPLSSTATLNIKVEs 255 cattle
Q95XP9       208 HFNNENSERVVKQLNQAcgtSQLNKYRAVYeeirkiatenrpapgEVTIDVRWSTK---STLVLLEHPDNAADCTIKIDl 284 Caenorhabditis ...
P0C664       220 YF-NENSQKLVKQLNEAcgaAQVNRYRAVYdvirkiatptreapgEVIIDMRWNTK---SSLVLLEQPDNAADCTIKIDl 295 Caenorhabditis ...
Q29CE6       183 SLVRQHS-IAGGAPMET---SIENRYQVNP---------------KMTLRCSWVTSspqPQLVNLRECEVALSHTFRVG- 242 Drosophila pseu...
Q9VA00       186 ALVRHH----GKTPDET---LIENSYQVNP---------------HMRLRCSWTSSaalPLLVNLNDCDVALNHTFRVG- 242 fruit fly
NP_080783    191 NLKTSHKKRHHVSAVTArgfAQYELFKSDDlddtv-----apsqtTVTLDLSWSPV---DEMLQTPPLSSTAALNIRVQs 262 house mouse
XP_003098253 212 HF-NEINQKLIKQLNEAagaAQVNRYRAVYdgirkiatptrespgEVIIDMRWNTK---SSLVLLEQPDNAADCIIKIDl 287 Caenorhabditis ...
XP_314811    191 QLIDIHRQRAGEGMKFSpkiQIQQWCKLHA---------------QITLRLSWNAMgegSTFAVERNARVRLSQEFPVNn 255 Anopheles gambi...
XP_001954734 185 FLVKQHSMVGGGAPMET---SIENSYQVNP---------------QMTIRCSWTTNaslPLLVNLHDCEVVLNHTFRAG- 245 Drosophila anan...
Q8R060       256 ---gESRGCLSHLHRELKFLLVLADGIRTGVTEWLEPLETKSALEFVQEF-LNDL-NKLDEFDDS-TKKDkqKEA--VNH 327 house mouse
A6QM04       256 ---gEPRGPLSQLHRELKFLLVLADGLRTGVTEWPEPLEAKSAVELVQEF-LNEL-SKLNEFGDS-TKKD--TEI--VKH 325 cattle
Q95XP9       285 gwgdKRFFVDDEIFEQLFFVLNLADVLANPDNEVIFPMAPPAN--------FDDLvQEMDALVEAsSRED---------- 346 Caenorhabditis ...
P0C664       296 gwgdNRFFIDETIFEQLFFVLNLADVLANPEKEVVFRSESDK---------FDDLvQEMKQLVEAcSHED---------- 356 Caenorhabditis ...
Q29CE6       243 ----DCSSLTQDFMNQLRILVYIREDIVSYHNDERQGLIRDPTYRCGSGIdMDELrDSINKTMTDvSDLM--DTY--ITG 314 Drosophila pseu...
Q9VA00       243 ----DCGPLTQDFMNQLRILVYIREDIVSYHTDVKQGVSRDPTYRCGSGIdMDELrESINQTMTDvSGLI--GRY--SIS 314 fruit fly
NP_080783    263 ---gESRGCLSHLHRELKFLLVLADGIRTGVTEWLEPLETKSALEFVQEF-LNDL-NKLDEFDDS-TKKD--KQKeaVNH 334 house mouse
XP_003098253 288 gwrdNRFFIDESIFEQLFFVLNLADVLANPEKEVIFPMEYVK---------FGDLvKEMDDIVEA-CSHE--D------- 348 Caenorhabditis ...
XP_314811    256 g-afSRSSPAEYFWQQLQRLAMMRERIMDIRANRESGYARNDVCGEAEMD-LEYIkQKVNNIL---SSFL--EVE--PVT 326 Anopheles gambi...
XP_001954734 246 ----ECTPLTQDFMNQLRILVYIREDIVSYHKDIQHGKMRDPTYRCGTGIdMDELrESINKTMTDvSGFI--DPY--SNG 317 Drosophila anan...
Q8R060       328 DAAAVVRSM--LLTVRGDLDFAEQLWCRMSSSvVSYQDLVKCFTLILQSLQRGDIQPwlHSGSNSLLSKLIHQSYHGAMD 405 house mouse
A6QM04       326 DAAAVDGSIecLLTVRGDLDFAEQLWCKMSSSvISYQDLVKCFSLVIQSLQRGAIQPwlHSGSNSLLSKLIHQSYYGTMD 405 cattle
Q95XP9       347 -------NVfvSNENFRGGDITDKVWNIVRKC-NDVKQVTLLFRNFLQALAYGKIKShaQERNKSHLASLIRISKSSEFK 418 Caenorhabditis ...
P0C664       357 -------NVfaSNE--KSEQVTDKVWNIVRKC-SDVKQATMLFKNFLQALTYGKIKShvQEGNKSHLASLIRASKTCDFR 426 Caenorhabditis ...
Q29CE6       315 ASEFDIEEVvhRAKGRRLTDLTDKLWELLKCC-GSYKDLKMAFNMLFQCAARCNIVN--TPTNKNRLAEIITELANRRLA 391 Drosophila pseu...
Q9VA00       315 NAEFDIEDVvqRAKVRQLTDLTDKLWELLKCC-HSYKDLKIAFSMLFQCAARCNIVN--TPTNKNRLAKIITELANRRLA 391 fruit fly
NP_080783    335 DAAAVVRSM--LLTVRGDLDFAEQLWCRMSSSvVSYQDLVKCFTLILQSLQRGDIQPwlHSGSNSLLSKLIHQSYHGAMD 412 house mouse
XP_003098253 349 -------NVfaSNE--KNEEVTDKVWNIVRKC-GDIKHATMLFKNFLQALTYGKIKShvQEGNKSHLASLIRASKTCDFR 418 Caenorhabditis ...
XP_314811    327 YNSSTIIDMvsLVQKRKLTDVMERLYDALTLC-SSYEDLKAAIDYIFHLSTHSNIVN--VPTNGTRFSQLILAMIQDRLA 403 Anopheles gambi...
XP_001954734 318 LAEFDIEEVvqRAKVRRLTDLTDKLWELLKCC-ASYKDLKVAFSLLFQCAARCNIVN--TPTNKNRLAEIITELSNRRLA 394 Drosophila anan...
Q8R060       406 SVPLSGTTPLQMLLEIGLDKLKKDYISFFVSQELASLNHLEYFI------------------------------------ 449 house mouse
A6QM04       406 TVSLSGTVPVQMLLEIGLDKLKKDYICFFIGQELASLNHLEYFI------------------------------------ 449 cattle
Q95XP9       419 IPVLERLSTIDMMMEIGVESLRRRVIDIFSSQLLYPSDELEFILqtcendlp---------------------------- 470 Caenorhabditis ...
P0C664       427 MPILERLSTIEMMMEIGVESLRGRIINKFSDTLQFPSDELTFILktcendls---------------------------- 478 Caenorhabditis ...
Q29CE6       392 IPCLSGAEALELLLEVGLEKVYKDYEFIYTESKMCSTNLLKESSetadgspqnvpqlrkslhnavrgdatpgg----gmr 467 Drosophila pseu...
Q9VA00       392 MPCLSGAEPLELLLEIGLEKLYKDYEFIYTESKMCSTNLLKDDSsgasmddgspqnlpqlrkslhnavrgdptpgagmrk 471 fruit fly
NP_080783    413 SVPLSGTTPLQMLLEIGLDKLKKDYISFFVSQELASLNHLEYFI------------------------------------ 456 house mouse
XP_003098253 419 MPILERLSTIEMMMEIGVESLRGRIINKFSSTLQFPADELTFILktcenelt---------------------------- 470 Caenorhabditis ...
XP_314811    404 IPLLTGSEPYELLLECGFSKLMNDYRTIFTEAGIYELEFEKLFQpqvtntrksryatgngpqldahhga----------- 472 Anopheles gambi...
XP_001954734 395 MPCLSGAEPLELLLEIGLEKVLKDYEFIYSESKLCSTHLLRDTNetandegspqnvpqvrkslhnavrgdpaaga-gmrk 473 Drosophila anan...
Q8R060       450 --------------------------SPSVSTQEQVCRVQKLHHILEILv--ICMLFIKPQHELLFSLTQSCIKYYKQNP 501 house mouse
A6QM04       450 --------------------------SPSVDTQEQVHRVQKLHHILEIVv--SCMLFIKPQHELLFSLTQSCIKYYEQNP 501 cattle
Q95XP9       471 -------------------agngamnSAAISLLPITMALATANRIYELLnekDHVILPDLTRRILQKYTASMIEKSRRGE 531 Caenorhabditis ...
P0C664       479 -------------------tlegtlhSSVVSLLPITMAMATIHQIFGFLnvkDLVVLPDLARRVLTKYTTGMVEKAKRGE 539 Caenorhabditis ...
Q29CE6       468 ktllhldadsratavkygdddvagikNSHFDEHESMERISKLFQIHCTM---EHLLMIHIHLNLPNVYSDVCSELLKKTP 544 Drosophila pseu...
Q9VA00       472 tllhhhgavnsrstkyagsdddagfkNSHFDEHESTERISKLFQIHCTL---EHLLMMHIHLNLANVYNDVCSELLKKPP 548 fruit fly
NP_080783    457 --------------------------SPSVSTQEQVCRVQKLHHILEILv--ICMLFIKPQHELLFSLTQSCIKYYKQNP 508 house mouse
XP_003098253 471 -------------------tgegalnSSVVSLLPITMALATVNQIFGLLnekDYVLLPELARRVLTKFTSGMIEKAKRGE 531 Caenorhabditis ...
XP_314811    473 -pskrsatqlfqsaageervreksilLSNFDEDEVKLRLNRLAQVHLLLe--HLLLLES-AVNVPSIYGRVCELYLGRAP 548 Anopheles gambi...
XP_001954734 474 tllhhnasaktgnakygkvdddsgfkNSHFDEQESLERVSKLFQIHCTL---EHLLMIHINLNLPNVYSDVCSELLKKAP 550 Drosophila anan...
Q8R060       502 LDEQHIFQ--LPVRPAAVKNLY-----QSEKPQKWRVELSN-----SQKRVKTVWQLSD--------------------- 548 house mouse
A6QM04       502 LDEQHIFQ--LPVRPTAVKDLY-----QNEKPQKWRVEINS-----GQKKVKTVWQLSD--------------------- 548 cattle
Q95XP9       532 TETEYTFEttLPLLRMYKEGFM-----SKR-PCIWTCENSNtvganVQARVLTSLELQPslehinrlvnd--srpvwtat 603 Caenorhabditis ...
P0C664       540 TETDYVFEttLPLLRMNKEAFM-----HKR-PRIWTCENTNtvganVQTRAMTTLELEPslehvcrlvnasrpvrpided 613 Caenorhabditis ...
Q29CE6       545 KQVEAIDDqlSDVMDIHLAAHYvrdhlDGKEPYSRHITMKSv---nKFRELQTTFYFNS--------------------- 600 Drosophila pseu...
Q9VA00       549 KLVESIDDqlSDVMDIRLSAHYvrdhlDGKDPYSRHITMRSh---nKFRELKTTFYFNS--------------------- 604 fruit fly
NP_080783    509 LDEQHIFQ--LPVRPAAVKNLY-----QSEKPQKWRVELSn-----SQKRVKTVWQLSD--------------------- 555 house mouse
XP_003098253 532 TETDYTFEttLPLLRMSKEKFM-----DKR-PRIWTCENMStvgahCQTRIMTSLELESsmehvsri--------vnagr 597 Caenorhabditis ...
XP_314811    549 YSYGEVYNrrTDLLEFELDEFMllrkaDHVLPCARRVTMSSa---nMLQKLETVFYQNV--------------------- 604 Anopheles gambi...
XP_001954734 551 KIVDAIDEnvNDVMDIQLSALYvrehlEGKEPYSRHISMRSh---nKFREIKTTFYFNS--------------------- 606 Drosophila anan...
Q8R060       549 --SSPVDHSSFHR----PEFP-ELTLNGSL 571 house mouse
A6QM04       549 --SPPIDHLNFHR----PDFS-ELTLSGSL 571 cattle
Q95XP9       604 eeKPAMIK----------DLNaDYTVVHTI 623 Caenorhabditis elegans
P0C664       614 nrKPTEE-----------ERNaDYTVSHTI 632 Caenorhabditis briggsae
Q29CE6       601 --ENICPPQLAQC----FQCD-DKELVKER 623 Drosophila pseudoobscura
Q9VA00       605 --ENICPPNLAQC----FQCD-DKEMVKER 627 fruit fly
NP_080783    556 --SSPVDHSSFHR----PEFP-ELTLNGSL 578 house mouse
XP_003098253 598 piREIVETEETQRkptiEELNaDYTVSHTv 627 Caenorhabditis remanei
XP_314811    605 --KPILPGRFYPQ----FECKeldskhefw 628 Anopheles gambiae str. PEST
XP_001954734 607 --ENICPPELAKC----FQCD-DKEMVKER 629 Drosophila ananassae
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