Conserved Protein Domain Family
Membralin

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pfam09746: Membralin (this model, PSSM-Id:313042 is obsolete and has been replaced by 462877)
tumor-associated protein
Membralin is evolutionarily highly conserved; though it seems to represent a unique protein family. The protein appears to contain several transmembrane regions. In humans it is expressed in certain cancers, particularly ovarian cancers. Membralin-like gene homologs have been identified in plants including grape, cotton and tomato.
Statistics
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PSSM-Id: 313042
Aligned: 14 rows
Threshold Bit Score: 337.102
Created: 27-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q7K4L9        45 NMMNMRDRLFHAIYFRAAATYAELVPRKVQLTIEFLLLAKALLFFFTLIYVHNSFIKNPCTCLQDVKN-WPREGVIRVEI 123  fruit fly
Q0VA72        27 PLINVRDRLFHALFFKMAVTYARLFPPSFRRIFEFFVLLKALLVLFILAYIHIAFSRSPINCLEHVREkWPRDGILRVEI 106  tropical clawe...
XP_002600564  13 HLGNVRDRLFHALFFKVAITYARAFPKPVRRVFEFLVLLKALVVLFILVYIHIAFSRTPITCLDHVQKeWPRDGILRVEI 92   Florida lancelet
XP_009024019  22 pffNVRERLFHALFHRIAVAYCRAVPSSFRIALEIFALLKALVLFFVLCYIHVVLARGPKHCLQHIKQnWPRDGVLRVEV 101  Helobdella rob...
KRY13964      12 aLGTPRDRLFQALYYRAAYIYHITVAVSVRRFIEFIVLLMAILLFGLVTYVHIVFTRQQPSCLESVRHlWPRNGILNVHI 91   Trichinella pa...
XP_014208465  49 pLFSVRDRLFHALFIKSALLYAKTFPRPVRRMIEFFVLLKAIMAFFVLVYIHVVFSRTPANCLEHVRDdWPRDGILRVEI 128  Copidosoma flo...
XP_002923582  19 PLINVRDR--HALFFKMAVTYSRLFPPAFRRLFEFFVLLKALFVLFVLAYIHIVFSRSPINCLEHVRDkWPREGILRVEV 96   giant panda
XP_003098362  55 SLNAARDRLFHAMLVRIALKYSGRVSLRWRKAIEGSILFVALLLFASLIFIHFNFTRSPATCLDSMQAdWIRKGIVRIEV 134  Caenorhabditis...
EJW82959      46 QFGAVRDRLFHAMLVRVAISYNRHVPVFGKRFIEFSSLVTAIVLLSVMIYVHHFFDETESNCLAPFVDqWPRNGVLRVEV 125  Wuchereria ban...
XP_003137694  47 QFGAVRDRLFHAMLVRVAISYNRHVPMLGKRFIEFSSLITAIILLSIMVYVHHFFDETDSNCLAPFMDqWPRNGVLRVEV 126  eye worm
Q7K4L9       124 IPHlae----kraIWQGIKRDQEIVRS----------LKDSYYYGIGPQ-TR--QNHeTLKR------------------ 168  fruit fly
Q0VA72       107 QLNssr----apiFLQFYDSDT-----------------------FPGL-VKepSGEdEEEE------------------ 140  tropical clawe...
XP_002600564  93 QRNstr----pplFLYDYESESGIPGLevpfpnatiqGLNENFENLSISa---vEFLrGDDN------------------ 147  Florida lancelet
XP_009024019 102 LRNapp----gysLAHSYRKEDDDNGGv----------NDSNVTSHDDQ-RAavAATaAEDE------------------ 148  Helobdella rob...
KRY13964      92 TSGls------kvLLVNYNPDTYQSPDesmlhnnsstFSYEFSNSPSLS-VFrpSLYwSKEH------------------ 146  Trichinella pa...
XP_014208465 129 LRNage----dysVEKSYAKEE----------------------------------KlRQEKvddlsgvlgilagdgfin 170  Copidosoma flo...
XP_002923582  97 QHNssr----apvFLQFCD----------------------------GGxVEpgSPElGEEE------------------ 126  giant panda
XP_003098362 135 VRN----------LEVLEEKENFISSYisdnshrtchFNPIDVFRFGPS-VIpySMK-ERQA------------------ 184  Caenorhabditis...
EJW82959     126 VRNlkkfntyqdrLLEKSYGKQNSESNttvydlkrvlMKGPSALPKELR-SRprHHFrKKND------------------ 186  Wuchereria ban...
XP_003137694 127 VRNlkrfnayqdrLLEKSYGKQ-SESNttvydlkrvlMKGPSALPKELQ-SRpkHYFrKRSD------------------ 186  eye worm
Q7K4L9       169 ------YEsilgk-----------------------lglpvRPTFAYSNESLYyyfdainild-tydhpnaiqLKNEE-- 216  fruit fly
Q0VA72       141 ------EE---------------------------------MSVEMYHNSSIKfeldiep-------kvflkpSLESV-- 172  tropical clawe...
XP_002600564 148 ------Pvpqkg-------------------------lqkvRetvs-----------------------efdmFKEAV-- 171  Florida lancelet
XP_009024019 149 ------NRsv-------------------------------------gwSRMLsnllalhd----lsissltsLIFNNvg 181  Helobdella rob...
KRY13964     147 ------PAdvstk-----------------------ppeevELYMPVSSSEVNnnnhhnygddsiseefwlypQEVEN-- 195  Trichinella pa...
XP_014208465 171 iepsavESeqdnrsdgeglqnltlseeelnlrdttsdilhnYSAAEAASSPFL--------------------------- 223  Copidosoma flo...
XP_002923582 127 ------AE---------------------------------LAVDMFGNTSVKfeldiep-------kvlkppGGTEA-- 158  giant panda
XP_003098362 185 ------AKarqmk-----------------------iaspfRPMTYYSSVLSFlrpnlff------deeeeetVKHYD-- 227  Caenorhabditis...
EJW82959     187 ------YWssflt-----------------------sedslLNLFIRSDNGLKkklfleeld--ddefdfeseDLFDD-- 233  Wuchereria ban...
XP_003137694 187 ------HWssflt-----------------------aedslLSFFIRSDSNLKkklfledld--ddeldfesqDLIDD-- 233  eye worm
Q7K4L9       217 -------------------DD---------------------------------EEQ-----YIVEYSLEYGHLRLSSST 239  fruit fly
Q0VA72       173 -------------------TQasenqsqtls-------------fsdaaskvwpQEE-----YIVEYSLEYGFLRLSQST 215  tropical clawe...
XP_002600564 172 -------------------WP---------------------------------SDE-----YIVEYSLEYGFLRLSPQT 194  Florida lancelet
XP_009024019 182 nndggdddngkvasdvgtiWP---------------------------------EDK-----YIVEYSLEYGFLRLTPNT 223  Helobdella rob...
KRY13964     196 -------------------NE---------------------------------EEP-----SAIEYAVEYGFLRLSSAT 218  Trichinella pa...
XP_014208465 224 --------------------StqfwggysvesfdepsstlmeiqengtmeeifsEDE-----YIVEYSLEYGFLRLSPAA 278  Copidosoma flo...
XP_002923582 159 -------------------PNdsqelpfp-----------------etptkawpQDE-----YVVEYSLEYGFLRLSQAT 197  giant panda
XP_003098362 228 -------------------SVeeleyqdpleaea--------hiafyetmkdrpEPReyeylYRVEYAMLYGVLRLPPDF 280  Caenorhabditis...
EJW82959     234 -------------------SDas--------------------------------fE-----YVVEYSLYYGLLKLPHSY 257  Wuchereria ban...
XP_003137694 234 -------------------SDas--------------------------------fE-----YVVEYSLYYGLLKLPHSY 257  eye worm
Q7K4L9       240 RKRLRIPVLTVQLDpNTDKCFGDSLTRYLLKRLLGYDDLLMASVRTIAEQ-------EENKGYLRNVITGEHYRFVSMWw 312  fruit fly
Q0VA72       216 RQRLNIPVMVVTLDpTRDLCFGDRFSRFLLDEFLGYDDILMSSVKALAEN-------EENKGFLRNVVSGEHYRFVSMW- 287  tropical clawe...
XP_002600564 195 RQRLNIPIMVVTLDpTKDECFGDSFSRFLLEEFLGYDDILMSSIKGLAEH-------EDNKGYLRNVVSGEHYRFVSMW- 266  Florida lancelet
XP_009024019 224 RQQLNISVKLVVLDpMKDECFGDQLSRFLLDEFLGYDDVLMSSVKQLAED-------ETNKGYLRNVVNGEHYRFVSIW- 295  Helobdella rob...
KRY13964     219 RDRLKIPIMYVALNpYQEVCFGESFNRFLLDHFFGYDFLLISSVKSLASN-------ESEKGYMRNLVTGEQYRFVTMW- 290  Trichinella pa...
XP_014208465 279 RQKLNIPVKIVTLDpATDKCFGDSFSRLILDEFLGYDDLLMASIKTLAEH-------EDNKGFLRNVVTGEHYRFVSMW- 350  Copidosoma flo...
XP_002923582 198 RQRLSIPVMVVTLDpSRDQCFGDRFSRLLLAEFLGYDDILMSSVKGLAEN-------EENKGFLRNVVSGEHYRFVSMW- 269  giant panda
XP_003098362 281 REEHGIPTTWIRID-SKSRCFGDQMSRLMMRLFVGYEDTIIAALRGQAYNlslvhpeTHSMGYLHNLQTHDHYHFVANS- 358  Caenorhabditis...
EJW82959     258 RLEHNISFLLVRLDpEVDSCFGDWVSRALMKNFIGYEDVLMSSVKALAEN-------ETDKGYLRDMITGEHYRFVTMG- 329  Wuchereria ban...
XP_003137694 258 RLEHNIPFLLVRLDpEVDSCFGDWVSRTLMKNFIGYEDVLMSSVKALAEN-------ETDKGYLRDMITGEHYRFVTMG- 329  eye worm
Q7K4L9       313 AAWSSYPAAFCVMLLFTFSVSMLLRYSHHQIFVFIVDLLQMLEYNVSARFPIAPLLTVILALVGMEAIMSEFFNDTTTAF 392  fruit fly
Q0VA72       288 MARTSYLAAFVIMVIFTLSVSMLLRYSHHQIFVFIVDLLQMLEMNMSIAFPAAPLLTVILALVGMEAIMSEFFNDTTTAF 367  tropical clawe...
XP_002600564 267 MARTSYIAAAFVMFMFTISVSMLLRYSHHQIFVFIVDLLQMLEMNVTIAFPAAPLLTVILALVGMEAIMSEFFNDTTTAF 346  Florida lancelet
XP_009024019 296 MAKSSYLAAAFIMVVFTLAVSMLLRYSHHQIFVFIVDLLQMLEMNRSLAFPAAPLLTVILALVGMEAIMSEFFSDTTTAF 375  Helobdella rob...
KRY13964     291 MSRSSYISAFLTMLTFTFSISALLRFSHQQFFVFIINVFQLFELNAAF-VQVAPLISVILGLVGMEAVMSEFFNDTNIAF 369  Trichinella pa...
XP_014208465 351 MSRSAYIAAFFIMIIFTVSISMLLRYSHHQIFVFIVDLLQMLEFNASVSFPAASLLTVILALVGMEAIMSEFFNDTSTAF 430  Copidosoma flo...
XP_002923582 270 MARTSYLAAFVIMVIFTLSVSMLLRYSHHQIFVFIG------------NLPA-----------GMEAIMSEFFNDTTTAF 326  giant panda
XP_003098362 359 LGKWSYITAAVLMIIFTFAISMLLRFSHHQIFVFIIDLLHMFELQQPLNPPVAPLITVVLALVGMEAIMAEVFNDTSIAF 438  Caenorhabditis...
EJW82959     330 NPRASYFTALIVMLIFTFAISMLLRFSHHQIFLFIVDLLQMFELNQALVFPAAPLLTVILALVGMEAIMSEVFNDTSTAF 409  Wuchereria ban...
XP_003137694 330 NPRASYFTALIVMLIFTFAISMLLRFSHHQIFLFIVDLLQMFELNQALVFPAAPLLTVILALVGMEAIMSEVFNDTSTAF 409  eye worm
Q7K4L9       393 YIILIVWIADQYDAICCHTSITKR 416  fruit fly
Q0VA72       368 YIILIVWLADQYDAICCHTNTSKR 391  tropical clawed frog
XP_002600564 347 YIILMVWVADQYDAICCHTNISKR 370  Florida lancelet
XP_009024019 376 YIILIVWIADQYDAICCHTAVTKK 399  Helobdella robusta
KRY13964     370 CVILMIWFADQYDFICCTSPLSRR 393  Trichinella patagoniensis
XP_014208465 431 YIMLIVFIADQYDAVCCHTPITKR 454  Copidosoma floridanum
XP_002923582 327 YIILIVWLADQYDAICCHTNTSKR 350  giant panda
XP_003098362 439 YVILIVWVADQYDAICCHSPTSKK 462  Caenorhabditis remanei
EJW82959     410 YVILLIWIADQYDAICCHSPISKR 433  Wuchereria bancrofti
XP_003137694 410 YVILLVWIADQYDAICCHSPISKR 433  eye worm
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