2J5H


Conserved Protein Domain Family
CFC
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pfam09443: CFC (this model, PSSM-Id:312817 is obsolete and has been replaced by 462800)
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Cripto_Frl-1_Cryptic (CFC)
CFC domain is one half of the membrane protein Cripto, a protein overexpressed in many tumors and structurally similar to the C-terminal extracellular portions of Jagged 1 and Jagged 2. CFC is approx 40-residues long, compacted by three internal disulphide bridges, and binds Alk4 via a hydrophobic patch. CFC is structurally homologous to the VWFC-like domain.
Links
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Statistics
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PSSM-Id: 312817
Aligned: 30 rows
Threshold Bit Score: 48.7731
Created: 22-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2J5H_A         5 CGSILHGTWLPKKCSLCRCWHGQLHCLPQTFLPGC 39  house mouse
EKC29226      61 CRHVPHGYWIRSDCDKCRCFNGRIFCIPKYYFGcd 95  Pacific oyster
XP_787941    144 CGRVPHGRWVYLNCNSCHCVAGVLKCQPHPMPGcd 178 purple sea urchin
EFB25271     116 CGALMHGAWTFHRCLLCRCVFAALHCLPQQTPGRC 150 giant panda
XP_003133870 122 CGAVMHGAWTFRGCRLCRCVFATLHCLPRQTTGRC 156 pig
XP_014308507 112 CGTLVHGSWTVCGCQLCRCVFGTLHCLPRQTSGRC 146 little brown bat
BAF82783     123 CGALEHGAWTLRACHLCRCIFGALHCLPLQTPDRC 157 human
XP_004836052 121 CGALGHGAWTVRSCHLCRCVFGALHCLPSQTHGSC 155 naked mole-rat
XP_007607676 131 CGALGHGAWTLHSCRLCRCIFSALYCLPRQTFSHC 165 Chinese hamster
XP_003416743 137 CGAHAHGAWTVRGCRLCRCVYGALHCLPRQTPGPC 171 African savanna elephant
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