2DAY,2DAX,2DAW


Conserved Protein Domain Family
RWD
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pfam05773: RWD (this model, PSSM-Id:310403 is obsolete and has been replaced by 399058)
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RWD domain
This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices.
Links
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Statistics
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PSSM-Id: 310403
Aligned: 117 rows
Threshold Bit Score: 41.1549
Created: 25-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2DAY_A     11 WVLPSEVEVLESIY-LDELQVIKgn-grTSPWE----IYITLHPATAEDQd----------------------------- 55  human
A9UMG5     13 QSQIEEIEALSSIY-GEEWCVID---------EaarvFCIRISETQQP-------------------------------- 50  tropical clawed frog
Q9W625     10 QRQIDEVEALTSIY-GDEWCVIDe---aERIFC----ITISDSSNKP--------------------------------- 48  African clawed frog
Q4WDC1      9 DERSVELSSITAIY-PEIKIDPT------SPFKasldIPVKPSTPLPVCFeqqldagfpevltpptslda---------- 71  Aspergillus fumigatus
Q5AYM1      9 DERSEELSSIAAIF-PEIKIDPS------SPYRasldIPVKPATPLNVCFyqrpevgfpsvltpptsldasev------- 74  Aspergillus nidulans
Q5ANG1     18 DIRVQELQSCKYIY-PDCEIDLS-------SLSgtvnIKVKSDNDITIRLiertskgt---------------------- 67  Candida albicans
Q6BWT3     20 DIRIQELQSLEAIY-SNTTDINY------KNLTgsaiIPIRLEKDIEIILhdgnllvsdkqvqid--------------- 77  Debaryomyces hansenii
Q3ZAU6      7 EAQEDELLALASIYdGDEFRKAEsvqggETRIYldlpQNFKIFVSGNSNEclqnsg------------------------ 62  Norway rat
Q4RIS5      5 EAQEDELLALTSIYdEEEFHRADsaqggEIQLClelpADFKIVVKGHTQTey---------------------------- 56  spotted green puff...
XP_961495  11 SPRDTELSSLVAIY-PEIQHPRS-----DDPYAiaidIPVNPSKPVLVYFpaaadsnpdpraqgtlqqngashvngsasg 84  Neurospora crassa ...

2DAY_A     56 ------------------------------SQYVCFTLVLQVPAEYP-HEVPQISIRNPR-GLSDEQIHTILQVLGHVAK 103 human
A9UMG5     51 --------------------------------KWTVCLQIILPPDYPsSAPPIYQINAAW--LRGQDRMTLSNSLEEIYV 96  tropical clawed frog
Q9W625     49 --------------------------------TWTLCLQVILPPDYPvASPPLYQLNAPW--LRGEDRLTLSNCLEEMYL 94  African clawed frog
Q4WDC1     72 -----------sdvelgfatkddgrdvhtlSYLPPLRLEIDLPEGYPsEKAPIFRLETNPpWLSHSIILRLTEDGNRLWE 140 Aspergillus fumigatus
Q5AYM1     75 -------glgskaklddqsmadtekdvhvlAHLPPLNLEIELPEGYPsIKPPIFKLNTNPrWLPLWAVSKLLDDGKRLWE 147 Aspergillus nidulans
Q5ANG1     68 ----------------------riiatnkiSNLPPIVLNFQLSADYPfVAPPEIKVTCVW--LATSKTDLLTKDLYDIWK 123 Candida albicans
Q6BWT3     78 ---------------lateitdrhvrkdkiKNLPPVQLTFKVTEKYPfEEPPEFHINTTI--LSDSDVESLYSSLHKLWD 140 Debaryomyces hansenii
Q3ZAU6     63 -------------------------feytiCFLPPLVLNFELPPDYPsSSPPSFTLSGKW--LSPTQLSALCKHLDNLWE 115 Norway rat
Q4RIS5     57 ----------------------------nvCFLPPLVLNFELPEDYPsKSPPIFALSSKW--MTAAQMSCLCRRLDELWE 106 spotted green puff...
XP_961495  85 gplngtdrvggagsaegagagagaldrhevAHLPPVHLEIIFGPDYPaEKPPVITISADPpWLSKDTIKRLEDDGPRLWE 164 Neurospora crassa ...

2DAY_A    104 AGLGTAMLYELIEKGKEIL 122 human
A9UMG5     97 ENAGESILYLWVEKIREFL 115 tropical clawed frog
Q9W625     95 QNLGENILYQWVEKIREFL 113 African clawed frog
Q4WDC1    141 DCGRDLVVYTYIDHLQQLA 159 Aspergillus fumigatus
Q5AYM1    148 EFGRSLVVFSYIDHLQQLA 166 Aspergillus nidulans
Q5ANG1    124 EY-RDQVLFNLIDHLQDQV 141 Candida albicans
Q6BWT3    141 DF-KDQVLYALIDFIQEKI 158 Debaryomyces hansenii
Q3ZAU6    116 EHRGRVVLFAWMQFLKEET 134 Norway rat
Q4RIS5    107 ENRGCEILFTWIQFLKEET 125 spotted green pufferfish
XP_961495 165 EMGRDMVGFTYIDHIQQAA 183 Neurospora crassa OR74A
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