2NPP


Conserved Protein Domain Family
B56

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pfam01603: B56 (this model, PSSM-Id:307642 is obsolete and has been replaced by 460264)
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Protein phosphatase 2A regulatory B subunit (B56 family)
Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit. There are multiple families of B subunits (See also pfam01240), this family is called the B56 family.
Statistics
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PSSM-Id: 307642
Aligned: 124 rows
Threshold Bit Score: 240.192
Created: 13-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2NPP_B         32 DVPPADQEKLFIQKLRQCCVLFDFvSD-----PLSDLk-wKEVKRAALSEMVEYI--------THnr--nVITEPIYPEV 95  human
10_pfamImport   5 SVKENEVKDLIVSKCKIAKQNVDL--------SRQDLavyATGKEGYLFDILETL--------QDknfnlPQDPDVYSAI 68 
22_pfamImport   5 PVKDPQFGRILEQKLEICKNVYDF-ND-----NGPTAa-dRDIKSRSLCEIVQFF--------ENpnevkKLNEDLQVKI 69 
12_pfamImport   6 QIESSSFQGIFEKKIEACCQICPF-AD-----EELERv-sIERKTTHLTKLYRLFlgai-------pqstKLTDKNYELL 71 
19_pfamImport   5 KPNNPEFKNIFLHKLNLGCQVF----------SDMDPn-qRLAKRIVLHQVAECI--------ITlgigpFIDSEMTSKV 65 
26_pfamImport   6 KPNDSQFKSILLKKLDLCKQLCDF-EN-----PCNDRq-aKDIKKHTLIEINNSF--------TTlglnsISDDEIKDTI 70 
25_pfamImport   6 KAGDPSFKNIMMKKIELCKQMCDF-DN-----PNNDKd-aKIIKANALQEISNRF--------SNlginsYIDEDIRVNL 70 
17_pfamImport   7 RQNNINPSKVLLDK-------VNYmIEnpvisPLTEFe----RKIETLSSINHLVpriwdgqpSN-------IPRLLDPL 68 
5_pfamImport    1 ---spaatSHLVEILQYCKTIIDFnNP-----QTMNSr---cKKADYLTRLFNSV--------NNvhvfrNLTDDIRAEI 61 
14_pfamImport   1 ---spalaTQFVEALQFCKTIVDFdNP-----QTINMr---sKKADYLTKIFNTV--------NNvhvfrSLDESLRVEL 61 
2NPP_B         96 VHMFAVNMFRT---LPpssnpT-GA-EFDPEEDEpTLEAAWPHLQLVYEFFLRFLESPd-fQPNIAKKYIDQKFVLQLLE 169 human
10_pfamImport  69 ISLVAFHIFRTvtiLPdl-wnS-VHdDYYFEMDT-FSDPQWPHRVIIYDTAIALFKRSd-fNIEKCKLLATDLFKL-VVY 143
22_pfamImport  70 FKMIKKNIFDQdliFPdplisq--------syvnvVIETGWHHLFYCYQILNRFAQLFpesPL------LNMRLIKKIFH 135
12_pfamImport  72 YGMVMRNIVRR---LPtidplalenydvsP-----FTEPSWPHLSIAYSILGKILAEFpnaPF------FDFKTLSNILL 137
19_pfamImport  66 YEMIYVNIKRP---VPkfelnqflnsdsgC-----FSVPEWEHLEFVYTIFQIFYKTFpklEF------WTTQFFESLIP 131
26_pfamImport  71 LDVIKINLLRP---LNkldeltlfnpdvgA-----FKEFDFEHMEYIYRMLNTLYRDMpkyKG------FNIDLLVQLLP 136
25_pfamImport  71 VQMIKTNLIRP---LSklddislffsdinS-----FHLEDFQHTQHIYKILTFFFRDFpkyEI------FDIKFMKELIP 136
17_pfamImport  69 FRMIKMHIFQP---LPkfspfllysetkvA-----VSRQFWPALSIIYKTLAYIIKNTshqEL---NNYINQDFIKSLMG 137
5_pfamImport   62 FEMIKINLIRE---IPpipltiiyadsrvP-----LNTNSWLHLSLIHRILFSFVSNSevsQL---QNLLTKEFLTNFVA 130
14_pfamImport  62 FDMIKVNILRE---IPpipltiiyadsriP-----INTNSWLHLSTVHRILYSFVSNSeisAL---QNLLTKDFLTRYIT 130
2NPP_B        170 LFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNG------IAELLEILGSIING-FALPLKEE 242 human
10_pfamImport 144 LMRTPNKEEQRKLTELYVCMIPKLGEFRSFAINVTNSALARIAFSDENFIA------TKPLLQVMRSHAEG-FHTPLKKV 216
22_pfamImport 136 LIDIPDNNERLQLLSFLRTYYDFHNAERPILLQMTYDHLIEYQN------KmlppycVPPLLVFSSHMFTR-LNRTFTPE 208
12_pfamImport 138 VAGSADGRERQQIVIFISRFISLNQQFNDPLIQKFASIIENYLD------SmhnpfiILTILTTFVAIIRDlGEIP--PL 209
19_pfamImport 132 LISSRDTLERDRLAIILSTYY----INNPILLHGFALKLAKIIE---NHFItpdpcaVYTALTIFSNIIAS--SIENRNM 202
26_pfamImport 137 VLSSKDKRERELIIQFYVNVL----TAKPKLFPEIFPKLIRILI---SDYFdpdpcgIYSALSIIYSCQQS--NNNLKDI 207
25_pfamImport 137 VLSSRDIRERDMIIAFMVSLI----QAKNNLFNQILPSLIKIID---HHFVdidpcgVYSALGIMKGVIKE--IPSFWRV 207
17_pfamImport 138 VLQSPDANESLASEDCITEIFDKFLRYQVFIFKSAVSLLSSFVDGAINHVS------VAPCIRLSHYFLLF-NKVDLHSI 210
5_pfamImport  131 LLESPDPKETAAVETFVLLVFDSVSGYRQILFQIILRQILKYQENFALYSC------VAPCLRFLLHFLKA-QPLPLKPT 203
14_pfamImport 131 LLESPDPKEIQAVESFILLVFDTVSGYRQIIFQIILRQLLKYRDNYMLYPC------VAPCLRFLHHFLKA-QTLPLKPP 203
2NPP_B        243 HKIFLLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVK 322 human
10_pfamImport 217 HQIFYLDVILPLHKHKHSHYFWQDLVSTVTAFLDKEPNLVFPTYEFIVNVWPRMCTTKQLDFIDEIGILASFVPDEETSK 296
22_pfamImport 209 ILKLIRNAVFPLIKSPHIYLFGQHLQQLLTSLFTSDPLIANEFYDYLLTHWQSDNTLIMSAHIEFLIYVCQKMTPEQMMN 288
12_pfamImport 210 FSRFFRHFIVRLLSDIHLPFYDQIMCTIIDLYIEDDSRNSICVVHQVLRHWPYTKLAKQSIFLYLIIKCFPKLPNKEIQP 289
19_pfamImport 203 AFNLCNNLCIQLIQNQYLSIFISPFSNLLKMILPLSETLTLILLNGIVKYWPVSDPAKQVPMIKLIIAALFSNHSMNDGV 282
26_pfamImport 208 IKPYYHSHFLPLIRHEHFGVFYFPLLQLLKMFFTNNYSNTNEFVRLIINIWPISKPAKEEMMLDFLVQSLEFARNIDYRL 287
25_pfamImport 208 IQPMFQTHLLNLLRYDCLRVYADPLSEIFSLFYNNNSIYSKNTIELLVSIWPVSNPSKEEIMINILSSALDF-PEAINNA 286
17_pfamImport 211 AF----NVVAPLISCHFSSDYFDDLEKIIMFLCDNDPGLNPFFSQYLIAHFPASDSAKSCLFLDLIARLDVKCPNEAF-- 284
5_pfamImport  204 FFQMYKTIIFPLMSSQLSSEFFSPFNQLAEFFVQQDPTISTWTLQEMVKHWPKTDTNKECSFISHFTYIAPYIPPNDILE 283
14_pfamImport 204 FFTLYKTIIFPLISSQMSSEFFGPFNQLAEFFESQDGTISTWTLYELVKHWPKTDTNKETAFLSHFSYLAPHLPPKDIES 283
2NPP_B        323 IMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAAKILPIMFPSLYRnSKTHWNKTIHGLIYNALKLFMEMNQ 402 human
10_pfamImport 297 VTKILLPQYCRTIVGVNAWSSKRALALFDINDFVWLMTEVPGDVYPSLIPSLYEcAKIHWDGDARNLALACLNVLRDNNR 376
22_pfamImport 289 VSKRTFIILTICLLSTHLRIINATLFLWLRPKLDQWVENDSRHAVTVMYDNVKRlSELHWSQSIREKASQVLAEMGKLNR 368
12_pfamImport 290 NLTRILNILATSTDSECYRVAEAAFQMWTTHGFDRIINENIKLINHIFAVHVFNaRENHWSPTVRNNANFVLSILMKKDP 369
19_pfamImport 283 ILKKVFLLLGELCDTEFFKVADQACKCLQEEVILGLLSNNCREIVPYIMTHVRSsLK-HWYAPLRETAQVTLRVLCQIC- 360
26_pfamImport 288 L-GRAFKIIGSLCDSPSFKVAEKANKIIISPVLMELISQASTKILPFLLVHIENaRN-HWSNTVRIAAEDSMTSISRLMG 365
25_pfamImport 287 LLCHIVDIVAISIDSPSHKIAEAANRLFVQPSFTELVSKNRKTFTVKLLPHVENaRT-HWNEKIRSLGNESNLAILRMNP 365
17_pfamImport 285 -----VRLVSDCVMSPNFRVSLAALQVITRN----FIQRNP-RAARLLVNNVSKaRS-HWCDMVRDLAQVIYKLLMDADR 353
5_pfamImport  284 SGKIIFSILKQSLESLNFKTNVAALNVISNRNFIIVFSAFASQLIPLIMNGVNKcSQ-HWNVAVQKSAIDAVRVLVSVLS 362
14_pfamImport 284 CGLIIFNILKESLDSLNFKTNISALNVITNKNFLIVFSSFSTKLVPIILKGVDRcST-HWNVVVSKAALDAARVLMSVNH 362
2NPP_B        403 ----KLFDD-CTQQfkaEKLKEKLKMKEREE---AWVKIENLA 437 human
10_pfamImport 377 ----KIFNVvGKA----MKMLENQRIVTDIKramKWKELI--- 408
22_pfamImport 369 ----TAFLK-MRNKnt--nDSRRKRYEIEHQcmkNWAAIAKEA 404
12_pfamImport 370 -------------KfgnNFNQESTIDDADCKklrFWVYIAREA 399
19_pfamImport 361 -------------------QERRSDDIGLNVrtsNWVSIARTA 384
26_pfamImport 366 ----RSAN-----------RKKQEDLNNSKEklkSWASIARAA 393
25_pfamImport 366 ----NIKSK----------KIQDATTDTNKTklkGWASIARAA 394
17_pfamImport 354 gamrAAL------------HLNEREAKKGKEkaqIWKEIFEK- 383
5_pfamImport  363 ----DIEKGiDLS------LLEKEAQEKETVlisGWNFVLDE- 394
14_pfamImport 363 ----DVGSRlEIG------RIESERNRAIQSkrrNWEVLVE-- 393
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