Conserved Protein Domain Family
GPS2_interact
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pfam15784: GPS2_interact (this model, PSSM-Id:292412 is obsolete and has been replaced by 464868)
G-protein pathway suppressor 2-interacting domain
GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.
Links
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Statistics
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PSSM-Id: 292412
Aligned: 12 rows
Threshold Bit Score: 99.9084
Created: 24-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_011926812  169 TGKLEPVSPP-SPPHTDpeLELVPPRLSKEELIQNMDRVDREITMVEQQISKLKKKQQQ-LEEEAAKPPEP---EKPVSP 243  sooty mangabey
XP_006562020  462 TPQTEAISPT-LPEPNT--QEDAQFRSTKDDLLQQISKVDREIAKRESQINKLRKKLKE-LEEAANKPLEAsglKRQVEE 537  honey bee
XP_008206436  338 TPQTEAISPT-LPEPNT--QEDTVFKITKDDLLQQIAKVDREIAKRESQISKLRKKVKE-IEEVASKPLEApgtKRPVEE 413  jewel wasp
EHJ79243      260 NNSVEVLSPN-PPSEPT--VEDQSFRTTKDDLLQQISKVDREMALSEQTLLKLKKKQEE-LEQSASKPA------RAEEP 329  monarch butte...
EKC21189      242 NPQVEAISPT-LPPDETs-------pSSKDQLLQAISKVDREISKVDKDIQKLKKKQEQ-LELEKCKPPEE---KQKVKD 309  Pacific oyster
XP_012548131   97 YNTVEVLSPN-PPSETS--GEDQTLRTTKDVLLKQISKVDREMALVETSLAKLKRKQEE-LQQSASKPA------RAEEP 166  domestic silk...
EFN66084      134 TPQTEAISPT-LPEPNT--QEDA-LRSTKDELLQQIGKVDREIAKRENQLNMLRKRIKE-LEEAANKPLEAtglKRNIEE 208  Florida carpe...
XP_010609908  148 GGKHEAPSSPiSGQPCGddQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQ-LEEEAAKPPEP---EKPVSP 223  Fukomys damar...
XP_011609440  143 TVKVESLSPGgHTLHIGedQDTSPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQ-LEEEAAKPMEP---EKPVTP 218  torafugu
XP_012397924  140 AGKLEPVSPA-SPAHAEseLDLLPPRLSKEELIQNMDRVDREITMVEQQISKLKKKQRRpVGVCGTRveeqgpradapqn 218  Tasmanian devil
AEE80960       88 iGKIEPISPV-SPVPMEadLDLVPSRLSKEELIQNMDRVDREITMVEQQISKLRKKQQQ-LEEEAAKPQEP---ERTISP 162  zebrafish
XP_011678604  182 MPKVENISPTp-------cDQETTNKISKEGLISSMDKVDREIAKVESQISKLKKKQQE-LEQRAARPIDT---DKPLSP 250  purple sea ur...

XP_011926812  244 Pp-I-ESKHRSLVQ 255  sooty mangabey
XP_006562020  538 Qs-Q-QPKHQSLAQ 549  honey bee
XP_008206436  414 As-S-QPKHQSLVQ 425  jewel wasp
EHJ79243      330 Ee-A-PPRHRSLAQ 341  monarch butterfly
EKC21189      310 Iv-VtETKHQSIAQ 322  Pacific oyster
XP_012548131  167 Ee-A-PSRHRSLAQ 178  domestic silkworm
EFN66084      209 Qs-Q-QPKHQSLAQ 220  Florida carpenter ant
XP_010609908  224 Pp-V-EQKHRSIVQ 235  Fukomys damarensis
XP_011609440  219 Pp-V-EHKHRSIVQ 230  torafugu
XP_012397924  219 grgvglgpglrgpl 232  Tasmanian devil
AEE80960      163 Pp-S-EAKHRSLVQ 174  zebrafish
XP_011678604  251 AfgS-EPKQQNIIQ 263  purple sea urchin
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