Conserved Protein Domain Family
PAG
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pfam15347: PAG (this model, PSSM-Id:291992 is obsolete and has been replaced by 434654)
Phosphoprotein associated with glycosphingolipid-enriched
PAG, or Cbp/PAG (Csk binding protein/phospho-protein associated with glycosphingolipid-enriched microdomains) is a transmembrane family that has a negative regulatory role in T-cell activation through being an adapter for C-terminal Src kinase, Csk. This family of proteins is found in eukaryotes.
Links
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Statistics
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PSSM-Id: 291992
Aligned: 13 rows
Threshold Bit Score: 429.589
Created: 17-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q3U1F9         2 GPAGSVLS-SGq----------mQMQMVLWGSLAAVAMFFLITFLVLL-CSTCDREKKPRq--HSGDHENLMNVPSDKDM 67  house mouse
Q9NWQ8         2 GPAGSLLG-SG------------QMQITLWGSLAAVAIFFVITFLIFL-CSSCDREKKPRq--HSGDHENLMNVPSDKEM 65  human
XP_012396700   2 GPEGSLLH-GG------------QVHIIIWGSLAAVATFLLITFLIFL-CSSCEREKKPKq--QNGDHENLMNVPSDKEM 65  Tasmanian devil
XP_003408410   6 GPVGSMLSiSG------------QVQIVLWETLAAVAIFFLIAFLIFL-CSSCDREKKPRp--QSGDDENLMNVTSDKEM 70  African savanna...
ETE71852       2 GPDGNFLS-TG------------VLHIIVWGSLGAMAMLLVFSFLLFL-CSGCDREKRPEq--QNGDHENLMNVPSDKEA 65  king cobra
XP_003205191   2 GPDSGFLS-SG------------RVHVILWGSLAAVTTLLFLTFLIFL-CSSCNREKKSKh--QNGDHENLMSVPSEKEV 65  turkey
XP_006102204   2 GPSGSLL--GG------------HLQIALWGSLAAAATFFLITFLIFL-CSSCDREKKPRq--YSGDHENLMNVPSDKEV 64  little brown bat
XP_003219618   2 GPDVGFFS-TS------------LLHIIVWGGLAAMTMLLVLIFLIFL-CSSCDREKRPKq--LNGDHENLMNVPSDKEV 65  green anole
XP_007659573   2 GPAGGLLS-SG------------QVPVVFWGSLATVGTFLLLLTFLLFlCSSCDREKKPK---QSGDHENLMNVPSDKGL 65  platypus
XP_002936667  10 GSPSNDLS-GE------------QAAFMAWGGLAAVSTIIFLSILLFL-CSSCYREKKKKh--QNGDHENLMTAPSDKET 73  western clawed ...
XP_005997607  10 GDEEGLLS-SG------------QPQVVLWGTLAAITSFLLLNLLVFL-CTSCEREQKAKt--QTEDHEILMNMPSDKET 73  coelacanth
XP_005478543  11 GPEAGVVG-SGtaastgvaswlgSGQLILIATLSILTALLLVSVLLLL-CASCQGQKKAVnghPAGDHQSLVNGVSERDV 88  Nile tilapia
XP_003969430  23 aDAGAALW-SG------------GVQLVLAVVLSTLTLLLLVSVLLLL-CASCQGQKKAAngpEEGDHENLMNGVPQKET 88  torafugu

Q3U1F9        68 FSHSATSLTTDALASSEQNGVLTNGDILSEDSTLTCMQHYEEVQTSASDLLDSQDSTGKA-KCHQSRELPRIPPENAV-- 144 house mouse
Q9NWQ8        66 FSRSVTSLATDAPASSEQNGALTNGDILSEDSTLTCMQHYEEVQTSASDLLDSQDSTGKP-KCHQSRELPRIPPESAV-- 142 human
XP_012396700  66 FSHSVTSLGTELPASSEQNGGLTNGDILSEDSTMTCMQHYEEVQTSISDLLESQDSTGKSaKCHQSRELPRIPPNDTL-- 143 Tasmanian devil
XP_003408410  71 FSHSVTSLATDALASSDHNGALTNGDILSEDSTMTCMQHYEEVETSASDLLDSQDSAGRPsKCHQSRELPRIPPNSTV-- 148 African savanna...
ETE71852      66 FSHSVTSLATDPIASSEQNGGLSNGD---EDSTAATLQPYEEVQTSVTDLLDQQDTLGRSlKCHQSRELPRIPPNNAI-- 140 king cobra
XP_003205191  66 FSHSITSSATEPPPSSEQNGALSNGDVLSEDSTTACIQPYEEVQTSISDLLE-QDSLGKSlKCHQSRELPSIPPNNTM-- 142 turkey
XP_006102204  65 FSRSVTSLATDAPLSSDQNGALTNGDIASEGSAGTCAQHYEEVLAAASDLLDAQDGSGKP-KGHQSRELPQIPPDSAV-- 141 little brown bat
XP_003219618  66 FSHSVTSLATDPLASSEQNGGLSNGDVLSEDSTTACIQPYEEVQTSVTDLLEPQDSLGRSlKCHQSRELPRIPPNNAI-- 143 green anole
XP_007659573  66 LSHSVTSLTTDAAASSEPNGGLSNGDILSEDSTKAYTLPYEEVQTSVSDLLDSQESVGKSiKCHQSRELPRIPPNGTL-- 143 platypus
XP_002936667  74 YSHSVTSLGTEAPASY-RNGAVSNGDV-SEDSSAACIQPYEDVQGSLPDLCDLQDCTSKSiRCHQSRELPRIPPNSNL-- 149 western clawed ...
XP_005997607  74 FSHSVTSLGTDPPVSSCQNGELSNGDVLSEDNAGTNTQPSEEMKTSLPDLISQQDSMGKPlRYPQSRELPSIPPNSSV-- 151 coelacanth
XP_005478543  89 -SQSADSPATDAAVSTSHNGPLTSGTILT-DTQDTSPQLSEEMLSSQSEL--------RSsKCPQDRELPSIPPNNALig 158 Nile tilapia
XP_003969430  89 GSQSAESPATDVAVSSSRNGPLTSGTILT-DTQDSSPQPSEEILSSQSEL--------RSsKCPQDRELPSIPPDNAL-- 157 torafugu

Q3U1F9       145 DEILTARAADTELGPGVEGPYEVLKD--SSSQENMVEDCLYETVKEIKEVA-----DKGQGG--KSKSTS------ALKE 209 house mouse
Q9NWQ8       143 DTMLTARSVDGDQGLGMEGPYEVLKD--SSSQENMVEDCLYETVKEIKEVAaaahlEKGHSG--KAKSTS------ASKE 212 human
XP_012396700 144 DTILTTSNVESDQGLGMEGPYEVLKD--SSSQENMVEDCLYETVKEIKEVGtsanlEKGQNG--RPNSVT------AFKE 213 Tasmanian devil
XP_003408410 149 DTTVNASSVDGDQSGGMEGPYEVLKD--SSSQENMVEDCLYETVKEIKEVGatthpDKGHNG--KSKSIT------TLKE 218 African savanna...
ETE71852     141 ETILTTRNAENDQSLGMEGPYEVLKD--SSSQENIVEDCLYETVKEIKDLGaaansEKC-----KPKTTV------MVNG 207 king cobra
XP_003205191 143 ETIISARNAENDQGLGMEGPYEVLKD--SSSQENIVEDCLYETVKEIKDVGaaanmERSCNR--KSAASM------MVTE 212 turkey
XP_006102204 142 DTLASTGSVDGDQGAGAEGPYEVLKD--SSSQENMVEDCLYETVKEIKEAAap--pgKGPGG--RSRAAP------APKE 209 little brown bat
XP_003219618 144 ETILSTRNTENDQGLGMEGPYEVLKD--SSSQENIVEDCLYETVKEIKELGatsgtEKC-----KPKTAV------LVNG 210 green anole
XP_007659573 144 EPILPPRTEARERGLGTEGPYEVLKV--SCSQENMVEDCLYETVKEIKEAGasadaDPSHGGghQEGSAT------AGRG 215 platypus
XP_002936667 150 ETISPAEDDENELPLGNEGPYEVLKD--SSSHENIIEDSLYETVKEIKDAHalplnEETERS------------------ 209 western clawed ...
XP_005997607 152 EGPKSSNATENDQALVTDVTYEVLKD--SSSQDNIIEDSLYETVKELKEECgparnDTASLS--RPSTTA------EEVE 221 coelacanth
XP_005478543 159 NGPPPSGDST----------YEVVKEmaVASRDVSADESLYETVKELKEPAaeaglPNGTIQ--PSPDEP------PPHP 220 Nile tilapia
XP_003969430 158 AGPPASGDST----------YEVVKEiaATSRDVSAEDSLYETVKEIKDPPahlglPNGTTQ--PSPDVPphhphaLLNG 225 torafugu

Q3U1F9       210 ---LQGAP-MEGK---ADF-----AEYASVDRNKKCRHSANAESILG-T-C-SDLD--------EE---------SPPPV 257 house mouse
Q9NWQ8       213 ---LPGPQ-TEGK---AEF-----AEYASVDRNKKCRQSVNVESILG-N-S-CDPE--------EE---------APPPV 260 human
XP_012396700 214 ---IQGPQ-VLNK---IES-----AEYASVDRNKKSRHSVNAESILG-N-S-VDVE--------EE---------APPPV 261 Tasmanian devil
XP_003408410 219 ---LPEPQ-TQGK---MEF-----AEYASVDKNKKCRQSANSEIVLG-S-S-HDPE--------EE---------TPPPV 266 African savanna...
ETE71852     208 ---ILNHV-LEKK---TES-----AEYASVDRNKKSCHSVNSESPLS-S-TtPDVE--------EE---------APPPV 256 king cobra
XP_003205191 213 ---DQDQI-PECR---IES-----AEYASVDRNKKSRQSANSESPLD-N-T-PDIE--------DE---------LPPPV 260 turkey
XP_006102204 210 ---PPAPQ-APGR---ADF-----AEYASVDRNKKCRQSMNVDSVLG-P-A-RDAE--------EE---------APPPV 257 little brown bat
XP_003219618 211 ---SLDHV-LAHK---VES-----AEYASVDRNKKSRQSANSESPLS-N-T-PDVE--------DE---------PPPPV 258 green anole
XP_007659573 216 ---LLGSV-SEGQ---TGS-----AEYASVDRNKKGRQSLSAESVLG-G-L-ADLE--------EE---------APPPV 263 platypus
XP_002936667 210 ----MDAV-SPKR---QEFrieagAEYASVDHNRKSRQSINTQSAGS-T-P-TSQE--------ED---------VPPPL 261 western clawed ...
XP_005997607 222 ---AQSPEnAAGA---TQS-----AEYASVDWNKKSHRSQVLCAGDR-A-S-ANSD--------EE---------APPPV 270 coelacanth
XP_005478543 221 palLNGHVsPSTP---ERGpifagAEYASVNLNKKSRHSADMEAKRR-SgN-AAVP--------QQkpqeepeedLPPPV 287 Nile tilapia
XP_003969430 226 ---HLSPV-TPERgplCTG-----AEYASIDLKKKSRHSADMESKRRsN-N-ANVPshgppeepED---------LPPPV 285 torafugu

Q3U1F9       258 PVKLLDENANLPQ--E------G-----GGQA-EEQAAEGTGGHSKRFSSLSYKSREEDPTLTEEEISAMYSSVNKP-GQ 322 house mouse
Q9NWQ8       261 PVKLLDENENLQE--K------E-----GGEA-EESATDTTSETNKRFSSLSYKSREEDPTLTEEEISAMYSSVNKP-GQ 325 human
XP_012396700 262 PVKLLDENENVQD--K------V-----DGETvNKGATESTGQINKRLSSLSYKSREEDPTLTEEEISAMYSSISKP-GQ 327 Tasmanian devil
XP_003408410 267 PVKLLDEKENLQE--K------E-----ERPAdEEGATEGTTEINKRFSSLSYKSREEDPTLTDEEISAMYSSVNKP-GQ 332 African savanna...
ETE71852     257 PIKLLDENENVQD--K------G-------AKeEEEVMERLNEPDKRLSSLIYKSREDDPSLTEDEISAMYSSINKT-GQ 320 king cobra
XP_003205191 261 PMKLLDENENVQE--N------E--------VdEGEGTEGASKPEKRLSSMSYKSREEDPSLTEDEISAMYSSVSKP-GQ 323 turkey
XP_006102204 258 PVKLLDKNENLQA--Q-----------------DNSASEGTQETNKRFSALSYKSREEDPTLTDEEISAMYSSVNKP-GQ 317 little brown bat
XP_003219618 259 PLKLLDENENVQE--K------E-----AEEEkEATE--GPSDPDKRLSSLSYKSREDDPSLTEEEISAMYSSVNKP-GL 322 green anole
XP_007659573 264 PVKLLDENENVWE--K------EdersaAVKEeEGEASESPVDTSKRLSSLSYKSREDDPALTEEEISAMYSSVNKP-GL 334 platypus
XP_002936667 262 PKKLLDENENVQS--KepeaepE-----AEPEaLKENIEGASQDDKRQSLVSYKSREEDPCLTETDISAMYSTVSKTsGQ 334 western clawed ...
XP_005997607 271 PTKILDENENVQN--K------G-----T----EGEHLKEASEVEKK--RLSYRVHGDGPPLTEEEISAMYSTVNRP-AQ 330 coelacanth
XP_005478543 288 PEKVLDENDNQPAlmM------N-----GLAEaGLHNGE-------LHSPPSPAPKFDNHVLSDNE-SAVYSTVNKT-NC 347 Nile tilapia
XP_003969430 286 PEKVLDENDNQPV--L------Vn----GSAGaGLHNGE-------LDSPLSPAPGIDSPTLSDKE-APLYSSVAKT-NC 344 torafugu

Q3U1F9       323 --SahkpgpcMK--------------GP--E--SACHSMK-GLPQRSSSSCNDLYATVKDFEKTPNs-iSTLPParRP-S 379 house mouse
Q9NWQ8       326 --LvnksgqsLT--------------VP--E--STYTSIQ-GDPQRSPSSCNDLYATVKDFEKTPN---STLPPagRP-S 380 human
XP_012396700 328 --T-------LK--------------VP--E--STYSCIQeVAPKRSPSSGNDLYATVRDFEKNPNi---lPPPgvHS-N 376 Tasmanian devil
XP_003408410 333 --S-------VNkpgqsvnksaqllqVP--E--SSYTCIQdGAPQSSPSSCNDLYATVKEFEKAPNs-vSTPPPaeRP-S 397 African savanna...
ETE71852     321 --P-------SR--------------DL--E--STYTCIPeLVPQKSPSICSGLYASVKDLETNPNl-tDLPQStiLL-N 371 king cobra
XP_003205191 324 --A-------IR--------------AM--D--SPYTCIQeITSQRSPSVCSGLYASVKDFENTLSa-tTVPQSagRP-N 374 turkey
XP_006102204 318 --S-------LK--------------VP--E--SSDTCSP-GAARRSPSSCNDLYATVKDFEQPPSg-aGTLAPaaRP-- 366 little brown bat
XP_003219618 323 --A-------TR--------------DL--E--PAYTCIPeIAPQKSPSICSGLYASVKDLENTPNi-tTFPQSgeRL-N 373 green anole
XP_007659573 335 --A-------NR--------------LA--P--APSVAIQeVGPPRSPSSSNDLYATVTDFENLTDg-qEPPPP--RR-D 383 platypus
XP_002936667 335 --S-------FE--------------LQ--EefSHYAYIQdIAQDTSPTTCNGTYATVRDLDKSPDs-iAGPHAmdKA-N 387 western clawed ...
XP_005997607 331 --S-------VK--------------SL--E--CDYVEVKaLSLERTPSMNSDLYATVRDFEKEPNvlwPTPSPsdQTiQ 383 coelacanth
XP_005478543 348 ddA-------VN--------------EEdkE--HDYSSIAeIKGLVPASSSGDLYATVRDIYSQPDe-pG-------P-A 395 Nile tilapia
XP_003969430 345 deA-------VK--------------EEdkE--HDYSSIAeIKGLVTSSS--DLYATVRDIYSQPEq-pEEPA------L 392 torafugu

Q3U1F9       380 EEPEPDYEAIQ----TLNREDEKVPLETNGHHV--PK-ESDYESIGDLQQCRDVTRL 429 house mouse
Q9NWQ8       381 EEPEPDYEAIQ----TLNREEEKATLGTNGHHGlvPK-ENDYESISDLQQGRDITRL 432 human
XP_012396700 377 GEPEPDYEAIQ----SLNKDEEKTVSMANGNHItfPK-ENDYESIGDLQQSKDITRL 428 Tasmanian devil
XP_003408410 398 VEPEPDYEAIQ----TLNREEEKATQETNGLHVlfPK-ENDYESIGDLEQCRSITRL 449 African savanna elephant
ETE71852     372 GDLEPDYEAIQ----TLSREEERNVLMSSTIQTilPQ-ENDYESIGDLQQNKDVTRL 423 king cobra
XP_003205191 375 GELEPDYEAIQ----AVSQDEDRTLSVPHTNHIapSG-ENDYESIGDLQHHRDVTRL 426 turkey
XP_006102204 367 REPEPDYEAIQ----ALSREDEKATLEPSSLRGpfPK-ENDYESIGDLQQCREVTRL 418 little brown bat
XP_003219618 374 GELEPDYEAIQ----TVHHDEDRNGLIPHSSQStlSQ-ENDYESIGDLQQHKDVTRL 425 green anole
XP_007659573 384 NEPEPDYAAIQ----SLGRDEGRAGPGPERGRPlpAQpESDYESIGDLHHGKDFTRL 436 platypus
XP_002936667 388 GGPDPEYEAIA----NLSREEERTMLYTNAGQTllAHgESDYESIGDLVQNGDFTRL 440 western clawed frog
XP_005997607 384 QETDPGYEPIS----SVKNEDETTESQLSASPAtdQKiENDYEIISEFQKD-EITRL 435 coelacanth
XP_005478543 396 DSTDPGYETIRipktNSSEDEHRA----EGSDVgkA--EPDYESVGELGLGPEMSRL 446 Nile tilapia
XP_003969430 393 DGTDPGYETIRlpktSSSDDDRRAGAGEEGPDAatA--EPDYECVGEVGLTGEMSRL 447 torafugu
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