Conserved Protein Domain Family
Dppa2_A
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pfam14049: Dppa2_A (this model, PSSM-Id:290756 is obsolete and has been replaced by 433674)
Dppa2/4 conserved region in higher vertebrates
Developmental pluripotency associated genes (Dppa) in lower vertebrates have remained undetected until the discovery of a Dppa homologue in Xenopus laevis, reporting a new domain termed Dppa2/4 conserved region (DCR). In higher vertebrate Dppa proteins the DCR domain is located next to the here-reported domain. The domain is subject to structure determination by the Joint Center of Structural Genomics.
Links
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Statistics
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PSSM-Id: 290756
Aligned: 15 rows
Threshold Bit Score: 108.743
Created: 23-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9CWH0       127 IPNTSREARMKQGPKKS-----KIVFRGIGPPSGCQR--KKEES--------GVLEILTSPKESTFAAWARIAMRAAQSM 191 house mouse
XP_003261833 134 MPEMSQETRLQRCSRKR-----KAVTKRARLQKSYEMneRAEET--------NTVEVITSAPGAMLASWARIAARAVQPK 200 northern white-...
XP_005324388 117 IPETSQEARLKPVSRKW-----KAVANAAGLQESHNKvkREEET--------NMIEVVNSAQESILASWARITARANQHK 183 thirteen-lined ...
XP_003358870 126 IPETSWETRLQSASRKH-----KMVTKRPRVQKS-KMseRGEKT--------NMVEVVTPAQEAMLAAWSRIASRAVHPK 191 pig
XP_002723488 139 VPDTPREAKMQSCPRKS--------TNRARLQDSCTRsnGEEET--------NIVEVITSAQEATLASWARIAARVSQPK 202 rabbit
XP_012664525 132 IPETPKEARLHSCSRKL-----KAETKRARPQERSKTseKTEKM--------DRVEVITSAQESVLASWARIAAKAGQPK 198 small-eared galago
XP_003421293 136 IPDTPREAKLQPCSRKQarfpgNMAAKRAKLQESCKAreREEGM--------NIVEVVSSAQEATLASWARISSKALQPR 207 African savanna...
XP_005674957 131 IPKSSREARMHSCSRKH-----SMVTKRGSVQKR-KMseSEERT--------KTVEVVTSAQVAMLAAWSRIAARAVQPK 196 goat
XP_011380444 116 VPETSQEATLQSSSKKC-----KMVTKRTRNQKSYKMseREKGT--------NTVEVITSAQEAMLAAWARIAARAVQPK 182 large flying fox
XP_006106699 121 VAGTPEEATLQSCSGKL--------TKRSRSKKSHQMskREEEThtvemtmtNTVEVITSAREAMLAAWSRIAARGSLSK 192 little brown bat

Q9CWH0       192 SKNRCPLPSNVEAFL 206 house mouse
XP_003261833 201 ALNSCSIPVSVEAFL 215 northern white-cheeked gibbon
XP_005324388 184 AVNSCPIPTSVEAFL 198 thirteen-lined ground squirrel
XP_003358870 192 AVNLPPVPASVETFL 206 pig
XP_002723488 203 AVNSSSIPTSVEAFL 217 rabbit
XP_012664525 199 TVNLRSIPVSAEAFL 213 small-eared galago
XP_003421293 208 TVNSRPIPASAETFL 222 African savanna elephant
XP_005674957 197 AVNSRALRTS-ESFL 210 goat
XP_011380444 183 TVNSCFIPTSAENFL 197 large flying fox
XP_006106699 193 AANSYSIPISVENFL 207 little brown bat
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