Conserved Protein Domain Family
GHBP
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pfam12772: GHBP (this model, PSSM-Id:289538 is obsolete and has been replaced by 463696)
Growth hormone receptor binding
Growth hormone receptor binding protein is produced either by proteolysis of the GHR (growth hormone receptor) at the cell surface thereby releasing its extracellular domain, the GHBP (growth hormone-binding protein), or, in rodents, by alternative processing of the GHR transcript. The sheddase proteolytic enzyme responsible for the cleavage is TACE (tumour necrosis factor-alpha-converting enzyme). Growth hormone (GH) binding to GH receptor (GHR) is the initial step that leads to the physiological functions of the hormone. The biological effects of GHBP are determined by the serum levels of growth hormone (GH), which can vary. Low levels of GH can result in a dwarf phenotype and have been positively correlated with an increased life expectancy. High levels of GH can lead to gigantism or a clinical syndrome termed acromegaly and have been implicated in diabetic eye and kidney damage.
Links
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Statistics
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PSSM-Id: 289538
Aligned: 15 rows
Threshold Bit Score: 300.582
Created: 29-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q3UP14       325 EGKLEEVNTILGIHD-----N-----YKPDFYNDDSWVEFIELDIDe-aDVD----EK--TEGSDTDRLLS-------ND 380 house mouse
NP_001001293 289 KGKLDEVNSILASHD-----N-----YKTQLYNDDLWVEFIELDID---DSD----EK--NRVSDTDRLLS-------DD 342 chicken
XP_005060638 292 KGKLDEVNSILACHD-----I-----YKTQLYSDDLWVEFIELDIE---DPD----EK--NRASDTDRLLS-------ED 345 collared flycat...
XP_007487299 299 KGKLEEVNTILASHD-----S-----YKPQFYNDDSWVEFIELDID---DPD----EK--AEESDTDRLLS-------SE 352 gray short-tail...
ETE73537     253 KGKLDEVNSILASHG-----S-----YMPQLYGDDSWVEFIELDID---DAE----DR--TEGSDTDRLLG-------DV 306 king cobra
XP_008101044 291 KGKLDEVNSILASHG-----S-----YMPQLYGEDSWVEFIELDIE---ENE----ER--TEGSDTDRLLG-------DD 344 green anole
XP_005794966 303 KGKLEELNFILNGGGvdglpA-----YATDFYQEEPWVEFIEVDEE---DAEggdkED--NYNSDTQRLIGl-----pHR 367 southern platyfish
NP_001267007 309 KGELDDLNFILSSGGmgslpS-----YAPEFYRDEPWVEFIEVDVEe-gDAG----EKlnSRDSDTLKLLGlplsvshSV 378 torafugu
XP_011477148 303 KGKLEELNFILNGGS-----IgglqtFSPDFYQDEPWVEFIEVDEE---DADsrekED--DQASDTQKLLGppqpisdHR 372 Japanese medaka
NP_001266530 304 KGKLDELNFMLSGRG-----MdglpiYAPDFYQDEPWVELMEVDETedvDNG----EKkdNRGSDTQKLLGqsqpvsqHI 374 Nile tilapia

Q3UP14       381 HEKSAGILGAKDDDSGRTSCYDPDILDTDFHTSDMCDGTLKFAQSQK-L-NMEADLLCLDQK-NLKNLPY-DASLGSLHP 456 house mouse
NP_001001293 343 HLKSHSCLGAKDDDSGRASCYEPDIPETDFSASDTCDAISDIDQFKKvT-EKEEDLLCLHRKdDVEALQSlANTDTQQPH 421 chicken
XP_005060638 346 DLKSHNCLGAKDDDSGRASCCEPDIPETDFSASDTCDATSDSDQFKKaA-EKEEDLLCLDRQdNDESLPSlANTDPQGRH 424 collared flycat...
XP_007487299 353 RQKSLNYLGAKDDDSGRTSCYEPDILETDLSAPASCDSTSDIAHSQR-L-PGTADLFCLEPK--NEASPS-----TTPPP 423 gray short-tail...
ETE73537     307 HTKSHGCLTVRDDDSGRASCCEPDIPETDFSASDTCDGTSDIDQSKK-IsDKEEDLLCLDQKdNKKSIPGlDVASACLPS 385 king cobra
XP_008101044 345 HLKTHGCLAVRDDDSGRASCCEPDIPETDFSVSDTCDGTSDIDQSKK-TsDKEKDLLCLEQKdSEKPSSSfDESPTQLSP 423 green anole
XP_005794966 368 NVEGFRAISHPDDDSGRASCYDTDLPE------------------------HLASLLPGQPEdNKTCLD----APATEMG 419 southern platyfish
NP_001267007 379 NTMGSNTISIPHDDSGHISFYDPETFNPDTQ-------------------VLMGALLPSQAEeDSSKDGSvTGSPSQDTR 439 torafugu
XP_011477148 373 TIRCSETIRHPEEVFGHGSCYNADRPEEDSK-------------------VQMDAPPPGQAGdKESSTEFtERTPALDRC 433 Japanese medaka
NP_001266530 375 NINCSNSVSGPDAESSQATCYNTDLPEEET------------------L-MLMATLLPGQPDeEETSLDTvERSSASETG 435 Nile tilapia

Q3UP14       457 S-ItQTVEENKPQPLL--SseTEATHQLASTPMSNPTSLANIDFYAQVSDITPAGGVVLSPGQKIKAGIAQGNT------ 527 house mouse
NP_001001293 422 T-S-TQSESRESWPPF--AdsTDSANPSVQTQLSNQNSLTNTDFYAQVSDITPAGSVVLSPGQKSKVGRAQCES------ 491 chicken
XP_005060638 425 R-N-TQSENSLLWAPFgdS--LESPRPSVHTQMSNQNSLTSTDFYAQVSDITPAGRVVLSPGQKSKLGRAQREG------ 494 collared flycat...
XP_007487299 424 SgG-LLSEGGQPRPLL--PngMESSSLAVHAHLSNQSSLANIDFYAQVSDITPAGSVVLSPGQKSKAGISQCDG------ 494 gray short-tail...
ETE73537     386 D-NpTKEQDLKSHVPA--P---EITNPLVQTQLSNHSSLGNIDFYTQVSNITPRGSVVLSPGQKMKTGKTQSEV------ 453 king cobra
XP_008101044 424 D-NpAKTQQPKAHASA--TdsNEMTSPPVQTQLSNQSSVANIDFYTQVSDITPGGSVVLSPGQKMKMAKIQSEA------ 494 green anole
XP_005794966 420 E-K-----------------------PLIQTQIGGPQTWINTDLYAQVSNVMPSGGVVLSPGQQPKIQENTSGS------ 469 southern platyfish
NP_001267007 440 K-T-----------------------PGVQGQAGGAQTWVNTDFYAQVSNVMPSGGVVLSPGQQLRIQESMAAT------ 489 torafugu
XP_011477148 434 R-A-----------------------PPVQTQTGTPQTWVNTDFYAQVSNVMPSGGVVLSPGQQLRTQESTPAS------ 483 Japanese medaka
NP_001266530 436 E-R-----------------------QLIQTQTRGPQTWVNTDFYAQVTNVMPTGGVVLSPGQQLRIQESISAAeketkk 491 Nile tilapia

Q3UP14       528 ---------------QREVATPCQEN------------------YSMN---SAYFCESDAKKC---------------IA 556 house mouse
NP_001001293 492 ---------------CTE------QN------------------FTMD---NAYFCEADVKKC---------------IA 514 chicken
XP_005060638 495 ---------------CTE------QN------------------FAVD---NTYFCEADVKKC---------------IA 517 collared flycat...
XP_007487299 495 ---------------HRE-ASPCRGN------------------FILD---NTYFCEADAKKC---------------VS 522 gray short-tail...
ETE73537     454 ---------------QREPVAQCQPT------------------LAMD---NAYFCELDVKKC---------------VT 482 king cobra
XP_008101044 495 ---------------GKEPVTQCQPS------------------IAMD---SAYFCETDVKKC---------------VI 523 green anole
XP_005794966 470 ---------------ERETQKGGKQNedvegikeqkrnepqfqlFVLVpegSGYTAENNTQQ-----------------T 517 southern platyfish
NP_001267007 490 ---------------KVEKQKKAKDPedgedaedkkegeqrpqvLLMDpegSGYTTESSARQF----------------- 537 torafugu
XP_011477148 484 ---------------EHGAQTKGKQRdesgdmdgqrqkepqfhlLVVDpegSGYTTESNCWQN---------------SP 533 Japanese medaka
NP_001266530 492 krkesedseeseerkQKEPQF---QL------------------LVVDpegSAYSTESSIQQIstpppsspmpgegyhII 550 Nile tilapia

Q3UP14       557 V--------------APRMEATSCIKPSF---------------NQEDIYITTESLTTTA--QMSETADI-----Ap--- 597 house mouse
NP_001001293 515 V--------------ISQEEDEPRVQEQS---------------CNEDTYFTTESLTTTGinLGASMAET-----P---- 556 chicken
XP_005060638 518 V--------------TSHEENEPRVQEQG---------------YNEDGYFTTESLTTTVanFGASTAAA-----P---- 559 collared flycat...
XP_007487299 523 V--------------APHAEPEPRTEPRF---------------SPEDVYITTESLTTTA--GSSGIAGG-----Ps--- 563 gray short-tail...
ETE73537     483 V--------------TPPKEEEPEVQVQS---------------FSEDAYLTTDSLVIHP--VIPAMVAT-----Aaeek 526 king cobra
XP_008101044 524 V--------------PPHKEAEPEVQDQS---------------FSEGAYIVTESLTTSA--VNPVTAAEdeelpE---- 568 green anole
XP_005794966 518 S--------------TPPSTSVPGVGYQTiqpqpmetkpaatgdTNESPYILPEPSQSQL--F----------------- 564 southern platyfish
NP_001267007 538 N--------------TPPCSPEPAEGYGAttpqa-----aataeRHQSPYILPDSPQTQV--L----------------- 579 torafugu
XP_011477148 534 PsnspnpgagyqtipPPPVEIKPAASADA----------------NQLPYILPDSPQ----------------------- 574 Japanese medaka
NP_001266530 551 H--------------PQPVEPRPAATME----------------LNQSPYIIPDSPQ----------------------- 577 Nile tilapia

Q3UP14       598 ---DAEMSVPDYTTVHTVQSPRGLILNATALPLP 628 house mouse
NP_001001293 557 ---SMEMPVPDYTSIHIVHSPQGLVLNATALPVP 587 chicken
XP_005060638 560 ---SSETPVADYTSIHIVQSPQGLVLNATALPLP 590 collared flycatcher
XP_007487299 564 ---GAEMPVPDYTSIHIVQSPQGLVLNATALPVP 594 gray short-tailed opossum
ETE73537     527 dpeTSEIPVADYTSIHMVQSPQCLVLNATALHVP 560 king cobra
XP_008101044 569 ---SSEMPVADYTSIHVVQSPQGLVLSATSLPVP 599 green anole
XP_005794966 565 ------TPVADYTVVQELDTHRSLLLNPPPSQSP 592 southern platyfish
NP_001267007 580 ------APVADYTVVQELDSQHSLLLNpparhsp 607 torafugu
XP_011477148 575 ----LVAPVADYTVVQELDTHHSLLLDPTPIqsp 604 Japanese medaka
NP_001266530 578 ----FFAPVADYTVVQELDSHHSLLLNPPCHQTP 607 Nile tilapia
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