Conserved Protein Domain Family
ELL
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pfam10390: ELL (this model, PSSM-Id:287376 is obsolete and has been replaced by 463068)
RNA polymerase II elongation factor ELL
ELL is a family of RNA polymerase II elongation factors. It is bound stably to elongation-associated factors 1 and 2, EAFs, and together these act as a strong regulator of transcription activity. by direct interaction with Pol II. ELL binds to pol II on its own but the affinity is greatly increased by the cooperation of EAF. Some members carry an Occludin domain pfam07303 just downstream. There is no S. cerevisiae member.
Links
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Statistics
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PSSM-Id: 287376
Aligned: 36 rows
Threshold Bit Score: 244.87
Created: 21-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_001958280   16 STGNYGMSQRHRYTD-DSKEYIIVKLTDSAFRAIEEYQRddhaK----RLPPGQRAKIQF-TGNEGVIQFP--------- 80   Drosophila an...
XP_694180       6 QEHRYGLSCGKINKSiPNKTIFHVKLTDTAIRTLEAYQN----L----KGSLPNQPAICF-KGNQGYIKIPa-------- 68   zebrafish
XP_005989805    6 EAGHFSLSYSKVSQV-SRKTFYHVKLTDSALRTLQAFRN----L----KISLPKQSLISF-RGNRGYIKIP--------- 66   coelacanth
XP_008187674   14 SNQNNGLMPKQRT-G-KNKTLFFVKLTDSCLKAVEDYLR----CcqqgNSENLPKPRIQF-KGNEGQLCVP--------- 77   pea aphid
XP_002116407    5 QSGNYTLSRNR-STD-DSIVAVQVKLTDSCLNALDSYIKf---A----LKLNEDHPTLSC-DGKTGRIFIP--------- 65   Trichoplax ad...
XP_001623286   19 PKTDYKLLSESHSNQ-D-KLIVHVKLTDSCLKALQEYQS----S----KGSTQAKPSIRF-TGQDGILEFSyrygffsee 87   starlet sea a...
NP_741375      60 pptpvNLDVQRIDCT-DETTVVMVKLTDEMFAALQESQR------------SGKPLRINV-NDKEGRVEIG--------- 116  Caenorhabditi...
EHJ71272        6 agvQYALSSEASYKE--NKELVFVKLTDSALKAIEDFIR----N----NRDKLAKPKIEFlPGNQGKISIP--------- 66   monarch butte...
XP_002085554   16 STGNYGMSQSHRYTD-DSKEYIIVKLTDSAFRAIEEYQRddnaK----RLQPGQRAKIQF-VGNTGVIHFP--------- 80   Drosophila si...
XP_002008740   17 sSGNYGMSQSHRYTD-DTKEYIFLKLTDSAYRAIEEYQRnenaK----RLAPGQCAKIQC-NGNTGFIHFP--------- 81   Drosophila mo...

XP_001958280   81 RSSSDanghhnnpstngngngngngnsgNDpGRKF----------------------LF-------TIN----------- 120  Drosophila an...
XP_694180      69 SSDSP-----------------------DA-FRVF----------------------SF-------YLS----------- 84   zebrafish
XP_005989805   67 DDNYP-----------------------NG-LRVF----------------------SF-------DVS----------- 82   coelacanth
XP_008187674   78 SI--------------------------SK-NYTF----------------------DF-------SLS----------- 90   pea aphid
XP_002116407   66 DKNGG---------------------------RDF----------------------QF-------SCT----------- 78   Trichoplax ad...
XP_001623286   88 KNISP-----------------------SE-LRNLiniecleslgfernikgsvwvnTFirlydkaYISkhaifmtisip 143  starlet sea a...
NP_741375     117 DGTAS-----------------------SKtNNTF----------------------YF-------QKQ----------- 133  Caenorhabditi...
EHJ71272       67 TPSSSn---------------------gTSsESTF----------------------RF-------SIN----------- 85   monarch butte...
XP_002085554   81 RPATDangipnangng-----sdatgaggggsRKF----------------------GF-------TIN----------- 115  Drosophila si...
XP_002008740   82 LPSSDssnsvn-----------ngsgsgMEaGRKF----------------------GF-------TID----------- 110  Drosophila mo...

XP_001958280  121 ---NME------GTLEC--VQQ-----QQQNLGV------------LGAVTFRMRIHANDDVYDTTRTKMAIAEETEKSK 172  Drosophila an...
XP_694180      85 ---SDSkdk-pqASFDC--VHQfvsgdGRDRLEG------------QGSIQDKITVCATDDSYQMTRERMSQVEKDIWSR 146  zebrafish
XP_005989805   83 ---NDSkdk-phSGFDC--IRQns-cgGQCQLGF------------LGSIQDKITICATDDSYQATRDRVTQVEKESWSR 143  coelacanth
XP_008187674   91 ---NTTdaaaprSSFEC--IRQnts----rsLEY------------VGTLNRHIRVLANDDVYEATRHRMVAVEELHKKS 149  pea aphid
XP_002116407   79 ---TLPed---rGPFECysMHQs----HSDKMIY------------EGSITTRMSIQATDEIYAKTKIKMEKAEEERKES 136  Trichoplax ad...
XP_001623286  144 ikkSSTgda-rqFQFGC----StlqslGHGCLDClhqpgrgttlqsLGSITHKINICATDDSYTMTRDRMKEAEEERKEI 218  starlet sea a...
NP_741375     134 ---TVPe-------------QTdtlvhSGGGVRN------------VGTYKTKYQIQATDRSFQETKKRAELRAEVEKSR 185  Caenorhabditi...
EHJ71272       86 ---SNAemegpqGSFEC--VRSg----GAKRLES------------CGPLPRRMRVQANDDSYEATKDRMSRTIAAEQSK 144  monarch butte...
XP_002085554  116 ---NME------GTLEC--VQQ-----QQRNLGV------------LGAVTLRMRIHANDDVYDSTRTKMAIAEETEKSK 167  Drosophila si...
XP_002008740  111 ---DLE------GTLEC--IQQ-----QQQELDV------------LGALARRMRIHANDDVYDTTRSKMARVEETEKSK 162  Drosophila mo...

XP_001958280  173 CIREIKPN--Q--SDIGRKV---K-----KPPsmmsssnnnnnnnnassfssfnsssansgsmttttafhhhnnnnnnsg 240  Drosophila an...
XP_694180     147 SAIEIKPG--S--TRPSKCVk-iK-----KK------------------------------------------------- 167  zebrafish
XP_005989805  144 TAIEIKPG--A--TYRSKGVnvaK-----KPG------------------------------------------------ 166  coelacanth
XP_008187674  150 CTREIELDs-K--SALSRKIr--K-----NPA------------------------------------------------ 171  pea aphid
XP_002116407  137 RAKLVNPVskA--TKGGRNK---S-----KPVl----------------------------------------------- 159  Trichoplax ad...
XP_001623286  219 RSKLIKT---P--NKGGK-----K-----RPP------------------------------------------------ 235  starlet sea a...
NP_741375     186 GTKQMKKS--GvtSSSSRYHn-sS-----NST------------------------------------------------ 209  Caenorhabditi...
EHJ71272      145 CTRVIKPN--Q--TDIGRRVkvrScgfsnGPAaqlaarleraerperperperaerperrlaglaglaglaglaperper 220  monarch butte...
XP_002085554  168 CIREIKPN--Q--SDIGRKV---K-----KPPttiqssastasafsssnssnsgltttafhhhsncnnsgnnnnsissfn 235  Drosophila si...
XP_002008740  163 CIREIKPN--Q--SDIGRKV---K-----KPAsasshhsgnnnsnnnssnsnsfnsnnsrklvsspfngl---------- 220  Drosophila mo...

XP_001958280  241 innnnnsssnsfnnnnnnnnhsrklasspfnglgvgmgggsnsatnsasssinsssaaaaayssrspnpsmlgasgtvng 320  Drosophila an...
XP_694180         --------------------------------------------------------------------------------      zebrafish
XP_005989805      --------------------------------------------------------------------------------      coelacanth
XP_008187674      --------------------------------------------------------------------------------      pea aphid
XP_002116407      --------------------------------------------------------------------------------      Trichoplax ad...
XP_001623286      --------------------------------------------------------------------------------      starlet sea a...
NP_741375         --------------------------------------------------------------------------------      Caenorhabditi...
EHJ71272      221 pe------------------------------------------------rqdrperqewperperqerperperperqe 252  monarch butte...
XP_002085554  236 sfnsn-----------------------------------------nhsrklgsspfnglgvgssssssafasrspnpst 274  Drosophila si...
XP_002008740  221 --------------------------------------------------------------tsssvataatavaaaats 238  Drosophila mo...

XP_001958280  321 ttgggggryhhqyhggagaGAASSLAStfasg-isqgyN-------MSG------------------------SSPRDSa 368  Drosophila an...
XP_694180     168 -------------------QSLSASFD-----------S-------TNK------------------------HSPSN-- 184  zebrafish
XP_005989805  167 -------------------LCSISKGL-----------N-------FRK------------------------SSPASP- 184  coelacanth
XP_008187674  172 -------------------QIRANRHN-----------NnsynnvnITN------------------------NVPKPI- 196  pea aphid
XP_002116407  160 -------------------LRPTRTIP-----------A-------SKP------------------------LLP---- 174  Trichoplax ad...
XP_001623286  236 -------------------NKRTNLIM-----------N-------MKR------------------------SMQNQP- 253  starlet sea a...
NP_741375     210 -------------------PRSMNSAP-----------N-------SSRvspsfmssssskastshvttnnskGTPNN-- 250  Caenorhabditi...
EHJ71272      253 rperververpapaprpqpPAPVAAPP-----------H-------TQP------------------------QRPPPN- 289  monarch butte...
XP_002085554  275 lgasgtvngsgvgggryggGAASSLAStfangisqgynN-------LSG------------------------SSPRDSm 323  Drosophila si...
XP_002008740  239 iasrspnpnilgasgtvngSRSTALANtfang-isqgyA-------LSG------------------------SSPRDSn 286  Drosophila mo...

XP_001958280  369 qgqmsggangr---------srmasgggnatGASS------RSannks--------sggnKMSEVSRRNIRERLVHLLAL 425  Drosophila an...
XP_694180     185 -----------------------------------------KRn---------------gGPSLVTHRPLRERVIHILAL 208  zebrafish
XP_005989805  185 -------------------------------TQMP------KKa---------------aATSTLTHRALRERLIHLLAL 212  coelacanth
XP_008187674  197 -------------------------------ISKPipphipLPt---------------nHASDISKKPLRDRIIHLLAL 230  pea aphid
XP_002116407  175 ----------------------------------S------RSt---------------nYVTTSSNKPYKDRVIHYLAI 199  Trichoplax ad...
XP_001623286  254 ------------------------------------------------------------KLSNGASKSLRERVLHLLAI 273  starlet sea a...
NP_741375     251 -------------------------------GSES------KKi---------------dMTPQLMKHSIKKRIIHLIVT 278  Caenorhabditi...
EHJ71272      290 --------------------------------------------------------------PDLTRRPLKERLIQLLAL 307  monarch butte...
XP_002085554  324 tagtsgatassaissrnkmpsggltssnsnsSSSS------RSannks--------sggnKMSDVSRRNIRERLIHLLAL 389  Drosophila si...
XP_002008740  287 sttagtvagtalgg---sfnsngrnkmlngsGSNS------RSgntksggangngggngnKMSDVSRRSIRERLIHLLAL 357  Drosophila mo...

XP_001958280  426 KAFKKPE-LFARLKNEG-I-RDRER-NQITNILMDISTM--SHNTYNLRRQMWNDVDEN-WPFFSEQELQQLKRRKPQ 496  Drosophila anan...
XP_694180     209 KPYSKPE-LLLWLEREK-A-SPKDK-ADLSPVLDEVAKLnpKEHSFTLKDDFYRHVRKD-WPGYVEEERQLIQRVLAR 281  zebrafish
XP_005989805  213 KPFRKPE-LILWLEREG-A-HPRDK-TELPSLLDEVAKLnpKENSYSLKEELYRLVQTD-WPGYSKEDrqllhrlllr 285  coelacanth
XP_008187674  231 RPYKKPE-LISILNRDG-L-KDKDR-TQIMSVLSHVAQa--KDNAYYLLRHIWNEVQED-WPFYSSQDHIVLKRRKPQ 301  pea aphid
XP_002116407  200 QPLNKLE-LLTRLHKDGrA-NKKDT-NRLGSILKEVAVM--KNNKFYLHKHLYSEVQVDkFSSYTENDKRLValnisk 272  Trichoplax adha...
XP_001623286  274 RPYKKPE-LILRLRKDG-V-ILKDK-NTLTNLLQQVATIs--NNQYTLMKHIYAEVQDT-WPCYTDEERKVVQRKLkp 344  starlet sea ane...
NP_741375     279 QKYSNWEeVYKKLKSDG-LpEEKDEiEKIRSCVEEVSETrpEMSVMSLRTSFLSEVDQR-WMFFNQEEKSHVRRLcns 354  Caenorhabditis ...
EHJ71272      308 KPFKKPE-LYARLISEG-I-KEKER-SMVNKILPEIGTL--KDNCYHLRRHIWNDVNED-WPFYTEEEKHMLKRRKPQ 378  monarch butterfly
XP_002085554  390 KAFKKPE-LFARLKNEG-I-RDRER-NQITNILMDISTM--SHNTYNLRRQMWNDVDEN-WPFFSEQEVQQLKRRKPQ 460  Drosophila simu...
XP_002008740  358 KPFKKPE-LYARLKNEG-I-KDRER-NLIGNILTDISTM--SHNTFNLRRQMWNDVDEN-WPFFSEQELQQLKRRKPQ 428  Drosophila moja...
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